scholarly journals Fine Particulate Matter (PM2.5) Air Pollution and Type 2 Diabetes Mellitus (T2DM): When Experimental Data Explains Epidemiological Facts

2018 ◽  
Author(s):  
Thiago Gomes Heck ◽  
Pauline Brendler Goettems Fiorin ◽  
Matias Nunes Frizzo ◽  
Mirna Stela Ludwig
Keyword(s):  
Diabetes Mellitus ◽  
Experimental Data ◽  
Type 2 Diabetes ◽  
Air Pollution ◽  
Type 2 Diabetes Mellitus ◽  
Particulate Matter ◽  
Fine Particulate Matter ◽  
Fine Particulate

scholarly journals Estimates of Type 2 Diabetes Mellitus Burden Attributable to Particulate Matter Pollution and Its 30-Year Change Patterns: A Systematic Analysis of Data From the Global Burden of Disease Study 2019

2021 ◽  
Vol 12 ◽  
Author(s):  
Ying Wu ◽  
Rongguo Fu ◽  
Chen Lei ◽  
Yujiao Deng ◽  
Weiyang Lou ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Air Pollution ◽  
Type 2 Diabetes Mellitus ◽  
Particulate Matter ◽  
Burden Of Disease ◽  
Global Burden ◽  
Disease Study ◽  
Particulate Matter Pollution

BackgroundEpidemiological trends of type 2 diabetes mellitus attributable to fine particulate matter (PM2.5) pollution remain unclear. Here, we estimated spatiotemporal trends of type 2 diabetes mellitus burden attributable to PM2.5 pollution, including ambient particulate matter pollution (APMP) and household air pollution (HAP), from 1990–2019.MethodsData were obtained from the Global Burden of Disease Study 2019 and were analyzed by age, sex, year, and location. Joinpoint regression analysis was applied in the analysis of temporal trends in type 2 diabetes mellitus burden over the 30 years.ResultsGlobally, PM2.5 pollution contributed to 292.5 thousand deaths and 13 million disability-adjusted life-years (DALYs) in 2019. APMP ranked third among all risk factors, causing an increase in type 2 diabetes mellitus burden from 1990, whereas the impact of HAP significantly fell during the same period. Both APMP and HAP contributed the most to deaths and DALYs of type 2 diabetes mellitus among older people. However, the age-standardized death and DALY rates of type 2 diabetes mellitus attributable to APMP were greater among males and people in the middle socio-demographic index countries, especially in Southern Sub-Saharan Africa. For HAP, type 2 diabetes mellitus burden was modestly higher in females and was highest in Oceania, which was the only region with an increase from 1990.ConclusionsPM2.5 pollution resulted in substantial and increasing type 2 diabetes mellitus burden worldwide. Hence, governments and health systems should take steps to reduce air pollution to mitigate this increasing burden.

scholarly journals MECHANISMS IN ENDOCRINOLOGY: Effect of long-term exposure to air pollution on type 2 diabetes mellitus risk: a systemic review and meta-analysis of cohort studies

2014 ◽  
Vol 171 (5) ◽  
pp. R173-R182 ◽  
Author(s):  
Bin Wang ◽  
Donghua Xu ◽  
Zhaohai Jing ◽  
Dawei Liu ◽  
Shengli Yan ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Air Pollution ◽  
Type 2 Diabetes Mellitus ◽  
Cohort Studies ◽  
Meta Analysis ◽  
Elevated Risk ◽  
Prospective Cohort Studies

ObjectiveTo assess the effect of long-term exposure to air pollution on type 2 diabetes risk, a meta-analysis of prospective cohort studies was performed.MethodsLiterature search was conducted with Pubmed, Embase, and Web of Science for prospective cohort studies investigating the association of type 2 diabetes risk with increments in particulate matter (PM, diameter <2.5 μm (PM2.5) or <10 μm (PM10)) or nitrogen dioxide (NO2). We used a random-effects model to calculate the overall relative risk (RR) with 95% CI.ResultsOf 808 identified articles, ten cohort studies were finally included, which involved a total of 2 371 907 participants and 21 095 incident cases of type 2 diabetes. Elevated risk of type 2 diabetes was significantly associated with long-term exposures to high levels of PM2.5 (RR=1.28, 95% CI 1.06–1.55,P=0.009,I2=83.5%), PM10 (RR=1.15, 95% CI 1.02–1.30,P=0.022,I2=0%), and NO2(RR=1.12, 95% CI 1.02–1.23,P=0.015,I2=63.5%). When using standardized risk estimates, the RRs of type 2 diabetes were significant for increments in concentrations of PM2.5 (1.39 per 10 μg/m3increment, 95% CI 1.14–1.68,P=0.001), PM10 (1.34 per 10 μg/m3increment, 95% CI 1.22–1.47,P<0.001), and NO2(1.11 per 10 μg/m3increment, 95% CI 1.07–1.16,P<0.001). No obvious evidence of publication bias was observed.ConclusionLong-term exposure to high levels of main air pollutants is significantly associated with elevated risk of type 2 diabetes mellitus.

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