Primary histiocytic sarcoma of the clivus with focal extension into central nervous system and neurologic manifestations: First description at an unusual site with an overwhelming and rapid progression

2021 ◽  
Author(s):  
Ivette Perez ◽  
Murat Gokden ◽  
John D. Day ◽  
Hadi Yaziji ◽  
Sergio Pina-Oviedo
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Histiocytic Sarcoma ◽  
Rapid Progression ◽  
Neurologic Manifestations ◽  
Unusual Site

Primary central nervous system histiocytic sarcoma

2012 ◽  
Vol 30 (3) ◽  
pp. 192-195 ◽  
Author(s):  
Yosef Laviv ◽  
David Zagzag ◽  
Suzana Fichman-Horn ◽  
Shalom Michowitz
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Histiocytic Sarcoma

Tumor microenviromental reaction would diminish incomparable accuracy and swiftness of flow cytometric diagnosis of primary central nervous system lymphoma

2021 ◽  
Author(s):  
Hayato Takeuchi ◽  
Tohru Inaba ◽  
Yukiko Shishido-Hara ◽  
Taku Tsukamoto ◽  
Shinsuke Mizutani ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Lymphoma ◽  
Rapid Progression ◽  
Cell Type ◽  
Eligibility Criteria ◽  
Initiation Of Therapy ◽  
Fcm Analysis ◽  
Histological Confirmation ◽  
Pattern Sensitivity

Abstract Background Primary central nervous system lymphoma (PCNSL), a relatively rare brain tumor, bears a dire prognosis. On occasion, rapid progression of the tumor makes immediate diagnosis and initiation of therapy imperative. To achieve swift diagnosis, we adopt flow cytometry (FCM) in addition to conventional histopathology. The aim of this study is to reveal utility and drawbacks of FCM diagnosis for PCNSL. Methods Patients with suspected PCNSL on neuroradiological findings and received both FCM and histological diagnosis between August 2015 and April 2020 were retrospectively enrolled into the study. Tumor samples were collected by craniotomy with either of endoscope or microscope. The patients’ electronic medical records were investigated, and histological findings, results of FCM, and other clinical data were evaluated. Results Twenty seven patients met the eligibility criteria. Twenty three patients (11 males and 12 females) were diagnosed with PCNSL by histological confirmation, and 22 cases were B-cell type lymphoma and 1 was T-cell type. Median age at diagnosis was 65. FCM analysis showed lymphoma pattern in 20 cases, but in the other 3 lymphoma cases (FCM discordant: FCM-D) and 4 non-lymphomatous tumor cases, FCM results did not show lymphoma pattern (sensitivity: 86.4%, specificity: 100%). Analysis of FCM-D cases showed infiltration of T lymphocytes or astrocytes into the tumor tissue, indicating tumor microenvironmental reaction, were observed, and it is assumed that those reactions deceived FCM diagnosis. Conclusions Despite some disadvantages, diagnosis of PCNSL by FCM is rapid and reliable.

scholarly journals Antemortem Diagnosis of Localized Central Nervous System Histiocytic Sarcoma in 2 Dogs

2009 ◽  
Vol 23 (2) ◽  
pp. 369-374 ◽  
Author(s):  
L. Tzipory ◽  
K.M. Vernau ◽  
B.K. Sturges ◽  
T.S. Zabka ◽  
M.A. Highland ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Histiocytic Sarcoma

scholarly journals Primary Histiocytic Sarcoma of the Central Nervous System

2014 ◽  
Vol 47 (2) ◽  
pp. 322-328 ◽  
Author(s):  
Hoonsub So ◽  
Sun A Kim ◽  
Dok Hyun Yoon ◽  
Shin Kwang Khang ◽  
Jihye Hwang ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Histiocytic Sarcoma ◽  
The Central Nervous System

scholarly journals Primary central nervous system histiocytic sarcoma

Medicine ◽  
2018 ◽  
Vol 97 (26) ◽  
pp. e11271 ◽  
Author(s):  
Shuang Ma ◽  
Michael Schild ◽  
Diana Tran ◽  
Xuefeng Zhang ◽  
Wan-Lin Zhang ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Histiocytic Sarcoma

scholarly journals Histiocytic sarcoma of the central nervous system: a challenging diagnosis

QJM ◽  
2010 ◽  
Vol 105 (1) ◽  
pp. 77-79 ◽  
Author(s):  
P. Devic ◽  
G. Androdias-Condemine ◽  
N. Streichenberger ◽  
F. Berger ◽  
J. Honnorat ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Histiocytic Sarcoma ◽  
System A ◽  
The Central Nervous System

An unusual case of chronic meningitis due to histiocytic sarcoma of the central nervous system with meningeal dissemination

2016 ◽  
Vol 37 (11) ◽  
pp. 1875-1877 ◽  
Author(s):  
Tatsuya Ueno ◽  
Haruo Nishijima ◽  
Hidekachi Kurotaki ◽  
Akira Kurose ◽  
Masahiko Tomiyama
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Unusual Case ◽  
Histiocytic Sarcoma ◽  
Chronic Meningitis ◽  
Meningeal Dissemination ◽  
The Central Nervous System
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