Effect of Playing Interactive Computer Game on Distress of Insulin Injection Among Type 1 Diabetic Children

The recurrence of hypoglycemic episodes leads to attenuation of the normal counter-regulatory mechanisms that are controlled by the hypothalamus, which results in hypoglycemia unawareness (HU). In this case report, we described for the first time the differential expression of TNF-α, IL-1β, IL-6, and IFN-γ in a blood sample that was taken from a 27-year-old patient with type 1 diabetes mellitus (T1DM) who was diagnosed with HU. The anti-diabetic regimen is currently based on insulin injection, but the patient is planning to start the use of an insulin pump to have better control of glucose levels. Our results showed a trend toward an increase in the expression of IL-1β, IL-6, and IFN-γ in T1DM patient with HU. However, the mRNA level of TNF-α showed a significant decrease. These observations suggest that systemic inflammation could be an underlying cause of HU.

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Personalized Hybrid Models for Exercise, Meal, and Insulin Interventions in Type 1 Diabetic Children and Adolescents

Industrial & Engineering Chemistry Research ◽

10.1021/ie402531k ◽

2013 ◽

Vol 52 (36) ◽

pp. 13020-13033 ◽

Cited By ~ 7

Author(s):

Naviyn Prabhu Balakrishnan ◽

Lakshminarayanan Samavedham ◽

Gade Pandu Rangaiah

Keyword(s):

Children And Adolescents ◽

Hybrid Models ◽

Diabetic Children

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The Feasibility and Applicability of Stem Cell Therapy for the Cure of Type 1 Diabetes

Cells ◽

10.3390/cells10071589 ◽

2021 ◽

Vol 10 (7) ◽

pp. 1589

Author(s):

Ryota Inoue ◽

Kuniyuki Nishiyama ◽

Jinghe Li ◽

Daisuke Miyashita ◽

Masato Ono ◽

...

Keyword(s):

Type 1 Diabetes ◽

Stem Cell ◽

Cell Therapy ◽

Stem Cell Therapy ◽

Islet Cells ◽

Autologous Transplantation ◽

Insulin Injection ◽

Islet Cell Transplantation ◽

The Impact

Stem cell therapy using islet-like insulin-producing cells derived from human pluripotent stem cells has the potential to allow patients with type 1 diabetes to withdraw from insulin therapy. However, several issues exist regarding the use of stem cell therapy to treat type 1 diabetes. In this review, we will focus on the following topics: (1) autoimmune responses during the autologous transplantation of stem cell-derived islet cells, (2) a comparison of stem cell therapy with insulin injection therapy, (3) the impact of the islet microenvironment on stem cell-derived islet cells, and (4) the cost-effectiveness of stem cell-derived islet cell transplantation. Based on these various viewpoints, we will discuss what is required to perform stem cell therapy for patients with type 1 diabetes.

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Insulin sensitivity in Type 1 diabetic children and adolescents

Diabetic Medicine ◽

10.1111/j.1464-5491.2007.02357.x ◽

2008 ◽

Vol 25 (3) ◽

pp. 282-288 ◽

Cited By ~ 45

Author(s):

A. Szadkowska ◽

I. Pietrzak ◽

B. Mianowska ◽

J. Bodalska-Lipińska ◽

H. A. Keenan ◽

...

Keyword(s):

Insulin Sensitivity ◽

Children And Adolescents ◽

Diabetic Children

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Increased Urinary Excretion of Collagen Crosslinks in Type 1 Diabetic Children in the First 5 Years of Disease

Hormone Research in Paediatrics ◽

10.1159/000023353 ◽

1999 ◽

Vol 51 (4) ◽

pp. 173-177 ◽

Cited By ~ 3

Author(s):

G. Valerio ◽

A. Franzese ◽

A. Esposito-Del Puente ◽

S. Formicola ◽

S. Di Maio ◽

...

Keyword(s):

Urinary Excretion ◽

Collagen Crosslinks ◽

Diabetic Children

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An Analysis of Patient Acceptance and Safety of a Prefilled Insulin Injection Device

Journal of Diabetes Science and Technology ◽

10.1177/193229680900300625 ◽

2009 ◽

Vol 3 (6) ◽

pp. 1439-1441 ◽

Cited By ~ 4

Author(s):

Lisa Kroon

Keyword(s):

Insulin Injection ◽

Ease Of Use ◽

Patient Acceptance ◽

Delivery Device ◽

Injection Device ◽

Randomized Controlled ◽

Clinical Advantage ◽

Injection Force

This article summarizes and interprets the findings of Carter and colleagues in this issue of Journal of Diabetes Science and Technology, a study of the real world use of a prefilled insulin pen device. In this observational study, people with type 1 and type 2 diabetes rated their experience with the SoloSTAR pen device after 6–10 weeks of use. Data on patient satisfaction, product technical complaints, and adverse effects were reported. Randomized, controlled trials are needed that compare the various pen devices and the vial/syringe in terms of accuracy of dosing, adherence to therapy, and ease of use (including patient perception of injection force required) to assess whether a particular method of insulin delivery or pen delivery device provides a clinical advantage over another.

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