scholarly journals Alternative Roles of STAT3 and MAPK Signaling Pathways in the MMPs Activation and Progression of Lung Injury Induced by Cigarette Smoke Exposure in ACE2 Knockout Mice

2016 ◽  
Vol 12 (4) ◽  
pp. 454-465 ◽  
Author(s):  
Yi-Han Hung ◽  
Wen-Yeh Hsieh ◽  
Jih-Sheng Hsieh ◽  
Fon-Chang Liu ◽  
Chin-Hung Tsai ◽  
...  
Keyword(s):  
Lung Injury ◽  
Signaling Pathways ◽  
Cigarette Smoke ◽  
Knockout Mice ◽  
Mapk Signaling ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure ◽  
Mapk Signaling Pathways

scholarly journals Cigarette Smoke Exposure Worsens Endotoxin-Induced Lung Injury and Pulmonary Edema in Mice

2017 ◽  
Vol 19 (9) ◽  
pp. 1033-1039 ◽  
Author(s):  
Jeffrey E Gotts ◽  
Jason Abbott ◽  
Xiaohui Fang ◽  
Haru Yanagisawa ◽  
Naoki Takasaka ◽  
...  
Keyword(s):  
Lung Injury ◽  
Pulmonary Edema ◽  
Cigarette Smoke ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure

Acute Cigarette Smoke Exposure Causes Lung Injury in Rabbits Treated with Ibuprofen

1987 ◽  
Vol 13 (2) ◽  
pp. 113-126 ◽  
Author(s):  
Mark L. Witten ◽  
Richard J. Lemen ◽  
Stuart F. Quan ◽  
Richard E. Sobonya ◽  
Judith L. Magarelli ◽  
...  
Keyword(s):  
Lung Injury ◽  
Cigarette Smoke ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure

scholarly journals NOD-like receptors mediate inflammatory lung injury during plateau hypoxia exposure

2020 ◽  
Vol 39 (1) ◽  
Author(s):  
Haiyan Wang ◽  
Xue Lin ◽  
Xiaoyan Pu
Keyword(s):  
Lung Injury ◽  
Signaling Pathways ◽  
P38 Mapk ◽  
Enrichment Analysis ◽  
Mapk Signaling ◽  
The Body ◽  
Inflammatory Factors ◽  
Hypoxia Exposure ◽  
Tnf Α ◽  
Mapk Signaling Pathways

Abstract Background The lung is an important target organ for hypoxia treatment, and hypoxia can induce several diseases in the body. Methods We performed transcriptome sequencing for the lungs of rats exposed to plateau hypoxia at 0 day and 28 days. Sequencing libraries were constructed, and enrichment analysis of the differentially expressed genes (DEGs) was implemented using the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). Subsequently, experimental validation was executed by quantitative real-time PCR (qRT-PCR) and western blot. Results The results showed that the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) signaling pathway that was involved in immunity may play a crucial function in lung injury caused by plateau hypoxia. And the expressions of NOD1, NOD2, IL-1β, TNF-α, IL-6, and IL-18 were higher at 28 days of exposure to plateau hypoxia than that at 0 day. Similarly, CARD9, MYD88, p38 MAPK, and NF-κB p65, which are related to the NF-κB and MAPK signaling pathways, also demonstrated increased expression at 28 days exposure to plateau hypoxia than at 0 day. Conclusions Our study suggested that the NF­κBp65 and p38 MAPK signaling pathways may be activated in the lungs of rats during plateau hypoxia. Upregulated expression of NF­κBp65 and p38 MAPK can promote the transcription of downstream inflammatory factors, thereby aggravating the occurrence and development of lung tissue remodeling.

Cigarette smoke exposure aggravates air space enlargement and alveolar cell apoptosis in Smad3 knockout mice

2011 ◽  
Vol 301 (4) ◽  
pp. L391-L401 ◽  
Author(s):  
Laszlo Farkas ◽  
Daniela Farkas ◽  
David Warburton ◽  
Jack Gauldie ◽  
Wei Shi ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Knockout Mice ◽  
Cell Apoptosis ◽  
Transforming Growth Factor ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure ◽  
Chronic Obstructive ◽  
Specific Gene ◽  
Alveolar Cell ◽  
Air Space

The concept of genetic susceptibility factors predisposing cigarette smokers to develop emphysema stems from the clinical observation that only a fraction of smokers develop clinically significant chronic obstructive pulmonary disease. We investigated whether Smad3 knockout mice, which develop spontaneous air space enlargement after birth because of a defect in transforming growth factor-β (TGF-β) signaling, develop enhanced alveolar cell apoptosis and air space enlargement following cigarette smoke exposure. We investigated Smad3−/− and Smad3+/+ mice at different adult ages and determined air space enlargement, alveolar cell proliferation, and apoptosis. Furthermore, laser-capture microdissection and real-time PCR were used to measure compartment-specific gene expression. We then compared the effects of cigarette smoke exposure on Smad3−/− and littermate controls. Smad3 knockout resulted in the development of air space enlargement in the adult mouse and was associated with decreased alveolar VEGF levels and activity and increased alveolar cell apoptosis. Cigarette smoke exposure aggravated air space enlargement and alveolar cell apoptosis. We also found increased Smad2 protein expression and phosphorylation, which was enhanced following cigarette smoke exposure, in Smad3-knockout animals. Double immunofluorescence analysis revealed that endothelial apoptosis started before epithelial apoptosis. Our data indicate that balanced TGF-β signaling is not only important for regulation of extracellular matrix turnover, but also for alveolar cell homeostasis. Impaired signaling via the Smad3 pathway results in alveolar cell apoptosis and alveolar destruction, likely via increased Smad2 and reduced VEGF expression and might represent a predisposition for accelerated development of emphysema due to cigarette smoke exposure.

scholarly journals Acute pulmonary inflammation is inhibited in CXCR3 knockout mice after short-term cigarette smoke exposure

2008 ◽  
Vol 29 (12) ◽  
pp. 1432-1439 ◽  
Author(s):  
Li Nie ◽  
Ruo-lan Xiang ◽  
Yong Liu ◽  
Wei-xun Zhou ◽  
Lei Jiang ◽  
...  
Keyword(s):  
Cigarette Smoke ◽  
Knockout Mice ◽  
Pulmonary Inflammation ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure ◽  
Short Term

Effect of Cigarette Smoke Exposure on Biomarkers of Lung Injury in the Rat

1996 ◽  
Vol 8 (8) ◽  
pp. 803-817 ◽  
Author(s):  
K. Miller ◽  
B. Hudspith ◽  
M. Cunninghame ◽  
C. Prescott ◽  
C. Meredith
Keyword(s):  
Lung Injury ◽  
Cigarette Smoke ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure

Chronic Sidestream Cigarette Smoke Exposure Causes Lung Injury in Rabbits

1992 ◽  
Vol 1 (6) ◽  
pp. 341-347
Author(s):  
Mark L. Witten ◽  
Patricia M. Joseph ◽  
R. Clark Lantz ◽  
David S. Lazarus ◽  
Walter K. Jung ◽  
...  
Keyword(s):  
Lung Injury ◽  
Cigarette Smoke ◽  
Smoke Exposure ◽  
Cigarette Smoke Exposure
Sign in / Sign up

Export Citation Format

Share Document