Attention enhances category representations across the brain with strengthened residual correlations to ventral temporal cortex

How does attention enhance neural representations of goal-relevant stimuli while suppressing representations of ignored stimuli across regions of the brain? While prior studies have shown that attention enhances visual responses, we lack a cohesive understanding of how selective attention modulates visual representations across the brain. Here, we used functional magnetic resonance imaging (fMRI) while participants performed a selective attention task on superimposed stimuli from multiple categories and used a data-driven approach to test how attention affects both decodability of category information and residual correlations (after regressing out stimulus-driven variance) with category-selective regions of ventral temporal cortex (VTC). Our data reveal three main findings. First, when two objects are simultaneously viewed, the category of the attended object can be decoded more readily than the category of the ignored object, with the greatest attentional enhancements observed in occipital and temporal lobes. Second, after accounting for the response to the stimulus, the correlation in the residual brain activity between a cortical region and a category-selective region of VTC was elevated when that region's preferred category was attended vs. ignored, and more so in the right occipital, parietal, and frontal cortices. Third, we found that the stronger the residual correlations between a given region of cortex and VTC, the better visual category information could be decoded from that region. These findings suggest that heightened residual correlations by selective attention may reflect the sharing of information between sensory regions and higher-order cortical regions to provide attentional enhancement of goal-relevant information.

Surround Modulation Properties of Tectal Neurons in Pigeon Characterized by Moving and Flashed Stimuli

Surround modulation is a phenomenon whereby costimulation of the extra-classical receptive field and classical receptive field would modulate the visual responses induced individually by classical receptive field. However, there lacks systematic study about surround modulation properties existing in avian optic tectum. In this study, neuronal activities are recorded from pigeon optic tectum, and the responses to moving and flashed squares and bars of different sizes are compared. The statistical results showed that most tectal neurons presented surround suppression as stimuli size grew larger both in moving and flashed paradigms, and the suppression degree induced by larger flashed square was comparable with that by moving one when it crossed near the cell’s RF center, which corresponds to fully surrounding condition. The suppression degree grew weaker when the stimuli move across the RF border, which corresponds to partially surrounding condition. Meanwhile, the fully surround suppression induced by flashed square was also more intense than partially surrounded by flashed bars. The results provide new insight for understanding the spatial arrangement of lateral inhibitions from feedback or feedforward streams, which would help to make clear the generation mechanism of surround modulation found in avian optic tectum.

Surround Modulation Properties of Tectal Neurons in Pigeon Characterized by Moving and Flashed Stimuli

Surround modulation is a phenomenon whereby costimulation of the extra-classical receptive field and classical receptive field would modulate the visual responses induced individually by classical receptive field. However, there lacks systematic study about surround modulation properties existing in avian optic tectum. In this study, neuronal activities are recorded from pigeon optic tectum, and the responses to moving and flashed squares and bars of different sizes are compared. The statistical results showed that most tectal neurons presented surround suppression as stimuli size grew larger both in moving and flashed paradigms, and the suppression degree induced by larger flashed square was comparable with that by moving one when it crossed near the cell’s RF center, which corresponds to fully surrounding condition. The suppression degree grew weaker when the stimuli move across the RF border, which corresponds to partially surrounding condition. Meanwhile, the fully surround suppression induced by flashed square was also more intense than partially surrounded by flashed bars. The results provide new insight for understanding the spatial arrangement of lateral inhibitions from feedback or feedforward streams, which would help to make clear the generation mechanism of surround modulation found in avian optic tectum.

THE LIGHT-DOSIMETER – A NEW DEVICE TO HELP ADVANCE RESEARCH ON THE NON-VISUAL RESPONSES TO LIGHT

Research on the non-visual responses to light under real-world conditions has been hindered by the lack of suitable measuring devices. Here, we present a novel, portable and miniaturised light-dosimeter attached to a spectacle frame, taking measurements in the near-corneal plane. The recorded data is processed with the help of the custom-made software package Lido Studio. In addition to commonly used metrics such as illuminance and correlated colour temperature (CCT), it also provides metrics standardised in CIE S 026:2018. Data can be analysed directly in Lido Studio or exported as a PDF report or a comma-separated values (CSV) file for further in-depth time-series analyses. The Federal Institute of Metrology (METAS) optics laboratory (Bern-Wabern, Switzerland) assessed the light-dosimeter’s spectral and geometric properties. Subsequentially, the team at the Centre for Chronobiology (Basel, Switzerland) confirmed that measurements performed with a light-dosimeter were comparable to those from a commercial spectroradiometer.

A cortical circuit for audio-visual predictions

Learned associations between stimuli in different sensory modalities can shape the way we perceive these stimuli. However, it is not well understood how these interactions are mediated or at what level of the processing hierarchy they occur. Here we describe a neural mechanism by which an auditory input can shape visual representations of behaviorally relevant stimuli through direct interactions between auditory and visual cortices in mice. We show that the association of an auditory stimulus with a visual stimulus in a behaviorally relevant context leads to experience-dependent suppression of visual responses in primary visual cortex (V1). Auditory cortex axons carry a mixture of auditory and retinotopically matched visual input to V1, and optogenetic stimulation of these axons selectively suppresses V1 neurons that are responsive to the associated visual stimulus after, but not before, learning. Our results suggest that cross-modal associations can be communicated by long-range cortical connections and that, with learning, these cross-modal connections function to suppress responses to predictable input.

Structural and functional organization of visual responses in the inferior olive of larval zebrafish

The olivo-cerebellar system plays an important role in vertebrate sensorimotor control. According to a classical theory of cerebellar cortex, the inferior olive (IO) provides Purkinje cells with error information which drives motor learning in the cerebellum. Here we investigate the sensory representations in the IO of larval zebrafish and their spatial organization. Using single-cell labeling of genetically identified IO neurons we find that they can be divided into at least two distinct groups based on their spatial location, dendritic morphology, and axonal projection patterns. In the same genetically targeted population, we recorded calcium activity in response to a set of visual stimuli using 2-photon imaging. We found that most IO neurons showed direction selective and binocular responses to visual stimuli and that functional properties were spatially organized within the IO. Light-sheet functional imaging that allowed for simultaneous activity recordings at the soma and axonal level revealed tight coupling between soma location, axonal projections and functional properties of IO neurons. Taken together, our results suggest that anatomically-defined classes of inferior olive neurons correspond to distinct functional types, and that topographic connections between IO and cerebellum contribute to organization of the cerebellum into distinct functional zones.

Optocollic responses in adult barn owls (Tyto furcata)

Barn owls, like primates, have frontally oriented eyes, which allow for a large binocular overlap. While owls have similar binocular vision and visual-search strategies as primates, it is less clear whether reflexive visual behavior also resembles that of primates or is more similar to that of closer related, but lateral-eyed bird species. Test cases are visual responses driven by wide-field movement: the optokinetic, optocollic, and optomotor responses, mediated by eye, head and body movements, respectively. Adult primates have a so-called symmetric horizontal response: they show the same following behavior, if the stimulus, presented to one eye only, moves in the nasal-to-temporal direction or in the temporal-to-nasal direction. By contrast, lateral-eyed birds have an asymmetric response, responding better to temporal-to-nasal movement than to nasal-to-temporal movement. We show here that the horizontal optocollic response of adult barn owls is less asymmetric than that in the chicken for all velocities tested. Moreover, the response is symmetric for low velocities (< 20 deg/s), and similar to that of primates. The response becomes moderately asymmetric for middle-range velocities (20–40 deg/s). A definitive statement for the complex situation for higher velocities (> 40 deg/s) is not possible.

Are We There Yet?

<p>This research will address American gender theorist Butler's assertion of third wave feminism and gender ethics and advocate that despite education and modernization, a duplicity still exists in the way gender has been depicted in western culture as well as in indigenous culture. This investigation seeks to acknowledge this duplicity by performing a comparative study of the western superhero Wonder Woman and the indigenous Indian Goddess Durga. Ultimately, this study challenges the contemporary terminologies and the interpretations concerning gender roles within the society to show the duplicity inherent in these contrasting renditions. Through a theoretical and practical framework and with the help of academic works and social media, the study conveys more visually empathetic ways to define the feminine gender as being powerful and multifaceted. These investigations will include traditional and contemporary examples of visual illustrations that contain their own social and cultural narratives and offer visual evidence of the perceptions and preconceptions that Butler refers to in her ‘Undoing Gender’ as “social and sexual constraints” (Butler, 2004, p. 10-15). The findings include visual responses that explore the personal counter-reaction towards duplicity that I argue is rife within social constructions of the feminine gender in both the Western and Eastern cultures. The illustration techniques in this research will provide more in-depth representations of the multifarious feminine characteristics. The study concludes that the sense of gender inequality still exists in contemporary society and only acceptance of this fact can resolve the issue.</p>

Are We There Yet?

<p>This research will address American gender theorist Butler's assertion of third wave feminism and gender ethics and advocate that despite education and modernization, a duplicity still exists in the way gender has been depicted in western culture as well as in indigenous culture. This investigation seeks to acknowledge this duplicity by performing a comparative study of the western superhero Wonder Woman and the indigenous Indian Goddess Durga. Ultimately, this study challenges the contemporary terminologies and the interpretations concerning gender roles within the society to show the duplicity inherent in these contrasting renditions. Through a theoretical and practical framework and with the help of academic works and social media, the study conveys more visually empathetic ways to define the feminine gender as being powerful and multifaceted. These investigations will include traditional and contemporary examples of visual illustrations that contain their own social and cultural narratives and offer visual evidence of the perceptions and preconceptions that Butler refers to in her ‘Undoing Gender’ as “social and sexual constraints” (Butler, 2004, p. 10-15). The findings include visual responses that explore the personal counter-reaction towards duplicity that I argue is rife within social constructions of the feminine gender in both the Western and Eastern cultures. The illustration techniques in this research will provide more in-depth representations of the multifarious feminine characteristics. The study concludes that the sense of gender inequality still exists in contemporary society and only acceptance of this fact can resolve the issue.</p>