scholarly journals The effect of combined Epidural-general Anesthesia on Hemodynamic Instability during Pheochromocytoma and Paraganglioma Surgery: A multicenter retrospective cohort study

2020 ◽  
Vol 17 (13) ◽  
pp. 1956-1963
Author(s):  
Soeun Jeon ◽  
Ah-Reum Cho ◽  
Hyun-Su Ri ◽  
Hyeon-Jeong Lee ◽  
Jeong-Min Hong ◽  
...  
Keyword(s):  
Cohort Study ◽  
General Anesthesia ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Hemodynamic Instability

scholarly journals A Single-center Retrospective Cohort Study on Cesarean Section under General Anesthesia

2019 ◽  
Vol 34 (4) ◽  
pp. 256-262
Author(s):  
Li Xu ◽  
Wu Biye ◽  
Zhang Mingzhu ◽  
Shen Le ◽  
Keyword(s):  
Cohort Study ◽  
Cesarean Section ◽  
General Anesthesia ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Single Center

scholarly journals Risk of general anesthesia in pediatric skin procedures: A retrospective cohort study

2020 ◽  
Vol 24 (1) ◽  
pp. 41
Author(s):  
AhmedMahmoud El-Malky ◽  
BaderMoustafa Alhabeeb ◽  
AliMohammed Nasser Alhazmi ◽  
OsamaAbdulaziz Alobaid ◽  
AhmedAbdulrahman Alharthi ◽  
...  
Keyword(s):  
Cohort Study ◽  
General Anesthesia ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort

scholarly journals Etiology-associated heterogeneity in acute respiratory distress syndrome: a retrospective cohort study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Sheng-Yuan Ruan ◽  
Chun-Ta Huang ◽  
Ying-Chun Chien ◽  
Chun-Kai Huang ◽  
Jung-Yien Chien ◽  
...  
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Cohort Study ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Bacterial Pneumonia ◽  
Distress Syndrome ◽  
Hemodynamic Instability ◽  
Significant Difference

Abstract Background Heterogeneity in acute respiratory distress syndrome (ARDS) has led to many statistically negative clinical trials. Etiology is considered an important source of pathogenesis heterogeneity in ARDS but previous studies have usually adopted a dichotomous classification, such as pulmonary versus extrapulmonary ARDS, to evaluate it. Etiology-associated heterogeneity in ARDS remains poorly described. Methods In this retrospective cohort study, we described etiology-associated heterogeneity in gas exchange abnormality (PaO2/FiO2 [P/F] and ventilatory ratios), hemodynamic instability, non-pulmonary organ dysfunction as measured by the Sequential Organ Failure Assessment (SOFA) score, biomarkers of inflammation and coagulation, and 30-day mortality. Linear regression was used to model the trajectory of P/F ratios over time. Wilcoxon rank-sum tests, Kruskal–Wallis rank tests and Chi-squared tests were used to compare between-etiology differences. Results From 1725 mechanically ventilated patients in the ICU, we identified 258 (15%) with ARDS. Pneumonia (48.4%) and non-pulmonary sepsis (11.6%) were the two leading causes of ARDS. Compared with pneumonia associated ARDS, extra-pulmonary sepsis associated ARDS had a greater P/F ratio recovery rate (difference = 13 mmHg/day, p = 0.01), more shock (48% versus 73%, p = 0.01), higher non-pulmonary SOFA scores (6 versus 9 points, p < 0.001), higher d-dimer levels (4.2 versus 9.7 mg/L, p = 0.02) and higher mortality (43% versus 67%, p = 0.02). In pneumonia associated ARDS, there was significant difference in proportion of shock (p = 0.005) between bacterial and non-bacterial pneumonia. Conclusion This study showed that there was remarkable etiology-associated heterogeneity in ARDS. Heterogeneity was also observed within pneumonia associated ARDS when bacterial pneumonia was compared with other non-bacterial pneumonia. Future studies on ARDS should consider reporting etiology-specific data and exploring possible effect modification associated with etiology.

Pain and Distress from Bone Marrow Aspirations and Lumbar Punctures

2003 ◽  
Vol 37 (1) ◽  
pp. 17-22 ◽  
Author(s):  
Mark T Holdsworth ◽  
Dennis W Raisch ◽  
Stuart S Winter ◽  
Jami D Frost ◽  
Michele A Moro ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Cohort Study ◽  
General Anesthesia ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Eutectic Mixture ◽  
Pain Scale ◽  
Emla Cream ◽  
Relieve Pain ◽  
Oral Midazolam

OBJECTIVE To compare the efficacy of 3 different pharmacologic regimens to relieve pain and distress in children with cancer undergoing bone marrow aspirations (BMAs) and lumbar punctures (LPs). DESIGN Retrospective cohort study with crossovers for some patients. PATIENTS AND METHODS The pain and distress ratings of patients undergoing BMAs (n = 73) and LPs (n = 105) were examined in a comparison of 3 different interventions: (1) a topical eutectic mixture of lidocaine and prilocaine (EMLA cream), (2) oral midazolam and EMLA cream, or (3) propofol/fentanyl general anesthesia. The choice of the intervention depended on patient/parent request. A validated faces pain scale was completed by the child or parent following each BMA or LP. The faces pain scale includes ratings of the severity of pain (from 0 = none to 5 = severe) and ratings of how frightened (from 0 = not scared to 5 = scared) the child was prior to each procedure. Comparisons of the pain and distress ratings were made among all patients for their first procedure and also within individual patients who had received >1 of the 3 interventions. Independent comparisons between the first treatments received by each patient were analyzed using Kruskal–Wallis tests. Comparisons of different crossover treatments received by individual patients were analyzed using Wilcoxon tests. RESULTS For all first procedures, mean ± SD pain and distress ratings during LPs were significantly lower when propofol/fentanyl was used (n = 43; 0.4 ± 1.0 and 1.4 ± 1.7) versus either EMLA (n = 29; 2.4 ± 1.7 and 2.9 ± 1.9) or midazolam/EMLA (n = 33; 2.4 ± 1.8 and 2.7 ± 1.8), respectively. Pain and distress ratings during BMAs were also significantly lower with propofol/fentanyl (n = 29; 0.5 ± 1.0 and 1.2 ± 1.7) versus EMLA (n = 21; 3.5 ± 1.6 and 3.3 ± 1.8) or midazolam/EMLA (n = 23; 3.3 ± 1.5 and 3.0 ± 1.9), respectively. When data were analyzed within each patient, these differences were also present. CONCLUSIONS Children receiving propofol/fentanyl general anesthesia experienced significantly less procedure-related pain and distress than did those receiving either EMLA or oral midazolam/EMLA.

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