Development of intervertebral disk calcification in the dachshund: a prospective longitudinal radiographic study

2001 ◽  
Vol 37 (3) ◽  
pp. 274-282 ◽  
Author(s):  
VF Jensen ◽  
J Arnbjerg
Keyword(s):  
Selective Breeding ◽  
Clinical Signs ◽  
Incidence Rates ◽  
Intervertebral Disk ◽  
Radiographic Examination ◽  
Intervertebral Disks ◽  
High Incidence ◽  
Steady Level ◽  
Prospective Longitudinal

Plain spinal radiography was performed in 40 dachshunds at regular intervals from 6 or 12 months of age to 2 years of age. A follow-up study at 3 to 4 years of age included 12 dogs. High incidence rates of intervertebral disk calcification were seen at 6 to 18 months of age. The number of dogs affected and number of calcified disks seemed to reach a steady level or a maximum at about 24 to 27 months of age. Dissolution of previously calcified disks without clinical signs was demonstrated, causing decreasing numbers of visibly calcified disks after 2 years of age. Radiographic examination for calcified intervertebral disks in the dachshund is recommended at 24 to 30 months of age for heritability studies and selective breeding.

Clinical pathways and outcomes of patients with Barrett’s esophagus in tertiary care settings: a prospective longitudinal cohort study in Australia, 2008–2016

2020 ◽  
Author(s):  
Renhua Na ◽  
Kyoko Miura ◽  
Suzanne O’Brien ◽  
Guy D Eslick ◽  
Bradley J Kendall ◽  
...  
Keyword(s):  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Clinical Pathways ◽  
Tertiary Care ◽  
Incidence Rates ◽  
Segment Length ◽  
Low Grade ◽  
Adjusted Incidence ◽  
Prospective Longitudinal

Summary Background Clinical services for Barrett’s esophagus have been rising worldwide including Australia, but little is known of the long-term outcomes of such patients. Retrospective studies using data at baseline are prone to both selection and misclassification bias. We investigated the clinical characteristics and outcomes of Barrett’s esophagus patients in a prospective cohort. Methods We recruited patients diagnosed with Barrett’s esophagus in tertiary settings across Australia between 2008 and 2016. We compared baseline and follow-up epidemiological and clinical data between Barrett’s patients with and without dysplasia. We calculated age-adjusted incidence rates and estimated minimally and fully adjusted hazard ratios (HR) to identify those clinical factors related to disease progression. Results The cohort comprised 268 patients with Barrett’s esophagus (median follow-up 5 years). At recruitment, 224 (84%) had no dysplasia, 44 (16%) had low-grade or indefinite dysplasia (LGD/IND). The age-adjusted incidence of esophageal adenocarcinoma (EAC) was 0.5% per year in LGD/IND compared with 0.1% per year in those with no dysplasia. Risk of progression to high-grade dysplasia/EAC was associated with prior LGD/IND (fully adjusted HR 6.55, 95% confidence interval [CI] 1.96–21.8) but not long-segment disease (HR 1.03, 95%CI 0.29–3.58). Conclusions These prospective data suggest presence of dysplasia is a stronger predictor of progression to cancer than segment length in patients with Barrett’s esophagus.

scholarly journals Guided Tissue Regeneration Principle with Inserts of PerioGlas in Endodontic Surgery: Two Case Reports

2013 ◽  
Vol 3 (2) ◽  
pp. 72-77
Author(s):  
Sattyam V Wankhade ◽  
Jyoti Lokade ◽  
Monaj Chandak ◽  
Anuja Lanjewar
Keyword(s):  
Tissue Regeneration ◽  
Root Canal ◽  
Case Reports ◽  
Healing Process ◽  
Clinical Signs ◽  
Guided Tissue Regeneration ◽  
Radiographic Examination ◽  
Endodontic Surgery ◽  
Source Of Infection

ABSTRACT Most periapical radiolucent lesions associated with infections of the root canal system heal uneventfully after endodontic treatment. However, some cases may require periradicular surgery in order to remove pathologic tissue from the periapical region and simultaneously eliminate any source of infection that could not be removed by orthograde root canal treatment. With an adequate technique, surgery can address these issues, although it may be insufficient in some situations. This report describes the healing process after surgery in two cases with a 12 months follow-up. In these cases, apicoectomy was followed by retrograde sealing with Super EBA (Harry J. Bosworth Company, Illinois, USA). The bone defect was filled with PerioGlas (NovaBone, Austin, TX, USA) and covered with a resorbable Guidor membrane (Sunstar, Foster Ave, Chicago, USA). No intraoperative or postoperative complications were observed. After 24 months of follow-up, the patient showed no clinical signs or symptoms associated with the lesion and radiographic examination showed progressive resolution of radiolucency. How to cite this article Lokade J, Wankhade S, Chandak M, Lanjewar A. Guided Tissue Regeneration Principle with Inserts of PerioGlas in Endodontic Surgery: Two Case Reports. Int J Prosthodont Restor Dent 2013;3(2):72-77.

Letter to the Editor

PEDIATRICS ◽  
1978 ◽  
Vol 61 (2) ◽  
pp. 330-331
Author(s):  
Frederic N. Silverman
Keyword(s):  
Child Abuse ◽  
Physical Examination ◽  
Clinical Signs ◽  
Radiographic Examination ◽  
Skeletal Injury ◽  
Necessary And Sufficient ◽  
Prior Injury ◽  
Roentgenographic Examination ◽  
Careful Physical Examination

There are several reasons for a roentgenographic examination of the suspected child abuse victim, including radiographic confirmation and evaluation of obvious trauma for purposes of medical management as well as diagnosis; screening to identify clinically silent, recent injury or evidence of prior injury; and to provide a baseline for comparison with follow-up films. Under no circumstances should a radiographic examination be a substitute for a careful physical examination. Assuming that all areas of the child's body where clinical signs can be found have been examined, what constitutes a necessary and sufficient roentgenographic examination to complement the medically indicated examination or to identify occult evidence of skeletal injury where clinical signs are lacking?

scholarly journals Report of a pregnant woman with mosaic Turner syndrome

2021 ◽  
pp. 46-48
Author(s):  
Yunus Emre TOPDAĞI
Keyword(s):  
Pregnant Woman ◽  
High Risk ◽  
Turner Syndrome ◽  
First Trimester ◽  
Cardiovascular Complications ◽  
Incidence Rates ◽  
Spontaneous Pregnancy ◽  
High Incidence ◽  
History Of

Spontaneous pregnancy in women with Turner syndrome is rare (5%) and relative- ly high risk. A number of methods to preserve fertility in such women have been discussed. Careful follow-up is required during these pregnancies due to the high incidence rates of neonatal, obstetric, maternal, and cardiovascular complications. A 39-year-old multigravid woman (G5, P3, A2) with mosaic Turner syndrome with a history of three spontaneous pregnancies and two miscarriages was evaluated at our clinic. The analysis showed mos 45,X [9]/46,XX [38] mosaic Turner syndrome. Her first and fourth pregnancies resulted in miscarriages during the first trimester. Here, we discuss a pregnant woman with mosaic Turner syndrome with unaffected fertility but with a history of spontaneous pregnancies/miscarriages, with reference to the current literature.

Intervertebral disk disease in 10 cats

2001 ◽  
Vol 37 (4) ◽  
pp. 384-389 ◽  
Author(s):  
KR Munana ◽  
NJ Olby ◽  
NJ Sharp ◽  
TM Skeen
Keyword(s):  
Medical Records ◽  
Thoracolumbar Spine ◽  
Clinical Signs ◽  
Intervertebral Disk ◽  
Type I ◽  
Excellent Outcome ◽  
Intervertebral Disks ◽  
The Mean ◽  
Intervertebral Disk Herniation ◽  
Intervertebral Disk Space

The medical records of 10 cats diagnosed with intervertebral disk disease were reviewed. No apparent sex or breed predilection was found. The mean age of cats in the study was 9.8 years. Clinical signs included back pain, difficulty ambulating, and incontinence. Radiographs revealed narrowed disk spaces, mineralized intervertebral disks, and evidence of extradural compression on myelography or computed tomography. All intervertebral disk herniations occurred in the thoracolumbar spine, with a peak incidence at the fourth to fifth lumbar (L4-L5) intervertebral disk space. Eight cats had Hansen's type I intervertebral disk herniation. Surgery was performed in seven cats. All cats judged to have an excellent outcome had undergone surgical decompression.

scholarly journals Long-Term Risk of Hepatocellular Carcinoma Following Direct-Acting Antiviral Therapy in Compensated Liver Cirrhosis Induced by Hepatitis C Virus Infection

2021 ◽  
Vol 21 (6) ◽  
Author(s):  
Cristina Maria Muzica ◽  
Carol Stanciu ◽  
Cristina Cijevschi-Prelipcean ◽  
Irina Girleanu ◽  
Laura Huiban ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Incidence Rates ◽  
Cutoff Point ◽  
Compensated Cirrhosis ◽  
High Incidence ◽  
Direct Acting

Background: Considering the excellent safety profile and the high efficacy rates, great benefits were expected with the availability of the new direct-acting antivirals (DAAs) in treating hepatitis C virus (HCV) infection. Following the publication of two articles in 2016 on the high incidence rates of HCC following DAAs, several papers revealed contradictory results, thereby casting shadows on the role of DAAs in hepatocarcinogenesis. Objectives: The present study aimed to assess the incidence and risk factors of HCC in patients with HCV genotype 1b infection and compensated cirrhosis with the sustained virological response (SVR) following DAAs. Methods: This multicentric prospective study encompassed 479 patients with HCV genotype 1b compensated cirrhosis treated with paritaprevir/ritonavir/ombitasvir and dasabuvir (PrOD) +/- ribavirin (RBV) for 12 weeks in two tertiary centers in Northeastern Romania. The patients were prospectively followed up in the Institute of Gastroenterology Iasi, Romania, from November 2015 to December 2020. Results: During the follow-up period (mean 60.11 ± 3.87 months), 23 patients (4.8%) developed HCC. The 1-, 3-, and 5-year cumulative incidence rates of HCC were 1.1, 1.9, and 2.6%, respectively. At the time of the diagnosis, 15 patients (65%) had a single tumor, 12 patients (52.2%) were within the Milan criteria, and nine persons (39%) had Barcelona liver cancer stage 0-A. In this regard, the mean AFP level was 35.3 ± 93.1 ng/mL. A multivariate analysis, age above 65 years, and a cutoff point of AFP ≥ 10 ng/mL at the end of treatment were independent factors associated with HCC. A majority of the patients (n = 11, 47.8%) received curative treatment by surgical resection. In this study, histopathological examination identified a moderately differentiated tumor (G2) in 5 patients, five patients had a poorly differentiated tumor (G3), and only one patient had a well-differentiated tumor (G1). Conclusions: Our study revealed no evidence of the high incidence rate of HCC after the long-term follow-up of patients with HCV-related liver cirrhosis and SVR following DAA treatment. However, the cumulative 5-year risk remained above the cutoff point, and this makes the HCC screening cost-effective. The HCC occurrence appears to be associated with aging and a moderately increased AFP level at EOT (≥ 10 ng/mL).

Shigellosis in Mozambique: The 1993 Outbreak Rehabilitation—A Follow-up Study

1995 ◽  
Vol 25 (4) ◽  
pp. 159-162 ◽  
Author(s):  
Miguel Aragón ◽  
Avertino Barreto ◽  
Jonas Chambule ◽  
Antonio Noya ◽  
Maria Tallarico
Keyword(s):  
Incidence Rates ◽  
Shigella Dysenteriae ◽  
Aetiological Agent ◽  
Fatality Rate ◽  
Population Movements ◽  
Follow Up Study ◽  
High Incidence ◽  
Shigella Dysenteriae Type

In this paper we describe a dysentery outbreak in Mozambique during 1993. A total of 47 483 cases and 199 deaths were reported, with an incidence rate of 292.5/100 000 and a fatality rate of 0.25% for the whole country. Of the 144 districts in the country 123 were affected: those situated along the principal communications routes and corridors had high incidence rates, up to 3308/100000. All the provincial capitals were affected with incidence rates between 59.6 and 4381.8/100 000. Shigella dysenteriae type 1 was identified as the aetiological agent. This strain was sensitive to nalidixic acid, cephalosporins, gentamicin and kanamycin, and resistant to tetracyclines, trimethoprim, chloramphenicol, ampicillin, sulphisoxazole, Cotrimoxazol and erythromycin. This is the first dysentery epidemic caused by S. dysenteriae type 1 reported in Mozambique. The epidemic still continues. Population movements after the war, poor levels of sanitation and poverty contributed to the gravity of the outbreak.

Lumbosacral Intervertebral Disk Disease in Six Cats

2008 ◽  
Vol 44 (3) ◽  
pp. 109-115 ◽  
Author(s):  
Jennipher E. Harris ◽  
Sarit Dhupa
Keyword(s):  
Computed Tomography ◽  
Spinal Cord ◽  
Urinary Incontinence ◽  
Medical Records ◽  
Clinical Signs ◽  
Cord Compression ◽  
Intervertebral Disk ◽  
Decompressive Laminectomy ◽  
Pelvic Limb

Medical records of six cats diagnosed with lumbosacral intervertebral disk disease were reviewed. Clinical signs included reluctance to jump, low tail carriage, elimination outside the litter box, reluctance to ambulate, pelvic-limb paresis, urinary incontinence, and constipation. All cats had lumbosacral hyperpathia on palpation. Computed tomography in four cats revealed evidence of extradural spinal cord compression at the seventh lumbar (L7) to first sacral (S1) vertebral interspace. Compression was confirmed via myelography in three of these four cats, with confirmation in the fourth cat at the time of decompressive laminectomy. Each of the six cats underwent dorsal decompressive laminectomy at the L7 to S1 interspace. Postoperative clinical follow-up lasted 3 to 35 months, with most cats having excellent outcomes.

Unicameral bone cyst of the patella in a young dog

2015 ◽  
Vol 28 (05) ◽  
pp. 359-363 ◽  
Author(s):  
F. Briotti ◽  
B. Beale ◽  
M. Petazzoni
Keyword(s):  
Physical Examination ◽  
Soft Tissues ◽  
Proximal Tibia ◽  
Bone Cyst ◽  
Clinical Signs ◽  
Unicameral Bone Cyst ◽  
Radiographic Examination ◽  
Autogenous Bone ◽  
Hindlimb Lameness

SummaryThis report describes a case of a solitary unicameral patellar bone cyst in a young dog. A five-month-old, male Dobermann Pinscher dog was referred for a 10-day left hindlimb lameness. A mild swelling of the peripatellar soft tissues of the left patella was detected upon physical examination. Signs of pain were elicited upon direct palpation of the patella. Radiographic examination revealed an oval radiolucency within the medullary cavity at the base of the left patella. Radiographic examination, arthroscopy, and histopathology findings supported the diagnosis of a benign patellar bone cyst. The condition was treated by surgical curettage and autogenous bone graft harvested from the ipsilateral proximal tibia. Clinical signs, including lameness and signs of pain upon deep palpation, disappeared three weeks after surgery. Follow-up re-evaluation five years after surgery revealed no recurrence of the cyst and the patient was asymptomatic.

Respiratory Complications in Outpatient Endoscopy with Endoscopist-Directed Sedation

2014 ◽  
Vol 23 (3) ◽  
pp. 255-259 ◽  
Author(s):  
Kilian Friedrich ◽  
Sabine G. Scholl ◽  
Sebastian Beck ◽  
Daniel Gotthardt ◽  
Wolfgang Stremmel ◽  
...  
Keyword(s):  
Antibiotic Treatment ◽  
Respiratory Infection ◽  
Endoscopic Procedure ◽  
Shortness Of Breath ◽  
Respiratory Complications ◽  
Endoscopic Procedures ◽  
Increased Risk ◽  
High Incidence ◽  
Respiratory Complaints

Background & Aims: Respiratory complications represent an important adverse event of endoscopic procedures. We screened for respiratory complications after endoscopic procedures using a questionnaire and followed-up patients suggestive of respiratory infection.Method: In this prospective observational, multicenter study performed in Outpatient practices of gastroenterology we investigated 15,690 patients by questionnaires administered 24 hours after the endoscopic procedure.Results: 832 of the 15,690 patients stated at least one respiratory symptom after the endoscopic procedure: 829 patients reported coughing (5.28%), 23 fever (0.15%) and 116 shortness of breath (SOB, 0.74%); 130 of the 832 patients showed at least two concomitant respiratory symptoms (107 coughing + SOB, 17 coughing + fever, 6 coughing + coexisting fever + SOB) and 126 patients were followed-up to assess their respiratory complaints. Twenty-nine patients (follow-up: 22.31%, whole sample: 0.18%) reported signs of clinically evident respiratory infection and 15 patients (follow-up: 11.54%; whole sample: 0.1%) received therefore antibiotic treatment. Coughing or vomiting during the endoscopic procedure resulted in a 156.12-fold increased risk of respiratory complications (95% CI: 67.44 - 361.40) and 520.87-fold increased risk of requiring antibiotic treatment (95% CI: 178.01 - 1524.05). All patients of the follow-up sample who coughed or vomited during endoscopy developed clinically evident signs of respiratory infection and required antibiotic treatment while this occurred in a significantly lower proportion of patients without these symptoms (17.1% and 5.1%, respectively).Conclusions: We demonstrated that respiratory complications following endoscopic sedation are of comparably high incidence and we identified major predictors of aspiration pneumonia which could influence future surveillance strategies after endoscopic procedures.

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