scholarly journals EFEK PEKERJAAN RUMAH TANGGA DALAM PENCEGAHAN PENURUNAN FUNGSI KOGNITIF PADA LANSIA PEREMPUAN BERPENDIDIKAN RENDAH

2017 ◽  
Vol 35 (1) ◽  
Author(s):  
Christina Permata Shalim ◽  
Julia Rahadian ◽  
Yuda Turana
Keyword(s):  
Physical Activity ◽  
Cognitive Function ◽  
Cognitive Decline ◽  
Mental State ◽  
Significant Relationship ◽  
Mini Mental State Examination ◽  
Elderly Women ◽  
Education Level ◽  
Grocery Shopping ◽  
State Examination

   EFFECTS OF HOUSEWORK IN PREVENTION OF COGNITIVE DECLINE IN ELDERLY WOMEN WITH LOW EDUCATIONABSTRACTIntroduction: Physical activities have a role in preventing or slowing down cognitive decline. In Indonesia, physical activity in the elderly women is dominated with house work chores.Aims: This study was aimed to determine the relationship between house chores with cognitive function in elderly women.Methods: A cross sectional analytic descriptive of 65 women aged 60 years and over with highest education level of junior high school that live in Kalianyar, West Jakarta, between October to November 2014. Physical activity was measured by questionnaire about nine housework activities that Indonesian women usually do and cognitive function was assessed by Mini-Mental State Examination (MMSE).Results: In this study of 65 subjects with a mean age of 64.31 years and low education level, there was a significant relationship between the higher amount of physical activity and better cognitive level. The types of physical activity that had a significant relationship with better cognitive function was cooking, grocery shopping, and washing dishes, with the frequency of cooking and grocery shopping had a significant relationship.Discussion: Cooking and grocery shopping activity have a relationship with better cognitive function.Keywords: Cognitive function, daily physical activity, elderly, house choresABSTRAKPendahuluan: Aktivitas fisik dianggap memiliki peran dalam pencegahan atau perlambatan penurunan fungsi kognitif. Di Indonesia, aktivitas fisik pada lansia perempuan didominasi dengan pekerjaan rumah tangga.Tujuan:  Mengetahui  hubungan  aktivitas  fisik pekerjaan  rumah  tangga  terhadap  fungsi  kognitif  pada  lansia perempuan.Metode: Penelitian deskriptif analitik potong lintang terhadap lansia (>60 tahun) perempuan yang mengenyam pendidikanakhir paling tinggi tamat SMP dan tinggal di Kelurahan Kalianyar, Jakarta Barat, pada bulan Oktober-November 2014. Aktivitas fisik diukur menggunakan kuesioner sembilan aktivitas pekerjaan rumah tangga yang dilakukan lansia perempuan Indonesia dan penilaian fungsi kognitif menggunakan Mini-Mental State Examination (MMSE).Hasil: Pada penelitian terhadap 65 subjek dengan rerata usia 64,31 tahun berpendidikan rendah, terdapat hubungan bermakna antara jumlah aktivitas fisik yang dilakukan dengan fungsi kognitif yang lebih baik. Adapun jenis aktivitas fisik yang memiliki hubungan bermakna dengan fungsi kognitif yang lebih baik adalah memasak, berbelanja, dan mencuci piring, terutama frekuensi memasak dan berbelanja yang lebih sering memiliki hubungan secara bermakna.Diskusi: Aktivitas memasak dan berbelanja berhubungan dengan fungsi kognitif yang lebih baik.Kata kunci: Aktivitas fisik sehari-hari, fungsi kognitif, lansia, pekerjaan rumah tangga

scholarly journals HUBUNGAN STATUS PERKAWINAN, APOE ε4, DAN JENIS AKTIVITAS FISIK TERHADAP PENURUNAN KOGNITIF PADA LANSIA PEREMPUAN

2020 ◽  
Vol 36 (2) ◽  
Author(s):  
Nicholas Andrian Singgih ◽  
Yuda Turana ◽  
Yvonne Suzy Handajani ◽  
Nelly Tina Widjaja ◽  
Linda Suryakusuma
Keyword(s):  
Physical Activity ◽  
Cognitive Function ◽  
Cognitive Decline ◽  
Marital Status ◽  
Mini Mental State Examination ◽  
Elderly Women ◽  
Active Aging ◽  
Vascular Risk ◽  
Apoe Ε4 ◽  
State Examination

      RELATIONSHIP OF MARITAL STATUS, APOE ε4, AND TYPES OF PHYSICAL ACTIVITIES ON COGNITIVE DECLINE IN ELDERLY WOMENABSTRACTIntroduction: The number of elderly population in Indonesia continues to increase every year, especially women. Elderly women are at higher risk of experiencing decreased cognitive function.Aims: To determine the relationship between the characteristics  of the subject, vascular risk factors, APOE ε4 genotype, and the type of physical activity with the decline of cognitive function in elderly women.Methods: A cognitive cohort study of 114 elderly women who had been observed for a mean of ±2.5 years, as part of the Active Aging study at Atma Jaya Catholic University. The independent variables of this study included were age, education, marital status, vascular risk factors (hypertension, diabetes, dyslipidemia, and BMI), APOE ε4, and types of physical activity. Cognitive function is measured using Mini Mental State Examination (MMSE).Results: There were 114 subjects with mean age was 71.22±7.297 and 33.3% experienced a decline in cognitive function. There were 114 subjects with mean age was 71.22±7.297 and 33.3% experienced a decline in cognitive function. Age, marital status (single), and type of physical activity (cooking) have a significant relationship with Relative Risk (RR) of 4,45; 0,12; and 0,334.Discussions: Factors related to cognitive decline in elderly women were age. Marital status (single) and  cooking activities  were  protective factors.Keywords: APOE, cognitive decline, elderly, marital status, physical activityABSTRAKPendahuluan: Angka populasi lansia di Indonesia setiap tahunnya terus meningkat, terutama perempuan. Lansia perempuan berisiko lebih tinggi mengalami penurunan fungsi kognitif.Tujuan: Mengetahui hubungan antara karakteristik subjek, faktor risiko vaskuler, genotip APOE ε4, dan jenis aktivitas fisik terhadap penurunan fungsi kognitif pada lansia perempuan.Metode: Penelitian kohort terhadap 114 lansia perempuan >60 tahun yang diikuti fungsi kognitifnya selama rerata ±2,5 tahun, sebagai bagian dari penelitian Active Aging di Universitas Katolik Atma Jaya. Variabel bebas penelitian ini meliputi usia, pendidikan, status perkawinan, faktor risiko vaskuler (hipertensi, diabetes, dislipidemia, dan IMT), APOE ε4, dan jenis aktivitas fisik. Fungsi kognitif diukur menggunakan Mini Mental State Examination (MMSE).Hasil: Didapatkan 114 subjek dengan rerata usia 71,2±7,3 dan 33,3% mengalami penurunan fungsi kognitif. Analisis multivariat menunjukkan usia, status perkawinan (single) , dan jenis aktivitas fisik (memasak) memiliki hubungan bermakna dengan risiko relatif (RR) masing-masing 4,46; 0,12; dan 0,334.Diskusi: Faktor risiko gangguan fungsi kognitif pada lansia perempuan adalah usia. Status perkawinan (single) dan aktivitas memasak merupakan faktor protektif.Kata kunci: Status perkawinan, APOE, aktivitas fisik, penurunan kognitif, lanjut usia  

scholarly journals HUBUNGAN PENINGKATAN KADAR C-REACTIVE PROTEIN DENGAN PENURUNAN FUNGSI KOGNITIF PASIEN GERIATRI RAWAT JALAN

2019 ◽  
Vol 37 (1) ◽  
Author(s):  
Stefanus Erdana Putra ◽  
Muhammad Hafizhan ◽  
Raden Ajeng Hanindia Riani Prabaningtyas
Keyword(s):  
Cognitive Function ◽  
Cognitive Decline ◽  
Mental State ◽  
Geriatric Patients ◽  
Mini Mental State Examination ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Neurology Clinic ◽  
Serum Crp ◽  
State Examination

THE RELATIONSHIP BETWEEN ELEVATED C-REACTIVE PROTEIN AND COGNITIVE FUNCTION DETERIORATION OF GERIATRIC OUTPATIENTSABSTRACTIntroduction: Geriatric patients have different characteristics compared to other patients in general, in which they potentially experiencing cognitive impairment, decreasing of physiological and functional status, also the immunological system. This situation causes various inflammatory reactions that play a role in the development of neurodegenerative diseases, including the increase production of acute phase protein called C-reactive protein (CRP).Aims: To determine the association  between the CRP serum concentration  elevation and the deterioration  of geriatric outpatients’s cognitive function at Neurology Clinic Sebelas Maret University Hospital.Methods: A cross-sectional study of geriatric patients at the Neurology Clinic of Sebelas Maret University Hospital, Surakarta.   The cognitive state was evaluated using Mini-Mental State Examination (MMSE) and those with MMSE score<24 were considered cognitively declined. Concentrations of serum CRP were measured. Multiple logistic regression analysis was used to calculate Odds ratios (ORs) for cognitive decline, adjusted for the covariates of age, sex, body mass index, and disease history.Results: There were 73 participants with mean age was 65.6 years old. There were 56,2% who were experiencing a cognitive decline. Relative to the lowest (first) quartile of CRP concentration, adjusted ORs were 1,44 for the second, 1,97 for the third, and 2,33 for the highest quartiles (p=0,035). The association between CRP levels and decreased cognitive function was found to be significant after adjusting for covariates. When data were stratified by sex, the association between CRP concentration and cognitive decline was observed in women.Discussions: This research  suggested an association  between higher CRP concentration  and lower cognitive function. Chronic inflammation might affect cognitive function in geriatric, particularly in women.Keywords: C-reactive protein, cognitive function, geriatric outpatientsABSTRAKPendahuluan: Pasien geriatri memiliki karakteristik yang berbeda dengan pasien pada umumnya, yaitu selain berpotensi mengalami gangguan fungsi kognitif juga menurunnya daya cadangan fisiologis serta status fungsional dan sistem imunologi. Keadaan ini menimbulkan berbagai reaksi inflamasi yang berperan dalam perkembangan penyakit neurodegeneratif, antara lain peningkatan produksi protein fase akut bernama C-reactive protein (CRP) oleh hepar.Tujuan: Mengetahui hubungan antara peningkatan kadar CRP dengan penurunan fungsi kognitif pasien geriatri rawat jalan di Poliklinik Saraf RS Universitas Sebelas Maret.Metode: Penelitian potong lintang terhadap pasien geriatri di Poli Saraf RS Universitas Sebelas Maret, Surakarta. Evaluasi fungsi kognitif menggunakan Mini-Mental State Examination (MMSE); dengan skor <24 dikategorikan mengalami penurunan fungsi kognitif. Kadar serum CRP masing-masing subjek juga diukur. Analisis regresi logistik berganda digunakan dalam menghitung rasio Odds (RO) untuk penurunan fungsi kognitif, dengan pengaturan kovariat usia, jenis kelamin, indeks massa tubuh, dan riwayat penyakit sebelumnya.Hasil: Didapatkan 73 subjek dengan rerata usia 65,6 tahun. Sebanyak 56,2% subjek mengalami penurunan fungsi kognitif. Dengan perbandingan relatif terhadap kuartil konsentrasi CRP terendah (pertama), RO yang telah diatur adalah 1,44 untuk kuartil kedua; 1,97 untuk kuartil ketiga; serta 2,33 untuk kuartil keempat (p=0,035). Hubungan kadar CRP dan penurunan fungsi kognitif ditemukan signifikan setelah disesuaikan dengan kovariat. Setelah dilakukan sub-analisis berdasarkan jenis kelamin, peningkatan kadar CRP terhadap penurunan kognitif secara signifikan terjadi pada subjek perempuan.Diskusi: Penelitian ini menunjukkan adanya hubungan antara peningkatan kadar CRP dengan penurunan fungsi kognitif. Inflamasi kronis memengaruhi fungsi kognitif geriatri khususnya perempuan.Kata kunci: C-reactive protein, fungsi kognitif pasien rawat jalan, geriatri

scholarly journals Role of cholesterol in cognitive function in the elderly

2021 ◽  
Vol 8 (2) ◽  
pp. 56-59
Author(s):  
V K Deshpande ◽  
Vishwin Doda
Keyword(s):  
Cognitive Function ◽  
Cognitive Decline ◽  
Mental State ◽  
Mini Mental State Examination ◽  
Blood Cholesterol ◽  
Elderly Subjects ◽  
Blood Concentrations ◽  
Cholesterol Levels ◽  
State Examination

The role of cholesterol in Cognitive Decline is less known as compared to other pathologies linked with dyslipidaemia. However, Cholesterol is well-known to have multiple functions in normal functioning of the brain and the aging process. This study therefore aimed at finding a co-relation, if any, between Cholesterol and age-related cognitive decline.To assess Cognitive Function of subjects and compare it with respective blood cholesterol levels. The study included 50 elderly subjects from Maharashtra (females: 12%) assessed using Marathi version of Mini Mental State Examination (MMSE) and their cholesterol blood concentrations obtained using a Lipid Profile investigation. Cholesterol levels and cognitive function was then co-related using statistical analysis.The subjects with a higher Total Cholesterol & LDL Cholesterol had slightly less scores on the Mini Mental State Examination (MMSE) Test. However, the difference was found to be significant.Based on the results obtained, no relevant co-relation could be found between Blood Cholesterol Levels and Cognitive Function

scholarly journals Hubungan Antara Tingkat Aktivitas Fisik dengan Fungsi Kognitif pada Usila di Kelurahan Jati Kecamatan Padang Timur

2014 ◽  
Vol 3 (2) ◽  
Author(s):  
Milfa Sari Muzamil ◽  
Afriwardi Afriwardi ◽  
Rose Dinda Martini
Keyword(s):  
Physical Activity ◽  
General Practice ◽  
Cognitive Function ◽  
Mental State ◽  
Mini Mental State Examination ◽  
The Elderly ◽  
Chi Square ◽  
Cross Sectional ◽  
State Examination ◽  
Activity Questionnaire

AbstrakGangguan kognitif merupakan masalah yang sering terjadi pada golongan usia lanjut. Prevalensi gangguan kognitif tinggi pada negara yang memiliki populasi usila yang tinggi. Indonesia merupakan negara keempat dunia yang memiliki populasi usila tertinggi dan diperkirakan akan menjadi ketiga tertinggi pada 2020. Antara usaha preventif yang dilakukan adalah dengan beraktivitas fisik. Penelitian ini dilakukan untuk melihat apakah ada hubungan antara tingkat aktivitas fisik terhadap fungsi kognitif pada usila. Jenis penelitian ini adalah studi cross sectional dengan metode non probability sampling. Populasi penelitian adalah usila ≥60 tahun yang berada di Kelurahan Jati Kecamatan Padang Timur dan memenuhi kriteria inklusi dan eksklusi. Total sampel seramai 51 orang dengan 13 laki-laki dan 38 perempuan. Tingkat aktivitas fisik dinilai menggunakan General Practice Physical Activity Questionnaire (GPPAQ) dan fungsi kognitif dinilai menggunaan Mini Mental State Examination (MMSE). Data diolah dengan uji statistik chi square menggunakan program SPSS. Hasil univariat didapatkan persentase usila yang aktif sebanyak 29.4% dan yang kurang aktif 70.6%. Persentase usila dengan fungsi kognitif yang normal sebanyak 82.4% dan yang mengalami penurunan 17.6%. Hasil bivariat didapatkan ada hubungan antara tingkat aktivitas fisik dengan fungsi kognitif dimana nilai p = 0.044 (p < 0.05). Penelitian ini menunjukkan terdapat hubungan antara tingkat aktivitas fisik dengan fungsi kognitif usila di Kelurahan Jati Kecamatan Padang Timur.Kata kunci: fungsi kognitif, aktivitas fisik, usia lanjutAbstractCognitive impairment is common and highly age-related in the world. The prevalence of cognitive impairment is high in the country with high proportion of elderly. Indonesia is the fourth country with the highest population of elderly and estimated to be the third highest in 2020. Little attention has been paid to the identification of modifiable lifestyle habits for its prevention. This study aimed to determine whether there is a relationship between the level of physical activity and cognitive function in the elderly. This study was a cross sectional study with non probability sampling method. The study population was elderly ≥ 60 years who reside in the Village of Jati, East Padang district and fit the inclusion and exclusion criteria. There were 51 samples with 13 males and 38 females. The level of physical activity was measured by using General Practice Physical Activity Questionnaire (GPPAQ) and the cognitive function was assessed by using Mini Mental State Examination (MMSE). Data processed by the chi-square statistical tests using SPSS. Results of univariate analysis level of physical activity showed the percentage of active elderly is 29.4% and less active is 70.6%. Elderly with normal cognition is 82.4% and with impaired cognition is 17.6%. Results of bivariate analysis showed a significant relationship exists between the level of physical activity and cognitive function in the elderly p = 0.044 (p < 0.05). This study showed that there is a relationship between the level of physical activity and cognitive function in the elderly.Keywords: cognitive function, physical activity, elderly

scholarly journals PERBEDAAN GANGGUAN KOGNITIF SUBJEK STROKE ISKEMIK BERDASARKAN SISI HEMIPARESIS

2020 ◽  
Vol 37 (2) ◽  
Author(s):  
Gabriella Gabriella ◽  
Budi Riyanto Wreksoatmodjo ◽  
Andre Andre
Keyword(s):  
Ischemic Stroke ◽  
Cognitive Impairment ◽  
Cognitive Function ◽  
Mental State ◽  
Significant Relationship ◽  
Mini Mental State Examination ◽  
P Value ◽  
Stroke Patients ◽  
Cross Sectional ◽  
State Examination

DIFFERENCE OF COGNITIVE IMPAIRMENT IN ISCHEMIC STROKE PATIENTS BASED ON HEMIPARESIS SIDEABSTRACTIntroduction: Cognitive impairment in stroke has a significant impact on the quality of life and is different from the location of the lesion. Patients with a lesion in the left cerebral hemisphere tend to have cognitive impairment and dementia.Aim: This study investigates the relationship between the location of the lesion, which is manifested by hemiparesis side, and the occurrence of cognitive impairment in ischemic stroke patients.Method: A cross-sectional study was conducted in the population of ischemic stroke patients at Atma Jaya Hospital, who were registered from January 2014 to December 2018. Cognitive function was measured by the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment Indonesian Version (MoCA-Ina). Data were analyzed univariate and bivariate with the software program, statistical package for the social sciences (SPSS) version 25.0.Result: There were 125 patients included in this study, which predominantly was 55 years old and older (62.4%) and had a low education level (58.4%). The proportion of patients with right-sided hemiparesis (54.4%) was slightly higher than the left-side one (45.6%). No significant relationship was observed between the hemiparesis side and every cognitive function domain measured by MMSE and MoCA-Ina (p-value >0.05).Discussion Hemiparesis side indicating hemisphere lateralization in ischemic stroke patients showed no significant relationship with the occurrence of cognitive impairment based on MMSE and MoCA-Ina score.   Keywords: Cognitive impairment, hemisphere lateralization, ischemic stroke, MMSE score, MoCA-Ina scoreABSTRAKPendahuluan: Gangguan kognitif pada stroke menyebabkan penurunan kualitas hidup dan berbeda berdasarkan letak lesi. Berdasarkan letak lesi, lesi di hemisfer serebri kiri lebih sering menyebabkan gangguan kognitif dan demensia.Tujuan: Tujuan penelitian untuk mengetahui pengaruh perbedaan letak lesi dilihat dari sisi hemiparesis terhadap gangguan kognitif pada subjek stroke iskemik.Metode: Studi potong lintang dilakukan pada pasien stroke iskemik di RS Atma Jaya periode tahun 2014- 2018. Fungsi kognitif dinilai dengan menggunakan Mini Mental State Examination(MMSE) danMontreal Cognitive Assesment Indonesian Version(MoCA-Ina). Analisis data dilakukan secara univariat dan bivariat menggunakan menggunakan program sStatistical pPackage for the sSocial sSciences (SPSS) versi 25.0.Hasil: Sebanyak 125 pasien tergabung dalam penelitian ini, yang sebagian besar berusia ≥55 tahun (62,4%) dan memiliki tingkat pendidikan <9 tahun (58,4%). Proporsi pasien dengan hemiparesis kanan (54,4%) lebih besar daripada kiri (45,6%). Tidak terdapat hubungan antara sisi hemiparesis dengan skor MMSE dan MoCA-Ina pada semua ranah (nilai p >0,05).Diskusi: Sisi hemiparesis pasien stroke iskemik yang menunjukkan lateralisasi hemisfer serebri tidak berhubungan dengan gangguan kognitif berdasarkan skor MMSE dan MoCA-Ina.Kata kunci: Gangguan kognitif, lateralisasi hemisfer, skor MMSE, skor MoCA-Ina, stroke iskemik

scholarly journals 1 GAMBARAN FUNGSI KOGNITIF PADA LANSIA DI TIGA YAYASAN MANULA DI KECAMATAN KAWANGKOAN

e-CliniC ◽  
2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Daniar Aprilia Ramadian
Keyword(s):  
Cognitive Function ◽  
Elderly People ◽  
Mental State ◽  
Mini Mental State Examination ◽  
The Elderly ◽  
Health Problems ◽  
Education Level ◽  
Trail Making Test ◽  
Trail Making ◽  
State Examination

AbstractBackground: An increasing number of elderly people raises various social, economic, and health problems. Health problems are often occur in the elderly is impaired cognitive function. The rapid examination and practical, high value is the examination of the Mini Mental State Examination (MMSE) and Trail Making Test (TMT). These checks are done by giving series of commands at someone and assess their accuracy.Objective: To knowing overview of cognitive function in the elderly at three elderly people foundation in district Kawangkoan by sex, age, and education.Methods: The descriptive research with cross-sectional method, was conducted in November 2012 held at the Elderly Foundation Centre Kawangkoan Minahasa, Maupusan Foundation, and Pakakamangen Foundation in District Kawangkoan.Results: From the research gained 61 people who met the inclusion criteria consisted of 4 men and 57 women. Based on age, and education level showed decline in cognitive function is most at 75-90 years old and last education level is Elementary School.Conclusion: The results of the MMSE and TMT in the elderly at three elderly people foundation in district Kawangkoan mostly with normal results on the MMSE and TMT abnormal.Keywords: Elderly, cognitive function, MMSE, TMT-A & B.AbstrakLatar belakang: Peningkatan jumlah penduduk lanjut usia menimbulkan berbagai masalah sosial, ekonomi, dan kesehatan. Masalah kesehatan yang sering terjadi pada usia lanjut ialah gangguan fungsi kognitif. Pemeriksaan yang cepat dan praktis namun nilainya tinggi adalah pemeriksaan Mini Mental State Examination (MMSE) dan Trail Making Test (TMT). Pemeriksaan ini dilakukan dengan memberi serangkaian perintah pada seseorang dan menilai ketepatannya.Tujuan: Untuk mengetahui gambaran fungsi kognitif pada lansia di tiga yayasan manula di kecamatan kawangkoan berdasarkan jenis kelamin, umur, dan pendidikan.Metode: Penelitian deskriptif dengan metode potong lintang, dilaksanakan pada bulan November 2012 bertempat di Yayasan Manula Pusat Kawangkoan Minahasa, Yayasan Maupusan, dan Yayasan Pakakamangen di Kecamatan Kawangkoan.Hasil: Dari penelitian diperoleh 61 orang yang memenuhi kriteria inklusi terdiri dari 4 laki-laki dan 57 perempuan. Berdasarkan usia, dan tingkat pendidikan menunjukkan penurunan fungsi kognitif terbanyak adalah pada usia 75-90 tahun dan tingkat pendidikan terakhir SD.Kesimpulan: Hasil pemeriksaan MMSE dan TMT pada lansia di tiga yayasan manula di kecamatan Kawangkoan sebagian besar dengan hasil normal pada MMSE dan abnormal pada TMT.Kata kunci: Lansia, fungsi kognitif, MMSE, TMT-A & B.

Serum Level of Alkaline Phosphatase Correlates Negatively with Mini-Mental State Examination Score in the Very Elderly of Ashikaga City: Part of the Results of the Ashikaga Longevity Study

2021 ◽  
Author(s):  
Minoru Yamakado
Keyword(s):  
Oxidative Stress ◽  
Alkaline Phosphatase ◽  
Cognitive Function ◽  
Life Expectancy ◽  
Mental State ◽  
Mini Mental State Examination ◽  
Mmse Score ◽  
Healthy Life Expectancy ◽  
Healthy Life ◽  
State Examination

Objective: An important medical issue in both Japan and Ashikaga City is how to extend healthy life expectancy. To determine factors associated with healthy life expectancy, we established a joint study between Ashikaga City and the Ashikaga University Faculty of Nursing called the Ashikaga Longevity Study, using new biomarkers such as Diacron reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) tests as indicators of oxidative stress. In this study, factors related to cognitive function were clarified. Methods: Participants comprised 95 individuals (36 men; mean age, 91.0±5.1 years and 59 women; mean age, 92.2±5.9 years). Cognitive impairment was assessed using the Mini-Mental State Examination (MMSE). Results: MMSE score was ≤23 in 28 subjects (29.5%) and ≥24 in 67 subjects (70.5%). MMSE score showed significant negative correlations with age (p<0.0096), plasma alkaline phosphatase (p=0.0007), and peripheral leukocyte-to-lymphocyte ratio (p=0.0119), and positive correlations with plasma albumin (p=0.0096) and BAP-to-d-ROMs ratio (p=0.0427). Conclusions: These results suggest that cognitive decline may involve brain cell dysfunction due to inflammation based on a reduced ability to control oxidative stress. Not only anti-oxidative aerobic exercise but also anti-oxidative foods, may be necessary to maintain cognitive function.

scholarly journals The Relationship between Chronotype, Physical Activity and the Estimated Risk of Dementia in Community-Dwelling Older Adults

2020 ◽  
Vol 17 (10) ◽  
pp. 3701
Author(s):  
Ngeemasara Thapa ◽  
Boram Kim ◽  
Ja-Gyeong Yang ◽  
Hye-Jin Park ◽  
Minwoo Jang ◽  
...  
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Mental State ◽  
Mini Mental State Examination ◽  
Community Dwelling ◽  
Daily Physical Activity ◽  
Estimated Risk ◽  
Community Dwelling Older Adults ◽  
The Relationship ◽  
State Examination

Our study examined the association between chronotype, daily physical activity, and the estimated risk of dementia in 170 community-dwelling older adults. Chronotype was assessed with the Horne–Östberg Morningness–Eveningness Questionnaire (MEQ). Daily physical activity (of over 3 METs) was measured with a tri-axial accelerometer. The Korean version of the Mini-Mental State Examination (K-MMSE) was used to measure the estimated risk of dementia. The evening chronotype, low daily physical activity, and dementia were positively associated with each other. The participants with low physical activity alongside evening preference had 3.05 to 3.67 times higher estimated risk of developing dementia, and participants with low physical activity and morning preference had 1.95 to 2.26 times higher estimated risk than those with high physical activity and morning preference. Our study design does not infer causation. Nevertheless, our findings suggest that chronotype and daily physical activity are predictors of the risk of having dementia in older adults aged 70 years and above.

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