scholarly journals Diagnostic Challenges in Fine-Needle Aspiration Cytology of Mediastinal Tumors and Lesions

2021 ◽  
Author(s):  
Huihong Xu ◽  
Fang Fan ◽  
Yun Gong ◽  
Xin Jing ◽  
Xiaoqi Lin ◽  
...  
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Endobronchial Ultrasound ◽  
Metastatic Tumors ◽  
Aspiration Cytology ◽  
Mediastinal Tumors ◽  
Fine Needle ◽  
Wide Range ◽  
Needle Aspiration Cytology

Context.— Mediastinal tumors/lesions are frequently encountered in daily cytopathology practice. These lesions are accessible through endoscopic/endobronchial ultrasound-guided or computed tomography–guided fine-needle aspiration cytology and represent a wide range of primary and metastatic tumors. This often poses diagnostic challenges because of the complexity of the mediastinal anatomic structures. Tumors metastatic to mediastinal lymph nodes represent the most common mediastinal lesions and must be differentiated from primary lesions. Objective.— To provide an updated review on the fine-needle aspiration cytology of mediastinal tumors/lesions, with an emphasis on diagnostic challenges. This review encompasses thymic epithelial neoplasms, mediastinal lymphoproliferative disorders, germ cell tumors, neuroendocrine tumors, soft tissue tumors, and metastatic tumors. Differential diagnoses; useful ancillary studies, including targeted immunohistochemical panels; and diagnostic pitfalls are discussed. Data Sources.— Data were gathered from a PubMed search of peer-reviewed literature on mediastinal tumors. Data were also collected from the authors' own practices. Conclusions.— Fine-needle aspiration cytology plays a vital role in evaluation of mediastinal lesions. Being familiar with the clinical and cytomorphologic features of these lesions, appropriately triaging the diagnostic material for ancillary testing, and correlating with radiologic findings are important in arriving at correct diagnoses and guiding management.

scholarly journals Fine-needle aspiration cytology of extra mammary metastatic lesions in the breast: A retrospective study of 36 cases diagnosed during 18 years

CytoJournal ◽  
2010 ◽  
Vol 7 ◽  
pp. 10 ◽  
Author(s):  
Torill Sauer
Keyword(s):  
Fine Needle Aspiration ◽  
Primary Tumor ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
High Grade ◽  
Metastatic Tumors ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Metastatic Lesions ◽  
Needle Aspiration Cytology

Background: Metastatic tumors in the breast require treatment according to origin and type of tumor. It is important to recognize these lesions in fine-needle aspiration cytology (FNAC) in order to avoid unnecessary mastectomy or non-relevant chemotherapy. The aim of this study was to evaluate the cytological features of metastatic tumors and possible criteria that could alert us as to the possibility of a metastasis from an extra mammary malignancy. Methods: The material included 36 confirmed or suspected metastases in the breast registered in the pathology files at Oslo University Hospital, Ulleval, during 1990–2007. There were a total of 6,325 cases of malignant breast FNAC, representing 30 men and 6,295 women. Smears were evaluated for the amount of material, presence or absence of myoepithelial cells, microcalcifications, mitoses and necrotic material. All carcinomas were graded. Results: There were seven men (7/30 = 23.3%) and 29 women (29/6,295 = 0.46%). The primary tumor was known in 22 cases (22/36 = 61.1%). No other primary tumor was known and metastatic lesion was not initially suspected in 14 cases (14/36 = 38.9%). The most common origin was lung (15/36 = 41.7%). In five cases (5/36 = 13.9%), the origin remained uncertain. Conclusions: Metastases from extra mammary sites are (relatively) common in males (23.3%). In women, metastatic lesions are rare (0.46%). A large proportion of them (88%) are high-grade adenocarcinomas and poorly differentiated carcinomas that may resemble grade 3 ductal carcinomas. Unusual clinical and/or radiological presentation in combination with high-grade malignant cells should alert us to consider the possibility of a metastasis.

scholarly journals Clinicopathological evaluation of benign neck masses with emphasis on correlation of preoperative ultrasound and cytology with postoperative histopathology in tertiary care hospital

2019 ◽  
Vol 5 (4) ◽  
pp. 946
Author(s):  
Priyanka Garud ◽  
Surendra Gawarle ◽  
Prashant Keche
Keyword(s):  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
Needle Aspiration ◽  
Care Hospital ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Neck Masses ◽  
Number Of Patients ◽  
Wide Range ◽  
Needle Aspiration Cytology

<p class="abstract"><strong>Background:</strong> Benign neck mass is a common clinical condition which an ENT clinician routinely encounters. Commonly presenting benign neck masses occur within lymph nodes, thyroid, parotid and other salivary glands. Less common pathologies presenting as neck swellings are from thyroglossal cysts, branchial cleft cysts, carotid body tumors, cystic hygromas, pharyngeal pouch abnormalities and lumps of skin appendages.</p><p class="abstract"><strong>Methods:</strong> This is prospective observational based study. Duration of study is 1 yr 6 months. All palpable neck masses which are clinically diagnosed as benign were selected.</p><p class="abstract"><strong>Results:</strong> Study was conducted in Shri Vasantrao Naik Government Medical college, Yavatmal of 123 patients out of which 84 were thyroid swellings, 18 were salivary gland swellings and 21 were other swellings out of which 9 were lymph node swellings. 80.48% were female patients and 19.51% were male patients. Maximum number of patients were between the age group 31-40 years (28.45%) followed by 26.05% in 41-50 years. This is 1yr 6months observational study of epidemiological and clinicopathological spectrum and outcome of management of benign neck masses. This study also determines the histopathological correlation and accuracy of FNAC in the diagnosis of benign neck masses.</p><p class="abstract"><strong>Conclusions:</strong> We conclude from present study, that fine needle aspiration cytology is a safe, simple and more accurate than USG that can be done in diagnosing wide range of neck swellings. Probably USG guided fine needle aspiration cytology will be better investigation one can ask for. However confirmatory and accurate diagnosis is given by histopathology.</p>

Role of fine needle aspiration cytology in the preoperative diagnosis of malignancy in parotid and submandibular gland neoplasm

2014 ◽  
Vol 19 (2) ◽  
pp. 110-118
Author(s):  
Mohammad Amzad Hossain ◽  
Md Zahedul Alam ◽  
Md Rojibul Haque ◽  
Md Nazmul Haque ◽  
KM Nurul Alam ◽  
...  
Keyword(s):  
Submandibular Gland ◽  
Fine Needle Aspiration ◽  
Fine Needle Aspiration Cytology ◽  
False Negative ◽  
Needle Aspiration ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Medical College ◽  
Preoperative Diagnostic ◽  
Needle Aspiration Cytology

Objective: To evaluate the role of Fine Needle Aspiration Cytology in the preoperative diagnosis of malignancy in parotid and submandibular gland neoplasm. Methods: This cross sectional study on 50 cases was conducted in the Department of Otolaryngology and Head-Neck Surgery of Sir Salimullah Medical College Mitford Hospital and Dhaka Medical College Hospital from January’2009 to June 2010. Results: Fine needle aspiration cytology findings of our all 50 cases were compared with postoperative histopathological reports. Out of the 50 cases, in 36(72%) cases of benign neoplasm and 7(14%) cases of malignant neoplasm, pre-operative FNAC findings and post operative histopathological findings were same. In 7 cases, FNAC and post operative histopathological findings did not matched. These were 2 (4%) false positive and 5 (10%) false negative result.In our study sensitivity of FNAC for reporting malignancy was 58.33%, specificity to rule out malignancy was 94.73% and overall accuracy in detecting malignant tumour was 86%. Positive predictive value and negative value were 77.77% and 87.80% respectively. It can be concluded that fine needle aspiration cytology is a safe, cheap and useful preoperative diagnostic tool in the diagnosis of malignancy in parotid and submandibular gland, but as fine needle aspiration cytology partly depends on operator skill, it may give false negative and false positive result. Conclusion: FNAC is a useful preoperative diagnostic tool for malignant parotid and submandibular glands with high specificity and sensitivity. DOI: http://dx.doi.org/10.3329/bjo.v19i2.17634 Bangladesh J Otorhinolaryngol 2013; 19(2): 110-118

The “gray zone” in fine-needle aspiration cytology of the organized mammography screening. Cytohistological correlation

2011 ◽  
Vol 152 (8) ◽  
pp. 292-295
Author(s):  
Mihály Bak ◽  
Éva Konyár ◽  
Ferenc Schneider ◽  
Mária Bidlek ◽  
Éva Szabó ◽  
...  
Keyword(s):  
Fine Needle Aspiration ◽  
Mammography Screening ◽  
Fine Needle Aspiration Cytology ◽  
Benign Lesion ◽  
Needle Aspiration ◽  
Gray Zone ◽  
Aspiration Cytology ◽  
Surgical Biopsy ◽  
Fine Needle ◽  
Needle Aspiration Cytology

The National Public Health Program has established the organized mammography screening in Hungary. The aim of this study was to conduct an audit of “gray zone” smears of the organized mammography screening in comparison with histopathological diagnoses. Methods: Cytology results were rated to C3 atypia probably benign and C4 suspicious of malignancy. Results: 1361 women had aspiration cytology performed from a total of 47,718 mammography non-negative lesions. 105 (7.8%) were diagnosed as C3, whereas 78 (5.7) as C4. Of the 105 patients with C3 diagnosis 61 (58%) patients underwent surgical biopsy. Histology proved malignancy in 20 (32.8%) cases, and benign lesion in 41 (67.2%) cases. All (100%) of the 78 patients with C4 diagnosis had open biopsies; 69 (88.4%) cases were histologically malignant and 9 (11.6%) cases were benign lesions. Conclusion: The auditing results of fine needle aspiration cytology of “gray zone” in organized mammography screening meet the proposed threshold values. Authors conclude that the “gray zone” category in breast cytology is useful and of value if used judiciously. Orv. Hetil., 2011, 152, 292–295.

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