scholarly journals Relationship between circadian changes in ST elevation in daily life and occurrence of ventricular fibrillation in Brugada syndrome

2005 ◽  
Vol 25 (Suppl4) ◽  
pp. 75-80
Author(s):  
Koichi Mizumaki ◽  
Akira Fujiki ◽  
Masao Sakabe ◽  
Kunihiro Nishida ◽  
Takayuki Tsuneda ◽  
...  
Keyword(s):  
Ventricular Fibrillation ◽  
Brugada Syndrome ◽  
Daily Life ◽  
Circadian Changes ◽  
St Elevation

Abstract 1829: Circadian Changes in ST-RR and QT-RR Relationships During Daily Life of Patients with Brugada Syndrome

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Koichi Mizumaki ◽  
Akira Fujiki ◽  
Kunihiro Nishida ◽  
Takayuki Tsuneda ◽  
Tamotsu Sakamoto ◽  
...  
Keyword(s):  
Brugada Syndrome ◽  
Qt Interval ◽  
Daily Life ◽  
Type I ◽  
Circadian Changes ◽  
Rate Dependent ◽  
Asymptomatic Patients ◽  
Abnormal Rate ◽  
Late Evening ◽  
St Elevation

In patients with Brugada syndrome, abnormal rate-dependent repolarization dynamics has been proposed as a modulating factor of arrhythmogenesis. In the present study, we assessed the hypothesis that circadian changes in both ST-RR and QT-RR relationship could relate to occurrence of ventricular fibrillation (VF) in daily life of patients with Brugada syndrome. Methods: Thirty-five male patients with Brugada syndrome who had the type I ST elevation were categorized into 14 symptomatic (with documented VF or syncope) and 21 asymptomatic groups. Unipolar V 2 and V 5 leads digital Holter ECG was recorded, and ST level in V 2 and QT interval in V 5 were automatically measured. Both ST-RR and QT-RR relationships were evaluated by means of ST-RR and QT-RR linear regression lines according to four 6-hour periods. In all 14 symptomatic patients, the time of spontaneous episodes of VF were investigated from the implantable cardioverter defibrillator stored data. Results: In symptomatic patients, ST-RR slope was highest during 18:00–24:00 and was lowest during 0:00 – 6:00; however, these circadian changes were blunted in asymptomatic patients. ST-RR intercept was not different between the 2 groups and didn’t show distinct circadian changes in both groups. The QT-RR slope was always lower, except during 6:00–12:00, in symptomatic patients than in asymptomatic patients. Circadian changes in QT-RR relationship were not evident in both groups. QT-RR intercept was not different between the 2 groups and didn’t show distinct circadian changes in both groups. Nineteen (59%) of total 32 episodes of spontaneous VF of 14 symptomatic patients occurred between 18:00 and 24:00, and 9 episodes (28%), between 0:00 and 6:00. VF seldom occurred during the daytime. Conclusions: In symptomatic patients with Brugada syndrome, a combination of augmentation of ST elevation with inhibited prolongation of QT interval during bradycardia could relate to an occurrence of VF in the late evening. Circadian Changes in ST-RR and QT-RR Slopes

Importance of thorough investigation in a patient presenting with recurrent collapse and ST elevation

2021 ◽  
Vol 14 (2) ◽  
pp. e238057
Author(s):  
Georgia May Connolly ◽  
Eva Sammut ◽  
Alexander Carpenter ◽  
Ashley Nisbet
Keyword(s):  
Ventricular Fibrillation ◽  
Brugada Syndrome ◽  
St Elevation

There is increasing literature to suggest numerous subgroups of Brugada syndrome (BrS), including those with ST elevation in the lateral or inferior leads. We present a case of a patient presenting with recurrent collapse and inferior ST elevation degenerating to ventricular fibrillation and ultimately leading to a diagnosis of BrS.

scholarly journals The appearance of regional ST elevation after the defibrillation of ventricular fibrillation in the Brugada syndrome patient with coronary vasospasm

2008 ◽  
Vol 28 (Suppl4) ◽  
pp. 37-40
Author(s):  
Koji Fukuda ◽  
Koji Kumagai ◽  
Yuji Wakayama ◽  
Yoshinao Sugai ◽  
Masanori Hirose ◽  
...  
Keyword(s):  
Ventricular Fibrillation ◽  
Brugada Syndrome ◽  
Coronary Vasospasm ◽  
Syndrome Patient ◽  
St Elevation

Vagal Activity Modulates Spontaneous Augmentation of ST Elevation in the Daily Life of Patients with Brugada Syndrome

2004 ◽  
Vol 15 (6) ◽  
pp. 667-673 ◽  
Author(s):  
KOICHI MIZUMAKI ◽  
AKIRA FUJIKI ◽  
TAKAYUKI TSUNEDA ◽  
MASAO SAKABE ◽  
KUNIHIRO NISHIDA ◽  
...  
Keyword(s):  
Brugada Syndrome ◽  
Daily Life ◽  
Vagal Activity ◽  
St Elevation

Seasonal and circadian distributions of ventricular fibrillation in patients with Brugada syndrome

Heart Rhythm ◽  
2008 ◽  
Vol 5 (11) ◽  
pp. 1523-1527 ◽  
Author(s):  
Masateru Takigawa ◽  
Takashi Noda ◽  
Wataru Shimizu ◽  
Koji Miyamoto ◽  
Hideo Okamura ◽  
...  
Keyword(s):  
Ventricular Fibrillation ◽  
Brugada Syndrome
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