PLASMA RENIN SUBSTRATE AND BLOOD PRESSURE REDUCTION AFTER PORTOCAVAL ANASTOMOSIS

1976 ◽  
Vol 2 (11) ◽  
pp. 430-430
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Reduction ◽  
Plasma Renin ◽  
Pressure Reduction ◽  
Renin Substrate ◽  
Portocaval Anastomosis

Hypoxia attenuates the renin response to hemorrhage

1992 ◽  
Vol 263 (3) ◽  
pp. R664-R669
Author(s):  
M. R. Eichinger ◽  
J. R. Claybaugh
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Blood Loss ◽  
Atrial Natriuretic Factor ◽  
Blood Pressure Reduction ◽  
Plasma Renin ◽  
Experimental Period ◽  
Pressure Reduction ◽  
Arterial Blood ◽  
Inspired Oxygen

We studied hypoxia and hypotensive hemorrhage in conscious female goats. After control, goats continued an experimental period in normoxia or hypoxia [fractional inspired oxygen concentration (FIO2) = 0.10] for 120 min. After 60 min in the experimental period, a hemorrhage (0.5 ml.kg-1.min-1 for 30 min) was initiated (normoxic hemorrhage, NH; hypoxic hemorrhage, HH). Heart rate (HR) increased 51 +/- 18 beats/min with NH after 30 min of hemorrhage. HR increased 40 +/- 10 beats/min after hypoxic gas introduction, with no further increase during HH. Mean arterial blood pressure (MABP) was reduced 23 +/- 7 mmHg 30 min after completion of blood loss with normoxia but was reduced 23 +/- 7 mmHg at 20 min of HH. Arginine vasopressin (AVP) was increased to 2.60 +/- 2.08 and 160.40 +/- 49.74 microU/ml after 10 and 20 min of HH, respectively, and was only increased after 30 min (87.33 +/- 67.18 microU/ml) of NH. Unexpectedly, plasma renin activity (PRA) increased in parallel in both groups and was doubled at 30 min of hemorrhage. Atrial natriuretic factor was reduced to 8.8 +/- 1.6 pg/ml by 10 min of NH and to 11.4 +/- 3.3 pg/ml at 30 min of HH. Thus hypoxia leads to an earlier development of hypotension and increase in AVP with blood loss but may attenuate the PRA response to blood pressure reduction.

Effects of an Angiotensin Converting Enzyme Inhibitor on Psychosocial Hypertension in Mice

1979 ◽  
Vol 57 (s5) ◽  
pp. 153s-155s ◽  
Author(s):  
J. P. Henry ◽  
A. J. Vander ◽  
P. M. Stephens
Keyword(s):  
Blood Pressure ◽  
Angiotensin Converting Enzyme ◽  
Enzyme Inhibitor ◽  
Blood Pressure Reduction ◽  
Plasma Renin ◽  
Pressure Reduction ◽  
Converting Enzyme ◽  
Normal Range ◽  
Complex Population ◽  
Blood Pressures

1. Renin-associated, chronic psychosocial hypertension of 150–160 mmHg develops in groups of mice interacting socially in complex population cages. 2. The blood pressures of 16 males in a cage were measured and an intraperitoneal injection of the angiotensin coverting enzyme inhibitor captopril (SQ 14 225) was given. Three hours later blood pressures were measured again. 3. During the first 3 weeks of psychosocial hypertension SQ 14 225 was without effect. But at 1 month and subsequently up to 7 months, SQ 14 225 reduced blood pressure to the normal range of 120–130 mmHg. 4. Plasma renin activities were not related to the extent of blood pressure reduction by SQ 14 225. Hence other factors in addition to the renin—angiotensin mechanism play a part in maintaining chronic psychosocial hypertension.

Prizidilol (SKF 92 657) in Primary Hypertension

1981 ◽  
Vol 61 (s7) ◽  
pp. 461s-464s ◽  
Author(s):  
B. E. Karlberg ◽  
R. Larsson ◽  
K. P. öhman
Keyword(s):  
Blood Pressure ◽  
Peak Plasma ◽  
Peak Plasma Concentration ◽  
Blood Pressure Reduction ◽  
Plasma Renin ◽  
Dose Titration ◽  
Pressure Reduction ◽  
Once Daily ◽  
Standing Blood Pressure ◽  
Titration Study

1. Prizidilol (SKF 92 657), a new antihypertensive drug with combined precapillary vasodilator and non-selective β-adrenoceptor-blocking actions, was given to 24 patients with essential hypertension in a placebo-controlled, dose-titration study, Incremental doses from 200 to 800 mg were given once daily. Supine and standing blood pressure measured 24–27 h after drug intake was reduced during treatment with prizidilol (400–800 mg/day). Slight but significant decreases in heart rate were seen after moderate doses (mean: 447 mg once daily) of prizidilol. A more pronounced blood pressure reduction was noticed 2–7 h after drug administration. 2. Maximal blood pressure reduction coincided with peak plasma concentration of prizidilol, which was measured by a newly developed assay. 3. Plasma renin activity and 24 h urinary excretion of aldosterone and methoxycatecholamines were reduced after the highest doses (mean: 700 mg once daily) of prizidilol. 4. Prizidilol was well tolerated, although dizziness and tiredness were reported by four patients and oedema by two.

Improvement of Insulin Sensitivity Contributes to Blood Pressure Reduction After Weight Loss in Hypertensive Subjects With Obesity

Hypertension ◽  
1996 ◽  
Vol 27 (5) ◽  
pp. 1180-1186 ◽  
Author(s):  
Toshio Ikeda ◽  
Tomoko Gomi ◽  
Nobuhito Hirawa ◽  
Jun Sakurai ◽  
Nori Yoshikawa
Keyword(s):  
Blood Pressure ◽  
Weight Loss ◽  
Insulin Sensitivity ◽  
Blood Pressure Reduction ◽  
Pressure Reduction
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