Immunohistochemical Expression of Estrogen and Progesterone Receptors in Primary Pulmonary Neuroendocrine Tumors

2008 ◽  
Vol 132 (12) ◽  
pp. 1889-1895
Author(s):  
Gabriel Sica ◽  
Patrick L. Wagner ◽  
Nassar Altorki ◽  
Jeffrey Port ◽  
Paul C. Lee ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Neuroendocrine Tumors ◽  
Progesterone Receptors ◽  
Large Cell ◽  
Small Cell ◽  
Neuroendocrine Neoplasms ◽  
Typical Carcinoid ◽  
Combined Small Cell Carcinoma ◽  
Estrogen And Progesterone Receptor

Abstract Context.—Lung and breast carcinomas are among the most prevalent cancers. Advances in cancer therapies can provide survival benefit and be potentially curative, even in metastatic disease. Due to the high prevalence of these carcinomas, it is not unusual to encounter lung nodule(s) in a patient with breast carcinoma, and distinguishing between primary and metastatic disease is critical for management/treatment. Occasionally neuroendocrine differentiation is present in breast carcinoma, making its distinction from pulmonary/nonpulmonary neuroendocrine tumors in the lung difficult. Objective.—To assess estrogen and progesterone receptor expression in the entire spectrum of pulmonary neuroendocrine tumors. Design.—Seventy-one neuroendocrine neoplasms including typical carcinoids (42), atypical carcinoids (7), small cell carcinomas (14), large cell neuroendocrine carcinomas (2), and combined small cell carcinomas (6) were evaluated for estrogen and progesterone receptors. Mammary and non–small cell lung carcinomas were also stained for comparison. Results.—The entire spectrum of neuroendocrine neoplasms demonstrated focal to diffuse estrogen (typical carcinoid, 23; atypical carcinoid, 6; small cell carcinoma, 8; large cell neuroendocrine carcinoma, 2; combined small cell carcinoma, 4) and progesterone (typical carcinoid, 11; atypical carcinoid, 2; small cell carcinoma, 7; large cell neuroendocrine carcinoma, 0; combined small cell carcinoma, 2) expression. There was no correlation between sex and estrogen/progesterone status. Estrogen and progesterone staining were also noted in endothelial cells. Relative to neuroendocrine carcinomas, mammary carcinomas expressed estrogen and progesterone more frequently. Non–small cell carcinomas had greater and similar immunoreactivity for estrogen and progesterone, respectively. Conclusions.—Although estrogen and progesterone receptor staining is frequently associated with breast and gynecologic primaries, it can also be observed in “nontarget” organs. Therefore, presence of estrogen and/or progesterone expression in neuroendocrine tumors involving the lung should not exclude a primary pulmonary neoplasm.

Primary, combined, atypical carcinoid and squamous cell carcinoma of the larynx: a new variety of composite tumour

2009 ◽  
Vol 124 (2) ◽  
pp. 226-229 ◽  
Author(s):  
C R Davies-Husband ◽  
P Montgomery ◽  
D Premachandra ◽  
H Hellquist
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Squamous Cell ◽  
Small Cell ◽  
Neuroendocrine Neoplasms ◽  
Atypical Carcinoid ◽  
Typical Carcinoid ◽  
First Case ◽  
Carcinoma Of The Larynx

AbstractObjective:We report the first case of a laryngeal composite tumour consisting of a squamous cell carcinoma combined with an atypical carcinoid.Methods:Case report and review of the literature concerning laryngeal composite tumours.Results:Primary laryngeal carcinoma is the most common malignancy of the upper aerodigestive tract. The vast majority are of the squamous cell type. Primary neuroendocrine neoplasms represent a rare, heterogeneous subset of laryngeal malignancies, comprising typical carcinoid, atypical carcinoid, small cell carcinoma and paraganglioma. Primary combined neuroendocrine and squamous cell carcinoma of the larynx is even more rarely encountered, with only 14 publications of this so-called composite tumour to date. In each case, the neuroendocrine component has been small cell carcinoma.Conclusion:The treatment of primary neoplasms comprising more than one histological type is tailored to the most biologically aggressive tumour. Accurate diagnosis of the histological nature of laryngeal composite tumours is imperative to ensure optimal therapy.

Combined small-cell carcinoma of the lung with quadripartite differentiation of epithelial, neuroendocrine, skeletal muscle, and myofibroblastic type

2011 ◽  
Vol 458 (4) ◽  
pp. 497-503 ◽  
Author(s):  
Giuseppe Pelosi ◽  
Angelica Sonzogni ◽  
Domenico Galetta ◽  
Federica Perrone ◽  
Paola Braidotti ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Small Cell ◽  
Combined Small Cell Carcinoma

Large-cell variant of small cell carcinoma of the ovary with hypercalcaemia

2000 ◽  
Vol 264 (3) ◽  
pp. 157-158 ◽  
Author(s):  
G. Di Vagno ◽  
G. A. Melilli ◽  
G. Cormio ◽  
D. Piscitelli ◽  
A. Ciampolillo ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Large Cell ◽  
Small Cell ◽  
Cell Variant ◽  
Carcinoma Of The Ovary

scholarly journals A case of small cell carcinoma of the lung differentiated toward large cell carcinoma and adenocarcinoma during treatment.

1991 ◽  
Vol 30 (3) ◽  
pp. 507-511
Author(s):  
Hitoshi HIRATA ◽  
Yutaka MIZUSHIMA ◽  
Saburo YANO ◽  
Mikio KITASAWA ◽  
Ken FUKUMURA ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Large Cell Carcinoma ◽  
Large Cell ◽  
Small Cell

scholarly journals The cytomorphologic spectrum of small-cell carcinoma and large-cell neuroendocrine carcinoma in body cavity effusions: A study of 68 cases

CytoJournal ◽  
2011 ◽  
Vol 8 ◽  
pp. 18 ◽  
Author(s):  
Walid E. Khalbuss ◽  
Huaitao Yang ◽  
Qian Lian ◽  
Abdelmonem Elhosseiny ◽  
Liron Pantanowitz ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Single Cell ◽  
Small Cell Carcinoma ◽  
Neuroendocrine Carcinoma ◽  
Large Cell ◽  
Body Cavity ◽  
Small Cell ◽  
Cell Clusters ◽  
Cell Pattern ◽  
Ancillary Studies

Background: Small-cell carcinoma (SCC) and large-cell neuroendocrine carcinoma (LCNEC) are uncommon in serous body cavity effusions. The purpose of this study is to examine the cytomorphological spectrum of SCC and LCNEC in body cavity serous fluids. Materials and Methods: We have 68 cases from 53 patients who had metastatic SCC or LCNEC diagnoses. All cytology slides and the available clinical data, histological follow-up, and ancillary studies were reviewed. Results: A total of 68 cases (60 pleural, 5 peritoneal, and 3 pericardial effusions) from 53 patients with an average age of 73 years (age range 43-92 years) were reported as diagnostic or suspicious of SCC (52 cases) or LCNEC (16 cases). The primary site was lung in 56 cases, pancreas in 6 cases, and 2 cases each from cervix, colon, and the head and neck region. Of the 68 cases, 48 cases had no history of malignancy of the same type. Ancillary studies were used in 46 cases (68%) including flow cytometric studies in 5 cases. There were three predominant cytomorphological patterns observed including small-cell clusters with prominent nuclear molding (33 cases, 49%), large-cell clusters mimicking non-small-cell carcinoma (18 cases, 26%), and single-cell pattern mimicking lymphoma (17 cases, 25%). Significant apoptosis was seen in 22 cases (33%) and marked tumor cell cannibalism was seen in 11 cases (16%). Nucleoli were prominent in 16 cases (24%). The most frequent neuroendocrine markers performed were synaptophysin and chromogranin. Conclusions: The most common cytomorphologic patterns seen in body cavity effusions of SCC and LCNEC were small-cell clusters with nuclear molding. However, in 51% of the cases either a predominant single-cell pattern mimicking lymphoma or large-cell clusters mimicking non-small carcinoma were noted. In our experience, effusions were the first manifestation of disease in the majority of patients diagnosed with neuroendocrine carcinoma. Therefore, familiarity with the cytomorphological spectrum of neuroendocrine carcinomas in fluid cytology may help in rapidly establishing an accurate diagnosis and in directing appropriate management.

Chromosomal aberrations in a series of large-cell neuroendocrine carcinomas: Unexpected divergence from small-cell carcinoma of the lung

2001 ◽  
Vol 32 (10) ◽  
pp. 1059-1063 ◽  
Author(s):  
Reinhard Ullmann ◽  
Susanna Petzmann ◽  
Anu Sharma ◽  
Philip Theo Cagle ◽  
Helmut Hans Popper
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Chromosomal Aberrations ◽  
Large Cell ◽  
Small Cell ◽  
Neuroendocrine Carcinomas

Primary Combined Squamous and Small Cell Carcinoma of the Larynx: A Case Report and Review of the Literature

2004 ◽  
Vol 128 (11) ◽  
pp. 1279-1282
Author(s):  
Vilkesh R. Jaiswal ◽  
Mai P. Hoang
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Squamous Cell ◽  
Small Cell ◽  
Squamous Cell Carcinomas ◽  
Review Of The Literature ◽  
The Past ◽  
Laryngeal Carcinomas ◽  
Carcinoma Of The Larynx ◽  
Combined Small Cell Carcinoma

Abstract Primary laryngeal carcinomas comprise approximately 2% to 5% of all malignancies worldwide. Of these laryngeal carcinomas, approximately 99% are primary squamous cell carcinomas. During the past 30 years, about 160 cases of primary small cell carcinoma of the larynx have been reported. Combined primary squamous and small cell carcinoma of the larynx, the so-called composite tumor of the larynx, is even more rare, with only 13 published cases to date. Although the major risk factors for developing these composite tumors of the larynx are thought to be similar to other more common neoplasms of the larynx, such as squamous cell carcinoma, the treatment and prognosis are different. We report an additional case of combined small cell carcinoma of the larynx and discuss the histogenesis of this unusual neoplasm.

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