BackgroundFurin has been associated with glucose metabolic phenotypes in small sampled clinical studies. However, this association has not yet been studied in Chinese. Here, we aimed to examine the association between serum furin and fasting glucose in Chinese adults.MethodsSerum furin and fasting plasma glucose were assayed for 2,172 participants (mean aged 53 years, 38% men) in the Gusu cohort. A median regression model was applied to examine the association between serum furin and fasting glucose, adjusting for age, sex, education level, cigarette smoking, alcohol drinking, obesity, blood pressure, and lipids. To facilitate data interpretation, the association between serum furin and prevalent diabetes was also examined.ResultsSerum furin was negatively associated with fasting glucose (β=-0.18, P<0.001 for log-furin). In participants with diabetes, serum furin was significantly lower than those with normal glucose (median: 0.90 ng/mL vs. 1.05 ng/mL, P=0.001). Compared with participants in the highest quartile of serum furin, those in the lowest quartile had 42% and 80% increased risk of prevalent prediabetes (OR=1.42, 95%CI: 1.05-1.92, P=0.023) and diabetes (OR=1.80, 95%CI: 1.13-2.91, P=0.015), respectively.ConclusionsSerum furin was negatively associated with prediabetes and diabetes in Chinese adults. Our findings suggest that serum furin may be a risk factor or a biomarker of diabetes.

This study examines the judge's considerations in resolving marriage dispensation cases at the Parigi Religious Court. This research includes field research with qualitative methods. Data was collected through documentation studies, interviews, and observations. Data analysis techniques used are data reduction, data presentation, data interpretation, and drawing conclusions. The background of this research is Law No. 16 of 2019 Article 7 paragraph 1 regarding the minimum age of marriage, which is 19 years for men and women, as well as paragraphs 2 & 3 regarding the granting of marriage dispensation with very urgent reasons. The description in this journal departs from the factors that form the background of the application for a marriage dispensation and how judges consider in resolving a marriage dispensation case at the Parigi Religious Court. The results showed that the background of the application for marriage dispensation at the Parigi Religious Court was due to pregnancy outside of marriage, arranged marriages, and reasons to avoid adultery. The considerations made by the judge are through the principle of expediency, the necessity to refuse harm, the interests of the child and baby in the womb, and the legal compliance of the family. From the conclusions obtained, it is recommended that the government and community organizations intensively conduct speeches and counseling about the dangers of early marriage in the community, as well as increase parental and family supervision of the association and development of children. Abstrak Penelitian ini mengkaji tentang pertimbangan hakim dalam penyelesaian perkara dispensasi nikah di Pengadilan Agama Parigi. Penelitian ini termasuk penelitian lapangan dengan metode kualitatif. Pengumpulan data dilakukan melalui studi dokumentasi, wawancara, dan observasi. Teknik analisis data yang digunakan adalah reduksi data, penyajian data, penafsiran data, dan penarikan kesimpulan. Latar belakang penelitian ini adalah Undang-Undang No 16 Tahun 2019 Pasal 7 ayat 1 mengenai umur minimal pernikahan yaitu 19 tahun bagi pria dan wanita, serta ayat 2 & 3 mengenai pemberian dispensasi nikah dengan alasan sangat mendesak. Uraian dalam jurnal ini berangkat dari faktor-faktor yang menjadi latar belakang permohonan dispensasi nikah dan bagaimana pertimbangan hakim dalam menyelesaikan perkara dispensasi nikah di Pengadilan Agama Parigi. Hasil penelitian menunjukkan bahwa latar belakang permohonan dispensasi nikah di Pengadilan Agama Parigi akibat kondisi hamil di luar nikah, perjodohan, dan alasan menghindari zina. Adapun pertimbangan yang dilakukan hakim yaitu melalui asas kemanfaatan, keharusan untuk menolak mudharat, kepentingan anak dan bayi dalam kandungan, serta kepatuhan hukum pihak keluarga. Dari kesimpulan yang diperoleh, disarankan agar pemerintah serta organisasi kemasyarakatan gencar melakukan orasi dan penyuluhan tentang bahaya menikah dini di tengah masyarakat, serta meningkatkan pengawasan orang tua dan keluarga terhadap pergaulan dan perkembangan anak.

Abstract Awareness of the exposome and its influence on health has increased in the last decade. As past exposures can cause changes in human health many years later, delving into the past is relevant for both diagnostic and prevention purposes, but remains a challenging task. Lifestyle, diet and socioeconomic information of the past should be well documented and compatible with modern data science methods. While chemical analysis nowadays makes use of High Resolution Mass Spectrometry (HR-MS) for highly sensitive and comprehensive coverage of samples plus retrospective analysis, these data archives are in the very early stages. Since past measurements are often only available for a limited set of chemicals, adding to this knowledge requires careful selection of sample types and sampling sites, which may not always be available. The choice of analytes and analytical methods should be suitable for the study question—which is not always clear in advance in exposomics. Data interpretation and the use of appropriate databases are indispensable for a proper exposure assessment, and as databases and knowledge grow, re-analysis of physically or digitally archived samples could enable “continuous monitoring” efforts. This review focusses on the chemical analytical approaches necessary to capture the complexity of the historical exposome. Various sample types, analytes as well as analyses and data interpretation methods are discussed in relation to chemical exposures, while the connection to health remains in focus. It ends with perspectives and challenges in assessing the historical exposome, discussing how we can “learn from the past” to build a better future.

Color as a visual element cannot be separated from architectural design. The development of knowledge about color involved artists and scientists. In the past, color was always associated with the activities of artists as creators of decorative works using pigments produced by nature. Artists and scientists assume that color occurs due to the influence of light and dark which is homogeneous. This was later refuted by Newton's findings that color is produced by heterogeneous light. Different colors are a result of different refractive indexes. The discovery of artificial colors by Perkin encouraged the industry to create colors not only to produce colors that exist in nature, but also according to the wishes of the user as an individual. The opportunity to use colors according to the needs of individual users then encourages businesses to control colors so that the industry does not suffer losses if the colors of the products they produce do not sell well in the market. They work closely with color forecasters and color designers to determine color trends according to the interests of producers through color cards. This condition is followed by architects who create color schemes based on their own favorite color palette. This article finds out how the development of science positions color in architectural works? The research was conducted with a historical approach and data interpretation methods through a literature review.

The advantages and limitations of the petrography method and the relevance of its use for the study of natural ice are reviewed in the present work. The petrographic method of ground ice study is often used for solving paleogeographic issues. The petrofabric analysis of ground ice is not only useful for descriptive purposes but, like the study of cryostructures, helps to infer growth processes and conditions. Different types of natural ice have specific features that can help us to determine ice genesis. Surface ice, such as glacier ice is often presented by foliation formed by large crystals (50-60 mm); lake ice is characterised by the upper zone of small (6 mm x 3 mm) dendritic and equigranular crystals, which change with increasing depth to large (may exceed 200 mm) columnar and prismatic crystals; segregated ice is composed by crystals forming foliation. Ground ice, such as ice wedge is presented by vertical-band appearance and small crystals (2-2.5 mm); closed-cavity ice is often distinguished by radial-ray appearance produced by elongated ice crystals; injection ice is composed by anhedral crystals, showing the movement of water; snowbank ice is presented by a high concentration of circular bubbles and small (0.1-1 mm) equigranular crystals; icing is described by foliation and mostly columnar crystals. Identification of the origin of ground ice is a complicated task for geocryology because it is difficult to distinguish different types of ground ice based on only visual explorations. The simplest way to get an ice texture pattern is by using polarized light. Distinctions between genetic types of ground ice are not always made in studies, and that can produce erroneous inferences. Petrography studies of an ice object are helpful to clarify the data interpretation, e.g., of isotopic analyses. It is particularly relevant for heterogeneous ice wedges’ study.

This legal paper aimed to discuss the various views of legal experts on the Constitutional Court's Decision on the Manpower Act and Law derived from the Omnibus Law, which is full of controversy. The authors believe that the success of this discussion is closely related to the contributions of legal scholars from various disciplines and practitioners. Therefore, we have conducted a series of data collection virtually on literature sources such as journal publications, books, proceedings, and several legal websites. Furthermore, an in-depth study effort involves data evaluation, data coding, data interpretation, and drawing conclusions which will be used as data findings supported by scientific evidence from several experts with valid and convincing data considerations. This qualitative study relies on secondary data or evidence from previous scientific studies. Based on the data exposure and discussion, we can conclude that most legal experts, especially independent ones, say that the Constitutional Court's decision issued in October 2021 regarding the Manpower Act Derived from the Omnibus Law is legally binding flawed. They believe the decision will reap prolonged controversy. Thus, these findings should be the subject of further studies in the future.

Purpose: to study the peculiarities of the relationship between resilience and socio-psychological adaptation to activities in novice athletes; to develop a program of social and psychological training for the development of resilience and optimization of the adaptation process in athletes. Material and methods. The study involved 42 sportsmen of fire-applied sports at the age from 17 to 20 years. Research methods: theoretical analysis and generalization of scientific literature, system analysis and data interpretation; testing; methods of mathematical statistics. Results. As a result of the research, a resilience training was developed for novice athletes in order to optimize adaptation processes. The main goals of the training are: achieving a deeper understanding of stressful circumstances, ways to overcome them; finding ways to actively solve problems; constant use of feedback, thereby deepening the self-perception of involvement, control and risk taking. After the training, the level of resilience increased, the maladjustment of the participants decreased. Conclusions. The article presents a theoretical analysis and empirical study of the problem of the relationship between resilience and socio-psychological adaptation to sports activity of young sportsmen of adolescence. The results obtained in empirical research indicate that the level of resilience is associated with indicators of adaptation. The socio-psychological training has been developed to optimize the process of adaptation to sports activity by increasing the level of vitality. The effectiveness of the developed training program for athletes has been proven.

Fluorescence analysis of materials used as binders and coatings in artworks is often hampered by numerous factors, leading to uncertainties in data interpretation. Fluorescence lifetime (FL) measurements enable improvement of the specificity with respect to steady-state measurements by resolving the decay dynamics of the fluorophore emissions. In this work, layers of natural resin, oil, and wax—in pure form, pigmented, in mixtures, and spread on different substrates—were analyzed using a compact, portable, fiber-based FL instrument. FL data were processed via the phasor method and integrated with Raman spectroscopy to obtain complementary chemical information on the different substances. It was observed that the τ-phase of the mixtures is affected by both the pigments and the dispersing medium, and that the presence of the metal substrate contributes to changes in the FL of mixtures. The results obtained with our portable FL system combined with Raman spectroscopy pave the way for a systematic study of a larger number of materials for future in situ applications on works of art.