scholarly journals The role of intestinal microbiota in irritable bowel syndrome

2018 ◽  
Vol 72 ◽  
pp. 215-226
Author(s):  
Tomasz Dworzański ◽  
Rafał Fornal ◽  
Łukasz Koźba ◽  
Krzysztof Celiński ◽  
Ewa Dworzańska
Keyword(s):  
Irritable Bowel Syndrome ◽  
Intestinal Microbiota ◽  
Human Body ◽  
Intestinal Flora ◽  
Faecal Flora ◽  
Vast Number ◽  
Beneficial Effects ◽  
Irritable Bowel ◽  
Micro Organisms

In recent years, impressive advances in the knowledge about a vast number of microbes living in the human body and interactions between the microbiota and the human body have been observed. All micro-organisms that live in the human body consist of around 10 ^ 14 cells. The number of microbial cells colonizing the human body is ten times higher than the number of its own cells and the weight of all micro-organisms is about 2-2.5 kg. The number of bacterial genes is 50-100 times greater than the number of genes in the human body. Nowadays, the human microbiota is often regarded as a “newly discovered organ” or even as a “supergenome”. The results of many studies have revealed that disruption of the bowel microecosystem may affect the development of irritable bowel syndrome (IBS) symptoms. Therefore, manipulation of the gut microflora was hoped to be a new tool in the treatment of this disease. Various methods (probiotics, prebiotics, antibiotic therapy, transplantation of faecal flora) have been used to modify the intestinal microbiota by supporting the expansion of bacteria considered beneficial and reducing the number of those regarded as harmful, thus alleviating the IBS symptoms. There is much evidence in the literature to suggest that the intestinal microbiota and the gut-intestinal axis are important factors in the pathogenesis of IBS. Moreover, the literature findings have demonstrated beneficial effects of modifying the intestinal flora composition in alleviating IBS symptoms. Although the pathophysiology of IBS and the role of the intestinal microflora and gut-intestinal axis in it are well known, many issues are still to be elucidated. Further research into the bacteria identified in stool and colon mucosa of healthy individuals should provide more information on restoration of intestinal homeostasis in IBS patients.

The role of intestinal microbiota in the development of urolithiasis in patients with an irritable bowel syndrome

2020 ◽  
Vol 0 (3) ◽  
pp. 29-36
Author(s):  
I. A. Derkach ◽  
A. E. Dorofeyev ◽  
M. M. Rudenko ◽  
G. A. Dorofeyeva ◽  
Yu. Z. Dynia
Keyword(s):  
Irritable Bowel Syndrome ◽  
Intestinal Microbiota ◽  
Irritable Bowel

scholarly journals THE INTESTINAL MICROBIOTA AND THE ROLE OF PROBIOTICS IN IRRITABLE BOWEL SYNDROME: a review

2015 ◽  
Vol 52 (4) ◽  
pp. 331-338 ◽  
Author(s):  
Joaquim Prado MORAES-FILHO ◽  
Eamonn M M QUIGLEY
Keyword(s):  
Irritable Bowel Syndrome ◽  
Intestinal Microbiota ◽  
Health Benefit ◽  
Gastrointestinal Disorder ◽  
Evidence Base ◽  
Good Evidence ◽  
Specific Strain ◽  
Rome Iii ◽  
Irritable Bowel ◽  
Micro Organisms

Irritable bowel syndrome is a common, chronic relapsing gastrointestinal disorder that affects 7%-22% of the population worldwide. According to Rome III Criteria, the disorder is defined by the coexistence of abdominal discomfort or pain associated with an alteration in bowel habits. Its pathophysiology is not completely understood but, in addition to some important abnormalities, the disturbed intestinal microbiota has also been described supported by several strands of evidence. The treatment of irritable bowel syndrome is based upon several therapeutic approaches but few have been successful or without adverse events and more recently the gut microbiota and the use of probiotics have emerged as a factor to be considered. Probiotics are live micro-organisms which when consumed in adequate amounts confer a health benefit to the host, such as Lactic bacteria among others. An important scientific rationale has emerged for the use of probiotics in irritable bowel syndrome, although the data regarding different species are still limited. Not all probiotics are beneficial: it is important to select the specific strain which should be supported by good evidence base. The mechanisms of action of probiotics are described and the main strains are quoted.

The Role of Dietary Approach in Irritable Bowel Syndrome

2019 ◽  
Vol 26 (19) ◽  
pp. 3512-3520 ◽  
Author(s):  
Piero Portincasa ◽  
Antony Lembo ◽  
Ornella de Bari ◽  
Domenica M. Di Palo ◽  
Anna Maggio ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Gastrointestinal Tract ◽  
Intestinal Microbiota ◽  
Intestinal Motility ◽  
Gastrointestinal Diseases ◽  
Functional Disorder ◽  
First Line ◽  
Dietary Education ◽  
Irritable Bowel

Irritable bowel syndrome (IBS) is a chronic functional disorder of the gastrointestinal tract and is one of the most frequent gastrointestinal diseases. In IBS multiple pathophysiological mechanisms including alterations in intestinal motility, permeability, nutrient absorption, and intestinal microbiota have been implicated. Foods are commonly reported by patients to be a trigger of symptoms and therefore are likely involved in the generation of symptoms in IBS. Among all possible therapeutic options, a first-line approach to IBS is dietary education and identification of foods potentially responsible for the onset or worsening of symptoms. Dietary approaches include reduction of gas-producing foods (i.e. fermentable oligo-, di-, and monosaccharides and polyols (FODMAPs)), lactose and gluten. Further studies are required to link the ultimate role of diets in different IBS subtypes.

The putative role of the intestinal microbiota in the irritable bowel syndrome

2009 ◽  
Vol 41 (12) ◽  
pp. 850-853 ◽  
Author(s):  
S.M. Collins ◽  
E. Denou ◽  
E.F. Verdu ◽  
P. Bercik
Keyword(s):  
Irritable Bowel Syndrome ◽  
Intestinal Microbiota ◽  
Putative Role ◽  
Irritable Bowel

The intestinal microbiota changes paradigms in irritable bowel syndrome

Infectio ro ◽  
2017 ◽  
Vol 2 (50) ◽  
Author(s):  
Gabriela-Loredana Popa ◽  
Silvana-Adelina Gheorghe ◽  
Mădălina Preda
Keyword(s):  
Irritable Bowel Syndrome ◽  
Intestinal Microbiota ◽  
Irritable Bowel

Review: The Role of MOP and DOP Receptors in Treatment of Diarrheapredominant Irritable Bowel Syndrome

2016 ◽  
Vol 16 (18) ◽  
pp. 1462-1469 ◽  
Author(s):  
Agata Jarmu| ◽  
Marta Zieli|ska ◽  
Karolina Le| ◽  
Martyna Banaszek ◽  
Martin Storr ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Irritable Bowel

scholarly journals Diarrhea Predominant-Irritable Bowel Syndrome (IBS-D): Effects of Different Nutritional Patterns on Intestinal Dysbiosis and Symptoms

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1506
Author(s):  
Annamaria Altomare ◽  
Claudia Di Rosa ◽  
Elena Imperia ◽  
Sara Emerenziani ◽  
Michele Cicala ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Intestinal Microbiota ◽  
Gastrointestinal Disorder ◽  
Additional Energy ◽  
Nutritional Advice ◽  
Intestinal Dysbiosis ◽  
Gi Symptoms ◽  
Mutualistic Relationship ◽  
Irritable Bowel ◽  
Fodmap Diet

Irritable Bowel Syndrome (IBS) is a chronic functional gastrointestinal disorder characterized by abdominal pain associated with defecation or a change in bowel habits. Gut microbiota, which acts as a real organ with well-defined functions, is in a mutualistic relationship with the host, harvesting additional energy and nutrients from the diet and protecting the host from pathogens; specific alterations in its composition seem to play a crucial role in IBS pathophysiology. It is well known that diet can significantly modulate the intestinal microbiota profile but it is less known how different nutritional approach effective in IBS patients, such as the low-FODMAP diet, could be responsible of intestinal microbiota changes, thus influencing the presence of gastrointestinal (GI) symptoms. The aim of this review was to explore the effects of different nutritional protocols (e.g., traditional nutritional advice, low-FODMAP diet, gluten-free diet, etc.) on IBS-D symptoms and on intestinal microbiota variations in both IBS-D patients and healthy subjects. To date, an ideal nutritional protocol does not exist for IBS-D patients but it seems crucial to consider the effect of the different nutritional approaches on the intestinal microbiota composition to better define an efficient strategy to manage this functional disorder.

Gut dysbiosis and irritable bowel syndrome: The potential role of probiotics

2018 ◽  
Vol 76 (2) ◽  
pp. 111-120 ◽  
Author(s):  
Nicola Principi ◽  
Rita Cozzali ◽  
Edoardo Farinelli ◽  
Andrea Brusaferro ◽  
Susanna Esposito
Keyword(s):  
Irritable Bowel Syndrome ◽  
Potential Role ◽  
Gut Dysbiosis ◽  
Irritable Bowel

NaHS inhibits NF-κB signal against inflammation and oxidative stress in post-infectious irritable bowel syndrome

RSC Advances ◽  
2016 ◽  
Vol 6 (69) ◽  
pp. 64208-64214 ◽  
Author(s):  
Shenglan Yang ◽  
Danfang Deng ◽  
Yingying Luo ◽  
Yanran Wu ◽  
Rui Zhu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Irritable Bowel Syndrome ◽  
Hydrogen Sulfide ◽  
Murine Model ◽  
Irritable Bowel ◽  
And Oxidative Stress ◽  
Post Infectious

In this study, the alleviating role of hydrogen sulfide (H2S) was investigated in a Post-Infectious Irritable Bowel Syndrome (PI-IBS) murine model and Caco-2 cells.

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