scholarly journals A New Look at Causal Factors of Idiopathic Scoliosis: Altered Expression of Genes Controlling Chondroitin Sulfate Sulfation and Corresponding Changes in Protein Synthesis in Vertebral Body Growth Plates

2019 ◽  
Vol 16 (2) ◽  
pp. 221-230 ◽  
Author(s):  
Alla M. Zaydman ◽  
Elena L. Strokova ◽  
Alena O.Stepanova ◽  
Pavel P. Laktionov ◽  
Alexander I. Shevchenko ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Idiopathic Scoliosis ◽  
Chondroitin Sulfate ◽  
Vertebral Body ◽  
Body Growth ◽  
Growth Plates ◽  
Altered Expression ◽  
Causal Factors ◽  
Expression Of Genes ◽  
New Look

Glycosaminoglycans of the Vertebral Body Growth Plate in Patients with Idiopathic Scoliosis

2005 ◽  
Vol 139 (6) ◽  
pp. 738-740 ◽  
Author(s):  
T. V. Rusova ◽  
V. I. Rykova ◽  
A. V. Korel’ ◽  
A. M. Zaidman ◽  
D. S. Tkachev
Keyword(s):  
Idiopathic Scoliosis ◽  
Growth Plate ◽  
Vertebral Body ◽  
Body Growth

scholarly journals Multifaceted deregulation of gene expression and protein synthesis with age

2020 ◽  
Vol 117 (27) ◽  
pp. 15581-15590 ◽  
Author(s):  
Aleksandra S. Anisimova ◽  
Mark B. Meerson ◽  
Maxim V. Gerashchenko ◽  
Ivan V. Kulakovskiy ◽  
Sergey E. Dmitriev ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Ribosome Biogenesis ◽  
Cell Function ◽  
Altered Expression ◽  
Biomarkers Of Aging ◽  
Expression Of Genes ◽  
Age Related ◽  
Mouse Tissues ◽  
Terminal Oligopyrimidine ◽  
Age Related Changes

Protein synthesis represents a major metabolic activity of the cell. However, how it is affected by aging and how this in turn impacts cell function remains largely unexplored. To address this question, herein we characterized age-related changes in both the transcriptome and translatome of mouse tissues over the entire life span. We showed that the transcriptome changes govern those in the translatome and are associated with altered expression of genes involved in inflammation, extracellular matrix, and lipid metabolism. We also identified genes that may serve as candidate biomarkers of aging. At the translational level, we uncovered sustained down-regulation of a set of 5′-terminal oligopyrimidine (5′-TOP) transcripts encoding protein synthesis and ribosome biogenesis machinery and regulated by the mTOR pathway. For many of them, ribosome occupancy dropped twofold or even more. Moreover, with age, ribosome coverage gradually decreased in the vicinity of start codons and increased near stop codons, revealing complex age-related changes in the translation process. Taken together, our results reveal systematic and multidimensional deregulation of protein synthesis, showing how this major cellular process declines with age.

scholarly journals Multi-faceted deregulation of gene expression and protein synthesis with age

2020 ◽  
Author(s):  
Aleksandra S. Anisimova ◽  
Mark B. Meerson ◽  
Maxim V. Gerashchenko ◽  
Ivan V. Kulakovskiy ◽  
Sergey E. Dmitriev ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Ribosome Biogenesis ◽  
Cell Function ◽  
Altered Expression ◽  
Biomarkers Of Aging ◽  
Expression Of Genes ◽  
Age Related ◽  
Mouse Tissues ◽  
Terminal Oligopyrimidine ◽  
Age Related Changes

Protein synthesis represents a major metabolic activity of the cell. However, how it is affected by aging and how this in turn impacts cell function remains largely unexplored. To address this question, herein we characterized age-related changes in both the transcriptome and translatome of mouse tissues over the entire lifespan. Expression of the majority of differentially expressed genes followed a U-shaped curve with the turning point around 3-months-old. We showed that transcriptome changes govern changes in the translatome and are associated with altered expression of genes involved in inflammation, extracellular matrix and lipid metabolism. We also identified genes that may serve as candidate biomarkers of aging. At the translational level, we uncovered sustained down-regulation of a set of 5’ terminal oligopyrimidine (5’TOP) transcripts encoding protein synthesis and ribosome biogenesis machinery and regulated by the mTOR pathway. For many of them, ribosome occupancy dropped 3-fold or even more. Moreover, with age, ribosome coverage gradually decreased in the vicinity of start codons and increased near stop codons, revealing complex age-related changes in the translation process. Taken together, our results reveal systematic and multi-dimensional deregulation in protein synthesis, showing how this major cellular process declines with age.

scholarly journals SHOX gene is expressed in vertebral body growth plates in idiopathic and congenital scoliosis: Implications for the etiology of scoliosis in turner syndrome

2008 ◽  
Vol 27 (6) ◽  
pp. 807-813 ◽  
Author(s):  
Gregory Day ◽  
Attila Szvetko ◽  
Lyn Griffiths ◽  
I. Bruce McPhee ◽  
John Tuffley ◽  
...  
Keyword(s):  
Turner Syndrome ◽  
Vertebral Body ◽  
Congenital Scoliosis ◽  
Body Growth ◽  
Growth Plates ◽  
Shox Gene

scholarly journals Scoliotic disease: report to the teacher

2020 ◽  
Vol 17 (3) ◽  
pp. 117-133
Author(s):  
A. M. Zaidman
Keyword(s):  
Idiopathic Scoliosis ◽  
Growth Plate ◽  
Vertebral Body ◽  
Growth Process ◽  
Structural Changes ◽  
Body Growth ◽  
Deformity Progression ◽  
Genetically Determined ◽  
First Time ◽  
Chick Embryo Model

It is with gratitude that I dedicate my work to the teacher, Ya.L. Tsivyan, who not only provided a subject for research, but also, on his own example of a person devoted to his work, brought up a generation of scholars for whom life and science are inseparable.The paper presents the results of many years of research on idiopathic scoliosis in the form of a report to the teacher. Several fundamental topics were considered:1) for the first time in world practice, it was established, on the basis of a study of 50 patients with idiopathic scoliosis, that the etiological factor of scoliosis is ectopic localization of neural crest derivatives, which are not genetically determined to chondrogenic differentiation and the growth process, in the vertebral body growth plate;2) a local disturbance of chondrogenesis in the  vertebral body growth plate  is the cause of the growth asymmetry and formation of spinal deformity in idiopathic scoliosis;3) the degree of structural changes in the spine and the prognosis of the deformity progression  depend on the level of disturbance of the morphogenetic processes in the vertebral body growth plate embedded in embryogenesis;4) it is supposed to confirm the proposed hypotheses by inhibition of the PAX3 gene in the chick embryo model of idiopathic scoliosis and to get answers to many more unclear questions concerning scoliotic disease.

Continued vertebral body growth in patients with juvenile idiopathic scoliosis following vertebral body stapling

2020 ◽  
Vol 8 (2) ◽  
pp. 221-226 ◽  
Author(s):  
Erin Murray ◽  
Robert Tung ◽  
Ashley Sherman ◽  
Richard M. Schwend
Keyword(s):  
Idiopathic Scoliosis ◽  
Vertebral Body ◽  
Body Growth ◽  
Juvenile Idiopathic Scoliosis
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