scholarly journals EFEKTIVITAS EXTRA VIRGIN COCONUT OIL DAN OLIVE OIL TERHADAP FUNGSI MEMORI DAN BELAJAR MENCIT

Author(s):  
Gorga Menak Sihombing ◽  
Rizna Tyrani Rumanti ◽  
Decky Gunawan

  THE EFFECT OF EXTRA VIRGIN COCONUT OIL AND OLIVE OIL TOWARD MEMORY AND STUDY FUNCTION IN MICEABSTRACTIntroduction: Dementia is a neurodegenerative syndrome caused by chronic progressive abnormality and multiple malfunctions of the noble functions especially in memory and learning. Medium chain triglycerides (MCT) and polyphenol in extra virgin coconut oil (EVCO) and extra virgin olive oil (EVOO) can increase cognitive function.Aim: To discover the effect of extra virgin coconut oil (EVCO), extra virgin olive oil (EVOO) on increasing memory and learning ability of mice that are induced by aluminium chloride (AlCl3).Methods: A true experimental study was conducted using a completely randomized and comparative design. Experimental subjects were 24 mice, divided into 4 groups: K1 (negative control, aquades), K2 (AlCl3 + aquades), K3 (AlCl3 + EVCO 30mL/kg/day), and K4 (AlCl3 +EVOO 30mL/kg/day). Aluminium chloride was given for 15 days, then continued by EVCO and EVOO for 15 days. The dependent variable was recognition index (RI) with object recognition test post treatment. Data was analyzed using ANOVA, continued by LSD test with α=0.05.Results: Recognition index between K3 and both K1 and K2 showed a highly significant difference, and RI between K4 and both K1 and K2 also showed a highly significant difference. K4 was better in increasing RI compared with K3 with significant difference.Discussion: Extra virgin olive oil and EVOO improved the learning function and memory of mice induced by AlCl3. Extra virgin olive oil worked better than EVCO, because EVOO contains polyphenols that can work as neuro- inflammation, neurotoxicity and neuronal dysfunction inhibitors, while EVCO contains MCT as the main energy source when nerve damage occurs.Keywords: Dementia, extra virgin coconut oil (oleum cocos), extra virgin olive oil (oleum olivae), learning, memoryABSTRAKPendahuluan: Demensia adalah sindrom neurodegeneratif yang timbul karena adanya kelainan yang bersifat kronis dan progresif disertai dengan gangguan fungsi luhur multipel terutama pada memori dan belajar. Medium chain triglycerides (MCT) dan polifenol pada extra virgin coconut oil (EVCO) dan extra virgin olive oil (EVOO) dapat meningkatkan fungsi kognitif.Tujuan: Untuk mengetahui efek pemberian EVCO, EVOO, serta membandingkan keduanya dalam meningkatkan fungsi memori dan belajar mencit yang diinduksi aluminium klorida (AlCl3).Metode: Penelitian dengan desain studi eksperimental sungguhan menggunakan rancangan acak lengkap dan bersifat komparatif, dengan subjek penelitian 24 ekor mencit Swiss Webster yang dibagi menjadi 4 kelompok: K1 (kontrol negatif, akuades), K2 (AlCl3 +akuades), K3 (AlCl3 +EVCO 30mL/kgBB/hari), dan K4 (AlCl3 + EVOO 30mL/kgBB/hari). Aluminium klorida diberikan selama 15 hari, dilanjutkan dengan pemberian EVCO dan EVOO selama 15 hari. Variabel respons adalah indeks rekognisi (IR), dengan object recognition test setelah perlakuan. Analisis data dengan ANOVA dilanjutkan uji LSD dengan α=0,05.Hasil: Perbandingan IR K3 dengan K1 dan K2 memiliki perbedaan yang sangat bermakna, sedangkan K4 dengan K1 dan K2 memiliki perbedaan yang sangat bermakna. Kelompok 4 lebih baik dalam meningkatkan IR dibandingkan K3 dengan perbedaan bermakna.Diskusi: Extra virgin coconut oil dan EVOO meningkatkan fungsi belajar dan memori mencit yang diinduksi AlCl3. Extra virgin olive oil lebih baik dibandingkan EVOO, karena EVOO mengandung polifenol yang dapat bekerja sebagai penghambat neuroinflamasi, neurotoksisitas, dan disfungsi neuron, sedangkan EVCO mengandung MCT sebagai kandungan utama yang berperan sebagai sumber energi utama bila terjadi kerusakan saraf.Kata kunci: Belajar, demensia, extra virgin coconut oil (oleum cocos), extra virgin olive oil (oleum olivae), memori  

BMJ Open ◽  
2018 ◽  
Vol 8 (3) ◽  
pp. e020167 ◽  
Author(s):  
Kay-Tee Khaw ◽  
Stephen J Sharp ◽  
Leila Finikarides ◽  
Islam Afzal ◽  
Marleen Lentjes ◽  
...  

IntroductionHigh dietary saturated fat intake is associated with higher blood concentrations of low-density lipoprotein cholesterol (LDL-C), an established risk factor for coronary heart disease. However, there is increasing interest in whether various dietary oils or fats with different fatty acid profiles such as extra virgin coconut oil may have different metabolic effects but trials have reported inconsistent results. We aimed to compare changes in blood lipid profile, weight, fat distribution and metabolic markers after four weeks consumption of 50 g daily of one of three different dietary fats, extra virgin coconut oil, butter or extra virgin olive oil, in healthy men and women in the general population.DesignRandomised clinical trial conducted over June and July 2017.SettingGeneral community in Cambridgeshire, UK.ParticipantsVolunteer adults were recruited by the British Broadcasting Corporation through their websites. Eligibility criteria were men and women aged 50–75 years, with no known history of cancer, cardiovascular disease or diabetes, not on lipid lowering medication, no contraindications to a high-fat diet and willingness to be randomised to consume one of the three dietary fats for 4 weeks. Of 160 individuals initially expressing an interest and assessed for eligibility, 96 were randomised to one of three interventions; 2 individuals subsequently withdrew and 94 men and women attended a baseline assessment. Their mean age was 60 years, 67% were women and 98% were European Caucasian. Of these, 91 men and women attended a follow-up assessment 4 weeks later.InterventionParticipants were randomised to extra virgin coconut oil, extra virgin olive oil or unsalted butter and asked to consume 50 g daily of one of these fats for 4 weeks, which they could incorporate into their usual diet or consume as a supplement.Main outcomes and measuresThe primary outcome was change in serum LDL-C; secondary outcomes were change in total and high-density lipoprotein cholesterol (TC and HDL-C), TC/HDL-C ratio and non-HDL-C; change in weight, body mass index (BMI), waist circumference, per cent body fat, systolic and diastolic blood pressure, fasting plasma glucose and C reactive protein.ResultsLDL-C concentrations were significantly increased on butter compared with coconut oil (+0.42, 95% CI 0.19 to 0.65 mmol/L, P<0.0001) and with olive oil (+0.38, 95% CI 0.16 to 0.60 mmol/L, P<0.0001), with no differences in change of LDL-C in coconut oil compared with olive oil (−0.04, 95% CI −0.27 to 0.19 mmol/L, P=0.74). Coconut oil significantly increased HDL-C compared with butter (+0.18, 95% CI 0.06 to 0.30 mmol/L) or olive oil (+0.16, 95% CI 0.03 to 0.28 mmol/L). Butter significantly increased TC/HDL-C ratio and non-HDL-C compared with coconut oil but coconut oil did not significantly differ from olive oil for TC/HDL-C and non-HDL-C. There were no significant differences in changes in weight, BMI, central adiposity, fasting blood glucose, systolic or diastolic blood pressure among any of the three intervention groups.Conclusions and relevanceTwo different dietary fats (butter and coconut oil) which are predominantly saturated fats, appear to have different effects on blood lipids compared with olive oil, a predominantly monounsaturated fat with coconut oil more comparable to olive oil with respect to LDL-C. The effects of different dietary fats on lipid profiles, metabolic markers and health outcomes may vary not just according to the general classification of their main component fatty acids as saturated or unsaturated but possibly according to different profiles in individual fatty acids, processing methods as well as the foods in which they are consumed or dietary patterns. These findings do not alter current dietary recommendations to reduce saturated fat intake in general but highlight the need for further elucidation of the more nuanced relationships between different dietary fats and health.Trial registration numberNCT03105947; Results.


2021 ◽  
Vol 5 (3) ◽  
pp. 121-128
Author(s):  
Ainun Nikmah ◽  
◽  
Yuseva Sariati ◽  
Nur Aini Retno Hastuti ◽  
◽  
...  

Diaper rash is inflammation that occurs in the area around the folds of the thighs, buttocks and genetalia. Diaper rash can be divided into 3 degrees, mild, moderate and severe. Diaper rash can be handled with non-pharmacological treatment by giving olive oil and virgin coconut oil (VCO). Olive oil is a vegetable oil containing oleic acid containing reserves and tocopherol α which works as an antioxidant that counteracts free radicals while VCO is a vegetable oil containing lauric acid and tocopherol α which contains the same function as olive oil. Olive oil has the highest content of oleic acid and tocopherol α, namely extra virgin olive oil (EVOO). This research aimed to prove If there is a difference between the provision of EVOO with VCO to prevent mild or moderate diaper rash in infants aged 6-12 months.This study used a Quasi Experiment research design type pre-test and post-test design. Samples were selected based on inclusion criteria with the number of samples (n = 32). 16 babies receive EVOO and 16 babies therapy at VCO. Bivariate analysis using the Wilcoxon test. The results of the study showed the influence of giving EVOO showed a p-value of 0.011 and a negative rating of 4.00 while the contribution of giving VCO showed a p-value of 0,000 and a negative rating of 8.50. The negative rating difference of 4.50 can be considered in comparison with the help of EVOO with VCO for the recovery of mild or moderate degrees of diaper rash in infants aged 6-12 months.


2019 ◽  
Vol 1402 ◽  
pp. 055067
Author(s):  
A D Djalil ◽  
H Setyawan ◽  
M I Gumelar ◽  
N A Nurulita ◽  
A Budiman

Food Research ◽  
2020 ◽  
Vol 4 (6) ◽  
pp. 1937-1946
Author(s):  
M.M.D.R. Tugay ◽  
L.E. Mopera ◽  
E.B. Esguerra ◽  
K.A.T. Castillo-Israel

This study aimed to characterize and compare pili (Canarium ovatum Engl.) pulp oil from two different varieties of pili fruits in Bicol, Philippines namely M. Orolfo and Orbase varieties for possible utilization into oil-based products. The effects of varietal differences in pili fruits on physical, chemical and quality characteristics of its pulp oil were determined. These two oils were also compared with control oils, commercially available coconut oil and extra virgin olive oil. Pili pulp oil from M. Orolfo had dark color while Orbase had color close to extra virgin olive oil. The two varieties did not significantly differ from each other in terms of refractive index, moisture and volatile matters, acid value, iodine value, saponification number and percent unsaponifiable matter but significantly differed from coconut oil and extra virgin olive oil. On the other hand, the two varieties significantly differed from each other in terms of peroxide value, Vitamin A and α-tocopherol contents. In terms of fatty acid profile, high amounts of palmitic acid were determined in both pili varieties (19-25%) compared with coconut oil (6.34%). Oleic acid in Orbase was 71.5% while M. Orolfo had 58.1%, which are comparable with extra virgin olive oil (77.9%). Pili pulp oils from M. Orolfo and Orbase can be utilized into oilbased products because its chemical and quality characteristics are within the standard. Both can be stored for a longer period of time and healthier in terms of fatty acid composition and natural antioxidant content.


2019 ◽  
Vol 7 (14) ◽  
pp. 2226-2231 ◽  
Author(s):  
Putri Cahaya Situmorang ◽  
Syafruddin Ilyas ◽  
Salomo Hutahaean ◽  
Rosidah Rosidah

BACKGROUND: Andaliman (Zanthoxylum acanthopodium) is a spice traditional Northen Sumatera, Indonesia and these fruits contain alkaloids, steroids and terpenoids. Extra Virgin Olive Oil (EVOO) contains antioxidants. Combination of this plant have activities to reduce preeclampsia. AIM: To know the safety of the combination of nano herbal andaliman and Extra virgin olive oil (EVOO) on preeclampsia patients’ liver. METHODS: Pregnant rats were made to have preeclampsia with 3 ml of NaCl 6% injections. This research consists of 5 groups: K- (negative control): normal pregnant rats, K+: preeclampsia rats; P1: PE rats were given nano herbal andaliman 1 ml EVOO / day / 20 gBW from the 13th to the 19th day of pregnancy, P2: PE rats were given nano herbal andaliman 100 mg/day / 200 gBW from the 13th to the 19th day of pregnancy, P3: PE was given the combination of 1 ml EVOO/day / 200 gBW and andaliman nano herbal 100 mg/day/200 gBW on the 13th day of pregnancy to the 19th day given orally. Then on the 20th day of pregnancy, the subjects were dissected. RESULTS: There were significant differences (p < 0.05) on the value of SGOT, SGPT, and the average damage of the hepatocyte cells except parenchymatous degeneration after being given the nano herbal andaliman and EVOO. The compared mean of normal hepatocytes cell, hydropic degeneration and necrosis value between all groups were p < 0.05 and p < 0.01 compared to (K-). The non-significant difference was found in the mean of parenchymatous degeneration between the groups (p = 0.058). CONCLUSION: The combination of nano herbal andaliman (Zanthoxylum acanthopodium) and EVOO affected the level of necrosis in hepatocyte cells on preeclampsia rats.


2019 ◽  
Vol 25 (3) ◽  
pp. 205-220 ◽  
Author(s):  
Putri Cahaya Situmorang ◽  
Syafruddin Ilyas ◽  
Salomo Hutahaean

Background: Pre-eclampsia (PE) contributes to the second cause of maternal death in Indonesia. Andaliman is a typical spice of the Batak ethnic in Northern Sumatera Province, Indonesia. This study aimed to explore the potential of novel herbal medicine compound of nanoherbal andaliman and extra virgin olive oil (EVOO) as PE treatment. Methods: Nanoherbal andaliman was generated using High-energy Milling (HEM). The treatments were divided into the following five groups: K- (control): pregnant rats; K+: PE model rats; P1: PE model rats + 0.45 g of EVOO/200 g BW on the 13th–19th day of pregnancy; P2: PE model rats + nanoherbal andaliman 100 mg/200 g BW on the 13th– 19th day of pregnancy; and P3: PE model rats + combination of 0.45 EVOO/200 g BW and nanoherbal andaliman 100 mg/200 g BW on the 13th–19th day of pregnancy. Rats were dissected on the 20th day of pregnancy. The observed parameters were blood pressure, proteinuria, malondialdehyde (MDA), Heat Shock Protein-70 HSP-70 and histology of placenta. Results: A significant difference was noticed (p<0.05) in blood pressure, proteinuria, foetal weight, haematocrit, erythrocytes and trophoblastic cells after the administration of combined nanoherbal andaliman and EVOO. No significant differences in placental weight, foetal number, leukocytes, MDA and HSP-70 were found (p>0.05). Conclusion: The combination of nanoherbal andaliman and EVOO decreased systolic blood pressure and induced the expression of MDA and HSP-70, as well as placental histology of pre-eclamptic rats.


2018 ◽  
Vol 13 (3) ◽  
pp. 396-403 ◽  
Author(s):  
Nor Asiyah ◽  
Indah Risnawati ◽  
Fania Nurul Khoirunnisa'

Perineal massage is one of the way to reduce maternal morbidity and reduce the risk of bleeding caused by laceration of the perineum. Not only Virgin Olive Oil, but also Virgin Coconut Oil becomes the alternative thing that easily absorbed by the skin. This study aims to examine the effect of Virgin Coconut Oil and Virgin Olive Oil on perineal massage on the degree of perineal laceration. This research was Quasi experimental designs, with the subjects were pregnant women with gestational age ≥34-35 weeks. The data used the Mann-Whitney test and tested 2 proportions to assess the effectiveness of the essential oils used. The result showed that there was influence of perineal massage with perineal laceration (p <0,05). Therefore, there is influence of VCO and VOO on perineal massage against the perineal laceration event. Further research is needed to assess the determinants of perineal laceration with different variables or interventions.


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