scholarly journals The incidence and risk factors of bronchopulmonary dysplasia in extremely preterm infants included in the Polish National Program for Respiratory Syncytial Virus Prophylaxis

2021 ◽  
Author(s):  
Róża Borecka ◽  
Ryszard Lauterbach
Keyword(s):  
Risk Factors ◽  
Respiratory Syncytial Virus ◽  
Birth Weight ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia ◽  
Oxygen Therapy ◽  
National Program ◽  
Extremely Preterm ◽  
Extremely Preterm Infants ◽  
Syncytial Virus

IntroductionBronchopulmonary dysplasia (BPD) is a chronic lung disease diagnosed in premature infants, which may cause severe respiratory failure due to respiratory syncytial virus (RSV) infection. The aim of this study was to assess the incidence and severity of BPD in infants born before 28 weeks of gestational age (GA) enrolled into the Polish National Program for RSV Prophylaxis (PNPRSVP).Material and methodsA retrospective analysis of data on children born in 2013 included in a prophylaxis program during the seasons 2012–2013 and 2013–2014. The following data were evaluated: the need for oxygen therapy for at least 28 days and the need for oxygen therapy at 36 weeks of postmenstrual age (PMA).ResultsThe analysis was carried out in a group of 603 children, who constituted 87.7% of the population entitled to prophylactic administration of palivizumab. BPD was diagnosed in 80.9% of extremely preterm infants; however, in 70.7% of cases the disease was mild. The risk factors for the development of BPD were GA, birth weight and birth weight below the 10th centile for GA. During the program, the median number of doses received was 5 (range 1–5), and 82.3% of children received all of the expected doses.ConclusionsAlthough the incidence of BPD in extremely preterm infants was high, mainly its mild form was recognized. Monitoring of the incidence of the disease and identifying the risk factors can be carried out effectively based on long-term data collected during the PNPRSVP.

scholarly journals Risk Factors Associated with Retinopathy of Prematurity in Very and Extremely Preterm Infants

Medicina ◽  
2021 ◽  
Vol 57 (5) ◽  
pp. 420
Author(s):  
Claudia Ioana Borțea ◽  
Florina Stoica ◽  
Marioara Boia ◽  
Emil Radu Iacob ◽  
Mihai Dinu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Preterm Infants ◽  
Gestational Age ◽  
Retinopathy Of Prematurity ◽  
Univariate Analysis ◽  
Significant Risk ◽  
Extremely Preterm ◽  
Extremely Preterm Infants ◽  
Surfactant Administration ◽  
Stage 1

Background and Objectives: Retinopathy of prematurity (ROP) is the leading cause of blindness in preterm infants. We studied the relationship between different perinatal characteristics, i.e., sex; gestational age (GA); birth weight (BW); C-reactive protein (CRP) and lactate dehydrogenase (LDH) concentrations; ventilation, continuous positive airway pressure (CPAP), and surfactant administration; and the incidence of Stage 1–3 ROP. Materials and Methods: This study included 247 preterm infants with gestational age (GA) < 32 weeks that were successfully screened for ROP. Univariate and multivariate binary analyses were performed to find the most significant risk factors for ROP (Stage 1–3), while multivariate multinomial analysis was used to find the most significant risk factors for specific ROP stages, i.e., Stage 1, 2, and 3. Results: The incidence of ROP (Stage 1–3) was 66.40% (164 infants), while that of Stage 1, 2, and 3 ROP was 15.38% (38 infants), 27.53% (68 infants), and 23.48% (58 infants), respectively. Following univariate analysis, multiple perinatal characteristics, i.e., GA; BW; and ventilation, CPAP, and surfactant administration, were found to be statistically significant risk factors for ROP (p < 0.001). However, in a multivariate model using the same characteristics, only BW and ventilation were significant ROP predictors (p < 0.001 and p < 0.05, respectively). Multivariate multinomial analysis revealed that BW was only significantly correlated with Stage 2 and 3 ROP (p < 0.05 and p < 0.001, respectively), while ventilation was only significantly correlated with Stage 2 ROP (p < 0.05). Conclusions: The results indicate that GA; BW; and the use of ventilation, CPAP, and surfactant were all significant risk factors for ROP (Stage 1–3), but only BW and ventilation were significantly correlated with ROP and specific stages of the disease, namely Stage 2 and 3 ROP and Stage 2 ROP, respectively, in multivariate models.

scholarly journals Respiratory morbidity of preterm infants of less than 33 weeks gestation without bronchopulmonary dysplasia: a 12-month follow-up of the CASTOR study cohort

2013 ◽  
Vol 142 (7) ◽  
pp. 1362-1374 ◽  
Author(s):  
B. FAUROUX ◽  
J.-B. GOUYON ◽  
J.-C. ROZE ◽  
C. GUILLERMET-FROMENTIN ◽  
I. GLORIEUX ◽  
...  
Keyword(s):  
Risk Factors ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia ◽  
Respiratory Morbidity ◽  
Study Cohort ◽  
Recurrent Wheezing ◽  
Term Infants ◽  
Independent Risk Factors ◽  
Syncytial Virus

SUMMARYThe aim of this study was to describe the incidence and risk factors for respiratory morbidity during the 12-month period following the first respiratory syncytial virus (RSV) season in 242 preterm infants [<33 weeks gestational age (GA)] without bronchopulmonary dysplasia and 201 full-term infants (39–41 weeks GA) from the French CASTOR study cohort. Preterm infants had increased respiratory morbidity during the follow-up period compared to full-terms; they were more likely to have wheezing (21% vs. 11%, P = 0·007) and recurrent wheezing episodes (4% vs. 1%, P = 0·049). The 17 infants (14 preterms, three full-terms) who had been hospitalized for RSV-confirmed bronchiolitis during their first RSV season had significantly more wheezing episodes during the follow-up period than subjects who had not been hospitalized for RSV-confirmed bronchiolitis (odds ratio 4·72, 95% confidence interval 1·71–13·08, P = 0·003). Male gender, birth weight <3330 g and hospitalization for RSV bronchiolitis during the infant's first RSV season were independent risk factors for the development of wheezing episodes during the subsequent 12-month follow-up period.

Bubbly and cystic appearance on chest radiograph of extremely preterm infants with bronchopulmonary dysplasia is associated with wheezing disorder

2019 ◽  
Vol 109 (4) ◽  
pp. 711-719
Author(s):  
Hirokazu Arai ◽  
Masato Ito ◽  
Tomoo Ito ◽  
Syozo Ota ◽  
Tsutomu Takahashi ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Bronchopulmonary Dysplasia ◽  
Chest Radiograph ◽  
Extremely Preterm ◽  
Extremely Preterm Infants

Duration of significant patent ductus arteriosus and bronchopulmonary dysplasia in extremely preterm infants

2019 ◽  
Vol 39 (12) ◽  
pp. 1648-1655 ◽  
Author(s):  
Hussnain Mirza ◽  
Jorge Garcia ◽  
Genevieve McKinley ◽  
Laura Hubbard ◽  
Wendla Sensing ◽  
...  
Keyword(s):  
Patent Ductus Arteriosus ◽  
Preterm Infants ◽  
Bronchopulmonary Dysplasia ◽  
Ductus Arteriosus ◽  
Extremely Preterm ◽  
Extremely Preterm Infants ◽  
Patent Ductus

scholarly journals The coagulation system of extremely preterm infants: influence of perinatal risk factors on coagulation

2011 ◽  
Vol 32 (11) ◽  
pp. 869-873 ◽  
Author(s):  
C Poralla ◽  
C Traut ◽  
H-J Hertfelder ◽  
J Oldenburg ◽  
P Bartmann ◽  
...  
Keyword(s):  
Risk Factors ◽  
Preterm Infants ◽  
Coagulation System ◽  
Perinatal Risk Factors ◽  
Perinatal Risk ◽  
Extremely Preterm ◽  
Extremely Preterm Infants
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