scholarly journals Acute kidney injury in an extremely low birth weight infant with nephrolithiasis: a case report

2019 ◽  
Vol 25 (3) ◽  
pp. 166-172
Author(s):  
Rasa Garunkštienė ◽  
Rimutė Vaitkevičienė ◽  
Ieva Paulavičienė ◽  
Nijolė Drazdienė ◽  
Rimantė Čerkauskienė
Keyword(s):  
Risk Factors ◽  
Acute Kidney Injury ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Kidney Injury ◽  
Extremely Low Birth Weight ◽  
Low Birth Weight Infants ◽  
Low Birth Weight Infant ◽  
The Right

Acute kidney injury is associated with mortality of very low birth weight infants and reduces their survival regardless of other factors. The kidneys in the extremely preterm infants are very immature and susceptible to environmental factors. Clinical conditions and medications are risk factors for acute kidney injury in these patients. Nephrolithiasis in preterm infants is an extremely rare phenomenon that usually manifests as a complication of nephrocalcinosis. This is a case report that describes several episodes of acute kidney injury in the first two months of age in an extremely low birth weight infant with kidney stones in the background. The main causes that led to acute kidney injury in this patient were persistent ductus arteriosus, sepsis and captopril. At one month of age, ultrasound detected calcinates in the right kidney. Within two weeks a large number of linear stones formed across the collecting duct system. Small calcinates still remained in the right kidney when the girl was half a year of the corrected age. The evaluation of a neonate who develops acute kidney injury requires a systematic approach. Early identification of the emerging risk factors and prevention of nephrolithiasis along with effective treatment can reduce the risk of developing acute kidney injury in very low birth weight infants.

scholarly journals Diagnosis and Risk Factors of Acute Kidney Injury in Very Low Birth Weight Infants

2017 ◽  
Vol 58 (3) ◽  
pp. 258-263 ◽  
Author(s):  
Ankana Daga ◽  
Fredrick Dapaah-Siakwan ◽  
Sharina Rajbhandari ◽  
Cassandra Arevalo ◽  
Agnes Salvador
Keyword(s):  
Risk Factors ◽  
Acute Kidney Injury ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Kidney Injury ◽  
Low Birth Weight Infants

The concomitant use of vancomycin and piperacillin-tazobactam is associated with acute kidney injury (AKI) in extremely low birth weight infants (ELBW)

2021 ◽  
pp. 1-7
Author(s):  
Y. Al-Jebawi ◽  
K. Karalic ◽  
P. Shekhawat ◽  
M.J. Mhanna
Keyword(s):  
Acute Kidney Injury ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Late Onset ◽  
Kidney Injury ◽  
Extremely Low Birth Weight ◽  
Retrospective Case ◽  
Low Birth Weight Infants ◽  
Late Onset Sepsis ◽  
Increased Risk

BACKGROUND: Late-onset sepsis is common in extremely low birth weight (ELBW) infants, and it leads to the use of antibiotics to cover resistant organisms, which can be nephrotoxic. Here we have investigated the role of vancomycin plus piperacillin-tazobactam on the rate of acute kidney injury (AKI). METHODS: In a retrospective case-control study, medical records of all ELBW infants who were admitted to our Neonatal Intensive Care Unit (NICU) with late onset sepsis who were prescribed vancomycin plus piperacillin-tazobactam were reviewed for demographics, clinical characteristics, use of potential nephrotoxic medications and outcomes. RESULTS: During the study period, 264 patients were admitted, of whom 28.4%(75/264) received vancomycin plus piperacillin-tazobactam and were matched with 64 controls. There were no differences in gestational age or birth weight between cases and controls [688±160 vs. 689±162 grams (p = 0.99), and 24.7±1.8 vs. 24.7±1.6 weeks (p = 0.99) respectively]. There was no difference in the rate of sepsis between cases and controls [76%(55/72) vs. 64%(41/64) respectively, p = 0.11]. Infants exposed to vancomycin plus piperacillin-tazobactam had a higher percentage of concomitant use of vasopressors and amphotericin. To adjust for confounders, a logistic regression analysis was conducted with AKI as the dependent variable. Use of vasopressors and vancomycin plus piperacillin-tazobactam were the only risk factors associated with AKI with an adjusted OR (95%CI) of 4.08 (1.90–8.74), p <  0.001; and 2.87 (1.26–6.53), p = 0.01 respectively. CONCLUSION: The use of vancomycin plus piperacillin-tazobactam in ELBW infants is associated with an increased risk for AKI.

scholarly journals Urinary acute kidney injury biomarkers in very low-birth-weight infants on indomethacin for patent ductus arteriosus

2019 ◽  
Vol 85 (5) ◽  
pp. 678-686 ◽  
Author(s):  
Sina Waldherr ◽  
Alexander Fichtner ◽  
Bernd Beedgen ◽  
Thomas Bruckner ◽  
Franz Schaefer ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Patent Ductus Arteriosus ◽  
Very Low Birth Weight ◽  
Ductus Arteriosus ◽  
Kidney Injury ◽  
Low Birth Weight Infants ◽  
Patent Ductus

Peritoneal dialysis in extremely and very low-birth-weight infants

2020 ◽  
Vol 40 (2) ◽  
pp. 233-236 ◽  
Author(s):  
Kathrin Burgmaier ◽  
Agnes Hackl ◽  
Rasmus Ehren ◽  
Angela Kribs ◽  
Mathias Burgmaier ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Kidney Injury ◽  
Extremely Low Birth Weight ◽  
Low Birth Weight Infants ◽  
Daily Cycles ◽  
Good Clinical Condition ◽  
Increasing Demand

The outcome of extremely low-birth-weight (ELBW) and very low-birth-weight (VLBW) infants has substantially improved in recent years. As acute kidney injury is frequent in these infants due to various risk factors, there is an increasing demand for renal replacement therapy in these patients. Data on that topic, however, are scarce. We review the available literature on that topic and report our experience on temporary dialysis in three extremely immature infants (two ELBW and one VLBW) with acute kidney failure. Peritoneal dialysis (PD) was performed for 19, 23, and 44 days until recovery of native renal function. At recent follow-up of 18 and 24 months, two patients are in good clinical condition with chronic kidney disease stages 1 and 4, respectively. One patient deceased at the age of 12 months due to secondary liver failure. The dialysis regimen applied in our study differed significantly from older infants with extremely short dwell times and accordingly high numbers of daily cycles. The use of rigid acute PD catheters was associated with less catheter-related complications (leakage, dislocation, and obstruction) as compared to ascites drainage catheters. In summary, PD was technically feasible and effective also in extremely immature infants, but frequent adjustments of dialysis regimens and high numbers of daily cycles posed immense efforts on both, parents and medical staff.

scholarly journals Peritoneal dialysis in an extremely-low-birth weight infant with acute kidney injury resulting from circulatory dysfunction

2013 ◽  
Vol 26 (1) ◽  
pp. 116-121
Author(s):  
Jun Ishizuka ◽  
Mariko Sawada ◽  
Katsuji Kuwakado ◽  
Takahisa Yoshikawa ◽  
Daisuke Yoshinaga ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Peritoneal Dialysis ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Kidney Injury ◽  
Extremely Low Birth Weight ◽  
Low Birth Weight Infant

scholarly journals Urine Biomarkers Predict Acute Kidney Injury and Mortality in Very Low Birth Weight Infants

2011 ◽  
Vol 159 (6) ◽  
pp. 907-912.e1 ◽  
Author(s):  
David J. Askenazi ◽  
Angela Montesanti ◽  
Hayden Hunley ◽  
Rajesh Koralkar ◽  
Pushkar Pawar ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Kidney Injury ◽  
Low Birth Weight Infants ◽  
Urine Biomarkers
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