<p>Tenerife Island (2034 km<sup>2</sup>), the largest of the Canarian archipelago, is characterized by three main volcano-tectonic axes: the NS, NE and NW rifts and a central caldera, Las Ca&#241;adas, hosting the twin stratovolcanoes Pico Viejo and Teide. Although Teide volcano hosts a weak fumarolic system, volcanic gas emissions from the summit cone consist mostly of diffuse CO<sub>2</sub> degassing. The first continuous automatic geochemical station in Canary Islands was installed at the south-eastern foot of summit cone of Teide volcano in 1999, with the aim of improving the volcanic monitoring system and providing a multidisciplinary approach to the surveillance program of Teide volcano. The 1999-2020 time series shows diffuse CO<sub>2</sub> emission values ranging between 0 and 62.8 kgm<sup>-2</sup>d<sup>-1</sup>, with a mean value of 4.3 kgm<sup>-2</sup>d<sup>-1</sup>. Inspection of the CO<sub>2</sub> efflux time series shows significant temporal variations with anomalous values of more than 20 kgm<sup>-2</sup>d<sup>-1</sup> centred at years 2000, 2003, 2005, 2007, 2008, 2012, 2015 and 2016, always before a significant increase in the seismic activity beneath Tenerife Island. With the aim to filter out environmental variables, a multiple regression analysis (MRA) was applied to the first 12 years of the diffuse CO<sub>2</sub> flux time series (1999-2011), recorder on an hourly basis by the station, and we found that soil temperature, soil water content, wind speed and barometric pressure explained 16.7% of variability. The comparison between filtered CO<sub>2</sub> efflux (continuous, hourly, automated station) versus the temporal evolution of diffuse CO<sub>2</sub> emission estimated by ground CO<sub>2</sub> efflux surveys of summit cone of Teide (during summer season on an area of around 0.11 km<sup>2</sup>) for the period 1999-2011 (P&#233;rez et al., 2013), shows a nearly coincident marked peak in December 2001 and a similar shaped evolution from each sampling type as the increase from ~2005 to 2009 and the subsequent decrease from ~2009 to 2011, reaching maximum values of 161.6 and 179.9 t d<sup>-1</sup>, respectively. Seismic activity displayed as of monthly earthquakes (M>1) occurring in and around Tenerife island is well correlated with diffuse CO<sub>2</sub> efflux relevant peaks. In average, the seismicity recorded during the study period was mainly preceded by geochemical anomalies of the registered surface CO<sub>2</sub> efflux by about one year. After we analysed the CO<sub>2</sub> efflux time series by using the Continuous Wavelet Transform (Ricker wavelet) to detect relevant time-frequency patterns in the signal, we found at low frequencies quasi-periodical oscillations with periods of 3-4 years, which might reflect the internal dynamics of the magmatic-hydrothermal system. Moreover, during the intervals of highest levels of CO<sub>2</sub> efflux, the analysis evidenced also oscillations with a period of about 6 months during the interval 1999-2011. Our study reveals that continuous geochemical monitoring data is representative of the same trends in flux that are quantitatively captured by annual surveys, and provides the basis for accurate determination of background values. This combined approach offers a useful template for application to other volcanic systems for the purposes of constructing quantitative dynamic models of hydrothermal systems and identifying processes at depth in near-real-time.</p>