scholarly journals Air bubble after intrathecal triamcinolone acetonide application in a progressive multiple sclerosis patient

2021 ◽  
Vol 2 (2) ◽  
Author(s):  
Thomas Müller ◽  
◽  
Sven Lütge; Gunnar Gäde ◽  
Keyword(s):  
Multiple Sclerosis ◽  
Triamcinolone Acetonide ◽  
Fold Increase ◽  
Progressive Multiple Sclerosis ◽  
Walking Distance ◽  
Air Bubble ◽  
Upper Limb Function ◽  
Repulsive Guidance Molecule ◽  
Repulsive Guidance Molecule A ◽  
Guidance Molecule

Repeated intrathecal application of the sustained release steroid Triamcinolone Acetonide (TCA) is beneficial in progressive Multiple Sclerosis (MS) patients [1]. Particularly, patients with spinal lesions often show a distinct benefit with a three fold increase of the maximum walking distance [2]. This therapy ameliorates walking distance, improves upper limb function and reduces spastic symptoms [1]. The putative regenerative effect may result from declined synthesis of the repulsive guidance molecule A [3]. Visualization of air bubbles after a TCA injection prompted this case report.

scholarly journals Repeated Intrathecal Triamcinolone Acetonide Administration in Progressive Multiple Sclerosis: A Review

2011 ◽  
Vol 2011 ◽  
pp. 1-8 ◽  
Author(s):  
Mazen Abu-Mugheisib ◽  
Reiner Benecke ◽  
Uwe K. Zettl
Keyword(s):  
Multiple Sclerosis ◽  
Triamcinolone Acetonide ◽  
Progressive Multiple Sclerosis ◽  
Intrathecal Administration ◽  
Small Sample ◽  
Walking Distance ◽  
Advantages And Disadvantages ◽  
Therapy Option ◽  
Small Sample Sizes ◽  
Selection Of

At the present time, anti-inflammatory, immunomodulatory, or immunosuppressive treatments of multiple sclerosis (MS) are mainly effective in the early phases of the disease but are of less advantage in progressive phases. Current therapeutic strategies of both primary and secondary progressive MS are rare. One alternative may be intrathecal application of triamcinolone acetonide (TCA). Number of papers deal with advantages and disadvantages of intrathecal administration in MS. Former trials lacked detailed selection of MS patients, with small sample sizes, low steroid dosages, and only a small number of intrathecal administration of short acting steroids. The present paper summarizes recent trials performed following a different treatment regime. They were conducted in patients with progressive MS suffering mainly from spinal symptoms and documented a significant improvement of EDSS and walking distance (WD). Intrathecal TCA administration is a proposal to take into account as one therapy option in patients with a progressive clinical course and predominantly spinal symptoms.

scholarly journals Targeting Repulsive Guidance Molecule A to Promote Regeneration and Neuroprotection in Multiple Sclerosis

Cell Reports ◽  
2015 ◽  
Vol 10 (11) ◽  
pp. 1887-1898 ◽  
Author(s):  
Elena Demicheva ◽  
Yi-Fang Cui ◽  
Philip Bardwell ◽  
Stefan Barghorn ◽  
Martina Kron ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Repulsive Guidance Molecule ◽  
Repulsive Guidance Molecule A ◽  
Guidance Molecule

scholarly journals Repulsive Guidance Molecule A Regulates Adult Neurogenesis Via the Neogenin Receptor

2020 ◽  
Vol 15 ◽  
pp. 263310552094848
Author(s):  
Toke Jost Isaksen ◽  
Toshihide Yamashita
Keyword(s):  
Adult Neurogenesis ◽  
Neuronal Development ◽  
Neurite Growth ◽  
Granular Cell ◽  
Molecular Networks ◽  
Mammalian Brain ◽  
Repulsive Guidance Molecule ◽  
Repulsive Guidance Molecule A ◽  
Newborn Neurons ◽  
Guidance Molecule

Repulsive guidance molecule A (RGMa) exhibits repulsive guidance of axonal growth and regulates neuronal differentiation during development of the mammalian brain. In this commentary, we describe the findings of our recent paper, “Repulsive Guidance Molecule A Suppresses Adult Neurogenesis,” and discuss a possible model for RGMa suppression of newborn neurons that fail to properly migrate into the granular cell layer. In the study, we provided evidence that RGMa suppressed neurite growth and survival of newborn neurons in the adult dentate gyrus. This effect depends on the multifunctional Neogenin receptor expressed in adult neural stem cells through activation of the Rho-associated protein kinase leading to neurite growth inhibition and ultimately cell death. It should be noted that both RGMa and Neogenin interact with several well-described molecules, including bone morphogenetic proteins, that regulate neuronal development. Thus, it is likely that RGMa interacts with other intricate molecular networks that regulate adult neurogenesis.

Efficacy and safety of repeated intrathecal triamcinolone acetonide application in progressive multiple sclerosis patients

2003 ◽  
Vol 211 (1-2) ◽  
pp. 81-84 ◽  
Author(s):  
Volker Hoffmann ◽  
Sebastian Schimrigk ◽  
Saida Islamova ◽  
Kerstin Hellwig ◽  
Carsten Lukas ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Triamcinolone Acetonide ◽  
Progressive Multiple Sclerosis ◽  
Efficacy And Safety ◽  
Multiple Sclerosis Patients

scholarly journals LIM-only protein 4 interacts directly with the repulsive guidance molecule A receptor Neogenin

2008 ◽  
Vol 107 (2) ◽  
pp. 418-431 ◽  
Author(s):  
Gregor Schaffar ◽  
Junko Taniguchi ◽  
Tanja Brodbeck ◽  
Axel H. Meyer ◽  
Martin Schmidt ◽  
...  
Keyword(s):  
Repulsive Guidance Molecule ◽  
Repulsive Guidance Molecule A ◽  
Guidance Molecule
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