scholarly journals Study on the Reaction of Acetone Cyanohydrin with 3,5-Dimethyl-N-α,β-unsaturated Acyl Pyrazole

2020 ◽  
Vol 40 (9) ◽  
pp. 2871
Author(s):  
Guannian Fang ◽  
Jun You ◽  
Yanchao Yu ◽  
Junkai Jing ◽  
Bo Liu ◽  
...  
Keyword(s):  
Acetone Cyanohydrin ◽  
Unsaturated Acyl

Syntheses of Spiro(2-oxopyrrolidinyl)-5,4′-pyrazolones via Organocatalyzed Michael/Ammonolysis Cascade Reaction of 4-Aminopyrazolones and α,β-Unsaturated Acyl Phosphates

Synlett ◽  
2021 ◽  
Author(s):  
Lin Chen ◽  
You-Fen Li ◽  
Zheng-Jun Chen ◽  
Wen-Ya Jiao ◽  
Zhi-Jiao Chen
Keyword(s):  
Drug Discovery ◽  
Chemical Biology ◽  
Cascade Reaction ◽  
Unsaturated Acyl

AbstractThe efficient organocatalyzed Michael/ammonolysis cascade reaction of N-protected 4-aminopyrazolones and α,β-unsaturated acyl phosphates has been developed. This tactic gives rise to architecturally multifarious spiro(2-oxopyrrolidinyl)-5,4′-pyrazolones in good productiveness (up to 88% yield) and with moderate to good diastereoselectivities (up to 20:1 dr). These novel hybrid heterocycles would be promising candidates for drug-discovery programs and chemical biology.

scholarly journals α,β-Unsaturated acyl ammonium species as reactive intermediates in organocatalysis: an update

2020 ◽  
Author(s):  
Jacqueline Bitai ◽  
Matthew Westwood ◽  
Andrew D Smith
Keyword(s):  
Reactive Intermediates ◽  
Domino Reactions ◽  
Michael Additions ◽  
Unsaturated Acyl

α,β-Unsaturated acyl ammonium species are versatile intermediates that have been applied in a variety of transformation including Michael additions, domino reactions and cycloadditions. Many of these transformations are promoted by...

Glyceride studies. V. The distribution of unsaturated acyl groups in vegetable triglycerides

1965 ◽  
Vol 42 (11) ◽  
pp. 965-970 ◽  
Author(s):  
F. D. Gunstone ◽  
R. J. Hamilton ◽  
F. B. Padley ◽  
M. Ilyas Qureshi
Keyword(s):  
Unsaturated Acyl
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