Protection by microRNA-7a-5p Antagomir Against Intestinal Mucosal Injury Related to the JNK Pathway in TNBS-Induced Experimental Colitis

2021 ◽  
Vol 32 (5) ◽  
pp. 431-436
Author(s):  
Bao Yin ◽  
◽  
Huang Tian-Chu ◽  
Xu Ling-Fen ◽  
◽  
...  
Keyword(s):  
Experimental Colitis ◽  
Mucosal Injury ◽  
Jnk Pathway ◽  
Intestinal Mucosal Injury

Tu1698 – Fluoropyrimidine-Induced Intestinal Mucosal Injury is Associated with the Severity of Chemotherapy-Related Diarrhea

2019 ◽  
Vol 156 (6) ◽  
pp. S-1090-S-1091
Author(s):  
Kazuhiro Ota ◽  
Toshihisa Takeuchi ◽  
Yuichi Kojima ◽  
Satoshi Harada ◽  
Noriaki Sugawara ◽  
...  
Keyword(s):  
Mucosal Injury ◽  
Intestinal Mucosal Injury

Intestinal Mucosal Injury

1981 ◽  
Vol 10 (3) ◽  
pp. 583-604
Author(s):  
WILLIAM FAIRBANK DOE
Keyword(s):  
Mucosal Injury ◽  
Intestinal Mucosal Injury

scholarly journals Protective effects of glycoglycerolipids extracted from spinach on 5-fluorouracil induced intestinal mucosal injury

2010 ◽  
Vol 57 (3,4) ◽  
pp. 314-320 ◽  
Author(s):  
Asuka Shiota ◽  
Takahiko Hada ◽  
Tomoko Baba ◽  
Minako Sato ◽  
Hisami Yamanaka-Okumura ◽  
...  
Keyword(s):  
Mucosal Injury ◽  
Protective Effects ◽  
Intestinal Mucosal Injury

scholarly journals Influence of Helicobacter pylori Infection on the Small Intestinal Mucosa

2013 ◽  
Vol 2013 ◽  
pp. 1-5
Author(s):  
Mitsunori Maeda ◽  
Masakazu Nakano ◽  
Hideyuki Hiraishi
Keyword(s):  
Helicobacter Pylori ◽  
Negative Relationship ◽  
Mucosal Injury ◽  
Enzyme Linked Immunosorbent Assay ◽  
Small Intestinal Mucosa ◽  
Significant Negative Relationship ◽  
Positive Rate ◽  
Intestinal Mucosal Injury ◽  
Small Intestinal ◽  
H Pylori

Background/Aims. To investigate the role of Helicobacter pylori infection in the development of enteritis (small intestinal mucosal injury). Methodology. Between April 2007 and January 2013, 99 patients undergoing capsule endoscopy (CE) were tested for anti-H. pylori immunoglobulin G antibody (Hp-IgG) using an enzyme-linked immunosorbent assay (ELISA). None of the patients had been treated for H. pylori infection or diagnosed as having Crohn’s disease or any other clinically apparent small intestinal disorders prior to the CE. Results. The overall Hp-IgG-positive rate was 26.3%. The incidence of enteritis, as diagnosed by CE, tended to be lower in the Hp-IgG-positive patients (23.1%) than in the Hp-IgG-negative patients (38.4%) (). When patients receiving aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs), well-known causes of enteritis, were excluded, the incidence of enteritis in the Hp-IgG-positive patients (11.7%) was significantly lower than that in the Hp-IgG-negative patients (43.7%) (). A binomial logistic regression analysis revealed a significant negative relationship between Hp-IgG positivity and the presence of enteritis in patients receiving neither aspirin nor NSAIDs (). Conclusions. Our data indicated that H. pylori positivity was inversely associated with the prevalence of enteritis.

Variable Effects of Short Chain Fatty Acids and Lactic Acid in Inducing Intestinal Mucosal Injury in Newborn Rats

2002 ◽  
Vol 35 (4) ◽  
pp. 545-550 ◽  
Author(s):  
Jing Lin ◽  
Suhas M. Nafday ◽  
Sara N. Chauvin ◽  
Margret S. Magid ◽  
Sudha Pabbatireddy ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Lactic Acid ◽  
Mucosal Injury ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Newborn Rats ◽  
Intestinal Mucosal Injury ◽  
Chain Fatty Acids

Extent and Duration of Small Intestinal Mucosal Injury in Intractable Diarrhea of Infancy

PEDIATRICS ◽  
1980 ◽  
Vol 66 (5) ◽  
pp. 730-735
Author(s):  
Thomas M. Rossi ◽  
Emanuel Lebenthal ◽  
Kenneth S. Nord ◽  
Rafiqua R. Fazili
Keyword(s):  
Elemental Diet ◽  
Mucosal Injury ◽  
Height Velocity ◽  
Common Finding ◽  
Small Intestinal Mucosa ◽  
Intractable Diarrhea ◽  
Young Infants ◽  
Intestinal Mucosal Injury ◽  
Small Intestinal

Thirty infants with intractable diarrhea of infancy (IDI) underwent small bowel biopsies in order to determine the extent and duration of small intestinal mucosal injury. The onset of the persistent diarrhea occurred prior to 3 months of age and continued for an average of 48 days prior to investigation. In 18 cases, no associated entities were found. Mucosal injury was invariably found in all 30 infants: grade IV injury in 11, grade III in eight, grade II in nine, and grade I atrophy in one. Disaccharidase activities were diminished and corresponded to the degree of atrophy. Lactase activity was diminished to a greater extent than sucrase and maltase. Significant, persistent mucosal injury existed for an average of six months in 16 of the 23 (70%) repeat biopsies. All infants were given an elemental diet (ED). Twelve of the 30 infants required parenteral nutrition (PN). These infants were gradually advanced to an oral elemental diet and maintained on this diet until histologic findings and disaccharidase levels were normal. Eighteen infants were fed and maintained on an elemental diet by mouth from time of admission until normal histologic findings and disaccharidases were found. No mortality occurred during management and follow-up. Twenty-two of the 28 infants in whom follow-up growth data were available excelled in weight and height velocity. The data suggest that prolonged injury to the small intestinal mucosa is a common finding in many cases of intractable diarrhea of infancy. Elemental diets should be started early in the course of protracted diarrhea in young infants, and may need to be continued for several months since histologic and enzymatic changes of the small intestine may persist for extended periods.

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