scholarly journals Effect of Tiger Nut Meal on Some Sex Hormones and Sperm Cells in Androgen-induced Benign Prostate Hyperplasia in Adult Male Wistar Rats

2020 ◽  
pp. 74-82
Author(s):  
D. I. Izunwanne ◽  
J. N. Egwurugwu ◽  
C. L. Emegano
Keyword(s):  
Benign Prostate Hyperplasia ◽  
Semen Analysis ◽  
Reproductive Function ◽  
Reproductive Hormones ◽  
Male Rats ◽  
Estradiol Valerate ◽  
Sperm Cells ◽  
Prostate Hyperplasia ◽  
Ameliorative Effect ◽  
Benign Prostate

Introduction: It is generally believed that Cyperus esculentus (tiger nut) has some fertility boosting effects. However, scientific validation of some of the fertility boosting potentials as well as the ameliorative effect of tiger nut on Benign Prostate Hyperplasia (BPH) is lacking. Objective: The aim of the project is to determine the effect of tiger nuts in reproductive function in rats induced with Benign Prostate Hyperplasia (BPH). Methods: A total of sixty (60) male rats weighing between 160 – 200 g were used in this study. They were divided into six groups of ten rats per group. Benign prostate hyperplasia was induced in three groups of the rats (as stated in methodology) with 30 mg/kg sub-cutaneous injections of hormones containing dihydrotestosterone (DHT) and estradiol valerate dissolved in olive oil in the ratio of 10:1 (three times in a week, one day interval). Administration of tiger nut meal commenced immediately and lasted for two months. At the end of administration, assay of reproductive hormones (FSH, LH and Testosterone) was done. Comprehensive semen analysis was also done including (count, motility & morphology). Results: The study showed that the induction of BPH resulted in a very significant reduction of FSH while the administration of the tiger nut meal did not show any significant effect on FSH (P 0.05). The same trend was also observed on the effect of the tiger nut meal on LH level. For testosterone, it was observed that after the initial decrease as a result of the induction of infertility, 20% tiger nut meal administration significantly increased the testosterone level to 2.10±0.06 ng/ml from 0.30±0.01 ng/ml in the infertility-induced group. The effect of tiger nut meal on semen analyses namely, normal sperm cells and sperm motility showed a significant increase (P<0.05) following the induction of infertility. The effect of the tiger nut meal on sperm morphological toxicities were also examined. Sperm abnormalities like sperm cells with twisted tails were examined. Conclusion: The administration of tiger nut significantly ameliorated the abnormalities and thus, restored the morphology of the sperm cells such that it can enhance fertility.

scholarly journals Effect of Tiger Nut Meal on PSA, Relative Organ Weight Sperm Cell and Histological Changes in Androgen-induced Benign Prostate Hyperplasia in Adult Male Wistar Rats

2020 ◽  
pp. 1-10
Author(s):  
D. I. Izunwanne ◽  
J. N. Egwurugwu ◽  
C. L. Emegano
Keyword(s):  
Benign Prostate Hyperplasia ◽  
Relative Weight ◽  
Organ Weight ◽  
Male Rats ◽  
Histological Changes ◽  
Prostate Hyperplasia ◽  
Morphological Studies ◽  
Significant Difference ◽  
Relative Organ Weight ◽  
Benign Prostate

Introduction: It is generally believed that Cyperus esculentus (tiger nut) has some fertility boosting effects. However, scientific validation of some the fertility boosting belief concerning tiger nut is lacking. Objective: The aim of this project was to study the effects of tiger nuts on PSA, Sperm midpiece, relative organ weight and histological changes in BPH induced rats. Method: A total of sixty (60) male rats weighing between 160 – 200 g were used in this study. They were divided into six groups of ten rats per group. Benign prostate hyperplasia was induced in three groups of the rats (as stated in methodology) with 30 mg/kg sub-cutaneous injections of hormones containing dihydrotestosterone (DHT) and estradiol valerate dissolved in olive oil in the ratio of 10:1 (three times in a week, one day interval). Administration of tiger nut meal commenced immediately and lasted for two months. At the end of administration, blood sample was collected from the rat via cardiac puncture for the determination of PSA. Semen sample was also collected for semen morphological studies. Internal organs notably, the prostate and the testes of the rats were also removed for histological examination. Results: The study showed that the induction of BPH brought about some adverse effects. On PSA, the administration of the tiger nut meal ameliorated the BPH by significantly reducing the increased level of the PSA which is a biomarker for prostate hyperplasia (P<0.05). The effect of the tiger nut on sperm morphological toxicities were also examined. Sperm abnormalities like those with bent midpiece was examined. The result showed that the administration of tiger nut meal significantly ameliorated the abnormality and thus, restored the morphology of the sperm cells such that it can enhance fertility. A significant difference was also seen in the relative weight of the prostate. The enlarged prostate in the induced + treated group was later observed through histological studies to have reduced significantly following the administration of the tiger nut. Conclusion: Tiger nut meal ameliorates BPH by reducing the PSA and enlarged prostate. It also ameliorates semen toxicities in the BPH induced + treated rats.

HUBUNGAN USIA, OBESITAS DAN RIWAYAT PENYAKIT DIABETES MELLITUS DENGAN KEJADIAN BENIGN PROSTATE HYPERPLASIA (BPH) DERAJAT IV DI RSUD DR. M. HAULUSSY AMBON PERIODE 2012-2014

2017 ◽  
pp. 141-151
Author(s):  
Andrew Ruspanah
Keyword(s):  
Diabetes Mellitus ◽  
Benign Prostate Hyperplasia ◽  
Chi Square ◽  
Cross Sectional ◽  
Prostate Hyperplasia ◽  
Benign Prostate

Pendahuluan. Benign Postate Hiperplasia (BPH) adalah penyakit yang umumnya terjadi pada pria lansia yang disebabkan oleh penuaan. Hiperplasia prostat adalah pertumbuhan jaringan nodul fibroadenomatosa pada prostat. Pembesaran prostat jinak merupakan penyakit yang tersering kedua setelah batu saluran kemih didapatkan secara klinis di Indonesia. Tujuan. Penelitian ini bertujuan untuk mengetahui hubungan antara usia, obesitas dan riwayat diabetes mellitus dengan kejadian Benign Prostate Hyperplasia (BPH) grade IV di Rumah Sakit Dr. M. Haulussy Ambon periode 2012-2014. Metode. Jenis penelitian ini adalah penelitian analitik desain Cross-Sectional, dengan menggunakan catatan medis data di ruang operasi di Rumah Sakit Dr. M. Haulussy Ambon Tahun 2012-2014 dan memperoleh jumlah sampel yang memenuhi kriteria inklusi sebanyak 239, yang diambil dengan teknik total sampling. Analisis dilakukan dengan analisis univariat dan bivariat menggunakan uji Chi Square. Hasil yang di temukan dalam penelitian ini bahwa kejadian BPH lebih besar pada mereka yang berusia> 65 tahun dan 56-65 tahun dibandingkan dengan usia 46-55 dan <46 tahun dengan hasil tes menunjukkan adanya hubungan antara usia dengan BPH dengan nilai (p= 0,000), ada hubungan antara obesitas dengan nilai BPH (p=0,019) dan riwayat diabetes mellitus setelah menggunakan uji Chi-Square, hubungan antara riwayat diabetes mellitus dengan BPH dengan nilai (p = 0,000). Kesimpulan. Ada hubungan antara umur, obesitas dan riwayat diabetes mellitus dengan kejadian BPH.

scholarly journals PIH13 Consumption of Drugs for the Treatment of Benign Prostate Hyperplasia in Ukraine Compared to the Baltic Countries

2020 ◽  
Vol 23 ◽  
pp. S541
Author(s):  
L. Iakovlieva ◽  
O. Tkachova ◽  
N. Bezditko ◽  
O. Gerasymova ◽  
T. Bahlai ◽  
...  
Keyword(s):  
Benign Prostate Hyperplasia ◽  
Prostate Hyperplasia ◽  
Baltic Countries ◽  
The Baltic ◽  
Benign Prostate

The improvement in analgesic parametres of spinal anesthesia by the addition of intrathecal midazolam to bupivocaine in benign prostate hyperplasia surgery repair

2005 ◽  
Vol 22 (Supplement 34) ◽  
pp. 101
Author(s):  
E. Lykoudi ◽  
G. Gorantonakis ◽  
V. Theodoropoulos ◽  
E. Kapota ◽  
K. Alexandrakis ◽  
...  
Keyword(s):  
Spinal Anesthesia ◽  
Benign Prostate Hyperplasia ◽  
Prostate Hyperplasia ◽  
Benign Prostate

C30 DETECTION OF METHYLATION OF GSTP1, E-CAD AND PTGS2 IN PROSTATE ADENOCARCINOMA AND BENIGN PROSTATE HYPERPLASIA

2010 ◽  
Vol 9 (6) ◽  
pp. 626-627 ◽  
Author(s):  
P. Tilandyová ◽  
S. Grobarčiková ◽  
K. Kajo ◽  
J. Kliment ◽  
Z. Lasabová ◽  
...  
Keyword(s):  
Benign Prostate Hyperplasia ◽  
Prostate Adenocarcinoma ◽  
Prostate Hyperplasia ◽  
Benign Prostate
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