Current Status of Surgical Treatment for Middle Ear Cholesteatoma in Japan

Middle ear acquired cholesteatoma is a pathological condition associated with otitis media, which may be associated with temporal bone resorption, otorrhea and hearing loss, and occasionally various other complications. Cholesteatoma is characterized by the enhanced proliferation of epithelial cells with aberrant morphologic characteristics. Unfortunately, our understanding of the mechanism underlying its pathogenesis is limited. To investigate its pathogenesis, different animal models have been used. This paper provides a brief overview of the current status of research in the field of pathogenesis of middle ear acquired cholesteatoma, four types of animal models previously reported on, up-to-date cholesteatoma research using these animal models, our current studies of the local hybrid ear model, and the future prospect of new animal models of middle ear cholesteatoma.

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A Retrospective Analysis and Comparison of the STAM and STAMCO Classification and EAONO/JOS Cholesteatoma Staging System in Predicting Surgical Treatment Outcomes of Middle Ear Cholesteatoma

Otology & Neurotology ◽

10.1097/mao.0000000000002549 ◽

2020 ◽

Vol 41 (4) ◽

pp. e468-e474

Author(s):

HFE van der Toom ◽

MP van der Schroeff ◽

JMH Janssen ◽

AM Westzaan ◽

RJ Pauw

Keyword(s):

Surgical Treatment ◽

Treatment Outcomes ◽

Retrospective Analysis ◽

Middle Ear ◽

Staging System ◽

Middle Ear Cholesteatoma

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Age aspects of the course of chronic otitis media with cholesteatoma in children (clinical and immunological characteristics)

Pediatrician (St Petersburg) ◽

10.17816/ped10513-18 ◽

2020 ◽

Vol 10 (5) ◽

pp. 13-18

Author(s):

Galina V. Vlasova ◽

Pavel V. Pavlov

Keyword(s):

Surgical Treatment ◽

Middle Ear ◽

Case Reports ◽

Interleukin 2 ◽

Age Groups ◽

Chronic Otitis Media ◽

Upper Respiratory Tract ◽

Middle Ear Cholesteatoma ◽

Upper Respiratory ◽

Medical University

Cholesteatoma of the middle ear is the disease, the course and prognosis of which can not be considered without taking into account the patients age. In pediatric otorhinolaryngology, such patients require special attention due to the aggressiveness of cholesteatoma in children. The rapid growth and a high number of recurrences after surgical treatment are features of the course of this disease in children. The causes of the aggressiveness of this disease in children have not been studied. Objective: to identify clinical and immunological features in children with middle ear cholesteatoma in different age groups that contribute to the aggressive course of the disease. A retrospective analysis of 143 medical case reports of children from 1 to 17 years old who received surgical treatment of middle ear cholesteatoma was carried out in the Department of othorhinolaryngology (St. Petersburg State Pediatric Medical University) from 2000 to 2018. Comparative analysis of clinical manifestation, anamnesis of ear disease, concomitant diseases, immunological reactivity (the content of lymphocytes, their subpopulations and interleukin-2 in peripheral blood) and results of surgical treatment of middle ear cholesteatoma in different age groups has been performed. Cholesteatoma is more aggressive in young children. Frequent infections of the upper respiratory tract, eustachian tube dysfunctions, immune disorders in children under 7 years of age lead to an unfavorable course and prognosis of middle ear cholesteatoma.

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Is transcanal tympanoplasty an appropriate surgical treatment for congenital middle ear cholesteatoma with ossicular involvement?

International Journal of Pediatric Otorhinolaryngology ◽

10.1016/j.ijporl.2018.10.030 ◽

2019 ◽

Vol 116 ◽

pp. 102-106 ◽

Cited By ~ 3

Author(s):

Hantai Kim ◽

Shin Young Yoo ◽

Yun-Hoon Choung ◽

Hun Yi Park

Keyword(s):

Surgical Treatment ◽

Middle Ear ◽

Middle Ear Cholesteatoma

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Surgical Treatment of Retraction Pocket with Bone Pate: Scutum Plasty for Cholesteatoma

Otolaryngology ◽

10.1016/j.otohns.2005.06.006 ◽

2005 ◽

Vol 133 (4) ◽

pp. 625-628 ◽

Cited By ~ 16

Author(s):

Yasuyuki Hinohira ◽

Naoaki Yanagihara ◽

Kiyofumi Gyo

Keyword(s):

Retrospective Study ◽

Surgical Treatment ◽

Study Design ◽

Middle Ear ◽

Critical Issue ◽

Disease Recurrence ◽

Retraction Pocket ◽

Second Stage ◽

Middle Ear Cholesteatoma ◽

Pocket Formation

OBJECTIVES: Postoperative attic retraction pocket is a critical issue and may be indicative of disease recurrence after canal-up tympanoplasty for middle ear cholesteatoma. Although scutum plasty is an acceptable procedure that can be used to prevent the pocket formation, how the scutum is reconstructed has remained controversial. The aim of this study was to clarify the value of scutum plasty using bone pate. STUDY DESIGN: Retrospective study. SETTING: Bone pate scutum plasty was performed in 69 ears during first-stage operations. We attempted to reconstruct a smooth attic bony wall. At the time of the second-stage operations, the results of the scutum plasty were examined. RESULTS: The incidence of retraction pocket was statistically reduced from 20.2% to 5.8%. CONCLUSION: Although the reconstructed scutum showed atrophy to some extent, bone pate scutum plasty is effective in preventing postoperative retraction pocket if a smoothly shaped attic wall can be reconstructed.

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Techniques of the tympanomastoidectomy with reconstruction of the posterior bone wall of the external auditory canal

Srpski arhiv za celokupno lekarstvo ◽

10.2298/sarh1508480d ◽

2015 ◽

Vol 143 (7-8) ◽

pp. 480-486 ◽

Cited By ~ 2

Author(s):

Dragan Dankuc ◽

Ljiljana Vlaski ◽

Nemanja Pejakovic

Keyword(s):

Surgical Treatment ◽

Middle Ear ◽

External Auditory Canal ◽

Ossicular Chain ◽

Sinus Tympani ◽

Middle Ear Cholesteatoma ◽

Ossicular Chain Reconstruction ◽

Oscillating Saw ◽

Novi Sad ◽

Nose And Throat

A combined tympanoplasty method, the mobile-bridge tympanoplasty, has been applied at the Clinic for Ear, Nose and Throat Diseases in Novi Sad since 1998. Mobile-bridge tympanoplasty is performed at our Clinic by applying Feldmann?s procedure utilizing a microsurgical oscillating saw. It is a combination of closed and open techniques for surgical treatment of middle ear diseases. In addition to this technique, a method for reconstruction of the posterior bone wall of the external auditory canal was introduced. This procedure is applied in cases of damage or impairment of the bony ear canal wall using mastoid cortical temporal bone graft or modeled cartilage of the concha. Maintenance of general anatomical relations in the middle ear enables good ventilation of pneumatic spaces of the middle ear and Eustachian tube permeability, thus providing good conditions for ossicular chain reconstruction. The incidence of recurrent cholesteatoma in combined mobile-bridge tympanoplasty and tympanoplasty with reconstruction of the posterior bone wall was 6% in total. The incidence values for the recurrent cholesteatoma in closed tympanoplasty and in cases of open techniques were 10%. Mobile-bridge tympanoplasty and reconstruction of the posterior bone wall of external auditory canal are methods of choice in surgical treatment of middle ear cholesteatoma that progressed to the attic space, sinus tympani and facial recess.

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