scholarly journals Perception of the risk of adverse reactions to analgesics: differences between medical students and residents

PeerJ ◽  
2016 ◽  
Vol 4 ◽  
pp. e2255 ◽  
Author(s):  
Sandra Castillo-Guzman ◽  
Omar González-Santiago ◽  
Ismael A. Delgado-Leal ◽  
Gerardo E. Lozano-Luévano ◽  
Misael J. Reyes-Rodríguez ◽  
...  
Keyword(s):  
Risk Perception ◽  
Medical Students ◽  
Gastrointestinal Bleeding ◽  
Adverse Drug Reactions ◽  
Prescription Drugs ◽  
Adverse Reactions ◽  
Risk Scores ◽  
Drug Reactions ◽  
Perception Of Risk ◽  
Prescription Behavior

Background.Medications are not exempt from adverse drug reactions (ADR) and how the physician perceives the risk of prescription drugs could influence their availability to report ADR and their prescription behavior.Methods.We assess the perception of risk and the perception of ADR associated with COX2-Inbitors, paracetamol, NSAIDs, and morphine in medical students and residents of northeast of Mexico.Results.The analgesic with the highest risk perception in both group of students was morphine, while the drug with the least risk perceived was paracetamol. Addiction and gastrointestinal bleeding were the ADR with the highest score for morphine and NSAIDs respectively.Discussion.Our findings show that medical students give higher risk scores than residents toward risk due to analgesics. Continuing training and informing physicians about ADRs is necessary since the lack of training is known to induce inadequate use of drugs.

scholarly journals Perception of the risk of adverse reactions to analgesics: Differences between medical students and residents

2016 ◽  
Author(s):  
Sandra Castillo-Guzman ◽  
Omar González-Santiago ◽  
Ismael A Delgado-Leal ◽  
Gerardo E Lozano-Luévano ◽  
Misael J Reyes-Rodríguez ◽  
...  
Keyword(s):  
Adverse Effect ◽  
Medical Students ◽  
Adverse Effects ◽  
Prescription Drugs ◽  
Adverse Reactions ◽  
Risk Scores ◽  
Gi Bleeding ◽  
Drug Reactions ◽  
Main Adverse Effect ◽  
Prescription Behavior

Background. Medications are not exempt from adverse drug reactions (ADR) and how the physician perceives the risk of prescription drugs could influence their availability to report ADR and their prescription behavior. Methods. We assess the perception of risk and the occurrence of ADR associated with COX2-Inbitors, paracetamol, NSAIDs, and morphine in medical students and residents. Results. The analgesic with the highest risk perception was morphine, while the drug with the least risk perceived was paracetamol. Addiction was perceived as the most probable adverse effects developed by morphine. In the case of NSAIDs, the main adverse effect perceived was GI bleeding. Discussion. Our findings show that medical students give higher risk scores than residents toward risk due to analgesics. It is probable that both groups of students have morphinophobia, although more studies are necessary to confirm this. Continuing training and informing physicians about ADRs is necessary since the lack of training is known to induce inadequate use of drugs.

scholarly journals Perception of the risk of adverse reactions to analgesics: Differences between medical students and residents

2016 ◽  
Author(s):  
Sandra Castillo-Guzman ◽  
Omar González-Santiago ◽  
Ismael A Delgado-Leal ◽  
Gerardo E Lozano-Luévano ◽  
Misael J Reyes-Rodríguez ◽  
...  
Keyword(s):  
Adverse Effect ◽  
Medical Students ◽  
Adverse Effects ◽  
Prescription Drugs ◽  
Adverse Reactions ◽  
Risk Scores ◽  
Gi Bleeding ◽  
Drug Reactions ◽  
Main Adverse Effect ◽  
Prescription Behavior

Background. Medications are not exempt from adverse drug reactions (ADR) and how the physician perceives the risk of prescription drugs could influence their availability to report ADR and their prescription behavior. Methods. We assess the perception of risk and the occurrence of ADR associated with COX2-Inbitors, paracetamol, NSAIDs, and morphine in medical students and residents. Results. The analgesic with the highest risk perception was morphine, while the drug with the least risk perceived was paracetamol. Addiction was perceived as the most probable adverse effects developed by morphine. In the case of NSAIDs, the main adverse effect perceived was GI bleeding. Discussion. Our findings show that medical students give higher risk scores than residents toward risk due to analgesics. It is probable that both groups of students have morphinophobia, although more studies are necessary to confirm this. Continuing training and informing physicians about ADRs is necessary since the lack of training is known to induce inadequate use of drugs.

scholarly journals Perception of risk of adverse drug reactions by medical students: influence of a 1 year pharmacological course

2007 ◽  
Vol 64 (2) ◽  
pp. 233-236 ◽  
Author(s):  
G. Durrieu ◽  
C. Hurault ◽  
V. Bongard ◽  
C. Damase-Michel ◽  
J. L. Montastruc
Keyword(s):  
Medical Students ◽  
Adverse Drug Reactions ◽  
Drug Reactions ◽  
Perception Of Risk

scholarly journals Perception of risk of adverse drug reactions with non-opioid analgesics by medical students

2020 ◽  
Vol 66 (03) ◽  
pp. 87-88
Author(s):  
Zorica Stanojević-Ristić ◽  
Dragana Valjarević ◽  
Aleksandar Čorac ◽  
Mirjana Dejanović ◽  
Nenad Miloševič
Keyword(s):  
Medical Students ◽  
Adverse Drug Reactions ◽  
Opioid Analgesics ◽  
Drug Reactions ◽  
Perception Of Risk

scholarly journals Precision Medicine and Adverse Drug Reactions Related to Cardiovascular Drugs

Diseases ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 55
Author(s):  
James D. Noyes ◽  
Ify R. Mordi ◽  
Alexander S. Doney ◽  
Rahman Jamal ◽  
Chim C. Lang
Keyword(s):  
Cardiovascular Disease ◽  
Adverse Drug Reactions ◽  
Prescription Drugs ◽  
Drug Effects ◽  
Drug Efficacy ◽  
Risk Scores ◽  
Drug Reactions ◽  
Pharmacological Management ◽  
Patient Morbidity ◽  
Current Guidance

Cardiovascular disease remains the leading global cause of death. Early intervention, with lifestyle advice alongside appropriate medical therapies, is fundamental to reduce patient mortality among high-risk individuals. For those who live with the daily challenges of cardiovascular disease, pharmacological management aims to relieve symptoms and prevent disease progression. Despite best efforts, prescription drugs are not without their adverse effects, which can cause significant patient morbidity and consequential economic burden for healthcare systems. Patients with cardiovascular diseases are often among the most vulnerable to adverse drug reactions due to multiple co-morbidities and advanced age. Examining a patient’s genome to assess for variants that may alter drug efficacy and susceptibility to adverse reactions underpins pharmacogenomics. This strategy is increasingly being implemented in clinical cardiology to tailor patient therapies. The identification of specific variants associated with adverse drug effects aims to predict those at greatest risk of harm, allowing alternative therapies to be given. This review will explore current guidance available for pharmacogenomic-based prescribing as well as exploring the potential implementation of genetic risk scores to tailor treatment. The benefits of large databases and electronic health records will be discussed to help facilitate the integration of pharmacogenomics into primary care, the heartland of prescribing.

Perception of risk of adverse drug reactions: a 3-year follow-up of a cohort of medical students

2009 ◽  
Vol 24 (4) ◽  
pp. 423-427 ◽  
Author(s):  
Geneviève Durrieu ◽  
C. Hurault ◽  
C. Damase-Michel ◽  
J.L. Montastruc
Keyword(s):  
Medical Students ◽  
Adverse Drug Reactions ◽  
Drug Reactions ◽  
Perception Of Risk

Adverse Drug Reactions to Radiographic Contrast Media in a Teaching Hospital in North India: An Observational Study

2019 ◽  
Vol 14 (2) ◽  
pp. 122-126
Author(s):  
Deepti Chopra ◽  
Abhinav Jain ◽  
Richa Garg ◽  
Shreya Dhingra
Keyword(s):  
Observational Study ◽  
Contrast Media ◽  
Adverse Drug Reactions ◽  
Teaching Hospital ◽  
Adverse Reactions ◽  
North India ◽  
Drug Reactions ◽  
Iodinated Contrast ◽  
Radiographic Contrast ◽  
Radiographic Contrast Media

Background: Radiocontrast media are used extensively nowadays to visualize internal organs. Currently, non-ionic iodinated contrast media are used which are generally considered to be safe but some adverse reactions have been reported. Thus, the present study was carried out to analyze the nature and incidence of adverse drug reactions (ADRs) to radiographic contrast media in a teaching hospital. Methods:An observational study carried out for a period of six months in a teaching hospital. Contrast media induced adverse reactions were analyzed in terms of affected organs, rate, causality assessment, severity and preventability. The treatment and outcomes of adverse events were also recorded. Naranjo Probability Scale was used to evaluate the relationship between the contrast agent used and the suspected ADR. The severity of the suspected ADRs was determined using Hartwig Scale and preventability was assessed using modified Schumock and Thornton criterion. Results:A total of 15 suspected ADRs occurred in 11 patients with an incidence of 1.4%. It included 5 (45.4%) males and 6 (54.5%) females (p < 05). The highest percentage (72.7 %) of ADRs was seen in adult patients, the mean age being 40.8 years. Vomiting (33.3%) was the most common ADR noted followed by severe nausea and rashes. 64.7 % of ADRs were categorized as probable and 35.3 % were possible. Adverse reactions required treatment in 46.6% patients. There was no fatality reported. Conclusion:The reactions observed were mild to moderate in severity and occurred within 30 minutes of the administration of the contrast.

scholarly journals The Wonderful DMARD with Multiple Toxicities

2021 ◽  
Vol 5 (7) ◽  
pp. RV5-RV10
Author(s):  
Yashika Kaushal ◽  
Ratibha Kausal ◽  
Isha Sharma
Keyword(s):  
Immune System ◽  
Adverse Drug Reactions ◽  
Adverse Reactions ◽  
Close Monitoring ◽  
Drug Reactions ◽  
Therapy Discontinuation ◽  
Chemotherapy Agent ◽  
Reduce Activity ◽  
Potential Risk Factors ◽  
Rheumatic Drug

Methotrexate is a type of disease-modifying anti-rheumatic drug (DMARD). It is used to reduce activity of the immune system for people who have certain conditions. Methotrexate is a chemotherapy agent and immune system suppressant. Its use may be limited by concerns regarding its adverse reactions. The occurrence of adverse drug reactions in some cases leads to the therapy discontinuation. Although adverse drug reactions (ADR) of methotrexate generally do not pose a serious threat to the health of patients and a reduction in the dose of methotrexate leads to their elimination, in some cases severe toxicities of the drug occur unpredictably. These facts explain the need for close monitoring of the patient’s condition and the identification of potential risk factors for drug toxicity on the part of different organs and functional systems. The purpose of this review is to detail about safety and tolerability of methotrexate.

scholarly journals Major Aspects of Detection and Monitoring of Adverse Reactions Associated with Cephalosporin Antibiotic Treatment

2021 ◽  
Vol 9 (1) ◽  
pp. 34-42
Author(s):  
E. Yu. Demchenkova ◽  
G. I. Gorodetskaya ◽  
I. A. Mazerkina ◽  
M. V. Zhuravleva ◽  
A. S. Kazakov ◽  
...  
Keyword(s):  
Adverse Events ◽  
Adverse Drug Reactions ◽  
Patient Information ◽  
Adverse Reactions ◽  
Stevens Johnson Syndrome ◽  
Drug Reactions ◽  
Patient Information Leaflets ◽  
Information Leaflets ◽  
Spontaneous Reports ◽  
Cephalosporin Antibiotics

Widespread use of cephalosporin antibiotics in clinical practice calls for greater attention to the risk of adverse drug reactions. Information on serious or unexpected adverse events reported during post-marketing experience is submitted to national and international pharmacovigilance databases. Analysis of these reports helps to identify new adverse drug reactions.The aim of the study was to analyse the safety profile of cephalosporin antibiotics based on spontaneous reports in the international VigiBase database.Materials and methods: the analysis of the adverse reaction profile of cephalosporin antibiotics was based on MedDRA system organ classes and included spontaneous reports submitted to VigiBase from the moment of its creation until August 2020.Results: the authors identified the most clinically significant adverse reactions for different cephalosporin generations. They compared and analysed information on adverse events in VigiBase and in patient information leaflets of medicinal products authorised in the Russian Federation. It was demonstrated that some serious events described in VigiBase spontaneous reports for V-generation cephalosporins are not included in the “Side effects” section of the patient information leaflets. According to VigiBase, the use of ceftaroline was associated with the development of generalised exfoliative dermatitis, Stevens–Johnson syndrome, tubulointerstitial nephritis, while the use of ceftolozane was associated with acute kidney injury, renal insufficiency, sepsis, pneumonia, and respiratory insufficiency.Conclusion: reporting of unexpected and serious adverse drug reactions to cephalosporin antibiotics is an important task of healthcare practitioners. Availability of information on class-specific and generation-specific serious adverse reactions will help predict and prevent their development.

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