Since the Second World War, the Middle East has been mentioned in connection with the national interest of America manifested by US presidents. This paper looks at the US foreign policy in the Middle East from Truman to Clinton on the premise that the US foreign policy has contributed to creating a breeding ground for dissatisfaction toward the US In this context, the paper focuses on the doctrines in use from the time of President Truman to Clinton. Thus, every American president has a doctrine, and this doctrine tells what political line the president follows regarding domestic and foreign policies. Keywords: Middle-East, Israel, US national interest, Soviet Union, Natural resources, ideologies.