scholarly journals Study of Serum Uric Acid in Different Stages of Chronic Kidney Disease

2021 ◽  
pp. 70-79
Author(s):  
Shahida Akhter ◽  
A. S. M. Rizwan
Keyword(s):  
Chronic Kidney Disease ◽  
Uric Acid ◽  
Kidney Disease ◽  
Serum Creatinine ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Medical College ◽  
Bonferroni Test

Background: Hyperuricaemia is a metabolic marker of decreased renal function in chronic kidney disease (CKD). It increases cardiovascular, cerebrovascular and mortality risk in patients with CKD. Objectives: To estimate serum uric acid level in different stages of CKD. Methods: The present study was a cross sectional analytical study and was conducted in the Department of Physiology, Dhaka Medical College, Dhaka from July 2012 to June 2013 on 300 participants. They were divided into group A (150 control healthy participants) and group B (150 diagnosed cases of CKD). Serum creatinine and serum uric acid levels were measured by auto analyzer in Department of Pathology, Dhaka Medical College. Estimated glomerular filtration rate (eGFR) was calculated from serum creatinine level by Modification of Diet in Renal Disease (MDRD) equation. For statistical analysis unpaired Student “t” test, one way ANOVA test, Bonferroni test, Pearson’s correlation coefficient (r) test and Linear regression were performed using SPSS for windows version 20. Result: In this study, serum uric acid level was significantly (p<0.05) higher and eGFR were significantly lower in study groups than that of control group. There was gradual rise of serum uric acid level in CKD subjects from stage I to V. A significant inverse correlation was observed between serum uric acid level and eGFR. Serum uric acid level increased 0.048 mg/dl for each ml/min/1.73m2 decrease of eGFR. Conclusion: This study concludes that serum uric acid level increases gradually in accordance with the higher stages of CKD. There is a negative correlation of serum uric acid with eGFR in all stages of CKD which was statistically significant (p<0.05). Screening of serum uric acid level in different stages of CKD may be beneficial for assessing renal damage as well as prediction of co-morbidities associated with it.

scholarly journals Serum Uric Acid Level and Endothelial Dysfunction in Patients with Nondiabetic Chronic Kidney Disease

2011 ◽  
Vol 33 (4) ◽  
pp. 298-304 ◽  
Author(s):  
Mehmet Kanbay ◽  
Mahmut Ilker Yilmaz ◽  
Alper Sonmez ◽  
Faruk Turgut ◽  
Mutlu Saglam ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Uric Acid ◽  
Endothelial Dysfunction ◽  
Kidney Disease ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level

Association between serum uric acid level and renal arteriolar hyalinization in individuals without chronic kidney disease

2017 ◽  
Vol 266 ◽  
pp. 121-127 ◽  
Author(s):  
Yuta Matsukuma ◽  
Kosuke Masutani ◽  
Shigeru Tanaka ◽  
Akihiro Tsuchimoto ◽  
Naoki Haruyama ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Uric Acid ◽  
Kidney Disease ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level

scholarly journals Hubungan Nilai Estimasi Laju Filtrasi Glomerulus dan Kadar Asam Urat Serum pada Subyek Penyakit Ginjal Kronik Non-Dialisis

e-CliniC ◽  
2017 ◽  
Vol 5 (2) ◽  
Author(s):  
Jonathan Moula ◽  
Emma Sy. Moeis ◽  
Cerelia Sugeng
Keyword(s):  
Chronic Kidney Disease ◽  
Uric Acid ◽  
Kidney Disease ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Elevated Serum ◽  
Negative Relationship ◽  
Public Health Problem

Abstract: Chronic kidney disease (CKD) is a global public health problem. The CKD Epidemiology Collaboration (CKD-EPI) equation is the most accurate result of GFR (eGFR) that has been evaluated in large varied populations and can be applied clinically in general. In CKD patient, uric acid excretion decreases linearly along the worsening renal function. This study was aimed to determine the relationship between serum uric acid level based on eLFGCKD-EPI value and eGFR CKD-EPI in non-dialysis CKD patients (male and female). This was an analytical study with a cross-sectional design using medical record data of CKD patients at Prof. Dr. R. D. Kandou Hospital from January to December 2016. There were 82 samples who met the inclusion criteria. The results showed that 45 of 54 males and 27 of 28 females with non-dialysis CKD had elevated serum uric acid levels. The correlation test between serum uric acid level and eLFG CKD-EPI value on males and females were P=0.0; r=-0.473 and P=0.0; r=-0,598 respectively. Conclusion: There was a significant negative relationship between serum uric acid level and eLFG CKD-EPI value in non-dialysis CKD patients for both sexes. Based on eLFGCKD-EPI value, most patients had elevated serum uric acid levels.Keywords: non-dialysis chronic kidney disease, serum uric acid, eLFG CKD-EPI Abstrak: Penyakit ginjal kronik (PGK) merupakan masalah kesehatan masyarakat global. Persamaan CKD-EPI (CKD Epidemiology Collaboration) adalah persamaan estimasi LFG (eLFG) yang paling akurat dan telah dievaluasi pada populasi beragam dalam jumlah besar dan dapat diterapkan pada penggunaan klinis secara umum. Pada pasien PGK, ekskresi asam urat menurun secara linier seiring dengan memburuknya fungsi ginjal. Penelitian ini bertujuan untuk mengetahui hubungan kadar asam urat serum berdasarkan nilai eLFGCKD-EPI dan nilai eLFG CKD-EPI pada PGK non-dialisis (PGK-ND) baik pada jenis kelamin laki-laki maupun perempuan. Jenis penelitian ialah analitik dengan desain potong lintang menggunakan data rekam medik pasien PGK di RSUP Prof. Dr. R. D. Kandou periode Januari-Desember 2016. Terdapat 82 sampel yang memenuhi kriteria inklusi. Hasil penelitian mendapatkan 45 dari 54 laki-laki dan 27 dari 28 perempuan dengan PGK-ND mengalami peningkatan kadar asam urat serum. Uji korelasi hubungan antara kadar asam urat serum dan nilai eLFGCKD-EPI pada jenis kelamin laki-laki dan perempuan masing-masing P=0,0; r=-0,473 dan P=0,0; r=-0,598. Simpulan: Terdapat hubungan negatif bermakna antara kadar asam urat serum dan nilai eLFGCKD-EPI pada kedua jenis kelamin. Pada sebagian besar pasien PGK-ND baik laki-laki mupun perempuan terdapat peningkatan kadar asam urat serum berdasarkan nilai eLFGCKD-EPI.Kata kunci: penyakit ginjal kronis non-dialisis, asam urat serum, eLFG CKD-EPI

A PROSPECTIVE STUDY TO EVALUATE THE ROLE OF URIC ACID FOR PROGRESSION TO PREECLAMPSIA IN GESTATIONAL HYPERTENSIVE PREGNANCIES IN THE DEPARTMENT OF OBSTRETICS AND GYNECOLOGY, SMS MEDICAL COLLEGE

2021 ◽  
Vol 5 (8) ◽  
Author(s):  
Hetal More ◽  
Archana Singh ◽  
B.S. Meena
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Gestational Hypertension ◽  
Serum Uric Acid Level ◽  
Characteristic Curve ◽  
Initial Presentation ◽  
Medical College

Background: The purpose of this study was to study the role of serum uric acid level in progression to preeclampsia in gestational hypertensive pregnancies. Methods: Hospital based comparative study was conducted at Department of Obstetrics and Gynaecology, SMS medical college, Jaipur. Results: Uric acid level was significantly higher in with PIH (6.68±0.36 mg/dl) as compared to without PIH (4.92±0.57 mg/dl). Receiver-operator characteristic curve showed relatively poor sensitivity and specificity performance (area under the curve= 1.00) of serum uric acid level at the initial presentation of gestational hypertension for predicting the progression to preeclampsia The best cut-off revealed from the curve was 6.18 mg/dl. Conclusion: In conclusion, higher serum uric acid levels at the initial presentation of gestational hypertension may indicate heightened risk of progression to preeclampsia and development of adverse maternal/ infant conditions. Keywords: Eclampsia, Uric acid, Hypertension

Estimation of Serum Uric Acid Level in Preeclamptic Women Determine the Severity of Preeclampsia

2020 ◽  
Vol 11 (1) ◽  
pp. 35-40
Author(s):  
Khairun Nahar ◽  
Sayada Fatema Khatun ◽  
Naila Atik Khan
Keyword(s):  
Uric Acid ◽  
Serum Uric Acid ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Severe Preeclampsia ◽  
College Hospital ◽  
Medical College ◽  
Mild Preeclampsia ◽  
Relationship Of

Background: Serum uric acid is a relatively insoluble metabolite of purine metalolism which is mainly secreted by the kidneys and the rate is dependant on renal blood flow. It increases in preeclampsia and studies show it may be a marker of severe preeclampsia. Objective: To determine the serum uric acid level in preeclampsia, to compare the serum uric acid level between mild and sever preeclampsia and to find out any relationship of the serum uric acid level with hypertension in preeclampsia. Methods and materials: This cross sectional study was conducted in Dhaka Medical College Hospital in eclampsia ward of Gynae & Obs department during the period from January 2010 to December 2011. This study group composed of 92 diagnosed case of preeclampsia patient. Out of the 92 cases, 42 were mild preeclampsia and 50 were severe preeclampsia. Result: The results of the study showed that the mean serum uric acid level was significantly high in severe preeclampsia compared to mild preeclampsia and there is a positive and significant relationship of serum uric acid level with hypertension in preeclampsia. Conclusion: There is significant association between serum uric acid level and hypertension in Preeclampsia. Anwer Khan Modern Medical College Journal Vol. 11, No. 1: Jan 2020, P 35-40

scholarly journals Uric acid levels in chronic kidney disease- a hospital based cross-sectional study in RIMS, Ranchi, Jharkhand

2021 ◽  
Vol 9 (2) ◽  
pp. 569
Author(s):  
Nivedita . ◽  
Abhishek Kumar ◽  
Abhishek Sinha ◽  
J. K. Mitra ◽  
Rashmi Sinha
Keyword(s):  
Chronic Kidney Disease ◽  
Uric Acid ◽  
Kidney Disease ◽  
Uric Acid Level ◽  
Acid Level ◽  
Serum Uric Acid Level ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Female Ratio ◽  
Institutional Ethics

Background: Uric acid is the final end product of purine metabolism and is excreted mainly by proximal tubules of the kidney. Raised uric acid levels may lead to proximal tubular injury, endothelial dysfunction, oxidative stress and intra renal inflammation in patients with normal renal function. Uric acid has been deemed as an independent risk factor for progression of CKD. Aim was to study the uric acid levels in different stages of chronic kidney disease and its association with age, sex and other co-morbidities.Methods: 140 patients of chronic kidney disease admitted in RIMS, Ranchi were included in this study and their serum uric acid level were analyzed. Uric acid level more than 7 mg/dl was considered as hyperuricemia. The study was approved by the Institutional Ethics Committee, Rajendra Institute of Medical Sciences, Ranchi, Jharkhand, India. Informed consent was taken from every patient included in the study.Results: Median age±SD was 55±13.47 years (IQR: 45,65; Range: 19-80). Mean±SD uric acid levels in stage 3 CKD was 4.4±1.9 mg/dl, stage 4 CKD was 6.5±4.1 mg/dl, stage 5 CKD was 8.8±3.1 mg/dl (p<0.05). Females were 31.4% and males were 69.6%. Male to female ratio was 2.2:1. The prevalence of hyperuricemia was 50% in females and 66.6% in males.Conclusions: Hyperuricemia is common among CKD patients and more common among males. Uric acid levels increase with progressive decline in eGFR. Monitoring and follow-up of such patients by may lead to delay in onset and progression of complications of CKD.

Sign in / Sign up

Export Citation Format

Share Document