Multifunctional Inorganic-Organic Hybrid Resins With Polymerizable Methacrylate Groups For Biomedical Applications; Effects Of Synthesis Parameters On Polymerisation Shrinkage And Molecular Weight

2016 ◽  
Vol 7 (4) ◽  
pp. 289-295 ◽  
Author(s):  
C. Vibha
Keyword(s):  
Molecular Weight ◽  
Biomedical Applications ◽  
Organic Hybrid ◽  
Synthesis Parameters

Poly(ethylene Glycol) Diacrylate-Nanogels Synthesized by Mini-emulsion Polymerization

2019 ◽  
Vol 56 (3) ◽  
pp. 514-519
Author(s):  
Anita Laura Radu ◽  
Ana Mihaela Gavrila ◽  
Bogdan Cursaru ◽  
Catalina Paula Spatarelu ◽  
Teodor Sandu ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Ethylene Glycol ◽  
Biomedical Applications ◽  
Gel Permeation Chromatography ◽  
Poly Ethylene Glycol ◽  
Glycol Diacrylate ◽  
Synthesis Parameters ◽  
Transmission Electron ◽  
Hydrophilic Lipophilic Balance ◽  
Poly Ethylene

New nanogels (NGs) with tailored properties were obtained using a mini-emulsion technique, from poly(ethylene glycol) diacrylate (PEGDA) self-crosslinking macromers of various molecular weight. By modifying synthesis parameters (hydrophilic-lipophilic balance, emulsifier and the ratio of organic-aqueous medium), optimum recipes of NGs were selected. Therefore, the molecular weight distribution and the functionalization degree of the PEGDA2000 macromer were assessed by Gel Permeation Chromatography (GPC) and Nuclear Magnetic Resonance (NMR), respectively. Furthermore, the PEGDA-NGs were investigated by Dynamic Light Scattering (DLS) and Transmission Electron Microscopy (TEM) for size distributions and morphology. DLS and TEM results confirm that these new PEGDA-NGs hold potential for biomedical applications.

Conjugates of Classical DNA/RNA Binder with Nucleobase: Chemical, Biochemical and Biomedical Applications

2019 ◽  
Vol 26 (30) ◽  
pp. 5609-5624
Author(s):  
Dijana Saftić ◽  
Željka Ban ◽  
Josipa Matić ◽  
Lidija-Marija Tumirv ◽  
Ivo Piantanida
Keyword(s):  
Molecular Weight ◽  
Small Molecules ◽  
Biomedical Applications ◽  
Protein Targets ◽  
New Class ◽  
Rna Targets ◽  
Covalently Linked ◽  
Structural Aspects

: Among the most intensively studied classes of small molecules (molecular weight < 650) in biomedical research are small molecules that non-covalently bind to DNA/RNA, and another intensively studied class is nucleobase derivatives. Both classes have been intensively elaborated in many books and reviews. However, conjugates consisting of DNA/RNA binder covalently linked to nucleobase are much less studied and have not been reviewed in the last two decades. Therefore, this review summarized reports on the design of classical DNA/RNA binder – nucleobase conjugates, as well as data about their interactions with various DNA or RNA targets, and even in some cases protein targets are involved. According to these data, the most important structural aspects of selective or even specific recognition between small molecule and target are proposed, and where possible related biochemical and biomedical aspects were discussed. The general conclusion is that this, rather new class of molecules showed an amazing set of recognition tools for numerous DNA or RNA targets in the last two decades, as well as few intriguing in vitro and in vivo selectivities. Several lead research lines show promising advancements toward either novel, highly selective markers or bioactive, potentially druggable molecules.

Optimizing the Cu-RDRP ofN-(2-hydroxypropyl) methacrylamide toward biomedical applications

2019 ◽  
Vol 10 (5) ◽  
pp. 564-568 ◽  
Author(s):  
Vladimír Raus ◽  
Libor Kostka
Keyword(s):  
Molecular Weight ◽  
Biomedical Applications ◽  
Hydroxypropyl Methacrylamide

Aqueous Cu-RDRP ofN-(2-hydroxypropyl) methacrylamide was optimized to achieve co(polymers) of low dispersity and controlled molecular weight at high conversions.

Production of oxygen-15, nitrogen-13 and carbon-11 and of their low molecular weight derivatives for biomedical applications

1979 ◽  
Vol 30 (9) ◽  
pp. 543-549 ◽  
Author(s):  
Guy Del Fiore ◽  
Jean-Claude Depresseux ◽  
P. Bartsch ◽  
Lino Quaglia ◽  
Jean-Marie Peters
Keyword(s):  
Molecular Weight ◽  
Biomedical Applications ◽  
Low Molecular Weight

Synthesis and Properties of a High-Molecular-Weight Polyimide Based on 4, 4'-(hexafluoroisopropylidene) Diphthalic Anhydride

2012 ◽  
Vol 550-553 ◽  
pp. 742-746
Author(s):  
Hui Wen Wu ◽  
Hua Li ◽  
He Zhou Liu
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Organic Solvents ◽  
Membrane Separation ◽  
Amic Acid ◽  
Molecular Weights ◽  
Chemical Structures ◽  
Synthesis Parameters ◽  
Soluble Polyimide

A soluble polyimide with high molecular weight was synthesized from 4, 4'-(hexafluoroiso propylidene) diphthalic anhydride (6FDA) and 2, 2’-bis(3-amino-4-hydroxyphenyl) hexafluoropropane (BAPAF) via two-step polycondesation procedure involving the preparation of poly(amic acid) (PAA) followed by chemical imidization. Effect of synthesis parameters on polyimide molecular weight involving material ratio, imidization temperature and imidization catalyst were studied. Synthesized PI was analyzed with respect to their molecular weights, chemical structures and solubility through GPC, FTIR, XRD and solubility tests respectively. The results showed that a high-molecular-weight PI was successfully synthesized from 4, 4'-(hexafluoroisopropylidene) diphthalic anhydride and 2, 2’-bis (3-amino-4-hydroxyphenyl) hexafluoropropane with imidization at 80°C for 3h, material ratio of n(BAPAF):n(6FDA) equal to 1:1 and catalyst of n(triethylamine):n (pyridine) less than1:3. The obtained PI showed excellent solubility in polar aprotic organic solvents such as NMP, DMAc, DMSO, THF and Acetone. Poly(6FDA-BAPAF) PI, with high molecular weight and excellent solubility, which was synthesized under lower imidization temperature that was equal to 80°C,could be easily obtained and convenient to process, thus it is a potential material for membrane separation.

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