scholarly journals Comparison of Two Rapid Tests for Detecting Group A Streptococcal Pharyngitis in the Pediatric Population at Wright-Patterson Air Force Base

2007 ◽  
Vol 172 (6) ◽  
pp. 644-646 ◽  
Author(s):  
Mygleetus Wright ◽  
Gita Williams ◽  
Lisa Ludeman
Keyword(s):  
Air Force ◽  
Pediatric Population ◽  
Streptococcal Pharyngitis ◽  
Group A ◽  
Rapid Tests ◽  
Air Force Base

New Colorimetric Test for Rapid Diagnosis of Streptococcal Pharyngitis: A Warning

PEDIATRICS ◽  
1990 ◽  
Vol 86 (3) ◽  
pp. 457-459
Author(s):  
Michael A. Gerber ◽  
Richard R. Facklam ◽  
Martin F. Randolph ◽  
Kathleen K. DeMeo
Keyword(s):  
Drug Administration ◽  
Diagnostic Tests ◽  
Streptococcal Pharyngitis ◽  
Rapid Diagnosis ◽  
Group A Streptococci ◽  
Pharmacologic Agent ◽  
The Past ◽  
Colorimetric Test ◽  
Group A ◽  
Rapid Tests

During the last few years there has been a dramatic proliferation of rapid tests for the diagnosis of group A β-hemolytic streptococcal pharyngitis.1 It is important for physicians to realize that the Food and Drug Administration does not approve these diagnostic tests as it would approve a pharmacologic agent, but simply permits a manufacturer to sell the test. Consequently, unacceptably inaccurate rapid tests for group A streptococci have been marketed in the past and could potentially appear again at anytime. In 1986, we studied a new enzyme fluorescence procedure (Strep-A-Fluor, Bio-Spec Inc, Dublin, CA) for the rapid diagnosis of group A β-hemolytic streptococcal pharyngitis.2

COMMENTS ON DR. KLEIN'S PAPER

PEDIATRICS ◽  
1973 ◽  
Vol 51 (2) ◽  
pp. 390-390
Keyword(s):  
Air Force ◽  
Streptococcal Infection ◽  
Staphylococcal Infection ◽  
Klein Group ◽  
Significant Difference ◽  
Group A ◽  
Air Force Base ◽  
Group B ◽  
Antibiotic Ointment ◽  
Boston Hospital

Dr. Ribble: In this study was the umbilicus included in bathing of the "diaper area"? Dr. Klein: Yes. Dr. Ribble: Have epidemics of streptococcal disease occured in nurseries in which hexachlorophene bathing was being carried out? Dr. Klein: Group B beta hemolytic streptococcal infections have been reported in nurseries where hexachlorophene bathing was being used. Dr. Schaberg: We have had cultural evidence of the presence of Group A streptococcal infection in infants on hexachlorophene bathing, and another Boston hospital had a nursery epidemic of Group A streptococcal infection in 1967 while using hexachlorophene bathing. Dr. Gezon: Mortimer also reported an epidemic occurring in a nursery where only the babies' faces were washed with hexachlorophene. Leadbetter's data from Lackland Air Force Base showed that he was unable to stop an epidemic of staphylococcal infection with intensive hexachlorophene bathing, including washing the umbilicus three times a day with hexachlorophene. He was also unable to get a significant difference in colonization rates when half the infants were washed with hexachlorophene and half were not. Dr. Gezon: Attention to the umbilicus is very important in controlling staphylococcal infection in the newborn. Jellard has shown this with triple dye, Gillespie with hexachlorophene powder, and Mortimer with antibiotic ointment applied to the umbilicus.

Rapid Group A Streptococcal Antigen Detection Kit: Effect on Antimicrobial Therapy for Acute Pharyngitis

PEDIATRICS ◽  
1988 ◽  
Vol 82 (4) ◽  
pp. 576-581
Author(s):  
Stephen C. Redd ◽  
Richard R. Facklam ◽  
Sheila Collin ◽  
Mitchell L. Cohen ◽  
Keyword(s):  
Antimicrobial Agents ◽  
Rapid Test ◽  
Streptococcal Pharyngitis ◽  
Prescribing Patterns ◽  
Indian Reservation ◽  
Acute Pharyngitis ◽  
Group A ◽  
Rapid Tests ◽  
Definition Of ◽  
Physician Prescribing

Newly introduced rapid diagnostic tests for group A streptococcal pharyngitis should facilitate appropriate antimicrobial use in patients with group A streptococcal pharyngitis. Because of high rates of acute pharyngitis in Tuba City, AZ, at the Navajo Indian reservation, the use of a rapid diagnostic test was prospectively evaluated. The sensitivity and specificity of the test was measured and changes in physician prescribing patterns attributable to use of the test were correlated. Of 320 patients with pharyngitis enrolled during the present 3-week study, 86 met the study's definition of a patient with streptococcal pharyngitis and 163 met the study's definition of a patient with nonstreptococcal pharyngitis. The rapid test was 62.8% sensitive and 96.9% specific in identifying patients from whom group A streptococci were isolated. Although treatment of patient with streptococcal pharyngitis at the time of the first visit increased from 36.5% in a retrospective sample to 72.5% during the study, treatment of patients in whom cultures were negative remained the same. Further analyses showed that physicians tended to treat patients with signs characteristic of streptococcal pharyngitis and, as the study prograssed, to rely less on negative rapid test results as a reason to withhold antimicrobial agents. It was concluded that rapid tests with good specificity but limited sensitivity may improve treatment of patients with streptococcal pharyngitis by allowing earlier specific therapy. A more sensitive test with a higher negative predictive value would be necessary to prevent treatment of persons with nonstreptococcal pharyngitis.

Cost-effectiveness of Treatment Options for Prevention of Rheumatic Heart Disease from Group A Streptococcal Pharyngitis in a Pediatric Population

2002 ◽  
Vol 35 (3) ◽  
pp. 250-257 ◽  
Author(s):  
Jacqueline E. Ehrlich ◽  
Byron P. Demopoulos ◽  
Kenneth R. Daniel ◽  
M.Christina Ricarte ◽  
Sherry Glied
Keyword(s):  
Heart Disease ◽  
Cost Effectiveness ◽  
Rheumatic Heart Disease ◽  
Pediatric Population ◽  
Treatment Options ◽  
Streptococcal Pharyngitis ◽  
Group A ◽  
Rheumatic Heart

Community-wide Outbreak of Group G Streptococcal Pharyngitis

PEDIATRICS ◽  
1991 ◽  
Vol 87 (5) ◽  
pp. 598-603
Author(s):  
Michael A. Gerber ◽  
Martin F. Randolph ◽  
Nancy J. Martin ◽  
Munir F. Rizkallah ◽  
P. Patrick Cleary ◽  
...  
Keyword(s):  
Antibiotic Therapy ◽  
Clinical Response ◽  
Pediatric Population ◽  
Streptococcal Pharyngitis ◽  
Clinical Findings ◽  
Isolation Rate ◽  
Acute Pharyngitis ◽  
Etiologic Role ◽  
Group A

Although several outbreaks of group G β-hemolytic streptococcal (GGBHS) pharyngitis have been described, doubt still remains regarding the etiologic role of GGBHS in acute pharyngitis beyond a limited number of situations. In the winter/spring of 1986/87, throat cultures were obtained from 222 consecutive children seen at a private pediatric office with acute pharyngitis and group A β-hemolytic streptococci (GABHS) were recovered from 91 children (41%) and GGBHS from 56 children (25%). One patient had both GABHS and GGBHS isolated. This isolation rate of GGBHS was dramatically greater than in previous and subsequent years, and 67% of the GGBHS isolates occurred during an 8-week period. Results of DNA fingerprinting of the 57 isolates of GGBHS demonstrated that 43 (75%) appeared to be the same strain. The patients with GGBHS were comparable to those with GABHS with respect to clinical findings, antistreptolysin-O titer response, and clinical response to antibiotic therapy. However, patients with GGBHS were significantly older (P < .05). This is the first well-documented, community-wide outbreak of GGBHS pharyngitis and the first respiratory outbreak of GGBHS pharyngitis in a pediatric population. GGBHS may be a more important cause of acute, treatable pharyngitis than had been previously recognized.

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