THE BIOLOGICAL ROLE OF VITAMIN D

Vestnik ◽  
2021 ◽  
pp. 169-172
Author(s):  
Д.Т. Джатдоева ◽  
А.А. Гочияев ◽  
М.Б. Семенов ◽  
З.М. Каппушева
Keyword(s):  
Vitamin D ◽  
Respiratory Diseases ◽  
Postoperative Recovery ◽  
The Body ◽  
Uv Treatment ◽  
Protective Properties ◽  
Acute Respiratory Diseases ◽  
The Moment ◽  
Positive Effect

В статье рассматриваются заболевания, зависящие от уровня витамина D в организме, возможные методы коррекции его уровня и их последствия. Рассматривается зависимость организма -как единого целого от уровня данного витамина в крови. На данный момент во всем мире наблюдается глобальный дефицит витамина D, у всех пациентов, которые сдают данный анализ, которое так же было выявлено на фоне глобальной пандемии “COVID-19”. Влияние витамина D на иммунитет абсолютно точно доказано, и поэтому его дефицитное состояние может ухудшать течение различных заболеваний. Также витамин D выступает в качестве гормона, недостаток которого приводит к патологиям сердечно-сосудистой системы, рахиту, остеопорозу, сахарному диабету, ожирению и другим серьезным заболеваниям. Неоднократно рассматривалось влияние его уровня на постоперационное восстановление. В статье так же приводятся методы коррекции посредством UV в зимнее время, которое как показали данные является опасной. В статье описываются нейродегенеративные расстройства, на которых оказывает огромное влияние уровень данного витамина и его профилактика. Проанализировано влияние его уровня на здоровье пациенток в постменопаузе, приводящее к нежелательным последствиям в том числе и остеопорозу. Приведены примеры влияния на защитные свойства ротовой полости при пародонте и кариесе. Описывается влияние на процесс течения острых респираторных заболеваний у детей, а также влияние на течение болезни при сахарном диабете. The article discusses diseases that depend on the level of vitamin D in the body, possible methods of correcting its level and their consequences. The dependence of the body on the level of this vitamin in the blood is considered. At the moment, there is a global vitamin D deficiency worldwide, which was revealed during the global COVID-19 pandemic. The positive effect of vitamin D on the immune system has been proven, and therefore its deficiency can worsen the course of various diseases. Vitamin D also acts as a hormone, the lack of which leads to pathologies of the cardiovascular system, rickets, osteoporosis, diabetes, obesity, and other serious diseases. The influence of its level on postoperative recovery is also considered. In addition, the article provides methods of correction by means of UV treatment in winter, which, as the data has shown, is dangerous. The article describes neurodegenerative disorders, which are greatly influenced by the level of this vitamin and its prevention. The influence of its level on the health of postmenopausal patients, leading to undesirable consequences, including osteoporosis, is analyzed. Examples of the effect on the protective properties of the oral cavity in periodontal disease and caries are given. The article describes the effect on the course of acute respiratory diseases in children, as well as the effect on the course of the disease in diabetes mellitus.

scholarly journals Influence of vitamin D provision on the course of acute respiratory infections in children

2021 ◽  
pp. 73-80
Author(s):  
Yu.V. Marushko ◽  
◽  
S.I. Esipova ◽  
T.V. Gishchak ◽  
◽  
...  
Keyword(s):  
Vitamin D ◽  
Respiratory Diseases ◽  
Conflicts Of Interest ◽  
Respiratory Infections ◽  
Vitamin D Supplementation ◽  
The Body ◽  
Skeletal System ◽  
D3 Receptors ◽  
The Relationship ◽  
Positive Effect

The review article provides data from modern studies confirming the multifaceted effect of vitamin D in the human body. Vitamin D3 receptors (VDRs) have been shown to be present in most organs and tissues of the body. This confirms the importance of vitamin D not only in the formation of the skeletal system, but also in many of its extraosseous effects. Calcitriol affects the modulation of cell growth, neuromuscular conduction, inflammation processes, and is also an important stimulator of innate immunity due to the synthesis of antimicrobial peptides that provide protection against bacteria and viruses. In recent years, the relationship between the concentration of vitamin D in the blood and the incidence of respiratory infections in children has been actively studied. Many studies have shown that low vitamin D status is characteristic of most children with respiratory infections, and an adequate level of 25(OH)D in serum has a positive effect on the frequency of these infections and the severity of their course. Most authors demonstrate the benefits of vitamin D supplementation in the prevention of respiratory diseases in children, but there is no consensus regarding the frequency and dosage of vitamin D. The authors declare that they have no conflicts of interest. Key words: vitamin D, children, deficiency, respiratory diseases, prevention.

Evaluation of clinical efficacy of Derinat® in form of spray in practice of district therapist

2019 ◽  
Vol 1 (9) ◽  
pp. 38-46
Author(s):  
A. P. Babkin ◽  
A. A. Zuikova ◽  
O. N. Krasnorutskaya ◽  
Yu. A. Kotova ◽  
D. Yu. Bugrimov ◽  
...  
Keyword(s):  
Clinical Efficacy ◽  
Respiratory Diseases ◽  
Viral Infections ◽  
Pharmacological Action ◽  
The Body ◽  
Natural Resistance ◽  
Acute Respiratory Diseases ◽  
T Helpers ◽  
T Killers ◽  
Stimulation Of

The widespread worldwide spread of acute respiratory diseases is an urgent problem in health care. Expressed polyetiology of respiratory diseases does not allow to limit the use of specific vaccine preparations and dictates the need to use to combat them a variety of non-specific means that stimulate the natural resistance of the human body. The main pharmacological action of sodium deoxyribonucleate is the stimulation of phagocytic activity of T-helpers and T-killers, increasing the functional activity of neutrophils and monocytes/ macrophages, providing regeneration and repair processes in the epithelial component of antiviral protection of the body. Based on the above, the study of the clinical efficacy of Derinat® in the form of spray in the treatment of acute respiratory viral infections is relevant.

scholarly journals Role of Vitamin D in Reducing the Frequency of Asthma Attacks in Patients with Frequent Exacerbation of Asthma

2021 ◽  
pp. 11-16
Author(s):  
Mubeen Ahmed Memon ◽  
Sheeba Faryal Ansari ◽  
Mumtaz Ali Lakho ◽  
Mukhtiar Hussain Jaffery ◽  
Syed Zulfiquar Ali Shah ◽  
...  
Keyword(s):  
Vitamin D ◽  
Corticosteroid Treatment ◽  
Vitamin D Supplementation ◽  
The Body ◽  
P Value ◽  
Care Hospital ◽  
Asthma Exacerbations ◽  
Vitamin D Levels ◽  
Interventional Group

Introduction: Vitamin D deficiency is common among asthmatics with literature suggesting that its low levels in the body may trigger exacerbations and decrease the response to corticosteroid treatment. It has also shown to inhibit the production of cytokines, which in turn enhances the body’s response to corticosteroid treatment during an exacerbation. Therefore, maintenance of adequate levels of vitamin D in patients with asthma may reduce the risk of exacerbation and improve their general health. This study aims to explore the role of vitamin D supplementation in preventing asthma exacerbations. Methods: This single blind parallel arm interventional study was conducted in the pulmonology ward in a tertiary care hospital from June 2018 to April 2020. Two hundred (n= 200) participants with a history of frequent acute exacerbation of asthma were enrolled in the study via consecutive convenient non-probability technique. Participants were divided into two groups; the placebo and the interventional group that received 200,000 IU of vitamin D capsule. Results: Compared to day 0, mean episodes of exacerbation in the interventional group were significantly lower after 180 days (1.1 ± 0.4 vs. 0.61 ± 0.3; p-value <0.0001). Similarly, number of asthma attacks in past 7 days was significantly lower in intervention group after 180 days (4.4 ± 2.7 vs. 3.1 ± 1.5; p-value 0.0001) Conclusion: Vitamin D supplementation is a safe and cost-friendly approach to reducing asthma exacerbations. It may also help to improve the condition in severe asthmatics with low vitamin D levels.

The role of vitamin D in the control of Leishmania infection

2015 ◽  
Vol 93 (5) ◽  
pp. 369-376 ◽  
Author(s):  
Espiridión Ramos-Martínez ◽  
Laila Gutierrez-Kobeh ◽  
Mónica Irais Villaseñor-Cardoso
Keyword(s):  
Vitamin D ◽  
Essential Element ◽  
The Body ◽  
Bone Architecture ◽  
Leishmania Infection ◽  
Vast Number ◽  
Clinical Syndromes ◽  
Leishmania Spp ◽  
Vector Borne

Vitamin D has been described as an essential element for maintaining the homeostasis of mineral content in the body and bone architecture. However, our view of the physiological functions of this micronutrient has radically changed, owing to the vast number of properties, not calcium-related, mediated by its nuclear receptor. This receptor has been found in a variety of cells, including the immune cells, where many of the functions performed by vitamin D are related to inflammation. Although the effect of vitamin D has been widely studied in many diseases caused by viruses or bacteria, very little is known about its role in parasitic diseases, such as leishmaniasis, which is a vector-borne disease caused by different species of the intracellular parasite Leishmania spp. This disease occurs as a spectrum of different clinical syndromes, all of them characterized by a large amount of tissue damage, sometimes leading to necrosis. Owing to the involvement of vitamin D in inflammation and wound healing, its role in leishmaniasis must be relevant, and could be used as an adjuvant for the control of this parasitic disease, opening a possibility for a therapeutic application.

scholarly journals MODERN VIEWS ON ROLE OF VITAMIN D IN PATHOGENESIS OF BRONCHIAL ASTHMA IN CHILDREN

2020 ◽  
Vol 8 (4) ◽  
pp. 617-628
Author(s):  
N.A. Belykh ◽  
◽  
I.V. Piznyur ◽  
Keyword(s):  
Vitamin D ◽  
Epithelial Cells ◽  
Bronchial Asthma ◽  
Airway Remodeling ◽  
Current Trend ◽  
Tissue Growth ◽  
The Body ◽  
Common Disease ◽  
Mesenchymal Transition

Bronchial asthma (BA) is a common disease of airways in children characterized by chronic inflammation, as well as respiratory symptoms varying in time and intensity. In recent years, an increase in the prevalence of BA has been seen, both among the adult and children’s population. The current trend stimulates scientists to continue studying the probable influence of various factors on this process, including the role of micronutrient deficiency, especially antioxidants, methylene donors and vitamin D (VD). Hypovitaminosis D has been considered as a provoking factor affecting the pathogenesis of various pathological processes. The results of numerous studies confirm the opinion that VD affects the intensity of inflammation, reducing the produc-tion of proinflammatory cytokines and secretion of mucus, and stimulates the secretion of the antiinflammatory cytokine IL-10. VD-regulated genes encode the synthesis of antimicrobial peptides that provide protection against bacteria and viruses provoking BA exacerbations. The article discusses the role of tissue growth factor (TGF-β) as an initiator of fibrosis in the epithelial cells of the respiratory tract through the activation of epithelial mesenchymal transition signals, and also discusses the inhibitory effect of VD on the processes of airway remodeling in BA. To-day it is known that VD can inhibit the progression of pulmonary fibrosis in various ways, in-cluding suppression of the expression of TGF, inhibition of the motility of epithelial cells induced by TGF-β, reduction of the excessive activation of RAS (antifibrotic effect), increase in the level of TGF antagonist. Separately, the issue of the possible strengthening of the antioxidant defense of the body in BA is considered through optimization of the supply of the organism with VD. Conclusion. Thus, taking into account the fact that to date, the results of clinical studies of the use of VD in the treatment of BA gave conflicting results, additional studies are needed to address controversial issues regarding the role of VD deficiency in the pathogenesis of BA and its control. Further understanding of the mechanisms underlying the airway remodeling will help develop a set of measures aimed at minimizing the risk of structural changes in AD.

scholarly journals An Updated Mini Review of Vitamin D and Obesity: Adipogenesis and Inflammation State

2016 ◽  
Vol 4 (3) ◽  
pp. 526-532 ◽  
Author(s):  
Zujaja-Tul-Noor Hamid Mehmood ◽  
Dimitrios Papandreou
Keyword(s):  
Vitamin D ◽  
Adipose Tissue ◽  
Hypovitaminosis D ◽  
The Body ◽  
Positive Energy ◽  
Vitamin D Receptors ◽  
The Past ◽  
Positive Energy Balance ◽  
Relationship Of

Vitamin D related research continues to expand and theorise regarding its involvement in obesity, as both hypovitaminosis D and obesity strike in pandemic proportions. Vitamin D plays an important role in immune system through Vitamin D Receptors (VDR), which are transcription factors located abundantly in the body. Due to this characteristic, it is potentially linked to obesity, which is a state of inflammation involving the release of cytokines from adipose tissue, and exerting stress on other organs in a state of positive energy balance. Research trials in the past couple of years and systematic reviews from SCOPUS and MEDLINE will be discussed. The role of Vitamin D throughout the lifespan (from fetal imprinting until older age), and in various other obesity mediated chronic conditions shall be highlighted. Various mechanisms attributed to the inverse relationship of Vitamin D and obesity are discussed with research gaps identified, particularly the role of adipokines, epigenetics, calcium and type of adipose tissue.

Water in Students’ Life and its Impact on their Health

2021 ◽  
Vol 63 (2) ◽  
pp. 99-104
Author(s):  
Grygoriy P. Griban ◽  
Olena V. Filatova ◽  
Anatolii I. Bosenko ◽  
Ganna V. Tamozhanska ◽  
Andrii M. Lytvynenko ◽  
...  
Keyword(s):  
Water Balance ◽  
Water Consumption ◽  
Health Indicators ◽  
The Body ◽  
High Quality ◽  
National University ◽  
Quality Water ◽  
The Impact ◽  
Positive Effect

Aim: Is to study the role of water in the life of students and to investigate the impact of its quality on the health of students who did sports. Materials and Methods: The study was conducted at Polissya National University (Zhytomyr, Ukraine) in 2018-2020. Thus, 509 students between the ages of 17 and 23 who did not do sports and 317 student-athletes were surveyed. The level of students’ health was examined according to the methodology of G.L. Apanasenko. Results: It was found that the majority of students who did not do sport (97.5% of males and 96.7% of females) did not stick to the water consumption schedule, while 50.8% of males and 52.2% of females who did sport followed strict norms of the water consumption schedule to maintain water balance. According to most health indicators, students-athletes had better average values of the studied indicators than those students did not do sport. Conclusions: Water plays an important role in the lives of students and especially those students who do sport. High-quality water, sticking to water consumption schedule, especially during prolonged physical exercise and at high temperatures have a positive effect on the body and improve the health of students.

Autoprobiotics for personalized nutrition of school children

2020 ◽  
pp. 65-68
Author(s):  
V.I. Ganina
Keyword(s):  
General Education ◽  
The Body ◽  
School Age Children ◽  
School Age ◽  
Individual Organism ◽  
Impaired Health ◽  
The Russian Federation ◽  
The Individual ◽  
Positive Effect

According to the Ministry of Health and Social Development of Russia, the health status of children and adolescents in the Russian Federation is characterized by the following indicators: more than half of school-age children have impaired health; two-thirds of children under 14 have chronic diseases; only 10-15 percent of graduates of general education institutions can be classified as healthy. In recent decades, with the development of nutrigenomics, the world community of scientists has come to understand the importance of the role of the microbiota in the human body and its relation with nutrition. Normal intestinal microbiota is involved in a variety of physiological functions of the body of school-age children: protective, digestive, detoxifying and anticarcinogenic, synthetic, genetic, immunogenic, metabolic, and others. Probiotic bacteria are one of the functional ingredients that have proven to have a positive effect on children's bodies. Methods of normoflora correction are proposed, aimed not only at restoring evolutionarily conditioned microbial populations, but also providing an effective impact on the individual organism.

scholarly journals Role of Farnesoid X Receptor in the Pathogenesis of Respiratory Diseases

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Jin-nan Wu ◽  
Jian-rong Chen ◽  
Jin-liang Chen
Keyword(s):  
Bile Acid ◽  
Respiratory Diseases ◽  
The Body ◽  
Farnesoid X Receptor ◽  
Bile Acid Metabolism ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Target Organs ◽  
The Stability

Farnesoid X receptor (FXR) is a bile acid receptor encoded by the Nr1h4 gene. FXR plays an important role in maintaining the stability of the internal environment and the integrity of many organs, including the liver and intestines. The expression of FXR in nondigestible tissues other than in the liver and small intestine is known as the expression of “nonclassical” bile acid target organs, such as blood vessels and lungs. In recent years, several studies have shown that FXR is widely involved in the pathogenesis of various respiratory diseases, such as chronic obstructive pulmonary disease, bronchial asthma, and idiopathic pulmonary fibrosis. Moreover, a number of works have confirmed that FXR can regulate the bile acid metabolism in the body and exert its anti-inflammatory and antifibrotic effects in the airways and lungs. In addition, FXR may be used as a potential therapeutic target for some respiratory diseases. For example, FXR can regulate the tumor microenvironment by regulating the balance of inflammatory and immune responses in the body to promote the occurrence and development of non-small-cell lung cancer (NSCLC), thereby being considered a potential target for immunotherapy of NSCLC. In this article, we provide an overview of the internal relationship between FXR and respiratory diseases to track the progress that has been achieved thus far in this direction and suggest potential therapeutic prospects of FXR in respiratory diseases.

Sign in / Sign up

Export Citation Format

Share Document