scholarly journals Coordinating a new approach to basic research into Parkinson’s disease

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Randy Schekman ◽  
Ekemini AU Riley
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Basic Research ◽  
Open Science ◽  
Research Community ◽  
International Network ◽  
New Approach ◽  
Science Practices ◽  
New Therapies

The Aligning Science Across Parkinson’s (ASAP) initiative is building an international network of researchers to improve our understanding of the biology underlying Parkinson's disease. Developing a better understanding of how the disease originates and progresses will, we hope, lead to new therapies. The ASAP initiative will incentivize collaboration between the existing PD research community and other researchers and will be committed to open-science practices.

Open Science, Closed Doors? Countering Marginalization through an Agenda for Ethical, Inclusive Research in Communication

2021 ◽  
Author(s):  
Jesse Fox ◽  
Katy E Pearce ◽  
Adrienne L Massanari ◽  
Julius Matthew Riles ◽  
Łukasz Szulc ◽  
...  
Keyword(s):  
Open Science ◽  
Research Community ◽  
Ethical Principles ◽  
Respect For Persons ◽  
Communication Research ◽  
Research Practices ◽  
Science Practices ◽  
Research Communication ◽  
The Future

Abstract The open science (OS) movement has advocated for increased transparency in certain aspects of research. Communication is taking its first steps toward OS as some journals have adopted OS guidelines codified by another discipline. We find this pursuit troubling as OS prioritizes openness while insufficiently addressing essential ethical principles: respect for persons, beneficence, and justice. Some recommended open science practices increase the potential for harm for marginalized participants, communities, and researchers. We elaborate how OS can serve a marginalizing force within academia and the research community, as it overlooks the needs of marginalized scholars and excludes some forms of scholarship. We challenge the current instantiation of OS and propose a divergent agenda for the future of Communication research centered on ethical, inclusive research practices.

scholarly journals Novel Immunotherapeutic Approaches to Target Alpha-Synuclein and Related Neuroinflammation in Parkinson’s Disease

Cells ◽  
2019 ◽  
Vol 8 (2) ◽  
pp. 105 ◽  
Author(s):  
Maria Zella ◽  
Judith Metzdorf ◽  
Friederike Ostendorf ◽  
Fabian Maass ◽  
Siegfried Muhlack ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Glial Cell ◽  
Dopaminergic Neurons ◽  
Basic Research ◽  
Alpha Synuclein ◽  
Models Of Disease ◽  
Novel Therapeutic Strategies ◽  
Lymphocyte Populations

The etiology of Parkinson’s disease (PD) is significantly influenced by disease-causing changes in the protein alpha-Synuclein (aSyn). It can trigger and promote intracellular stress and thereby impair the function of dopaminergic neurons. However, these damage mechanisms do not only extend to neuronal cells, but also affect most glial cell populations, such as astroglia and microglia, but also T lymphocytes, which can no longer maintain the homeostatic CNS milieu because they produce neuroinflammatory responses to aSyn pathology. Through precise neuropathological examination, molecular characterization of biomaterials, and the use of PET technology, it has been clearly demonstrated that neuroinflammation is involved in human PD. In this review, we provide an in-depth overview of the pathomechanisms that aSyn elicits in models of disease and focus on the affected glial cell and lymphocyte populations and their interaction with pathogenic aSyn species. The interplay between aSyn and glial cells is analyzed both in the basic research setting and in the context of human neuropathology. Ultimately, a strong rationale builds up to therapeutically reduce the burden of pathological aSyn in the CNS. The current antibody-based approaches to lower the amount of aSyn and thereby alleviate neuroinflammatory responses is finally discussed as novel therapeutic strategies for PD.

Intraoperative functional MRI as a new approach to monitor deep brain stimulation in Parkinson's disease

2004 ◽  
Vol 14 (4) ◽  
pp. 686-690 ◽  
Author(s):  
Bettina Sorger ◽  
Ralf Girnus ◽  
Oliver Schulte ◽  
Barbara Krug ◽  
Klaus Lackner ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Functional Mri ◽  
Brain Stimulation ◽  
New Approach ◽  
Deep Brain

scholarly journals Born-Open Data for E-Prime

2020 ◽  
Author(s):  
Denis Cousineau
Keyword(s):  
Open Access ◽  
Open Data ◽  
Open Science ◽  
Research Community ◽  
Data Repository ◽  
Data Frame ◽  
Science Practices ◽  
Data Practices ◽  
Data Files ◽  
Access Data

Born-Open Data experiments are encouraged for better open science practices. To be adopted, Born-Open data practices must be easy to implement. Herein, I introduce a package for E-Prime such that the data files are automatically saved on a GitHub repository. The BornOpenData package for E-Prime works seamlessly and performs the upload as soon as the experiment is finished so that there is no additional steps to perform beyond placing a package call within E-Prime. Because E-Prime files are not standard tab-separated files, I also provide an R function that retrieves the data directly from GitHub into a data frame ready to be analyzed. At this time, there are no standards as to what should constitute an adequate open-access data repository so I propose a few suggestions that any future Born-Open data system could follow for easier use by the research community.

Nasal administration of nanoencapsulated geraniol/ursodeoxycholic acid conjugate: Towards a new approach for the management of Parkinson's disease

2020 ◽  
Vol 321 ◽  
pp. 540-552 ◽  
Author(s):  
Edilson Ribeiro de Oliveira Junior ◽  
Eleonora Truzzi ◽  
Luca Ferraro ◽  
Marco Fogagnolo ◽  
Barbara Pavan ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Ursodeoxycholic Acid ◽  
Nasal Administration ◽  
New Approach ◽  
Acid Conjugate
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