scholarly journals Influence of technological processing on lipid-lowering activity of substances containing in porcine hearts and aortas

10.5219/1119 ◽  
2019 ◽  
Vol 13 (1) ◽  
pp. 331-336
Author(s):  
Elena Kotenkova ◽  
Irina Chernukha
Keyword(s):  
Molecular Weight ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Raw Material ◽  
Serum Lipid Profile ◽  
Lipid Lowering ◽  
Control Group ◽  
Standard Diet ◽  
Bioactive Substances ◽  
Wide Range

Edible by-products are a good source of nutrients and bioactive substances and could be used as functional ingredients or for biopeptides production natively contained in raw materials. A wide range of peptides are also formed during the enzymatic hydrolysis or food processing. The comparative results of the effectiveness of isolated certain protein and peptide fractions by ultrafiltration with the same natively presented in raw tissues, as well as the influence of heat treatment on biological activity of origin active substances are presented. The model of rat alimentary hyperlipidemia was developed by adding cholesterol and fat to the standard diet and vitamin D2 injection per os. Serum lipid profile was determined on automatic analyzer BioChem FC-360. Dynamic of changes in serum lipid profile was assessed as corresponding control group medium results in ratio to certain rat data. Two-dimensional electrophoresis (2DE) was performed according to the method of O’Farrell with isoelectric focusing in ampholine pH gradient (IEF-PAGE) with following identification by MALDI-TOF MS and MS/MS mass spectrometry. Consumption of native pig aorta and pig heart during 14th days led to normalization of lipid profile in serum of hyperlipidemic rats, while low molecular weight (LMUF, MW <5 kDa) and medium molecular weight (MMUF, MW = 5 – 30 kDa) ultrafiltrates of pig aorta extract did not strongly influenced on level of triglicerides and, on contrary, elevated high density cholesterol. Consumption of developed product by hyperlipidemic rats during 28th days did not lead to significant changes in serum lipid profile, while on 42nd day all ratios reached ones in group, which were treated with native raw material or isolated active fractions. The stability of developed product was confirmed by proteomic studies. Obtained results open prospects to modernization the technology, presumably use as a matrix dietary meat (e.g. poultry) with incorporated active identified components.

scholarly journals Effect of Ethanol Extract of Glycine Max (Soy Bean) on Serum Lipid Profile of Fat-Fed Hyperlipidemic Rats

2018 ◽  
Vol 10 (1) ◽  
pp. 21-26
Author(s):  
K Sharmin ◽  
R Ahmed ◽  
A Momtaz ◽  
SA Chowdhury ◽  
NA Maya ◽  
...  
Keyword(s):  
Glycine Max ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Serum Lipid Profile ◽  
Lipid Lowering ◽  
Control Group ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Experimentally Induced

Hypercholesterolemia is one of the important causes of cardiovascular disease related mortality and morbidity and recently it has become a significant issue in public health problem of developing countries. The purpose of the study was to see the effect of glycine max (soy bean) on serum lipid profile of experimentally induced hyperlipidemic rats. Hypercholesterolemia was induced by high cholesterol diet containing 1% cholesterol in olive oil. This study was done on 24 long Norwegian rats (Rattus norvegicus) weighing about 200-210 gram. For convenience, the study was divided into Experiment I and Experiment II. In experiment I, 12 rats were divided into two groups- Group A (n = 6, control group) fed on laboratory diet and Group B (n=6) fed on laboratory diet and soy bean extract for 35 days. In experiment II, the remaining 12 rats were divided into 2 groups, Group C (n=6) were fed on laboratory diet and high cholesterol diet (HCD) for 35 days and Group D (n=6) were fed laboratory diet and high cholesterol diet on initial 10 days and soy bean extract was added along with high cholesterol diet for next 25 days. Serum TC, TG, LDL-C and HDL-C were measured after 35 days. HCD increased TG, TC and LDL-C significantly in group C. Glycine max (soy bean) treated group showed that it decreased plasma TC, TG and LDL-C in experimentally induced hyperlipidemic rats but Glycine max (soy bean) did not show any significant lipid lowering effect in normolipidemic rats. The results of this experimental study indicate that Glycine max can act as a cholesterol lowering agent and thereby can improve cardiovascular functions.Bangladesh J Med Biochem 2017; 10(1): 21-26

scholarly journals Omega-3 polyunsaturated fatty acids-enriched hen eggs consumption enhances microvascular reactivity in young healthy individuals

2018 ◽  
Vol 43 (10) ◽  
pp. 988-995 ◽  
Author(s):  
Ana Stupin ◽  
Lidija Rasic ◽  
Anita Matic ◽  
Marko Stupin ◽  
Zlata Kralik ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Serum Lipid Profile ◽  
Control Group ◽  
Omega 3 ◽  
Healthy Individuals ◽  
Microvascular Reactivity ◽  
Significant Difference

The beneficial effect of omega-3 polyunsaturated fatty acids (PUFA) supplementation on the cardiovascular (CV) system is well supported in CV patients; however, the effect of the consumption of omega-3 PUFA-enriched functional food in healthy individuals is still not fully elucidated. This study aimed to determine the effect of the consumption of omega-3 PUFA-enriched hen eggs on the microvascular reactivity (primary outcome), blood pressure (BP), and serum lipid profile in young healthy individuals. The control group (N = 16) ate 3 ordinary hen eggs (277 mg of omega-3 PUFAs/day), and the OMEGA-3 group (N = 20) ate 3 omega-3 PUFA-enriched eggs containing 259 mg of omega-3 PUFAs/egg daily (α-linolenic acid (ALA), 167 mg/egg; eicosapentaenoic acid (EPA), 7 mg/egg; docosahexaenoic acid (DHA), 84 mg/egg) for 3 weeks (777 mg of omega-3 PUFA/day). Postocclusive reactive hyperemia (PORH) in skin microcirculation assessed by laser Doppler flowmetry, serum lipid profile, fasting blood glucose, high-sensitivity C-reactive protein (hsCRP), and arterial BP were measured in all subjects before and after the protocol. PORH was significantly enhanced, and triglycerides, hsCRP, and BP were significantly decreased in the OMEGA-3 group compared with baseline measurements, whereas there was no significant difference in the control group after the protocol when compared with baseline. To the best of our knowledge, this is the first study to demonstrate that consumption of a mixture of omega-3 PUFA (ALA + EPA + DHA), provided via enriched hen eggs, elicits changes in the microvascular reactivity, BP, and triglyceride level in healthy subjects that are associated with CV benefits, thus suggesting that daily consumption of omega-3 PUFA-enriched eggs in healthy individuals may potentially contribute to CV risk factor attenuation and disease prevention.

scholarly journals Lipid-Lowering and Antioxidative Activities of Aqueous Extracts ofOcimum sanctumL. Leaves in Rats Fed with a High-Cholesterol Diet

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Thamolwan Suanarunsawat ◽  
Watcharaporn Devakul Na Ayutthaya ◽  
Thanapat Songsak ◽  
Suwan Thirawarapan ◽  
Somlak Poungshompoo
Keyword(s):  
Lipid Profile ◽  
Bile Acids ◽  
Serum Lipid ◽  
Serum Lipid Profile ◽  
Lipid Lowering ◽  
Ocimum Sanctum ◽  
High Cholesterol ◽  
Leaf Extracts ◽  
Cardiac Tissues ◽  
High Level

The present study was conducted to investigate the lipid-lowering and antioxidative activities ofOcimum sanctumL. (OS) leaf extracts in liver and heart of rats fed with high-cholesterol (HC) diet for seven weeks. The results shows that OS suppressed the high levels of serum lipid profile and hepatic lipid content without significant effects on fecal lipid excretion. Fecal bile acids excretion was increased in HC rats treated with OS. The high serum levels of TBARS as well as AST, ALT, AP, LDH, CK-MB significantly decreased in HC rats treated with OS. OS suppressed the high level of TABARS and raised the low activities of GPx and CAT without any impact on SOD in the liver. As for the cardiac tissues, OS lowered the high level of TABARS, and raised the activities of GPx, CAT, and SOD. Histopathological results show that OS preserved the liver and myocardial tissues. It can be concluded that OS leaf extracts decreased hepatic and serum lipid profile, and provided the liver and cardiac tissues with protection from hypercholesterolemia. The lipid-lowering effect is probably due to the rise of bile acids synthesis using cholesterol as precursor, and antioxidative activity to protect liver from hypercholesterolemia.

scholarly journals Estimation of Serum Lipid Profile and Its Correlation with Alveolar Bone Height in Chronic Periodontitis

2019 ◽  
pp. 1-6
Author(s):  
Avadhut Kamble ◽  
Mukta Motwani ◽  
Naman Shah
Keyword(s):  
Lipid Profile ◽  
Total Cholesterol ◽  
Chronic Periodontitis ◽  
Serum Lipid ◽  
Fasting Blood Glucose ◽  
Screening Method ◽  
Serum Lipid Profile ◽  
Control Group ◽  
Group I ◽  
Significant Difference

Aim: Numerous studies have been previously carried out to find out any correlation between lipid profile and periodontitis but existence of an association does not establish whether periodontitis causes an elevation in serum lipid level or elevation in serum lipid profile predispose to periodontitis. The aim of the present study was to find any significant correlation between HDL, LDL, VLDL and cholesterol with periodontitis. Material and Methods: 100 patients with chronic periodontitis (group I) and 50 healthy patients (group II) were selected. The levels of serum lipid, including HDL, LDL, VLDL, and TOTAL CHOLESTEROL along with fasting blood glucose were assessed. The relationship between severity of periodontitis based on clinical and radiographic finding with serum lipid correlated. Results: There was no significant difference found between mean values of total cholesterol, LDL and VLDL among study and control group. Only HDL showed a highly significant difference (p< 0.00) between healthy and patient with chronic periodontitis. Conclusion: Estimation of serum lipid profile, especially HDL levels in subjects with periodontitis can be considered as a screening method for early diagnosis of atherosclerosis to avoid further progression of cardiovascular changes in early age of the life.

scholarly journals The Protective Role of Coenzyme Q10 in Metallothionein-3 Expression in Liver and Kidney Upon Rats’ Exposure to Lead Acetate

2021 ◽  
Author(s):  
Ardeshir Afshar Mazandaran ◽  
Parvin Khodarahmi
Keyword(s):  
Lipid Profile ◽  
Serum Lipid ◽  
Lead Acetate ◽  
Protective Role ◽  
Serum Lipid Profile ◽  
Control Group ◽  
Cytotoxic Effects ◽  
Cyt C ◽  
Renal Expression

Abstract Metallothionein-3 (MT3) is an antioxidant protein that alters after exposure to heavy metals. In this study, we investigated the hepatic and renal expression of MT3 gene following exposure to lead acetate (PbAc) alone and PbAc plus CoQ10 as an adjuvant antioxidant. Twenty-four rats were allocated into three groups, including control, PbAc (free access to drinking water contaminated with PbAc at 1g/100ml), and PbAc plus CoQ10 (10 mg/kg/day Oral). After 28 consecutive days of treatment, the mRNA expression of MT3 and Cyt-c genes and MT3 protein levels were assessed using real-time PCR and immunosorbent assay. The serum lipid profile was also monitored in the three groups. PbAc exposure significantly reduced the hepatic and renal MT3 mRNA and protein expression compared to the control group. This reduction was significantly increased with addition of CoQ10 to levels near those of the control group. The hepatic and renal expression of Cyt-c mRNA increased after treatment with PbAc, while such effect was reversed after addition of CoQ10. Alteration in lipid profile including increased cholesterol and low-density lipoprotein levels were observed after PbAc exposure which were counteracted by CoQ10. Our results confirm the cytotoxic effects of acute lead exposure manifested as changes in the serum lipid profile and cellular levels of Cyt-c mRNA. These cytotoxic effects may have been caused by decreased MT3 gene expression and be reduced by the protective role of CoQ10.

scholarly journals Effect of Stellaria media Tea on Lipid Profile in Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Virág Demján ◽  
Tivadar Kiss ◽  
Andrea Siska ◽  
Márton Richárd Szabó ◽  
Márta Sárközy ◽  
...  
Keyword(s):  
Body Weight ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Serum Lipid Profile ◽  
Control Group ◽  
Stellaria Media ◽  
Experimental Proof ◽  
Cardiac Morphology ◽  
Liver And Kidney ◽  
And Function

Background. In folk medicine, common chickweed (Stellaria media) has traditionally been applied for the treatment of hypercholesterolemia; however, there is no firm experimental proof to support the rationale of this practice. Therefore, we aimed to assess the efficacy and safety of Stellaria media tea in hypercholesterolemic rats. Materials and Methods. Adult male Wistar rats were divided into 3 groups. The (i) control group received standard laboratory chow, the (ii) hypercholesterolemic group received cholesterol-enriched diet, and the (iii) chickweed-treated hypercholesterolemic group received cholesterol-enriched diet and 100 mg/kg body weight Stellaria media tea lyophilizate for 8 weeks. Blood samples were collected to determine serum lipid profile as well as liver and kidney function, and echocardiography was performed to assess cardiac morphology and function. Results. Cholesterol-enriched diet significantly increased serum total cholesterol, LDL- and HDL-cholesterol levels, but did not affect triacylglycerol concentrations. The addition of chickweed to the diet did not cause any significant change in serum lipid profile or body weight increase. Liver and kidney functions were unaltered and cardiac morphology and function were not changed due to Stellaria media tea lyophilizate. Conclusion. Although chickweed does not seem to be toxic, our results do not support the rationale of its use in the treatment of hypercholesterolemia.

scholarly journals CORRELATION BETWEEN HEMOGLOBIN A1C AND SERUM LIPID PROFILE WITH TYPE 2 DIABETES: A CROSS-SECTIONAL STUDY

2021 ◽  
Vol 9 (07) ◽  
pp. 164-170
Author(s):  
Apurva Jha ◽  
◽  
Shreya Nigoskar ◽  
Sudhir Mourya ◽  
◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Significant Positive Correlation ◽  
Hemoglobin A1c ◽  
Metabolic Diseases ◽  
Serum Lipid Profile ◽  
Control Group ◽  
Positive Correlation

Background: Diabetes is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Patients with type 2 diabetes (T2DM) have an increased prevalence ofdyslipidemia, which contributes to their high risk of cardiovascular diseases (CVDs). This study is an attempt to determine the correlation between hemoglobin A1C (HbA1c) and serum lipid profile and to evaluate the importance of HbA1c as an indicator of dyslipidemia with Type II diabetes mellitus. Methods: The study had 240 participants between the age groups of 20-70 years included 80 males and 40 females in diabetic group whereas the control group included 78 males and 42 females. T.cholesterol, Triglycerides, HDL were calculated by semi automated analyzer and LDL and VLDL were calculated by Friedewald’s Formula. HbA1c was measured by turbidMetric Method. Results: Data was represented as mean ± standard deviation or median with statistically significant values of T. Cholesterol, LDL, HDL, TGs and HbA1c (P< 0.001). There was a significant positive correlation between HbA1c, TC, TG, and LDL-C. Patients with HbA1c value greater than 7.0% had significantly higher value of cholesterol, LDL-C, and compared with patients with an HbA1c value up to 7.0%. Conclusion: Significant positive correlation of HbA1c with Lipid profiles in our study suggests that HbA1c can also be used as a predictor of dyslipidemia in addition to a glycemic control parameter for prevention of complication.

scholarly journals Study of serum lipid profile in type 2 diabetes mellitus patients and its association with diabetic nephropathy

2017 ◽  
Vol 4 (6) ◽  
pp. 1513 ◽  
Author(s):  
Ullasini Kolhar ◽  
Priyanka P.
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Density Lipoprotein ◽  
Serum Lipid Profile ◽  
Lipid Lowering

Background: Dyslipidaemia is highly prevalent in type 2 Diabetes mellitus patients. The role of dyslipidaemia in macrovascular complications of Diabetes have been extensively studied but its role in microvascular complications namely nephropathy is still unclear. The present study was undertaken to study the prevalence and pattern of dyslipidaemia and its association with Diabetic nephropathy (DN) in patients with type 2 DM.Methods: 100 patients with type 2 DM attending OPD or admitted, over a period of 1 year were studied. Detailed history was taken and clinical examination was done. Serum lipid profile was studied in all patients and its association with DN was assessed.Results: The prevalence of dyslipidaemia in DM patients in our study was 90% and there was no statistically significant difference in the prevalence among males and females. Poorly controlled diabetics had high prevalence of dyslipidaemia as compared to well controlled diabetics. The prevalence of Diabetic nephropathy in our study was 41%. There was significant association of DN with high Total Cholesterol, high Low-density lipoprotein (LDL-C) and high Triglycerides. There was no significant association of DN with High density lipoprotein (HDL-C).Conclusions: Present study highlights the magnitude of dyslipidaemia in type2 DM patients and that there is a significant association of DN with lipid parameters. Hence patients should be managed with life style modifications with or without lipid lowering agents to achieve target lipid values along with adequate glycemic control to prevent or delay the appearance and progression of DN.

scholarly journals A comparative analysis of serum lipid profile between normotensive and hypertensive pregnant women

2019 ◽  
Vol 8 (5) ◽  
pp. 2060
Author(s):  
Sridhara S. K.
Keyword(s):  
Lipid Profile ◽  
Serum Lipid ◽  
Serum Lipid Profile ◽  
Control Group ◽  
P Value ◽  
Study Group ◽  
Hormonal Changes ◽  
Cross Sectional ◽  
The Mean ◽  
Pregnant Mothers

Background: The pregnancy results in the development of the placenta which is characterized by the hormonal changes in the women body, which results in the alteration of lipid profile, diabetic state of the pregnant mothers and many others. Objective of this study was to compare the of serum lipid profile between normotensive and hypertensive pregnant women.Methods: A hospital based cross sectional study was conducted by the department of OBG, Hassan Institute of Medical Sciences, Hassan from July 2018 to December 2018. A total of 6 months the study was conducted. A total of 50 pregnant mothers who were more than 20 weeks of gestation and suffering from Preeclampsia were include in the study group and 50 Pregnant mothers who were more than 20 weeks of gestation and normotensive were included in the controls.Results: Majority of the study subjects in both the groups were less than 25 years of age. The mean age of mothers in study group was 23.19 years and 24.19 years in the control group. The mean HDL level was more among the normotensive group than the pre eclamptic group and the p value was found to be statistically insignificant. The VLDL, LDL and triglyceride level was more in the pre eclamptic group than the normotensive group and the association was also found to be statistically significant.Conclusions: Hormonal changes in pregnancy results in physiological Hyperlipidemia, in conditions like pre-eclampsia triglyceride are elevated more than the normal rise seen in normal pregnancy. Increased lipid profile with raised TG, VLDL, LDL levels leads to the development of Preeclampsia by increasing the oxidative stress and the endothelial dysfunction.

scholarly journals Pulverized Mangifera indica (Mango) Seed-kernel Modulated Serum Lipid Profile in Monosodium Glutamate-challenged Rats

2017 ◽  
Vol 5 (2) ◽  
pp. 72 ◽  
Author(s):  
Anthony Cemaluk C. Egbuonu ◽  
Gladys A. Ekwuribe
Keyword(s):  
Lipid Profile ◽  
Serum Lipid ◽  
Mangifera Indica ◽  
Monosodium Glutamate ◽  
Density Lipoprotein ◽  
Serum Lipid Profile ◽  
Lipid Lowering ◽  
Oral Exposure ◽  
Seed Kernel ◽  
Sample Extract

Mangifera indica seed kernel was assessed for antinutirent content and effects on serum lipid profile of monosodium glutamate-challenged rats. Group A rats received 8000 mg/kg body weight, b.w of monosodium glutamate (MSG). Group B rats received the sample extract (300 mg/kg b.w). Group C rats were sham-administered distilled water. Groups D and E rats received 8000 mg/kg b.w of MSG in addition to 200 and 400 mg/kg b.w, respectively of sample extract. Tannin (29.21±5.39 mg/100 g) was highest (p<0.05) while phytate (0.38±0.02 mg/100g) was least. After fourteen days daily oral exposure, MSG-exposed rats had higher (p<0.05) total cholesterol (CHOL), triacylglycerol (TAG) and low density lipoprotein (LDL) but lower (p<0.05) high density lipoprotein (HDL) concentration compared to rats in the other groups. MSG-intoxicated rats co-treated respectively with 200 and 400 mg/kg b.w of the extract had dose dependent reduction (p<0.05) compared to the corresponding effects in non-extract-co-treated MSG-intoxicated rats. Compared to others, rats in the Extract group had higher (p<0.05) CHOL: TAG but lower (p<0.05) TAG:CHOL ratios while rats in the MSG-group had higher (p<0.05) HDL:LDL but lower (p<0.05) LDL:HDL ratios. Results demonstrated the preponderance of tannin in, and significant serum lipid lowering potential in normal and MSG-challenged rats of, the sample. Studies using antinutrient-process-reduced sample in hyperlipidemia-related health-challenged models and collaborating the suggested implication of lipid-profile-component-ratios are warranted and recommended.

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