scholarly journals Protective Role of N-Acetylcysteine on the Cytotoxic Effect of Paclitaxel in MCF7 Breast Cancer Cell Line

2020 ◽  
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Cytotoxic Effect ◽  
Cancer Cell Line ◽  
Protective Role ◽  
Mcf7 Breast Cancer Cell

scholarly journals Role of COX-2 in Tumorospheres Derived from a Breast Cancer Cell Line

2011 ◽  
Vol 168 (1) ◽  
pp. e39-e49 ◽  
Author(s):  
Balraj Singh ◽  
Kendra R. Cook ◽  
Laura Vincent ◽  
Carolyn S. Hall ◽  
Cecilia Martin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Cancer Cell Line ◽  
Cox 2

scholarly journals Anticancer activity of chicken cathelicidin peptides against different types of cancer

2021 ◽  
Author(s):  
Maged Mostafa Mahmoud ◽  
Ahmed M. Al-Hejin ◽  
Turki S. Abujamel ◽  
Modhi Alenezi ◽  
Fadwa Aljoud ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Cell Lines ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Cancer Cell Line ◽  
High Dose ◽  
Mcf 7

Abstract This study served as the pioneer in studying the anti-cancer role of chicken cathelicidin peptides. Chicken cathelicidins were used as anticancer agent against the breast cancer cell line (MCF-7) and human colon cancer cell line (HCT116). An in vivo investigation was also achieved to evaluate the role of chicken cathelicidin in Ehrlich ascites cell (EAC) suppression as a tumor model after subcutaneous implantation in mice. In addition, the mechanism of action of the interaction of cationic peptides with breast cancer cell line MCF-7 was also investigated. It was found during the study that exposure of cell lines to higher concentration of chicken cathelicidin for 72 h reduced cell lines growth rate by 90%-95%. These peptides demonstrated down-regulation of (cyclin A1 and cyclin D genes) which are essential for G1/S phase transient and S/G2 phase and consequently causes “prometaphase arrest” ultimately leading to death of MCF-7 cells. The study showed two- and three-times higher expression of the caspase-3, and − 7 genes respectively in MCF-7 cells treated with chicken peptides (especially cathelicidin-2 and − 3) relative to untreated cells which encouraged pro-apoptotic pathway, autophagy, and augmentation of the anti-proliferative activity. Our data showed that chicken ( CATH-1 ) enhance releasing of TNFα, INF-γ and upregulation of granzyme K in treated mice groups, in parallel, the tumor size and volume was reduced in the treated EAC-bearing groups after cathelicidin administration compared to untreated EAC-bearing group. Additionally, animals received high dose of cathelicidin-1 (40 µg/ml) displayed an apical survival rate compared to untreated carcinoma control and animals which received low dose of cathelicidin (10 and 20 µg/ml). Tumor of mice groups treated with chicken cathelicidin displayed high area of necrosis compared to untreated EAC-bearing mice. Based on histological analysis and immunohistochemical staining revealed that the tumor section in Ehrlich solid tumor exhibited a strong Bcl2 expression in untreated control compared to mice treated with 10 & 20 µg/ml of cathelicidin. Interestingly, low expression of Bcl2 were observed in mice taken 40 µg/ml of CATH-1. This study drive intention in treatment of cancer through the efficacy of anticancer efficacy of chicken cathelicidin peptides.

47 Upregulation of the miR-515 cluster in the MCF7 breast cancer cell line by epigenetic therapy

Apmis ◽  
2008 ◽  
Vol 116 (5) ◽  
pp. 437-437
Author(s):  
C. Hother ◽  
C. Cortez ◽  
T. Miranda ◽  
C. Yoo ◽  
C. Workman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Cancer Cell Line ◽  
Epigenetic Therapy ◽  
Mcf7 Breast Cancer Cell

scholarly journals Alpha-6 integrin is necessary for the tumourigenicity of a stem cell-like subpopulation within the MCF7 breast cancer cell line

2007 ◽  
Vol 122 (2) ◽  
pp. 298-304 ◽  
Author(s):  
Massimiliano Cariati ◽  
Ali Naderi ◽  
John P. Brown ◽  
Matthew J. Smalley ◽  
Sarah E. Pinder ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Stem Cell ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Cancer Cell Line ◽  
Mcf7 Breast Cancer Cell

Role of β-Estradiol in MCF-7 Breast Cancer Cell Line Based on the Bioinformatics Analysis

2018 ◽  
Vol 84 (3) ◽  
pp. 268-276
Author(s):  
Rong  Wang ◽  
Jinbin  Li ◽  
Chunyu  Yin ◽  
Di  Zhao ◽  
Yulan  Zhao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Breast Cancer Cell Line ◽  
Bioinformatics Analysis ◽  
Cancer Cell Line ◽  
Mcf 7
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