scholarly journals A Review on the Role of Ethylenediaminetetraacetic Acid (EDTA) in the Treatment and Understanding of Psoriasis

Cureus ◽  
2021 ◽  
Author(s):  
Amreen Sunil ◽  
Gurneet Shaheed ◽  
Akshay J Reddy ◽  
Neel Nawathey ◽  
Hetal Brahmbhatt
Molecules ◽  
2020 ◽  
Vol 25 (11) ◽  
pp. 2633 ◽  
Author(s):  
Atef M.K. Nassar ◽  
Yehia M.M. Salim ◽  
Khalid S.A. Eid ◽  
Hazem M. Shaheen ◽  
Abdullah A. Saati ◽  
...  

Sumithion (Fenitrothion) (SUM) is an organophosphorus insecticide used to combat a wide variety of plant pests. Exposure to SUM causes significant toxicity to the brain, liver, kidney, and reproductive organs through, for example, binding to DNA, and it induces DNA damage, which ends with oxidative stress. Therefore, the present study aimed to examine the protective role of bee products: a mixture of honey, propolis, palm pollen, and royal jelly (HPPJ) against SUM-induced toxicity. Twenty-four male albino rats (Rattus norvegicus) were classified into four groups, each containing six rats: control (corn oil), SUM (85 mg/kg; 1/20 LD50), HPPJ, and SUM + HPPJ once daily for 28 consecutive days. Blood samples were gently collected in sterilized ethylenediaminetetraacetic acid (EDTA) tubes for blood picture analyses and tubes without anticoagulant for serum isolation. Serum was used for assays of enzymatic and biochemical characteristics. The results revealed that SUM increased the weights of the liver, kidney, and brain as well as the enzymatic activity of glutathione peroxidase (GP), serum superoxide dismutase (SOD), and glutathione-S-transferase (GST). Additionally, SUM significantly increased the activity of lactate dehydrogenase (LDH), alkaline phosphatase (ALP), and γ-glutamyltransferase (γ-GT) and glucose, uric acid, and creatinine contents, while decreasing the acetylcholine esterase (AChE) activity and total lipids and total protein content. Furthermore, because of the inclusion of phenolic, flavonoids, terpenoids, and sugars, the HPPJ mixture counteracted the hematological, renal, and hepatic toxicity of SUM exposure.


2007 ◽  
Vol 26 (5) ◽  
pp. 1033 ◽  
Author(s):  
Guadalupe de la Rosa ◽  
Jose R. Peralta-Videa ◽  
Gustavo Cruz-Jimenez ◽  
M. Duarte-Gardea ◽  
Alejandro Martinez-Martinez ◽  
...  

1982 ◽  
Vol 98 (1) ◽  
pp. 203-207 ◽  
Author(s):  
S. P. Singh

SUMMARYThe modified EDTA (ethylenediaminetetraacetic acid) method of determining the ionic activities in soils developed by Norvell was used to measure Zn2+, Cu2+ and Mn2+ activities including the competition of Ca and Mg for the chelating ligand EDTA. In the Zn-EDTA system, the equilibrium mole fraction of CaL2− + MgL2− increased with an increase in pH of the soil solution, thereby leading to a decrease in the concentration of transition metal ions. In view of the pH dependence of the metal ion activities, the values of the expression pM + 2 pOH (where M may be Zn, Cu or Mn) were used to discuss the possible role of various oxides, hydroxides, carbonates, sulphides and unknown solid phases in regulating the activities of Zn2+, Cu2+ and Mn2+ ions in alkaline and calcareous soils.


2019 ◽  
Vol 25 (3) ◽  
pp. 817-821 ◽  
Author(s):  
Astari Dwiranti ◽  
Hideaki Takata ◽  
Kiichi Fukui

AbstractThe structural details of chromosomes have been of interest to researchers for many years, but how the metaphase chromosome is constructed remains unsolved. Divalent cations have been suggested to be required for the organization of chromosomes. However, detailed information about the role of these cations in chromosome organization is still limited. In the current study, we investigated the effects of Ca2+ and Mg2+ depletion and the reversibility upon re-addition of one of the two ions. Human chromosomes were treated with different concentrations of Ca2+and Mg2+. Depletion of Ca2+ and both Ca2+ and Mg2+ were carried out using 1, 2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid and ethylenediaminetetraacetic acid (EDTA), respectively. Chromosome structure was examined by fluorescence microscopy and scanning electron microscopy. The results indicated that chromosome structures after treatment with a buffer without Mg2+, after Ca2+ depletion, as well as after depletion of both Mg2+, and Ca2+, yielded fewer compact structures with fibrous chromatin than those without cation depletion. Interestingly, the chromatin of EDTA-treated chromosomes reversed to their original granular diameters after re-addition of either Mg2+ or Ca2+ only. These findings signify the importance of divalent cations on the chromosome structure and suggest the interchangeable role of Ca2+ and Mg2+.


Pathogens ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1482
Author(s):  
Christian Keller ◽  
Raphael Rakotozandrindrainy ◽  
Vera von Kalckreuth ◽  
Jean Noël Heriniaina ◽  
Norbert Georg Schwarz ◽  
...  

Rickettsiae may cause febrile infections in humans in tropical and subtropical regions. From Madagascar, no molecular data on the role of rickettsioses in febrile patients are available. Blood samples from patients presenting with fever in the area of the capital Antananarivo were screened for the presence of rickettsial DNA. EDTA (ethylenediaminetetraacetic acid) blood from 1020 patients presenting with pyrexia > 38.5 °C was analyzed by gltA-specific qPCR. Positive samples were confirmed by ompB-specific qPCR. From confirmed samples, the gltA amplicons were sequenced and subjected to phylogenetic analysis. From five gltA-reactive samples, two were confirmed by ompB-specific qPCR. The gltA sequence in the sample taken from a 38-year-old female showed 100% homology with R. typhi. The other sample taken from a 1.5-year-old infant was 100% homologous to R. felis. Tick-borne rickettsiae were not identified. The overall rate of febrile patients with molecular evidence for a rickettsial infection from the Madagascan study site was 0.2% (2/1020 patients). Flea-borne rickettsiosis is a rare but neglected cause of infection in Madagascar. Accurate diagnosis may prompt adequate antimicrobial treatment.


1964 ◽  
Vol 22 (1) ◽  
pp. 173-188 ◽  
Author(s):  
Albert W. Sedar ◽  
John G. Forte

In order to ascertain the role of calcium in maintaining the structure of the junctional complex between oxyntic cells, control gastric mucosae of the frog Rana pipiens were compared with those exposed to 1 to 4 mM ethylenediaminetetraacetic acid (EDTA). Changes in transmucosal potential difference and mucosal conductance were monitored. In one case a piece of EDTA-treated mucosa was washed and placed in a Ca++-containing solution. Material from all three categories was prepared for electron microscopy (glutaraldehyde and OsO4 fixation with Epon 812 embedding). Electron micrographs showed that after Ca++ depletion the intercellular electron-opaque material of the desmosome disappears and the walls of this component separate. Similar changes were observed in the zonula adhaerens. Consistent changes were difficult to detect in the zonula occludens although in some instances disorganization or separation within the tight junction was seen. These effects on the components of the junctional complex were reversible on readministration of Ca++. The results indicate that Ca++ is important in maintaining the integrity of the junctional complex. A model correlating the fine structural changes with physiological data is presented.


2019 ◽  
Vol 217 ◽  
pp. 105330 ◽  
Author(s):  
Daniel R McDougall ◽  
Andrew Chan ◽  
Duncan J McGillivray ◽  
Martin D de Jonge ◽  
Gordon M Miskelly ◽  
...  

1992 ◽  
Vol 294 ◽  
Author(s):  
Larry E. Hersman ◽  
Philip D. Palmer ◽  
David E. Hobart

ABSTRACTIron exists in aerobic soil and water environments most commonly as insoluble Fe(III). Siderophores are powerful, microbially produced chelating agents that are used to mobilize the insoluble Fe(III) cation. Over 80 siderophores have been isolated and characterized, with some reportedly having iron-binding constants as high as 1052. Fe(III) and Pu(IV) are similar in their charge/ionic radius ratio (4.6 and 4.2, respectively); therefore, Pu(IV) may serve as analog to Fe(III). It is possible that some radioactive wastes could be chelated by naturally occurring siderophores, thereby altering the transport rates of those elements through the subsurface environment. This investigation wn 9 initiated to investigate that possibility. The binding of 239Pu(IV) by four chelating agents is reported in this paper: a siderophore isolated and purified from a Pseudomonas sp.; desferal, a ferrioxamine siderophore commonly used for deferration therapy; EDTA, ethylenediaminetetraacetic acid; and, citrate, trisodium salt.


2021 ◽  
Vol 22 (6) ◽  
pp. 3273
Author(s):  
Mary Grace Sedanza ◽  
Hee-Jin Kim ◽  
Xerxes Seposo ◽  
Asami Yoshida ◽  
Kenichi Yamaguchi ◽  
...  

This study evaluated the larval settlement inducing effect of sugars and a conspecific cue from adult shell extract of Crassostrea gigas. To understand how the presence of different chemical cues regulate settlement behavior, oyster larvae were exposed to 12 types of sugars, shell extract-coated and non-coated surfaces, and under varied sugar exposure times. Lectin-glycan interaction effects on settlement and its localization on oyster larval tissues were investigated. The results showed that the conspecific cue elicited a positive concentration dependent settlement inducing trend. Sugars in the absence of a conspecific cue, C. gigas adult shell extract, did not promote settlement. Whereas, in the presence of the cue, showed varied effects, most of which were found inhibitory at different concentrations. Sugar treated larvae exposed for 2 h showed significant settlement inhibition in the presence of a conspecific cue. Neu5Ac, as well as GlcNAc sugars, showed a similar interaction trend with wheat germ agglutinin (WGA) lectin. WGA-FITC conjugate showed positive binding on the foot, velum, and mantle when exposed to GlcNAc sugars. This study suggests that a WGA lectin-like receptor and its endogenous ligand are both found in the larval chemoreceptors and the shell Ethylenediaminetetraacetic acid (EDTA) extract that may complementarily work together to allow the oyster larva greater selectivity during site selection.


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