scholarly journals Efektivitas Penggunaan Oral Antidiabetes Kombinasi Glimepiride Dengan Pioglitazone Pada Pasien Dibetes Mellitus Tipe 2

2020 ◽  
Vol 5 (1) ◽  
pp. 1-6
Author(s):  
Ninik Mas Ulfa ◽  
Nabila Arfiana
Keyword(s):  
Blood Glucose ◽  
Fasting Blood Glucose ◽  
Blood Glucose Control ◽  
Pharmacological Therapy ◽  
The Body ◽  
Type 2 Dm ◽  
Oral Antidiabetic ◽  
Retrospective Data Collection ◽  
Sugar Levels

Diabetes mellitus is a disorder of chronic metabolic syndrome from carbohydrates, lipids and fats resulting from the deficiency of insulin in the body so that it can cause hyperglycemia. Oral Antidiabetic and Insulin is pharmacological therapy that can control blood sugar levels. This study aims to observe the effectiveness of Glimepiride combination therapy with Pioglitazone in type 2 DM patients with fasting blood Glucose and blood Glucose 2 hour post prandial parameters compared to pre and post values. This research method is observational with retrospective data collection and data analyzed descriptively. The sample size was 30 type 2 DM patients who received therapy after 6 months. The results showed that there were significant differences between the value of  fasting blood Glucose pre and fasting blood Glucose post and blood Glucose 2 hour post prandial pre and blood Glucose 2 hour post from statistical analysis using paired t-test, with a value of α = 0.00 smaller than α = 0.05. This shows that the combination of Glimepiride with Pioglitazone is effective in blood glucose control in type 2 DM patients. Keywords: Dibetes Mellitus, Oral Antidiabetic, Glimepiride, Piogliatzone

scholarly journals Utilizing Technology-Enabled Intervention to Improve Blood Glucose Self-Management Outcome in Type 2 Diabetic Patients Initiated on Insulin Therapy: A Retrospective Real-World Study

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Jian Lin ◽  
Xia Li ◽  
Shan Jiang ◽  
Xiao Ma ◽  
Yuxin Yang ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Glycemic Control ◽  
Insulin Therapy ◽  
Fasting Blood Glucose ◽  
Blood Glucose Control ◽  
Diabetic Patients ◽  
Premixed Insulin ◽  
Type 2 Diabetic Patients ◽  
Self Monitoring

Background. The aim of this study was to assess the benefits of a mobile-enabled app through Lilly Connected Care Program (LCCP) in achieving blood glucose control and adhering to self-monitoring of blood glucose in patients with type 2 diabetes mellitus (T2DM). Methods. This retrospective study included T2DM patients who were initiated on insulin therapy (mostly premixed insulin) after failure to respond to oral antidiabetic drugs. Patients were provided with glucometers enabled with synchronous data transmission to healthcare providers and family members. The primary objective was to assess the benefits of LCCP based on changes in fasting blood glucose (FBG) and postprandial glucose (PPG) levels from baseline to 12 weeks. Paired t-test was used to assess the change in blood glucose (BG) from baseline to week 12. Results. In total, 14,085 T2DM patients were recruited. Compared with baseline, significant reductions in FBG and PPG were evident at week 12 (FBG: -0.39 mmol/L; PPG: −0.79 mmol/L; both P < 0.001 ). Furthermore, at week 12, the proportion of patients attaining a target glucose level of FBG <7.0 mmol/L and PPG <10.0 mmol/L was 25.37% and 59.68%, respectively, with a statistically significant increase compared with that at baseline (6.74% and 45.59%, respectively, both P < 0.001 ). The frequent monitoring of patients could gain a higher target achievement of FBG (28.1% vs 24.2%) and PPG (64.4% vs 55.1%) than the occasional monitoring patients. Additionally, the incidence of hypoglycemia gradually decreased and was significantly lower than the baseline level. Conclusions. In T2DM patients with poor glycemic control, the application of mobile enabled intervention (LCCP) along with insulin significantly reduced the hypoglycemia while improving glycemic control during period of naïve initiating insulin therapy. Additionally, the high frequency of BG self-monitoring was associated with better glycemic control.

scholarly journals Remodeling Intestinal Flora with Sleeve Gastrectomy in Diabetic Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Xiaofei Huang ◽  
Pan Weng ◽  
Huixin Zhang ◽  
Yingli Lu
Keyword(s):  
Type 2 Diabetes ◽  
Sleeve Gastrectomy ◽  
Blood Glucose ◽  
Glucose Metabolism ◽  
Fasting Blood Glucose ◽  
Blood Glucose Control ◽  
Intestinal Flora ◽  
Diabetic Rats ◽  
Sham Operation

Objective. As a complicated symbiotic system, intestinal flora is reported closely related to the development of type 2 diabetes recently. Sleeve gastrectomy is one of the approaches of bariatric surgery and could improve blood glucose control in type 2 diabetes patients. This study was to explore the relationship between remodeled intestinal flora and glucose metabolism in diabetic rats.Methods. 20 male diabetic rats were operated; 10 of them underwent sleeve gastrectomy, and 10 of them underwent sham operation. Meanwhile 10 male normal rats underwent sleeve gastrectomy as control. The animals’ weight and FBG had been measured. The composition changes of intestinal flora were detected by 16S rDNA sequence analysis.Results. In diabetic rats, weight and fasting blood glucose decreased significantly after sleeve gastrectomy. However, there was no significant change for weight and blood glucose in normal rats after operation. The intestinal flora of diabetic rats reduced in the proportion of Firmicutes and increased in the proportion of Bacteroidetes after sleeve gastrectomy.Conclusion. The change of dominant microorganisms in intestinal flora might play an important role in the glucose metabolism.

scholarly journals Uji Efektivitas Beras Herbal Forte terhadap Penurunan Kadar Glukosa Darah Pasien Diabetes Melitus Tipe 2 (Study of the Herbal Rice Forte Effectiveness on Decreasing Blood Glucose of Diabetes Mellitus Type 2 Patient)

2018 ◽  
Vol 6 (1) ◽  
pp. 85
Author(s):  
Gema Akbar Wakhidana ◽  
Ancah Caesarina Novi Marchianti ◽  
Ali Santosa
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Treatment Group ◽  
Metabolic Diseases ◽  
Fasting Blood Glucose ◽  
Control Group ◽  
Glucose Levels ◽  
Blood Glucose Levels ◽  
Type 2 Dm

Diabetes mellitus is metabolic diseases characterized by hyperglycemia caused by disturbances in insulin secretion or insulin activity. Herbal Forte Rice is rice synthetic material composed of main purple sweet potato and corn flour. It contains antioksidan, fiber, resistant starch and having moderate glycemic index. This study aimed to determine the effectivity of Herbal Forte Rice on decreasing blood glucose levels of patients type 2 DM. It used a cross-over design, the role of research subjects was both as control and treatment groups. Total sample of this research consisted of 60 samples. The treatment group was given Herbal Forte Rice for 7 days in 2 consecutive meals, while the control group did not receive any intervention. The results showed the average level of Fasting Blood Glucose (FBG) beginning and end of the treatment group 179.76 mg/dL and 138.7 mg/dL; FBG beginning and end of the control 180.87 mg/dL and 187.63 mg/dL; 2 hours post prandial Blood Glucose (2hppBG) levels of beginning and end of the treatment group 284.37 mg/dL and 183.8 mg/dL; 2hppBG levels beginning and end of the control 280.57 mg/dL and 284.13 mg/dL. This study concludes that Herbal Forte Rice effective on decreasing blood glucose levels of patients type 2 DM.   Keywords: diabetes mellitus, Rice Herbal Forte, GDP and GD2PP  

scholarly journals Effects of Fasting-Mimicking Diet and Specific Meal Replacement Foods on Blood Glucose Control in Patients with Type 2 Diabetes: A Randomized Controlled Trial

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Fang Tang ◽  
Xuan Lin
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
Venous Blood ◽  
Fasting Blood Glucose ◽  
Blood Glucose Control ◽  
Density Lipoprotein ◽  
Control Group ◽  
Meal Replacement ◽  
Experimental Group

Type 2 diabetes represents a serious societal health problem due to the vulnerability to cardiovascular events. Diet therapy is the most basic treatment for type 2 diabetes. The present study was conducted to study the effect of a fasting-mimicking diet and specific meal replacement foods on blood glucose control in patients with type 2 diabetes. Our study included 100 patients with type 2 diabetes who underwent a physical examination which were enrolled and randomly assigned as 50 patients each to the test group (with low energy-specific meal replacement meals during a fasting-mimicking diet) and the control group (with specific meal replacement foods given normal adult doses). After 4 months, efficacy indicators which were fasting blood glucose, 2-hour postprandial venous blood glucose, and glycosylated haemoglobin of the experimental group were all lower than those of the control group ( P < 0.05 ); observation indicators that include body mass index, waist circumference, blood lipids (triglyceride, cholesterol, and low-density lipoprotein), and blood pressure levels were all lower than the control group, and high-density lipoprotein levels were all higher than the control group (all P < 0.05 ). Both groups of fasting blood glucose, 2-hour postprandial venous blood glucose, and blood pressure had a relatively stable downward trend, but the experimental group had a more significant decline. In conclusion, the study revealed that a fasting-mimicking diet and specific meal replacement foods can safely and effectively reduce weight and improve metabolic syndrome in patients with type 2 diabetes.

The Research Progress of DPP-4 Inhibitors

2020 ◽  
Vol 20 (17) ◽  
pp. 1709-1718
Author(s):  
Zhi-Gang Sun ◽  
Zhi-Na Li ◽  
Hai-Liang Zhu
Keyword(s):  
Blood Glucose ◽  
Glucose Concentration ◽  
Blood Glucose Concentration ◽  
Research Progress ◽  
Dipeptidyl Peptidase 4 ◽  
Type 2 Dm ◽  
Reduce Blood Glucose ◽  
Sugar Levels ◽  
Diabetes Patients

Diabetes mellitus (DM) is a metabolic disease, and diabetes patients have long-term higher blood sugar levels than standard. Most people with diabetes have complications that greatly affect their standard of living. Patients with type 2 DM occupy the vast majority of all diabetes patients. Glucagonlike peptide-1 (GLP-1) secreted by intestinal enteroendocrine L-cells is a small molecule polypeptide, which is glucose concentration-dependent and can effectively reduce blood glucose concentration. Dipeptidyl peptidase-4 (DPP-4) is an important target for the treatment of type 2 DM because it can degrade GLP-1. DPP-4 inhibitors can enhance the blood glucose lowering effect of GLP-1 by inhibiting DPP-4. This article summarizes the development of DPP-4 inhibitors from 2015 to 2019, and can provide helpful information for the discovery of novel DPP-4 inhibitors in the future.

scholarly journals TCM Formula Xiaoyaosan Decoction Improves Depressive-Like Behaviors in Rats with Type 2 Diabetes

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Na Li ◽  
Qun Liu ◽  
Xiao-Juan Li ◽  
Xiao-Hui Bai ◽  
Yue-Yun Liu ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Blood Glucose ◽  
High Fat Diet ◽  
Hippocampal Formation ◽  
Morphological Changes ◽  
Fasting Blood Glucose ◽  
The Body ◽  
High Fat ◽  
Body Weights

The mechanism of depression with type 2 diabetes remains elusive, requiring further study.Objective. To evaluate the effect of TCM formula Xiaoyaosan on depressive-like behaviors in rats with type 2 diabetes.Methods. Rats were divided into 5 groups and drugs were administered during the model period of 21 days. The model of depressive-like behaviors in rats with type 2 diabetes was induced by a high fat diet, low doses of STZ injection, and chronic restraint stress for 21 days. The body weight, fasting blood glucose, ITT, OGTT, 5-HT, DA, depression behaviors, and morphological changes of formation were measured and observed.Results. After modeling, marked changes were found in model rats; behavioral analyses of rats indicated that this modeling method negatively impacts locomotor function. In the H&E staining, changes were found predominately in the CA1 and DG subregions of the hippocampus. After 21 days of treatment by fluoxetine and Xiaoyaosan, rats’ body weights, behaviors and fasting blood glucose, and hippocampal formation were modified.Conclusions. A new model of depressive-like behaviors in rats with type 2 diabetes was successfully created. Xiaoyaosan and fluoxetine in this study independently contribute to exacerbate the disease progression.

scholarly journals Correlation of HbA1c levels with Triglyceride, LDL and HDL levels in Type 2 Diabetes Mellitus Patients

2021 ◽  
Vol 3 (2) ◽  
pp. 138-145
Author(s):  
Tri Prasetyorini ◽  
Cindy ◽  
Salbiah
Keyword(s):  
Diabetes Mellitus ◽  
Blood Glucose ◽  
Significant Relationship ◽  
Metabolic Diseases ◽  
Blood Glucose Control ◽  
Design Data ◽  
Type 2 Dm ◽  
Hba1c Levels

Diabetes mellitus (DM) is a group of metabolic diseases with characteristics of increased blood glucose levels that occur due to abnormal insulin secretion, insulin action or both. It is necessary to monitor long-term glycemic status by measuring HbA1c levels to determine the quality of long-term blood glucose control. People with Type 2 DM are more at risk of suffering from cardiovascular disease characterized by dyslipidemia, with a characteristic description of high plasma triglyceride levels, elevated LDL levels and decreased HDL levels. The purpose of this study was to determine the relationship between HbA1c levels and levels of triglycerides, LDL and HDL. This study was an analytic observational study using a cross-sectional design. Data on each variable is secondary data obtained from patients with Type 2 DM at Jakarta Friendship Hospital for the period January-December 2018. The research sample used was 97 data of Type 2 DM patients. Chi-Square test showed an association between HbA1c levels and triglyceride levels with a value of p = 0.046 (< 0.05), there was a relationship between HbA1c levels and LDL levels with p = 0.742 (p > 0.05), and there was a relationship between HbA1c levels and HDL levels with p = 0.241 (p > 0.05). The conclusion obtained in this study is that there is a significant relationship between HbA1c levels and triglyceride levels and there was no significant relationship between HbA1c levels and LDL and HDL levels.

scholarly journals PENGARUH KONSELING DENGAN MEDIA LEMBAR BALIK DAN BROSUR TERHADAP PENGETAHUAN TENTANG GAYA HIDUP PADA PASIEN DM TIPE 2 DI POLI RAWAT JALAN RSUD DELI SERDANG

2020 ◽  
Vol 3 (2) ◽  
pp. 259
Author(s):  
Rosmawati Helmi Barus ◽  
Donal Nababan ◽  
Frida Lina Tarigan
Keyword(s):  
Type 2 Diabetes ◽  
Healthy Lifestyle ◽  
The Body ◽  
Bivariate Analysis ◽  
Type 2 Dm ◽  
Quasi Experimental ◽  
Sugar Levels ◽  
The Right ◽  
Media Group

Diabetes mellitus (DM) is a dangerous disease known by the people of Indonesia by the name of diabetes. DM is a metabolic disorder that occurs chronic or chronic because the body does not have enough insulin due to interference with the secretion of insulin, insulin hormone that does not work properly or both. The purpose of this study was to determine the effect of counseling with flipcharts and brochures on lifestyle knowledge in Type 2 DM patients in the Outpatient Clinic of Deli Serdang Hospital in 2019. This study used a quasi experimental design using the two group posttest design. The population was all patients with Type 2 DM in the Outpatient Hospital Deli Serdang as much as 199 and the sample was obtained by 48 respondents with the provisions of 24 for the flip sheet media group and 24 for the brochure media group. Data were analyzed using univariate and bivariate analysis. The results were obtained: a) There was an influence of counseling with flipchart media (p = 0,000) and media brochures (p = 0,000) on lifestyle knowledge in patients with Type 2 diabetes. B) Media brochures more effectively influenced knowledge about lifestyle in patients with Type 2 diabetes (p = 0.002). From the results of the study it is expected that sufferers of type 2 DM can maintain a healthy lifestyle by doing the right diet to maintain body fitness and control blood sugar levels in the body so that the disease is not a complication and the hospital can counsel with patients with type 2 DM using media brochures and flipchart media as a manifestation of concern for patients and the community. AbstrakDiabetes Melitus (DM) merupakan salah satu penyakit berbahaya yang dikenal oleh masyarakat Indonesia dengan nama penyakit kencing manis. DM adalah penyakit gangguan metabolik yang terjadi secara kronis atau menahun karena tubuh tidak mempunyai hormon insulin yang cukup akibat gangguan pada sekresi insulin, hormon insulin yang tidak bekerja sebagaimana mestinya atau keduanya. Tujuan penelitian ini adalah untuk mengetahui pengaruh konseling dengan media lembar balik dan brosur terhadap pengetahuan tentang gaya hidup pada pasien DM Tipe 2 di Poliklinik Rawat Jalan RSUD Deli Serdang Tahun 2019. Penelitian ini menggunakan quasi eksperimental design dengan menggunakan rancangan two group posttest. Populasi adalah seluruh pasien dengan penyakit DM Tipe 2 yang terdapat di Poli Rawat Jalan RSUD Deli Serdang sebanyak 199 dan sampel diperoleh 48 responden dengan ketentuan 24 untuk kelompok media lembar balik dan 24 untuk kelompok media brosur. Data dianalisis menggunakan analisis univariat dan bivariat. Hasil penelitian diperoleh: a) Ada pengaruh konseling dengan media lembar balik (p = 0,000) dan media brosur (p=0,000) terhadap pengetahuan tentang gaya hidup pada pasien penderita DM Tipe 2. b) Media brosur lebih efektif berpengaruh terhadap pengetahuan tentang gaya hidup pada pasien penderita DM Tipe 2 (p = 0,002). Dari hasil penelitian diharapkan penderita DM tipe 2 dapat menjaga gaya hidup yang sehat dengan melakukan  diet  yang  benar  untuk  menjaga  kebugaran  tubuh  dan  mengontrol  kadar  gula  darah  dalam  tubuh sehingga penyakitnya tidak menjadi komplikasi serta pihak rumah sakit dapat melakukan konseling kepada penderita DM tipe 2 menggunakan media brosur dan media lembar balik sebagai perwujudan kepedulian kepada pasien dan masyarakat.

scholarly journals Pengaruh Pemberian Koro Benguk (Mucuna pruriens L) terhadap Kadar Gula Darah Tikus Diabetes Melitus yang Diinduksi Streptozotocin

2020 ◽  
Vol 2 (2) ◽  
pp. 136-140
Author(s):  
Endang Widhiyastuti ◽  
Mastuti Widi Lestari
Keyword(s):  
Blood Glucose ◽  
Blood Sugar ◽  
Fasting Blood Glucose ◽  
Diabetic Rats ◽  
Observation Time ◽  
The Body ◽  
Mucuna Pruriens ◽  
Control Group ◽  
Sprague Dawley ◽  
Sugar Levels

Diabetes which is well-known in the community as diabetes in Indonesia is a chronic disease, which occurs when the pancreas does not produce enough insulin or when the body cannot utilize the insulin produced by its own products. The Provision of antioxidants in DM mice can reduce blood sugar levels. One of the herbs that can be used for control and management of blood sugar in diabetes is swollen koro. Koro Benguk (Mucuna pruriens L) is a plant that can be used as an alternative treatment because it contains antioxidants that can maintain health without causing toxic effects. The purpose of this study was to determine whether there is an effect of giving koro benguk coffee (Mucuna pruriens L) on blood sugar levels of Streptozotocin-induced Diabetes Mellitus Rats. This study is an experimental study of Sprague Dawley mice. A total of 35 male wistar rats were divided into 5 groups each: normal control (K1); diabetes control (K2); diabetic rats were given a large coffee extract 0.63 mg / g BW rat (P1); diabetic rats were given a large infusion of coffee koro 1.26 mg / g BW rats (P2). Diabetic rats were given an infusion of coffee koro benguk20,52 mg / g BW rats. Fasting blood glucose (GDP) levels were analyzed weekly for 3 weeks using the GOD-PAP method. The results of the study showed a decrease in blood sugar for 4 times the observation time in almost all treatment groups except the positive control group. The conclusions in this study were the provision of related coffee (Mucuna pruriens L) can reduce fasting blood glucose levels in Sprague Dawley rats with diabetes models significantly compared to controls.

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