Properties and potential application of modern adsorbents in formulation of solid drug delivery systems

The last few years of enhancing the design of hybrid mesoporous organosilica nanoparticleshas allowed their degradation under specific pathologic conditions, which finally is showing a lightin their potential use as drug delivery systems towards clinical trials. Nevertheless, the issueof controlling the degradation on-demand at cellular level still remains a major challenge, even if ithas lately been addressed through the incorporation of degradable organo-bridged alkoxysilanesinto the silica framework. On this basis, this mini review covers some of the most recent examplesof dierent degradable organosilica nanomaterials with potential application in nanomedicine,from degradable non-porous to mesoporous organosilica nanoparticles (MONs), functionalized withresponsive molecular gates, and also the very promising degradable periodic mesoporous organosilicamaterials (PMOs) only consisting of organosilica bridges.

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Transforming stealthy to sticky nanocarriers: a potential application for tumor therapy

Biomaterials Science ◽

10.1039/c9bm00724e ◽

2019 ◽

Vol 7 (9) ◽

pp. 3581-3593 ◽

Cited By ~ 4

Author(s):

Alidha Gafur ◽

Natalia Kristi ◽

Ali Maruf ◽

Guixue Wang ◽

Zhiyi Ye

Keyword(s):

Drug Delivery ◽

Potential Application ◽

Drug Delivery Systems ◽

Tumor Therapy ◽

Delivery Systems

Recently, chameleon-like drug delivery systems have shown great potential in achieving simultaneous stealthy and sticky surfaces of nanocarriers to target/retarget tumors.

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Poly(methyl vinyl ether-co-maleic acid) Hydrogels Containing Cyclodextrins and Tween 85 for Potential Application as Hydrophobic Drug Delivery Systems

Macromolecular Research ◽

10.1007/s13233-019-7074-8 ◽

2019 ◽

Vol 27 (4) ◽

pp. 396-403 ◽

Cited By ~ 7

Author(s):

Eneko Larrañeta ◽

Juan Domínguez-Robles ◽

Martha Coogan ◽

Emma Heaney ◽

Sarah A. Stewart ◽

...

Keyword(s):

Drug Delivery ◽

Vinyl Ether ◽

Maleic Acid ◽

Potential Application ◽

Drug Delivery Systems ◽

Delivery Systems ◽

Hydrophobic Drug ◽

Methyl Vinyl ◽

Methyl Vinyl Ether

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Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100120242 ◽

1985 ◽

Vol 43 ◽

pp. 710-711

Author(s):

G.E. Visscher ◽

R. L. Robison ◽

G. J. Argentieri

Keyword(s):

Drug Delivery ◽

Drug Delivery Systems ◽

Gastrocnemius Muscle ◽

Degradation Process ◽

Delivery Systems ◽

Tissue Reaction ◽

Electron Microscopic ◽

Tissue Samples ◽

Injectable Polymer ◽

Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

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