Primary squamous cell carcinoma of the ampulla of Vater - a rare entity

10.5580/1b23 ◽  
2010 ◽  
Vol 22 (2) ◽  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Ampulla Of Vater ◽  
Rare Entity ◽  
Primary Squamous Cell Carcinoma

scholarly journals Squamous Cell Carcinoma of Kidney and Its Prognosis: A Case Report and Review of the Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Tapan Kumar Sahoo ◽  
Saroj Kumar Das ◽  
Chandraprava Mishra ◽  
Ipsita Dhal ◽  
Rohani Nayak ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Radical Nephrectomy ◽  
Advanced Stage ◽  
Rare Entity ◽  
Primary Squamous Cell Carcinoma ◽  
Review Of The Literature ◽  
Radiological Features ◽  
The Right

Primary squamous cell carcinoma of the renal parenchyma is an extremely rare entity. The diagnosis of squamous cell carcinoma of the renal pelvis is usually unsuspected due to the rarity and inconclusive clinical and radiological features. Most of the patients are diagnosed at an advanced stage and are with poor outcome. Radical nephrectomy is the mainstay of the treatment. We reported a case of squamous cell carcinoma of the kidney in a 50-year-old female who presented with the right sided abdomen pain. The patient was treated with radical nephrectomy.

scholarly journals Primary squamous cell carcinoma of the stomach: a rare entity

2013 ◽  
Vol 2013 (may24 1) ◽  
pp. bcr2013009706-bcr2013009706 ◽  
Author(s):  
M. Little ◽  
P. C. Munipalle ◽  
Y. K. S. Viswanath
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Rare Entity ◽  
Primary Squamous Cell Carcinoma ◽  
Carcinoma Of The Stomach

scholarly journals Primary squamous cell carcinoma of the stomach: a rare entity

2018 ◽  
Vol 111 ◽  
Author(s):  
Miguel Fraile López ◽  
Guillermo Eduardo Mendoza Pacas ◽  
Fernando Fernández Cadenas
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Rare Entity ◽  
Primary Squamous Cell Carcinoma ◽  
Carcinoma Of The Stomach

Pure primary squamous cell carcinoma of breast: A rare entity

2015 ◽  
Vol 4 (2) ◽  
pp. 271
Author(s):  
Samreen Zaheer ◽  
ShahidA Siddiqui ◽  
RanaK Sherwani ◽  
Mohammed Akram
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Rare Entity ◽  
Primary Squamous Cell Carcinoma

Squamous Cell Carcinoma of the Thyroid: A Diagnostic Dilemma

1989 ◽  
Vol 98 (1) ◽  
pp. 59-65 ◽  
Author(s):  
Gwen S. Korovin ◽  
Hyun T. Cho ◽  
Daniel B. Kuriloff ◽  
Steven M. Sobol
Keyword(s):  
Squamous Cell Carcinoma ◽  
Thyroid Gland ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Distant Metastases ◽  
Diagnosis And Treatment ◽  
Rare Entity ◽  
Primary Squamous Cell Carcinoma ◽  
Diagnostic Dilemma ◽  
Direct Invasion

Four cases of primary squamous cell carcinoma of the thyroid gland are reported. Thorough evaluation confirmed these lesions to be of primary thyroid origin rather than from metastasis or direct invasion from contiguous structures. These cases illustrate the aggressive nature of the disease and the propensity for local and distant metastases. The clinicopathologic data presented here underscore the challenge in diagnosis and treatment of this rare entity.

scholarly journals S2972 Primary Squamous Cell Carcinoma of the Ileum - A Rare Entity

2021 ◽  
Vol 116 (1) ◽  
pp. S1230-S1230
Author(s):  
Gowthami Ramar ◽  
M'hamed Turki ◽  
Saif Bella ◽  
Amine Hila ◽  
Ali Timsar
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Rare Entity ◽  
Primary Squamous Cell Carcinoma

scholarly journals Unique Case of Primary Squamous Cell Carcinoma of Ampulla of Vater with microsatellite instability and response to pembrolizumab immunotherapy

2021 ◽  
Author(s):  
Muhammad Adeel Samad ◽  
Jarod Shelton ◽  
Martin Asplund ◽  
Diane C. Shih Della Penna ◽  
Dennis E. Johnson
Keyword(s):  
Squamous Cell Carcinoma ◽  
Microsatellite Instability ◽  
Cell Carcinoma ◽  
Surgical Resection ◽  
Squamous Cell ◽  
Pancreatic Head ◽  
Ampulla Of Vater ◽  
Treatment Modalities ◽  
Primary Squamous Cell Carcinoma ◽  
Persistent Symptoms

Abstract Background: Primary squamous cell carcinoma is a very rare entity and there are only 11 reported cases to date. We describe a case of primary SCC of the ampulla of Vater with microsatellite instability (MSI) and response to pembrolizumab immunotherapy. To the best of our knowledge, this is the first reported case of SCC of ampulla of Vater with MSI. We also performed a review of literature to determine the treatment modalities for this pathology.Case presentation: A 40-year-old male presented with direct bilirubinemia (total bilirubin: 10.7, direct bilirubin: 7.1) and was noted to have a pancreatic head mass which measured 6.6 x 5.5 x 5.5 cm. The patient underwent a pylorus preserving pancreatoduodenectomy with lymph node dissection. Pathology showed 5.5 x 3.5 x 3.5 cm squamous cell carcinoma of ampulla of Vater based on positive p40 and CK5 on immunohistochemistry. It was noted to be invading pancreatic head and duodenal mucosal. Surgical margins were negative. Adjuvant chemotherapy with mFOLFIRINOX (irinotecan, 5-fluorouracil, oxaliplatin) was not performed because of active Hepatitis C infection. Chemoradiotherapy with capecitabine and radiation therapy was initiated however patient had progression of disease despite that. The patient was transitioned to Pembrolizumab in context of MSI high tumour with palliative intent. He had an excellent response to immunotherapy. The therapy was stopped after 18 cycles on patient request because of persistent symptoms of dizziness and lethargy. At the eight-month follow-up after the last cycle of immunotherapy (2.5 years after surgical resection), the patient had no evidence of relapse on CT scan. Conclusions: Surgical resection is mainstay of treatment for primary squamous cell carcinoma of ampulla of Vater. Genetic testing for mismatch repair (MMR) genes should be performed for all patients and immunotherapy with Pembrolizumab should be considered in tumours with high microsatellite instability. Radiotherapy is not effective for this pathology.

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