scholarly journals Rare Case of Intestinal-Type Adenocarcinoma Arising in Cervical Oesophageal Heterotopic Gastric Mucosa

2021 ◽  
Author(s):  
Anuradha Sekaran ◽  
Veena Pawar Vanere ◽  
Sundeep Lakhtakia ◽  
Mohan Ramchandani ◽  
Duvuru Nageshwar Reddy
Keyword(s):  
Gastric Mucosa ◽  
Periodic Acid ◽  
Heterotopic Gastric Mucosa ◽  
Intestinal Type ◽  
Upper Gastrointestinal Endoscopy ◽  
Periodic Acid Schiff ◽  
Cervical Oesophagus ◽  
Gastric Heterotopia ◽  
Inlet Patch ◽  
Intestinal Type Adenocarcinoma

Heterotopic Gastric Mucosa (HGM) also termed gastric inlet patch or inlet patch, is a rare and benign phenomenon in cervical oesophagus and can be missed during endoscopy. It has an average incidence of 2.5%. Adenocarcinoma arising in the background of gastric heterotopia is very rare and uncommon in the upper oesophagus. A 46-year-old male presented with hoarseness and progressive dysphagia for solids for the past one month. Upper Gastrointestinal Endoscopy (UGIE) revealed a tight stricture at 19-20 cm from the incisors. Initial mucosal biopsies were not conclusive. With high clinical suspicion of malignancy, patient underwent bougie dilation of oesophageal stricture followed by repeat biopsy. Histology revealed an intestinal type of adenocarcinoma, arising in a background of gastric heterotopia of the cervical oesophagus. Alcian Blue/Periodic Acid Schiff (AB/PAS) staining was positive in both the heterotopic glands and in the cancer, indicating the presence of intestinal metaplasia. Tumour cells were immunopositive for cytokeratin-7. A Positron Emission Tomography – Computed Tomography scan revealed a metabolically active lesion located in the upper third of the oesophagus along with uptake in right supraclavicular node. This case report describes a patient with primary intestinal type adenocarcinoma of the cervical oesophagus in the background of HGM not related to Barrett’s oesophagus.

Prevalence and Clinical and Endoscopic Characteristics of Cervical Inlet Patch (Heterotopic Gastric Mucosa)

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Yue Yin ◽  
Hongyu Li ◽  
Ji Feng ◽  
Kexin Zheng ◽  
Eric Yoshida ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Heterotopic Gastric Mucosa ◽  
Inlet Patch ◽  
Endoscopic Characteristics

A novel method for the visualization of the in situ mucus layer in rat and man

1998 ◽  
Vol 95 (1) ◽  
pp. 97-106 ◽  
Author(s):  
NICOLA JORDAN ◽  
JULIA NEWTON ◽  
JEFFREY PEARSON ◽  
ADRIAN ALLEN
Keyword(s):  
Gastric Mucosa ◽  
Alcian Blue ◽  
Periodic Acid ◽  
Blue Staining ◽  
Mucus Layer ◽  
Gastric Mucus ◽  
Periodic Acid Schiff ◽  
Novel Method ◽  
The Mean ◽  
Thickness Measurements

1.The observed thickness of the gastric mucus barrier varies widely, even appearing discontinuous, depending on the methods used. Here we describe the development and application of a modified periodic acid Schiff/Alcian Blue staining technique for use on cryostat sections of gastric mucosa. This technique for the first time enables the preservation and visualization of the full thickness of the adherent gastric mucus layer and the underlying mucosa. 2.In designing this novel method we have selected those procedures which would result in the least alteration to the mucus layer. The methods used were snap freezing, cryostat sectioning of the whole stomach followed by brief ethanol pretreatment (10 min in 100% ethanol), a prolonged staining with periodic acid Schiff/Alcian Blue (15 min and 2.5 h respectively), a gentle post-fixation (45 min paraformaldehyde vapour at 37 °C) and the use of a water-soluble mountant. 3.A continuous, adherent mucus layer was observed over the surface of the rat gastric mucosa (periodic acid Schiff/Alcian Blue stained) and human gastric antral biopsies (periodic acid Schiff stained). In the rat the mean (S.D.) mucus thickness measurements along the antrum to oesophageal axis (which was divided histologically into four regions, A to D) were: A, 166 (47) μm; B, 179 (48) μm; C, 184 (50) μm; D (the non-glandular stratified epithelium at the top of the stomach), Absent. In human gastric antral biopsies the mean (S.D.) mucus thickness was 144 (52) μm. 4.This new technique has enabled the visualization and precise measurement of thickness of the gastric mucus layer in rat and man. The adherent gastric mucus layer was observed to be continuous in the rat glandular stomach and human antrum. In validation experiments in rat the mean mucus thickness measurements were found to be twice those measured by conventional histological techniques, in which the mucus layer appeared discontinuous and patchy. However, they were within the range of thickness values seen in unfixed tissues and in the rat in vivo preparation.

scholarly journals Heterotopic Gastric Mucosa in Gastric Propria Muscularis Treated by Endoscopic Submucosal Dissection: A Case Report and Literature Review.

2021 ◽  
Author(s):  
Yuting Jia ◽  
Erfeng Li ◽  
Zhen Zhang ◽  
Bin Guo ◽  
Xing Chen
Keyword(s):  
Gastric Mucosa ◽  
Endoscopic Submucosal Dissection ◽  
Submucosal Tumor ◽  
Anatomical Variation ◽  
Abdominal Distension ◽  
Normal Mucosa ◽  
Heterotopic Gastric Mucosa ◽  
Upper Gastrointestinal Endoscopy ◽  
Submucosal Dissection ◽  
Mucosal Glands

Abstract Background: Heterotopic gastric mucosa（HGM）is a congenital anatomical variation. It can occur in various tissues and organs of the gastrointestinal tract. Part of the HGM appeared as a solitary, sessile submucosal lesions covered with normal mucosa, and because it was relatively rare, thereby resulting in some HGM to be easily missed or misdiagnosed. We report on a case of heterotopic gastric mucosa in gastric propria muscularis.Case presentation: A 32-year-old man with abdominal distension for one month. Upper gastrointestinal endoscopy revealed hemispherical lesion covered with smooth mucosa located in gastric antrum. Endoscopic ultrasound (EUS) revealed that it might be derived from the submucosa, with no echogenic nodules, and a partition is visible inside. Endoscopic submucosal dissection (ESD) was performed and histological examination revealed scattered heterotopic mucosal glands (HGG) located in the propria muscularis. Regular follow-up, the patient's abdominal distension was significantly relieved.Conclusion: HGM of the type of submucosal tumor-like lesion is rare. EUS is a well-established method for submucosal lesion. On EUS, these lesions showed cystic anechoic central core in the submucosa with no solid component,which is similar to gastric cyst. Therefore, this requires us to be alert to the possibility of HGM in order to further evaluate and treat, and if necessary, it can be removed by ESD.

Heterotopic Gastric Mucosa in The Upper Esophagus (“Inlet Patch”): A Rare Cause of Esophageal Perforation

1999 ◽  
Vol 94 (10) ◽  
pp. 3047-3050 ◽  
Author(s):  
Andrés Sánchez-Pernaute ◽  
Florentino Hernando ◽  
Luis Díez-Valladares ◽  
Oscar González ◽  
Elia Pérez Aguirre ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Esophageal Perforation ◽  
Heterotopic Gastric Mucosa ◽  
Inlet Patch

Advanced Gastric Carcinoma With a Complete Intestinal Metaplasia Phenotype Associated With Early Intestinal-Type Carcinoma

2004 ◽  
Vol 128 (2) ◽  
pp. 218-221
Author(s):  
Francisco Rivera-Hueto ◽  
Encarnación Lag-Asturiano ◽  
JoséC. Utrilla-Alcolea ◽  
Juan M. Herrerías-Gutiérrez
Keyword(s):  
Intestinal Metaplasia ◽  
Alcian Blue ◽  
Periodic Acid ◽  
Intestinal Type ◽  
Gastric Disease ◽  
Low Grade ◽  
Phenotypic Properties ◽  
Periodic Acid Schiff ◽  
High Iron ◽  
Advanced Gastric Carcinoma

Abstract An unusual case of synchronous gastric carcinomas occurred in a 28-year-old man with a family history of gastric disease. Two tumor foci were identified: a well-differentiated advanced carcinoma with the phenotypic properties of complete intestinal metaplasia and an early intestinal-type carcinoma. Histochemical and immunohistochemical stains to demonstrate complete intestinal metaplasia, ie, Alcian blue pH 2.5/periodic acid–Schiff, high iron diamine/Alcian blue pH 2.5, CD10, and MUC2, were all positive in the advanced adenocarcinoma. Of all markers used, only high iron diamine/Alcian blue pH 2.5 and Alcian blue pH 0.5 were positive in the early carcinoma. In these cases, mistakes frequently are made during examination of endoscopic biopsies. Fortunately, the advanced adenocarcinoma was low grade (the patient has shown no signs of disease at 6 years postsurgery). Histopathologic, histochemical, and immunohistochemical findings suggest that an extensive substrate of complete intestinal metaplasia (corpus) and of complete and incomplete intestinal metaplasia (antrum) can be associated with two independent tumors with different phenotypes.

scholarly journals Gastritis and Hypergastrinemia Due to Acinetobacter lwoffii in Mice

2002 ◽  
Vol 70 (5) ◽  
pp. 2630-2639 ◽  
Author(s):  
Y. Zavros ◽  
G. Rieder ◽  
Amy Ferguson ◽  
J. L. Merchant
Keyword(s):  
Gastric Mucosa ◽  
Periodic Acid ◽  
Mucous Gland ◽  
Periodic Acid Schiff ◽  
G Cells ◽  
Blue Stain ◽  
D Cells ◽  
H Pylori ◽  
Histologic Changes ◽  
Entire Stomach

ABSTRACT In mouse models and humans, Helicobacter pylori is associated with an increase in serum gastrin and gastrin-expressing (G) cells with a concomitant decrease in somatostatin-expressing D cells. Inflammation of the gastric mucosa can progress to metaplastic changes in the stomach and to decreased colonization by H. pylori and increased colonization by non-H. pylori organisms. In addition, about 20% of individuals with chronic gastritis are H. pylori negative, suggesting that other organisms may induce gastritis. Consistent with this hypothesis, we report here that Acinetobacter lwoffii causes the same histologic changes as does H. pylori. Gastric epithelial cells were isolated from the entire stomach by an enzymatic method for quantitation by both flow cytometry and morphometric analysis. Two months after mice were inoculated with H. pylori or A. lwoffii, the mucosal T- and B-cell numbers significantly increased. After 4 months of infection, there was a threefold increase in the number of G cells and a doubling in the number of parietal cells. A threefold decrease in the number of D cells occurred in H. pylori- and A. lwoffii-infected mice. Plasma gastrin levels increased after both H. pylori and A. lwoffii infection. Histology revealed the presence of inflammation in the gastric mucosa with both A. lwoffii and H. pylori infection. A periodic acid-Schiff stain-alcian blue stain revealed mucous gland metaplasia of the corpus. Collectively, the results demonstrate that gastritis and hypergastrinemia are not specific for H. pylori but can be induced by other gram-negative bacteria capable of infecting the mouse stomach.

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