Diabetic neuropathic osteoarthropathy. A case report and discussion

1983 ◽  
Vol 73 (9) ◽  
pp. 485-489
Author(s):  
G McNamara ◽  
RI Shor
Keyword(s):  
Case Report ◽  
Diabetic Neuropathic Osteoarthropathy ◽  
Neuropathic Osteoarthropathy

Charcot's joint following Keller arthroplasty. A case report

1998 ◽  
Vol 88 (3) ◽  
pp. 140-143 ◽  
Author(s):  
MT Darst ◽  
TD Weaver ◽  
B Zangwill
Keyword(s):  
Diabetes Mellitus ◽  
Case Report ◽  
Peripheral Neuropathy ◽  
Diagnostic Tests ◽  
Foot Surgery ◽  
Radiographic Findings ◽  
Neuropathic Osteoarthropathy

Neuropathic osteoarthropathy, i.e., Charcot's joint, has not previously been reported as a sequela of elective foot surgery. The authors present a challenging case of a patient with long-standing diabetes mellitus and peripheral neuropathy who developed neuropathic osteoarthropathy after a Keller arthroplasty for a recalcitrant hallux ulcer. The radiographic findings, diagnostic tests, and histopathology are discussed. Finally, the authors offer suggestions for surgeons contemplating a Keller arthroplasty for patients with peripheral neuropathy.

Neuropathic osteoarthropathy in Meningomyelocele (MMC): A case-report

2005 ◽  
Vol 36 (02) ◽  
Author(s):  
M Walther ◽  
J Rössler ◽  
R Korinthenberg ◽  
V Mall
Keyword(s):  
Case Report ◽  
Neuropathic Osteoarthropathy

scholarly journals Diagnosing Osteomyelitis in Patients With Diabetic Neuropathic Osteoarthropathy

Diabetes Care ◽  
2001 ◽  
Vol 24 (12) ◽  
pp. 2154-2155 ◽  
Author(s):  
D. Devendra ◽  
K. Farmer ◽  
G. Bruce ◽  
P. Hughes ◽  
G. Vivian ◽  
...  
Keyword(s):  
Diabetic Neuropathic Osteoarthropathy ◽  
Neuropathic Osteoarthropathy

scholarly journals Pathological Characters and Molecular Pathogenesis of Diabetic Neuropathic Osteoarthropathy Cartilages Damage

2020 ◽  
Vol 5 (4) ◽  
pp. 2473011420S0025
Author(s):  
Zhao Hong-Mou
Keyword(s):  
Electron Microscopy ◽  
Flow Cytometry ◽  
Normal Control ◽  
Subchondral Bone ◽  
Normal Control Group ◽  
Molecular Pathogenesis ◽  
Control Group ◽  
Relative Expression ◽  
Diabetic Neuropathic Osteoarthropathy ◽  
Neuropathic Osteoarthropathy

Category: Basic Sciences/Biologics Introduction/Purpose: The aim of current study was to investigate the pathological characters and relative molecular pathogenesis of the cartilages damage in diabetic neuropathic osteoarthropathy (DNOAP) patients. Methods: The articular cartilages of ankle joint, subtalar joint and talonavicular joint of 8 patients with DNOAP from March 2017 to June 2018 were selected as DNOAP group. And the articular cartilage of matched joints from 8 amputation patients were selected as control group. Masson staining and safranine O/fixed green staining were used to observe the histopathological characteristics of cartilage, and the ultrastructural changes of chondrocytes were observed by electron microscopy. Chondrocyte culture was carried out in DNOAP group and control group. Western blot was used to detect the expression of RANKL, OPG, IL-1ß, IL-6, TNF-a, Aggrecan protein in chondrocyte. DCFH-DA probe was used to detect the level of reactive oxygen species in chondrocyte. Flow cytometry was used to detect the apoptotic rate of chondrocyte. Results: In DNOAP group, chondrocytes decreased, subchondral bone proliferated, structure disordered and osteoclasts formed in a large number in subchondral bone area. Under transmission electron microscopy, mitochondrial and endoplasmic reticulum swelling were observed in DNOAP chondrocytes. The chromatin was partially broken and concentrated at the edge of nuclear membrane. The ROS fluorescence intensity of chondrocyte in DNOAP group was higher than that in normal control group (28.1±2.3 VS 11.9±0.7, P<0.05). The relative expression of RANKL, TNF-a, IL-1ß and IL-6 protein in DNOAP group was higher than that in normal control group, while the relative expression of OPG and Aggrecan protein was lower than that in normal control group (both P < 0.05). Flow cytometry showed that the apoptotic rate of chondrocyte in DNOAP group was 3.3%±0.2%, which was higher than that in normal control group (1.2%±0.1%, P<0.05). Conclusion: Serious destruction of chondrocytes and organelles structure was the pathological characteristics of DNOAP. Inflammation plays a role in promoting the pathogenesis of DNOAP.

scholarly journals Pathogenesis and potential relative risk factors of diabetic neuropathic osteoarthropathy

2017 ◽  
Vol 12 (1) ◽  
Author(s):  
Hong-Mou Zhao ◽  
Jia-Yu Diao ◽  
Xiao-Jun Liang ◽  
Feng Zhang ◽  
Ding-Jun Hao
Keyword(s):  
Risk Factors ◽  
Relative Risk ◽  
Diabetic Neuropathic Osteoarthropathy ◽  
Neuropathic Osteoarthropathy
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