Glutathione S-transferase M1, T1 and P1 polymorphisms and bladder cancer risk in Egyptians

2005 ◽  
Vol 20 (1) ◽  
pp. 69-72 ◽  
Author(s):  
A.A. Saad ◽  
P.J. O'Connor ◽  
M.H. Mostafa ◽  
N.E. Metwalli ◽  
D.P. Cooper ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Risk ◽  
Bladder Cancer Risk ◽  
Glutathione S Transferase

Glutathione S-Transferase M1, T1 and P1 Polymorphisms and Bladder Cancer Risk in Egyptians

2005 ◽  
Vol 20 (1) ◽  
pp. 69-72 ◽  
Author(s):  
A.A. Saad ◽  
P.J. O'Connor ◽  
M.H. Mostafa ◽  
N.E. Metwalli ◽  
D.P. Cooper ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Risk ◽  
A Priori ◽  
Healthy Controls ◽  
Bladder Cancer Risk ◽  
Glutathione S Transferase ◽  
Egyptian Population ◽  
Genotype Frequencies ◽  
Increased Risk ◽  
History Of

Previous studies suggest that bladder cancer risk may vary with GST genotype but these results are inconsistent. The aim of this study was to explore whether GSTM1, GSTT1 and GSTP polymorphisms were associated with increased bladder cancer risk in an Egyptian population. GSTM1, GSTT1 and GSTP1 genotype frequencies were determined in bladder cancer cases (n=72) and healthy controls with no history of malignancies (n=82) using PCR-based techniques. The GSTT1*2 genotype was particularly associated with increased risk (OR 2.71, 95%CI 1.27–5.73) and the GSTM1*2 genotype to a lesser extent (OR 1.63, 95%CI 0.85–3.10). 18.1% of cases but only 7.3% of controls were GSTP1*B*B homozygotes (OR 2.38, 95%CI 0.83–6.87). The presence of two or more a priori at-risk genotypes was associated with increased bladder cancer risk (OR 2.42; 95%CI 1.47–3.97). These results suggest that polymorphisms in the GST genes are associated with increased risk of bladder cancer among Egyptians.

Quantitative assessment of the association between glutathione S-transferase P1 Ile105Val polymorphism and bladder cancer risk

Tumor Biology ◽  
2013 ◽  
Vol 34 (3) ◽  
pp. 1651-1657 ◽  
Author(s):  
Zhenlong Wang ◽  
Li Xue ◽  
Tie Chong ◽  
Hecheng Li ◽  
Haiwen Chen ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Risk ◽  
Quantitative Assessment ◽  
Bladder Cancer Risk ◽  
Glutathione S Transferase

Genetic polymorphisms of glutathione S-transferase T1 and bladder cancer risk: a meta-analysis

2009 ◽  
Vol 10 (1) ◽  
pp. 59-68 ◽  
Author(s):  
Fang-fang Zeng ◽  
Sheng-yuan Liu ◽  
Wen Wei ◽  
Song-po Yao ◽  
Shui Zhu ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Risk ◽  
Genetic Polymorphisms ◽  
Meta Analysis ◽  
Bladder Cancer Risk ◽  
Glutathione S Transferase

Combined effect of glutathione S-transferase M1 and T1 genotypes on bladder cancer risk

2002 ◽  
Vol 177 (2) ◽  
pp. 173-179 ◽  
Author(s):  
Seung-Joon Lee ◽  
Soo-Hun Cho ◽  
Sue Kyung Park ◽  
Soo-Woong Kim ◽  
Moon Soo Park ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cancer Risk ◽  
Combined Effect ◽  
Bladder Cancer Risk ◽  
Glutathione S Transferase

914 GLUTATHIONE S-TRANSFERASE M1, BLADDER CANCER RISK AND STRUCTURAL CHANGE IN THE LOCAL INDUSTRY

2013 ◽  
Vol 189 (4S) ◽  
Author(s):  
Daniel Ovsiannikov ◽  
Silvia Selinski ◽  
Marie-Louise Lehmann ◽  
Meinolf Blaszkewicz ◽  
Oliver Moormann ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Structural Change ◽  
Cancer Risk ◽  
Bladder Cancer Risk ◽  
Glutathione S Transferase
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