aplyronine a Latest Research Papers

The C29–C34 parts of antitumor macrolide aplyronine A serve as versatile actin-affinity tags

Chemical Communications ◽

10.1039/d1cc04259a ◽

2021 ◽

Author(s):

Didik Huswo Utomo ◽

Akari Fujieda ◽

Kentaro Tanaka ◽

Momoko Takahashi ◽

Kentaro Futaki ◽

...

Keyword(s):

Natural Products ◽

Drug Development ◽

Anticancer Drug ◽

Protein Interactions ◽

Side Chain ◽

Protein Protein Interactions ◽

Affinity Tags ◽

Promising Strategy ◽

Anticancer Drug Development ◽

Aplyronine A

Anticancer drug development inspired by natural products based on protein–protein interactions (PPI) is a promising strategy. We developed structurally-simplified C29–C34 side-chain analogs of aplyronine A (ApA), an antitumor marine macrolide....

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Recent Progress in the Structure-Activity Relationship Studies on Antitumor Macrolide Aplyronine A by Using Hybridization of Actin-Depolymerizing Natural Product

Chemistry Letters ◽

10.1246/cl.200866 ◽

2020 ◽

Author(s):

Takayuki Ohyoshi ◽

Hideo Kigoshi

Keyword(s):

Natural Product ◽

Recent Progress ◽

Structure Activity Relationship ◽

Activity Relationship ◽

Structure Activity ◽

Aplyronine A

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Synthesis and Biological Activities of Aplyronine A Analogues toward the Development of Antitumor Protein–Protein Interaction Inducers between Actin and Tubulin: Conjugation of the C1–C9 Macrolactone Part and the C24–C34 Side Chain

ACS Omega ◽

10.1021/acsomega.9b01099 ◽

2019 ◽

Vol 4 (5) ◽

pp. 8598-8613 ◽

Cited By ~ 2

Author(s):

Kentaro Futaki ◽

Momoko Takahashi ◽

Kenta Tanabe ◽

Akari Fujieda ◽

Hideo Kigoshi ◽

...

Keyword(s):

Protein Interaction ◽

Biological Activities ◽

Side Chain ◽

Protein Protein Interaction ◽

Aplyronine A

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Development of a novel inducer of protein–protein interactions based on aplyronine A

Chemical Communications ◽

10.1039/c8cc04613a ◽

2018 ◽

Vol 54 (68) ◽

pp. 9537-9540 ◽

Cited By ~ 2

Author(s):

Takayuki Ohyoshi ◽

Atsuhiro Takano ◽

Mayu Namiki ◽

Tomotaka Ogura ◽

Yuto Miyazaki ◽

...

Keyword(s):

Protein Interactions ◽

Biological Activities ◽

Side Chain ◽

Protein Protein Interactions ◽

Swinholide A ◽

Aplyronine A

An aplyronine A–swinholide A hybrid, consisting of the macrolactone part of aplyronine A and the side chain part of swinholide A, was designed, synthesized, and evaluated for biological activities.

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Development of photoaffinity derivatives of the antitumor macrolide aplyronine A, a PPI-inducer between actin and tubulin

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2017.09.044 ◽

2017 ◽

Vol 25 (24) ◽

pp. 6322-6331 ◽

Cited By ~ 3

Author(s):

Masaki Kita ◽

Kota Yamagishi ◽

Kota Tsuchiya ◽

Yu Seguchi ◽

Hiroki Nakane ◽

...

Keyword(s):

Derivatives Of ◽

Aplyronine A

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Second-generation total synthesis of aplyronine A featuring Ni/Cr-mediated coupling reactions

Organic & Biomolecular Chemistry ◽

10.1039/c6ob02241c ◽

2017 ◽

Vol 15 (1) ◽

pp. 124-131 ◽

Cited By ~ 5

Author(s):

Ichiro Hayakawa ◽

Keita Saito ◽

Sachiko Matsumoto ◽

Shinichi Kobayashi ◽

Ayaka Taniguchi ◽

...

Keyword(s):

Total Synthesis ◽

Second Generation ◽

Coupling Reactions ◽

Key Steps ◽

Aplyronine A

Second-generation total synthesis of aplyronine A, a potent antitumor marine macrolide, was achieved using Ni/Cr-mediated coupling reactions as key steps.

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Analysis of the aplyronine A-induced protein–protein interaction between actin and tubulin by surface plasmon resonance

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2016.04.049 ◽

2016 ◽

Vol 24 (12) ◽

pp. 2809-2814 ◽

Cited By ~ 3

Author(s):

Yuichiro Hirayama ◽

Kota Yamagishi ◽

Tomohiro Suzuki ◽

Hirokazu Kawagishi ◽

Masaki Kita ◽

...

Keyword(s):

Surface Plasmon Resonance ◽

Surface Plasmon ◽

Protein Interaction ◽

Plasmon Resonance ◽

Protein Protein Interaction ◽

Aplyronine A

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Mechanism-specified 5-exo termini differentiation of a C32-desmethyl C28–C34 aplyronine A analog segment

Tetrahedron Letters ◽

10.1016/j.tetlet.2015.04.098 ◽

2015 ◽

Vol 56 (28) ◽

pp. 4155-4158

Author(s):

Thomas P. Bobinski ◽

Philip L. Fuchs

Keyword(s):

Aplyronine A

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ChemInform Abstract: Recent Progress in the Synthetic Study of an Antitumor Marine Macrolide Aplyronine A and Related Molecules

ChemInform ◽

10.1002/chin.201530317 ◽

2015 ◽

Vol 46 (30) ◽

pp. no-no

Author(s):

Hideo Kigoshi ◽

Ichiro Hayakawa

Keyword(s):

Recent Progress ◽

Aplyronine A

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Target Identification and Mode of Action Studies of an Antitumor Compound Aplyronine A by Using Photoaffinity Derivatives

Journal of Synthetic Organic Chemistry Japan ◽

10.5059/yukigoseikyokaishi.73.151 ◽

2015 ◽

Vol 73 (2) ◽

pp. 151-160 ◽

Cited By ~ 4

Author(s):

Masaki Kita ◽

Hideo Kigoshi

Keyword(s):

Mode Of Action ◽

Target Identification ◽

Antitumor Compound ◽

Aplyronine A

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aplyronine a
Recently Published Documents

TOTAL DOCUMENTS

H-INDEX

The C29–C34 parts of antitumor macrolide aplyronine A serve as versatile actin-affinity tags

Recent Progress in the Structure-Activity Relationship Studies on Antitumor Macrolide Aplyronine A by Using Hybridization of Actin-Depolymerizing Natural Product

Synthesis and Biological Activities of Aplyronine A Analogues toward the Development of Antitumor Protein–Protein Interaction Inducers between Actin and Tubulin: Conjugation of the C1–C9 Macrolactone Part and the C24–C34 Side Chain

Development of a novel inducer of protein–protein interactions based on aplyronine A

Development of photoaffinity derivatives of the antitumor macrolide aplyronine A, a PPI-inducer between actin and tubulin

Second-generation total synthesis of aplyronine A featuring Ni/Cr-mediated coupling reactions

Analysis of the aplyronine A-induced protein–protein interaction between actin and tubulin by surface plasmon resonance

Mechanism-specified 5-exo termini differentiation of a C32-desmethyl C28–C34 aplyronine A analog segment

ChemInform Abstract: Recent Progress in the Synthetic Study of an Antitumor Marine Macrolide Aplyronine A and Related Molecules

Target Identification and Mode of Action Studies of an Antitumor Compound Aplyronine A by Using Photoaffinity Derivatives

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aplyronine aRecently Published Documents

TOTAL DOCUMENTS

H-INDEX

The C29–C34 parts of antitumor macrolide aplyronine A serve as versatile actin-affinity tags

Recent Progress in the Structure-Activity Relationship Studies on Antitumor Macrolide Aplyronine A by Using Hybridization of Actin-Depolymerizing Natural Product

Synthesis and Biological Activities of Aplyronine A Analogues toward the Development of Antitumor Protein–Protein Interaction Inducers between Actin and Tubulin: Conjugation of the C1–C9 Macrolactone Part and the C24–C34 Side Chain

Development of a novel inducer of protein–protein interactions based on aplyronine A

Development of photoaffinity derivatives of the antitumor macrolide aplyronine A, a PPI-inducer between actin and tubulin

Second-generation total synthesis of aplyronine A featuring Ni/Cr-mediated coupling reactions

Analysis of the aplyronine A-induced protein–protein interaction between actin and tubulin by surface plasmon resonance

Mechanism-specified 5-exo termini differentiation of a C32-desmethyl C28–C34 aplyronine A analog segment

ChemInform Abstract: Recent Progress in the Synthetic Study of an Antitumor Marine Macrolide Aplyronine A and Related Molecules

Target Identification and Mode of Action Studies of an Antitumor Compound Aplyronine A by Using Photoaffinity Derivatives

aplyronine a
Recently Published Documents