scholarly journals The Relationship between Helicobacter pylori Infection and Atherosclerosis: A Meta-analysis

Author(s):  
Mahdi Ramezani Binabaj ◽  
Abdolkarim Mobasher Jannat ◽  
Mahdi Safiabadi ◽  
Amin Saburi ◽  
Mohammad Saeid Rezaee Zavareh ◽  
...  
2019 ◽  
Vol 2019 ◽  
pp. 1-17 ◽  
Author(s):  
Huiqin Gao ◽  
Lunan Li ◽  
Chenjing Zhang ◽  
Jiangfeng Tu ◽  
Xiaoge Geng ◽  
...  

Background. Helicobacter pylori is an important carcinogenic factor in gastric cancer. Studies have shown that Helicobacter pylori infection is inversely associated with certain diseases such as esophageal cancer and whose infection appears to have a “protective effect.” At present, the relationship between Helicobacter pylori infection and esophageal cancer remains controversial. This study was designed to investigate the relationship between Helicobacter pylori infection and the risk of esophageal cancer in different regions and ethnicities. Methods. Systematic search of the articles on the relationship between Helicobacter pylori infection and esophageal cancer from the database with the duration time up to December 2018. This systematic review was performed under the MOOSE guidelines. Results. This meta-analysis included 35 studies with 345,886 patients enrolled. There was no significant correlation between Helicobacter pylori infection and esophageal squamous cell carcinoma in the general population (OR: 0.84; 95% CI: 0.64-1.09/OR: 0.74; 95% CI: 0.54-0.97). However, a significant correlation was found in the Middle East (OR: 0.34; 95% CI: 0.22-0.52/95% CI: 0.26-0.44). There was no significant difference in the prevalence of Helicobacter pylori between the case group and the control group in esophageal adenocarcinoma (8.87% vs. 9.67%). The pooled OR was 0.55 (95% CI: 0.43-0.70) or 0.23 (95% CI: 0.15-0.36). When grouped by match or not, the pooled OR of the nonmatching group and the matching group was 0.48/0.21 (95% CI: 0.36-0.65/95% CI: 0.13-0.36) and 0.73/0.71 (95% CI: 0.57-0.92/95% CI: 0.60-0.84), respectively. Conclusion. In the general populations, no significant association was found between Helicobacter pylori infection and the risk of esophageal squamous cell carcinoma. However, lower risk was found in the Middle East. Helicobacter pylori infection may reduce the risk of esophageal adenocarcinoma, but such “protection effect” may be overestimated.


2018 ◽  
Vol 1 (1) ◽  
pp. p43
Author(s):  
Ilija Barukcic

Objective: This study presents a systematic meta-analysis of the relationship between Helicobacter pylori (HP) infection and gastric cancer (GC). Materials and Methods: Twelve articles including 21589 subjects were selected (1237 cases and 20352 controls). These data were analyzed using the mathematical formula of the conditio sine qua non relationship and the causal relationship formula. Results: The data re-analyzed support the Null hypothesis without a Helicobacter pylori infection no human gastric cancer. The causal relationship between HP and GC is highly significant. Conclusion: Helicobacter pylori is the cause of human gastric cancer.


2003 ◽  
Vol 18 (3) ◽  
pp. 279-289 ◽  
Author(s):  
F. Cremonini ◽  
S. Di Caro ◽  
S. Delgado-Aros ◽  
A. Sepulveda ◽  
G. Gasbarrini ◽  
...  

2013 ◽  
Vol 25 (11) ◽  
pp. 1286-1294 ◽  
Author(s):  
Theodore Rokkas ◽  
Panos Sechopoulos ◽  
Dimitrios Pistiolas ◽  
Fotis Kothonas ◽  
Georgios Margantinis ◽  
...  

2016 ◽  
Vol 38 (3) ◽  
pp. 90-94
Author(s):  
Mahdi Ramezani Binabaj ◽  
Abdolkarim Mobasher Jannat ◽  
Mahdi Safiabadi ◽  
Amin Saburi ◽  
Mohammad Saeid Rezaee Zavareh ◽  
...  

2003 ◽  
Vol 124 (4) ◽  
pp. A535 ◽  
Author(s):  
Filippo Cremonini ◽  
Simona Di Caro ◽  
Silvia Delgado-Aros ◽  
Antonia Sepulveda ◽  
Giovanni Gasbarrini ◽  
...  

Author(s):  
Mohammad Zamani ◽  
Shaghayegh Alizadeh‐Tabari ◽  
Amir Hossein Hasanpour ◽  
Leonardo H. Eusebi ◽  
Alexander C. Ford

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