scholarly journals A Review on Protective Action of Herbal Drugs Against Fall-Off Libido Due to Chronic Use of Β-Blockers(Propranolol)

2021 ◽  
Vol 23 (09) ◽  
pp. 1225-1232
Author(s):  
Mr. Himanshu A ◽  
◽  
Shingade ◽  
Miss. Janhavi J. Pawar ◽  
Dr. Nilofar. S. Naikwade ◽  
...  
Keyword(s):  
Side Effects ◽  
Medicinal Plants ◽  
Protective Action ◽  
Sex Therapy ◽  
Sexual Disorders ◽  
Herbal Drugs ◽  
Synthetic Compound ◽  
Β Blockers ◽  
Loss Of Libido ◽  
Chronic Use

From the ancient times human have always tried to correct the sex related problems from various herbal medicinal plants and their extracts with various dosage forms. The history of sex therapy is very old and herbal drugs have been the great reliever as the sex therapy from the evolution of human. Instead of the current scenario with the synthetic compounds the herbal drugs are far more safe and comparatively effective without any serious side effects. Antihypertensives such as β-blockers can cause the side effects which are responsible for the diminished quality of life. The chronic use of such drugs can be more fatal in some cases than their actual gain. Several sexual problems can occur such as erectile dysfunction , loss of libido, ejaculation disorders etc. The phytochemicals found in the plants which are having aphrodisiac properties shows sildenafil like effect on human body without the side effects of synthetic compound. The pharmaceutically active compounds found in natural aphrodisiacs such as flavonoids , saponins, free amino acids and vitamins are known to be libido enhancer and hence useful in treating sexual disorders. The natural aphrodisiacs can be derived from any source including medicinal plants , vegetables, flowers ,roots or fruits and their pharmacological potential varies as per the part of the plant used. The target of this review article is to deliver information about medicinal plants for the protective action against fall-off libido due to chronic use of β-blockers and to investigate for further secondary phytochemicals for aphrodisiac potential.

Herbal medicines for diabetes management and its secondary complications

2020 ◽  
Vol 16 ◽  
Author(s):  
Shubham Kumar ◽  
Anu Mittal ◽  
Dinesh Babu ◽  
Amit Mittal
Keyword(s):  
Side Effects ◽  
Medicinal Plants ◽  
Diabetes Management ◽  
Tyrosine Phosphatase ◽  
World Health ◽  
High Tech ◽  
Herbal Drugs ◽  
Secondary Complications ◽  
The World ◽  
Treatment Of Diabetes

: Diabetic Mellitus (DM) is a metabolic disorder that has attracted worldwide concern. DM is caused due to lack of insulin or ineffective production of insulin in the pancreas. A total of 463 million people have diabetes mellitus in 2019 and it was predictedto raise upto 578 million by 2030 and 700 million by 2045. High blood sugar gives rise to many complications like diabetic retinopathy, diabetic nephropathy, atherosclerosis, hypercoagulability, cardiovascular disease, coronary heart disease, abdominal obesity, hypertension, hyperlipidemia, cerebrovascular disease, coronary artery disease, foot damage, skin complications, Alzheimer’s disease, hearing impairment, and depression. These life-threatening complications make diabetes more severe than other diseases. Many synthetic drugs are developed, but still cure is not provided by any of the molecules up to this date. Continuous use of some synthetic agents caused many severe side effects, and thus the demands for non-toxic, affordable drugs are still awaited. Traditional treatments have been an extremely valued source of medicine all over the human history. These are extensively used throughout the world indicating that herbs are a growing part of modern and high-tech medicines. The World Health Organization (WHO) has listed a total of 21,000 plants, which are used for medicinal purposes around the world, among them more than 400 plants are available for the treatment of diabetes. Despite the fact that there are many herbal drugs are available for treating diabetes, only a small number of these plants have received scientific and medical evaluation to assess their efficacy. Trigonella foenum-graecum, Allium sativum, Caesalpinia bonduc, Ferrulaassafoetida, etc., are some of the medicinal plants used for antidiabetic therapy. The presence of phenolic compounds, flavonoids, terpenoids and coumarins are responsible for the antidiabetic nature of the medicinal plants. These constituents have shown a reduction in blood glucose levels. Picnogenol, acarbose, miglitol, and voglibose are some of the examples of marketed drugs, which are obtained from the natural origin and used as antidiabetic drugs. The active principles derived from the plants work through many antidiabetic mechanisms, which include inhibition of α-glucosidase, α-amylase, and protein tyrosine phosphatase 1B activities. One of the major advantages of herbal drugs is the low level of side effects attributed to these medicines, and this attracted the various researchers to develop new molecules for treatment of diabetes. In this review, emphasis will be given on the recent advances in the field of herbal drugs to treat diabetes, to prevent the secondary complications arising due to diabetes, and various herbal molecules in different stages of clinical trials.

scholarly journals Indian Medicinal Plants with Antidiabetic Potential

2019 ◽  
Vol 9 (1) ◽  
pp. 257-265 ◽  
Author(s):  
Abu Sufiyan Chhipa ◽  
S.S. Sisodia
Keyword(s):  
Diabetes Mellitus ◽  
Side Effects ◽  
General Population ◽  
Medicinal Plants ◽  
Hypoglycemic Activity ◽  
Herbal Drugs ◽  
Disease Treatment ◽  
Drug Candidates ◽  
Indian Medicinal Plants

Medicinal plants should be evaluated extensively to determine the active principles present in them that are responsible for the hypoglycemic activity of these plants. Herbal drugs have gained popularity among the general population due to their ability to treat ailments with minimum side effects. The multi-target approaches of medicinal plants make them least susceptible to failure during the treatment therapy. Medicinal plants showing prominent anti-diabetic activity during the initial studies should be further explored to identify the active principles present in them that can become the promising drug candidates for the disease treatment in the coming future. Keywords: Anti-diabetic, Diabetes Mellitus, Insulin, hypoglycemic, anti-hyperglycemic, anti-hyperlipidemic  

scholarly journals Expanding the arsenal against Huntington's disease- Herbal drugs and their nanoformulations

2020 ◽  
Vol 18 ◽  
Author(s):  
Sukriti Vishwas ◽  
Monica Gulati ◽  
Bhupinder Kapoor ◽  
Saurabh Gupta ◽  
Sachin Kumar Singh ◽  
...  
Keyword(s):  
Side Effects ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Genetic Disease ◽  
Drug Solubility ◽  
Herbal Drugs ◽  
Neuroprotective Effects ◽  
Brain Barrier Permeability ◽  
Chronic Use

: Huntington’s disease (HD) is an autosomal fatal genetic disease in which degeneration of neuronal cells occurs in central nervous system (CNS). Commonly used therapeutics in cludemonoamine depletors, antipsychotics, antidepressants, and tranquilizers. However, these drugs cannot prevent the psychotic, cognitive and behavioral dysfunctions associated with HD. In addition to this, their chronic use is limited by their long-term side effects. Herbal drugs offer a plausible alternative to this and have shown substantial therapeutic effect against HD. Moreover, their safety profile is better in terms of side effects. However, due to limited drug solubility and permeability to reach the target site, herbal drugs have not been able to reach the stage of clinical exploration. In recent years, the paradigm of research has been shifted towards development of herbal drugs based nanoformulations that can enhance their bioavailability and blood-brain barrier permeability. The present review covers the pathophysiology of HD, available biomarkers, phytomedicines explored against HD, ongoing clinical trials on herbal drugs exclusively for treating HD and their nanocarriers along with their potential neuroprotective effects.

Application of Some Herbal Medicine Used for the Treatment of Osteoarthritis and Chondrogenesis

2020 ◽  
Author(s):  
Morteza Anvari ◽  
Hengameh Dortaj ◽  
Batool Hashemibeni ◽  
Majid Pourentezari
Keyword(s):  
Rheumatoid Arthritis ◽  
Low Back Pain ◽  
Back Pain ◽  
Side Effects ◽  
Herbal Medicine ◽  
Medicinal Plants ◽  
Herbal Medicines ◽  
Low Back ◽  
Herbal Drugs ◽  
Efficacy And Safety

Rheumatic diseases such as osteoarthritis (OA), rheumatoid arthritis (RA), and low back pain are very popular. The drugs available to treat these diseases are almost ineffective and have significant side effects. There are several approaches used to replace conventional drugs to treat these diseases. One of these methods is the use of herbal medicines. In this study, the effects of herbal medicines and medicinal plants used in the treatment of these diseases include. Searching for articles published in English from 1985 to 2020 using keywords include scientific and traditional names of plants reviewing Scopus and PubMed databases. There is limited research on the anti-rheumatic effects of these plants and the active ingredients. Therefore, further research is needed to determine the mechanism of action, the interaction of effects, the efficacy and safety of medicinal plants, and the potentially beneficial plant nutrients in treatment of these diseases seems necessary. The aim of this review was to update information on OA and chondrogenesis, also importance of herbal drugs for the management of arthritis.

Ethnoveterinary uses of medicinal plants as herbal drugs for sustainable livestock in southern deserts of Sindh Pakistan

2020 ◽  
Vol 53 (2) ◽  
Author(s):  
Amir Hussain ◽  
Muhammad Zafar ◽  
Shehla Shinwari ◽  
Zabta Khan Shinwari ◽  
Mushtaq Ahmad ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Herbal Drugs

Current Status and Future Perspective for Research on Medicinal Plants with Anticancerous Activity and Minimum Cytotoxic Value

2019 ◽  
Vol 20 (12) ◽  
pp. 1227-1243
Author(s):  
Hina Qamar ◽  
Sumbul Rehman ◽  
D.K. Chauhan
Keyword(s):  
Side Effects ◽  
Medicinal Plants ◽  
Anticancer Agents ◽  
Drug Targets ◽  
Psidium Guajava ◽  
Current Status ◽  
Future Perspective ◽  
Wide Range

Cancer is the second leading cause of morbidity and mortality worldwide. Although chemotherapy and radiotherapy enhance the survival rate of cancerous patients but they have several acute toxic effects. Therefore, there is a need to search for new anticancer agents having better efficacy and lesser side effects. In this regard, herbal treatment is found to be a safe method for treating and preventing cancer. Here, an attempt has been made to screen some less explored medicinal plants like Ammania baccifera, Asclepias curassavica, Azadarichta indica, Butea monosperma, Croton tiglium, Hedera nepalensis, Jatropha curcas, Momordica charantia, Moringa oleifera, Psidium guajava, etc. having potent anticancer activity with minimum cytotoxic value (IC50 >3μM) and lesser or negligible toxicity. They are rich in active phytochemicals with a wide range of drug targets. In this study, these medicinal plants were evaluated for dose-dependent cytotoxicological studies via in vitro MTT assay and in vivo tumor models along with some more plants which are reported to have IC50 value in the range of 0.019-0.528 mg/ml. The findings indicate that these plants inhibit tumor growth by their antiproliferative, pro-apoptotic, anti-metastatic and anti-angiogenic molecular targets. They are widely used because of their easy availability, affordable price and having no or sometimes minimal side effects. This review provides a baseline for the discovery of anticancer drugs from medicinal plants having minimum cytotoxic value with minimal side effects and establishment of their analogues for the welfare of mankind.

Antipyretic Plants: An Updated Review

2020 ◽  
Vol 16 (1) ◽  
pp. 4-12
Author(s):  
Vandana Garg ◽  
Rohit Dutt
Keyword(s):  
Side Effects ◽  
Body Temperature ◽  
Medicinal Plants ◽  
Inflammatory Mediators ◽  
Review Paper ◽  
The Body ◽  
Hypothalamic Area ◽  
Antipyretic Activity ◽  
Disease States ◽  
Elevated Body Temperature

Background: Fever, is known as pyrexia, may occur due to infection, inflammation, or any tissue damage and disease states. Normally, the infected or damaged tissue initiates the enhanced formation of pro-inflammatory mediators like cytokines which further increases the synthesis of prostaglandin E2 (PgE2) near the hypothalamic area and thereby trigger the hypothalamus to elevate the body temperature. Objective: Antipyretics are the agents which reduce the elevated body temperature. The most commonly used antipyretic agent, paracetamol, may be fatal due to its side effects. Methods: In this review paper, Chemical Abstracts, Google Scholar, PubMed, and Science Direct were the sources for the published article to collect information regarding antipyretic activity. Results: This review compiles the antipyretic plants that may be useful to treat fever due to various diseases. Conclusion: These medicinal plants could be good alternatives for traditional allopathic antipyretics.

scholarly journals Ameliorative effect of Allium atroviolaceum on sperm quality in cyclophosphamide-treated mice

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Alireza Hosseini ◽  
Mehrdad Shahrani ◽  
Shirin Asgharian ◽  
Maryam Anjomshoa ◽  
Ayoob Rostamzadeh ◽  
...  
Keyword(s):  
Side Effects ◽  
Alkylating Agent ◽  
Sperm Quality ◽  
Sperm Count ◽  
Reproductive Toxicity ◽  
Herbal Drugs ◽  
Sperm Viability ◽  
Complementary Treatment ◽  
Ameliorative Effect ◽  
Alternative Drugs

Abstract Background Cyclophosphamide (CP) is an anti-neoplastic alkylating agent that is extensively used in different chemotherapy regimens. Adverse effects on the reproductive system, especially spermatogenesis, are one of the most important side effects of this drug. It is medically essential to use complementary and alternative drugs. Herbal drugs have long been used as a complementary treatment. Our purpose was to study the effect of hydroalcoholic Allium atroviolaceum L. extract on spermatogenesis in CP-treated mice. Results CP affected a significant decrease in sperm count, motility, viability, and morphology. Sperm count was significantly higher in the all extract groups than in the group of control (p<0.001) and CP group (p<0.001, p<0.01). Sperm motility was significantly greater in the extract (100 and 200mg/kg) groups than in the group of control (p<0.05 and <0.001). Sperm immotility and rotational movement were significantly higher in the CP group than in the CP+extract groups (p<0.001). The sperm viability was significantly greater in the CP+extract (200mg/kg) group than in the CP group (p<0.001). The number of headless sperm, sperm with initial tail, with coiled tail, and sperm with curved body, was significantly lower in the CP+extract (200mg/kg) group than in the CP group (p<0.001). Conclusion A. atroviolaceum extract treatment significantly improved CP-induced reproductive toxicity.

Assessment of Calendula officinal growing in Iraq

2021 ◽  
pp. 5187-5189
Author(s):  
Noor Ali ◽  
Widad M K Al-Ani ◽  
Ibrahim S. Al-Jobouri
Keyword(s):  
Side Effects ◽  
Medicinal Plants ◽  
Medicinal Plant ◽  
Prior Knowledge ◽  
Research Evaluation ◽  
Chemical Constituents ◽  
Plant Constituents ◽  
Time Of Collection

Evaluation of Iraqi medicinal plants is very crucial to help people avoid the use of herbs without prior knowledge which results in many side effects and sometimes even leads to death. The plant constituents vary according to season, weather and type of soil, therefore it is necessary to evaluate the chemical constituents and determine the time of collection of medicinal plants. In this research evaluation of the medicinal plant Calendula officinal grown in Iraq was performed by measuring the quantity of hyperoside found in the plant together with macroscopical and microscopical evaluation of the plant.

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