scholarly journals Kikuchi Fujimoto Disease: A Case Report with Literature Review

2021 ◽  
pp. 114-117
Author(s):  
Eshwar Rajesh ◽  
Tamilvanan Swaminathan
Keyword(s):  
Lupus Erythematosus ◽  
Cervical Lymph Node ◽  
Cervical Lymphadenopathy ◽  
Excisional Biopsy ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Systemic Lupus ◽  
Inappropriate Treatment ◽  
Necrotizing Lymphadenitis ◽  
Mild Fever ◽  
Shed Light

Kikuchi-Fujimoto disease (KFD), also referred to as histiocytic necrotizing lymphadenitis, is an uncommon entity, usually benign, self-limiting disease characterised by fever and regional lymphadenopathy of unexplained aetiology. There is an increase in reported cases of KFD, particularly in Asia. It is important to recognize this condition because it may be confused for systemic lupus erythematosus (SLE), tuberculosis or lymphoma. The knowledge of this condition among clinicians and pathologists can help to avoid misdiagnosis and inappropriate treatment. It must be considered among the differential diagnoses of cervical lymphadenopathy. Here, we present a case of 20-year-old male who came to the hospital with complaints of mild fever, chills, fatigue and cervical lymphadenopathy. After radiological investigations an excisional biopsy of the cervical lymph node was done and the diagnosis of KFD was confirmed. Due to the paucity of cases in literature, reporting this case may help shed light on this rare disease.

scholarly journals Is recurrent Kikuchi-Fujimoto disease a precursor to systemic lupus erythematosus?

2019 ◽  
Vol 57 (1) ◽  
pp. 72-77
Author(s):  
Taro Horino ◽  
Osamu Ichii ◽  
Yoshio Terada
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Cervical Lymphadenopathy ◽  
Clinical Entity ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Systemic Lupus ◽  
Necrotizing Lymphadenitis

Abstract Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a rare, benign, self-limiting disease characterized by cervical lymphadenopathy and fever. Since KFD was first reported in 1972, the validity of this clinical entity has been controversial and its aetiology remains unknown. Herein, we report a case of a patient with KFD, which was believed to be associated with systemic lupus erythematosus.

Histiocytic necrotizing lymphadenitis in a sibling of a patient with systemic lupus erythematosus

Lupus ◽  
1993 ◽  
Vol 2 (3) ◽  
pp. 207-208 ◽  
Author(s):  
M. Satoh ◽  
Minoru Satoh ◽  
Hidetomo Nakamoto ◽  
Kenji Okubo ◽  
Ajay K. Ajmani
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Systemic Lupus ◽  
Necrotizing Lymphadenitis

scholarly journals A young woman presenting a kikuchi-fujimoto’s disease associated with induced lupus

2018 ◽  
Author(s):  
Galith Kalmi
Keyword(s):  
Lupus Erythematosus ◽  
Cervical Lymphadenopathy ◽  
Lymph Node Biopsy ◽  
Screening Tests ◽  
Unknown Etiology ◽  
Caucasian Woman ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Drug Induced ◽  
First Case ◽  
Necrotizing Lymphadenitis

Introduction: Kikuchi-Fujimoto’s disease (KFD) or histiocytic necrotizing lymphadenitis is a benign and self-limited disease of unknown etiology mainly affecting young women. Although the association with systemic lupus erythematosus (SLE) is well described, no case of drug-induced lupus erythematosus (DILE) associated KFD has not been reported so far. Case report: We herein report a 25-year old Caucasian woman, with no medical history and no medication except for oral estrogen-progestin contraception (levonorgestrel-ethinylestradiol), who presented with cervical lymphadenopathy, fever and arthralgia without weight loss, night sweats or skin involvement. An exhaustive infectious disease screening was negative and lymph node biopsy revealed histiocytic necrotizing lymphadenitis suggesting KFD. Autoimmune screening tests evidenced high titers of anti-histone antibodies suggesting DILE induced by estrogen-progestin medication. The patient received a short course of non-steroidal anti-inflammatory treatment for painful lymphadenitis and arthralgia. Oral levonorgestrel-ethinylestradiol contraceptive medication was stopped and KFD and DILE completely recovered with a long-term disappearance of anti-histone antibodies. Conclusion: We report the first case of KFD associated-DILE following oral levonorgestrel-ethinylestradiol medication. Even though levonorgestrel-ethinylestradiol induced lupus is well known, the association with KFD has never been reported and the physiopathology remained unknown. Keywords: Kikuchi-Fujimoto disease, Lupus, Levonorgestrel-ethinylestradiol

scholarly journals Kikuchi-Fujimoto disease

1970 ◽  
Vol 2 (3) ◽  
pp. 226-230
Author(s):  
RC Adhikari
Keyword(s):  
Lymph Nodes ◽  
Lupus Erythematosus ◽  
Spontaneous Recovery ◽  
Needle Aspiration ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Metastatic Adenocarcinoma ◽  
Systemic Lupus ◽  
Laboratory Findings ◽  
Fine Needle ◽  
Necrotizing Lymphadenitis

Kikuchi-Fujimoto disease or histiocytic necrotizing lymphadenitis is a benign, self limited condition with higher prevalence among Japanese and other Asiatic people. Though the cause of this disease remains unclear, viral cause has been suggested. It is clinically characterized by lymphadenopathy, fever, cutaneous erythema, diarrhea, vomiting, sore throat, arthralgia, myalgia and hepatosplenomegaly. Laboratory findings are non-specific and Kikuchi-Fujimoto disease is generally diagnosed based on characteristic histopathological findings. Affected lymph nodes demonstrate paracortical areas of apoptotic necrosis with abundant karyorrhectic debris, proliferation of histiocytes, plasmacytoid monocytes, small and transformed lymphocytes in the absence of neutrophils. Kikuchi-Fujimoto disease is thought to have three evolving phases: proliferative, necrotizing and xanthomatous. Fine needle aspiration smears from involved lymph nodes reveal characteristic intra- and extracellular apoptotic nuclear debris with admixed crescentic macrophages on a reactive lymphoid background. Differential diagnoses of this disease are lymphoma, systemic lupus erythematosus, toxoplasmosis, tuberculosis, myeloid tumor and even metastatic adenocarcinoma. Treatment is symptomatic and spontaneous recovery occurs in 1 to 4 months. DOI: http://dx.doi.org/10.3126/jpn.v2i3.6028 JPN 2012; 2(3): 226-230

scholarly journals Kikuchi histiocytic necrotizing lymphadenitis: clinicopathological and immunohistochemical study

2001 ◽  
Vol 7 (1-2) ◽  
pp. 153-162
Author(s):  
T. A. Helal ◽  
W. Talaat ◽  
M. F. Danial
Keyword(s):  
Lupus Erythematosus ◽  
Plasma Cells ◽  
Immunohistochemical Study ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Systemic Lupus ◽  
Cellular Infiltrate ◽  
Neutrophilic Infiltration ◽  
Abnormal Mitosis ◽  
Necrotizing Lymphadenitis ◽  
Sinusoidal Pattern

Clinical, morphological and immunohistochemical features of 10 cases having the lymphnodal histological pattern of Kikuchi disease were examined. Two of these were diagnosed as systemic lupus erythematosus [SLE]. Morphologically, Kikuchi disease and SLE were nearly indistinguishable. Plasma cells, neutrophilic infiltration, haematoxyphilic bodies and vasculitis were not useful in differentiating the conditions. Kikuchi lymphadenitis and malignant lymphoma however could be differentiated histologically. Morphological features that exclude malignancy included: polymorphous nature of cellular infiltrate, absence of abnormal mitosis, preservation of sinusoidal pattern on intervening areas and presence of extracellular and intracellular karyorrhectic debris.

scholarly journals Unexplained Fatigue in an Otherwise Healthy Man Linked to Kikuchi-Fujimoto Disease, A Case Report

2021 ◽  
Vol 4 (1) ◽  
pp. 454-456
Author(s):  
Vivek Pant ◽  
Santosh Pradhan ◽  
Vijay Kumar Sharma
Keyword(s):  
Bone Marrow ◽  
Cervical Lymphadenopathy ◽  
Excisional Biopsy ◽  
Bone Marrow Examination ◽  
Axillary Node ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Supportive Treatment ◽  
Radiological Investigation ◽  
Normal Peripheral Blood ◽  
Necrotizing Lymphadenitis

Kikuchi histiocytic necrotizing lymphadenitis is a benign and self-limited illness usually characterized by cervical lymphadenopathy and fever. We present a case of a 42-year male who complained of extreme fatigue for 2 weeks. On laboratory workup, he had leucopenia and thrombocytopenia with normal peripheral blood and bone marrow examination. The radiological investigation revealed multiple enlarged lymph nodes in the left axilla and left supraclavicular region. The subsequent excisional biopsy of the axillary node clinched the diagnosis of Kikuchi- Fujimoto disease. The patient was completely recovered and laboratory parameters were normal with supportive treatment. Kikuchi- Fujimoto disease should be considered in patients with unexplained fatigue with lymphadenopathy and early biopsy prevents unnecessary investigations as well as potentially harmful treatments.

A young woman presenting a kikuchi-fujimoto’s disease associated with induced lupus

2018 ◽  
Author(s):  
Galith Kalmi
Keyword(s):  
Lupus Erythematosus ◽  
Cervical Lymphadenopathy ◽  
Lymph Node Biopsy ◽  
Screening Tests ◽  
Unknown Etiology ◽  
Caucasian Woman ◽  
Histiocytic Necrotizing Lymphadenitis ◽  
Drug Induced ◽  
First Case ◽  
Necrotizing Lymphadenitis

Introduction: Kikuchi-Fujimoto’s disease (KFD) or histiocytic necrotizing lymphadenitis is a benign and self-limited disease of unknown etiology mainly affecting young women. Although the association with systemic lupus erythematosus (SLE) is well described, no case of drug-induced lupus erythematosus (DILE) associated KFD has not been reported so far. Case report: We herein report a 25-year old Caucasian woman, with no medical history and no medication except for oral estrogen-progestin contraception (levonorgestrel-ethinylestradiol), who presented with cervical lymphadenopathy, fever and arthralgia without weight loss, night sweats or skin involvement. An exhaustive infectious disease screening was negative and lymph node biopsy revealed histiocytic necrotizing lymphadenitis suggesting KFD. Autoimmune screening tests evidenced high titers of anti-histone antibodies suggesting DILE induced by estrogen-progestin medication. The patient received a short course of non-steroidal anti-inflammatory treatment for painful lymphadenitis and arthralgia. Oral levonorgestrel-ethinylestradiol contraceptive medication was stopped and KFD and DILE completely recovered with a long-term disappearance of anti-histone antibodies. Conclusion: We report the first case of KFD associated-DILE following oral levonorgestrel-ethinylestradiol medication. Even though levonorgestrel-ethinylestradiol induced lupus is well known, the association with KFD has never been reported and the physiopathology remained unknown. Keywords: Kikuchi-Fujimoto disease, Lupus, Levonorgestrel-ethinylestradiol

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