scholarly journals Lipid profile indices in young people with GCK-MODY and HNF1A-MODY

2022 ◽  
Vol 17 (4) ◽  
pp. 43-47
Author(s):  
A. K. Ovsyannikova ◽  
I. A. Belyaeva ◽  
R. B. Galenok ◽  
O. D. Rymar
Keyword(s):  
Body Mass Index ◽  
Young People ◽  
Lipid Profile ◽  
Clinical Significance ◽  
Molecular Genetic ◽  
Research Work ◽  
Young Patients ◽  
Lipid Spectrum

Despite the fact that most young patients with hyperglycemia are diagnosed with type 1 (T1DM) and type 2 (T2DM) diabetes, up to 10 % of all cases of the disease are MODY diabetes. The most common types of MODY are GCK-MODY and HNF1A-MODY, therefore the investigation of their clinical and laboratory characteristics, including lipid spectrum indicators is of high clinical significance. The aim of this research work was to study the values of lipid spectrum indicators in patients diagnosed with GCK-MODY and HNF1A-MODY at the age from 18 to 45 years. Lipid profile parameters were investigated in 56 patients aged 18 to 45 years with diagnosed GCK-MODY and HNF1A-MODY by molecular genetic tests, matched by sex, age and body mass index (BMI). No statistically significant differences were found for any of the indicators, however, in patients with HNF1A-MODY, the decrease in HDL-C is determined significantly more often than in GCKMODY. Thus, the group of persons with MODY differs in the level of lipid profile indices depending on the type of MODY.

scholarly journals Evaluation of Fasting Blood Sugar and Lipid Profile in Patients with Type 1 and Type 2 Diabetes and Normoglycemic Individuals in Gorgan, Northeastern

2019 ◽  
Vol 3 (1) ◽  
pp. 6-10 ◽  
Author(s):  
Nasim Arab Sarhadi ◽  
Mohammad-ebrahim Fakhreddin-nejad ◽  
Mohammad-hassan Rajabi ◽  
Soleiman Mokarrari ◽  
Ebrahim Naghipour ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Lipid Profile ◽  
Blood Sugar ◽  
Fasting Blood Sugar

scholarly journals Association between breastfeeding and insulin sensitivity among young people with Type 1 and Type 2 diabetes: the SEARCH Nutrition Ancillary Study

2016 ◽  
Vol 33 (10) ◽  
pp. 1452-1455
Author(s):  
N. S. The ◽  
C. M. Shay ◽  
A. P. Lamichhane ◽  
T. L. Crume ◽  
J. L. Crandell ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Sensitivity ◽  
Young People ◽  
Ancillary Study

Amiodarone-Induced Thyrotoxicosis and Thyroid Cancer: Clinical, Immunohistochemical, and Molecular Genetic Studies of a Case and Review of the Literature

2004 ◽  
Vol 128 (7) ◽  
pp. 807-810 ◽  
Author(s):  
Aly Saad ◽  
Mercedes Falciglia ◽  
David L. Steward ◽  
Yuri E. Nikiforov
Keyword(s):  
Thyroid Cancer ◽  
Molecular Genetic ◽  
Papillary Thyroid ◽  
Review Of The Literature ◽  
Genetic Studies ◽  
Hormone Synthesis ◽  
Histologic Pattern ◽  
Amiodarone Treatment

Abstract Amiodarone-induced thyrotoxicosis (AIT) is a well-known complication of amiodarone treatment found in 3% to 12% of patients. Two types of AIT have been described, each associated with a distinct histologic pattern of thyroid involvement. Type 1, which typically develops in the background of pre-existing thyroid disease, is due to iodine-induced excess thyroid hormone synthesis, whereas type 2 is due to destructive thyroiditis. The prevalence of thyroid cancer in patients with AIT is unknown. We report a case of papillary thyroid carcinoma associated with type 2 AIT.

scholarly journals Clinical Significance of the Maximum Body Mass Index Before Onset of Type 2 Diabetes for Predicting Beta-Cell Function

2020 ◽  
Vol 4 (4) ◽  
Author(s):  
Harutoshi Ozawa ◽  
Kenji Fukui ◽  
Sho Komukai ◽  
Yoshiya Hosokawa ◽  
Yukari Fujita ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Body Mass Index ◽  
Insulin Secretion ◽  
Beta Cell ◽  
Clinical Significance ◽  
Beta Cell Function ◽  
Cell Function ◽  
Duration Of Diabetes ◽  
Maximum Body

Abstract Objective This study aimed to clarify the clinical significance of the maximum body mass index (BMI) before the onset of type 2 diabetes (MBBO) for predicting pancreatic beta-cell function. Methods This was a cross-sectional observational study. Of 1304 consecutively admitted patients with type 2 diabetes, we enrolled 410 patients satisfying the criteria in this study. The correlations between the C-peptide index (CPI), which is one of the parameters that reflects beta-cell function, and various clinical parameters, including MBBO and duration of diabetes, were analyzed in multiple linear regression analyses. Results The analyses revealed that MBBO was correlated with CPI independently after adjustment for age, sex, HbA1c, and duration of diabetes. When we divided the subjects into three subgroups by MBBO (MBBO < 25 kg/m2; 25 kg/m2 ≤ MBBO < 30 kg/m2; MBBO ≥ 30 kg/m2), CPI was negatively correlated with duration of diabetes in each subgroup, while the rates of CPI based on the duration of diabetes were not different among the three MBBO subgroups. In contrast, the declining rates of CPI were higher in the BMI ≥ 25 kg/m2 group on admission than in the BMI < 25 kg/m2 group on admission. Conclusions MBBO may be an independent factor correlating with beta-cell function and may predict insulin secretion capacity at diagnosis, but it does not seem to affect the rate of decline in insulin secretion capacity after diagnosis. It is important to preserve beta-cell function by decreasing a patient’s BMI during treatment after diagnosis regardless of MBBO.

Implementation of the Type-2 Fuzzy Controller in PLC

2010 ◽  
Vol 164 ◽  
pp. 95-98 ◽  
Author(s):  
Ireneusz Dominik
Keyword(s):  
Fuzzy Logic ◽  
Fuzzy Logic Controller ◽  
Fuzzy Controller ◽  
Research Work ◽  
Problem Type ◽  
Object A ◽  
Develop Type ◽  
Linear Object

The main aim of the presented research work was to develop type-2 fuzzy logic controller, which by its own design should be “more intelligent” than type-1. Along with the intelligence it should provide better results in solving a particular problem. Type-2 fuzzy logic controller is not well-known and it is rarely used at present. The idea of type-2 fuzzy logic set was presented by Zadeh in 1975, shortly after the presentation of type-1 fuzzy set. At the beginning scientists and researchers worked on type-1. Only after developing type-1 the attention was directed towards the type-2. The first applications of type-2 fuzzy logic in control appeared in 2003. The fuzzy logic controller type-2 was tested experimentally by controlling a non-linear object: a shape memory alloy (SMA) actuator DM-01PL, made by Miga Motor company, which despite small size distinguishes itself by its 9 N strength. Comparison of experimental data of the fuzzy logic controller type-2 and type-1 clearly indicates the superiority of the former, particularly in reducing signal overshoots.

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