INVESTIGATIONS AND DIAGNOSIS OF GIANT PERIURETHRAL CONDYLOMA AND EFFICACY OF THE MANAGEMENT WITH CONVENTIONAL APPROACH: A CASE REPORT

Objective: This study aims to show our first case of female with periurethral condyloma and how we managed it. Case(s) Presentation: A 40-year-old female came with asymptomatic lesion in the genital area for 4 months, without any history of promiscuity. The physical examination showed a mass of 5 x 5 cm located in the periurethral area. The patient underwent mass excisions without any complication, further pathological examination confirmed the diagnosis of CA. Discussion: After operation and discharge there are no sign of recurrence after 6 months follow up. Conclusion: Despite the rare occurrence in periurethral region, clinicians should be aware of CA case in female and for our first case we used mass excision with satisfactory result.

Genital and Oral Microbiome and Behçet’s Disease Activity

BackgroundThe aetiopathogeneses of Behçet’s Disease (BD) remains elusive with multifactorial genetic and epigenetic factors resulting in multisystemic disease. Oral and genital ulceration are common and influences disease outcome. We hypothesised that dysregulation of genital and oral microbial communities contributes to BD disease activity. 153 BD patients’ samples, 70 matched oral and genital (Female: Male, 58:12; mean age, 42±13.9: 39.3±10.3), 12 unmatched samples; 16s rRNA sequencing utilised and V1/V2 and V3/V4 regions analysed. BD outcomes: oral and genital ulcer severity and BD activity scores, Psychological and Social Well-being scales, Headache Impact Test-6 (HIT-6) were included. All the analyses were performed with R software. ResultsThe alpha and beta diversity had anatomical specificity, with significant differences between genital and oral samples; p values<0.05 irrespective of presence or absence of ulcers. Interestingly, in the genital area Bacteroidota were present (G_U: 29% - 10%) and (G_nU: 27% - 14%) compared to less than 1% oral area of V1/V2 and V3/V4. Proteobacteria were uniquely present with (O_U: 9%) and (O_nU: 12%) in oral, and less than 0.01% in genital area for V3/V4 region. Gender anatomical specific communities were noted: females with genital ulcers Gardnerella, Lactobacillus, Atopobium were significantly increased compared to than males, with V3/V4 analysis indicating that Lactobacillus and Gardnerella were significantly increased by 20 times in females than males (p-adj <0.05). In contrast Peptoniphilus and Corynebacterium were significantly increased in males than females. Streptococcus was significantly increased with oral ulceration, while Veillonella was significantly decreased in patients without oral ulceration. Colchicine had a significant effect on the bacterial abundance irrespective of the presence or absence of ulceration. In this cohort, the WSAS (Work and Social Adjustment Scale) values were higher in active disease. ConclusionOur results suggest that dysregulated microbial communities occur in BD. V1/V2 demonstrates that during episodes of ulceration the pathogenic bacteria genus Escherichia-Shigella appear in both oral and genital ulcers. V3/V4 outcomes show that ulceration in both regions is assigned to genus; Lachnospiraceae, Saccharimonidales, Coriobacteriales. Streptococcus is related to the presence of oral ulcers, while Veillonella is presence when patients are ulcers free may be a useful marker of disease regression.

Herpes Vegetans, an atypical herpes lesion in HIV patient: a case report

Herpes vegetans is a rare form of Herpes simplex virus (HSV) infection in immunocompromised patients that clinically presents as a verrucous and hypertrophic lesion. In this case, we present a 36- year-old man with exophytic verrucous masses in the genital area that was initially suspected as a malignancy. Difficulty to properly diagnose the patient resulted in a few failed attempts at treating the lesion. After excluding other differential diagnoses, the atypical lesion proved to be caused by vegetative herpes infection due to a good response to HSV therapy. Reevaluation of biopsy also showed signs of HSV etiology. Atypical presentation of herpes simplex in immunocompromised patients still proves to be a challenge to diagnose and treat. Proper clinical identification and workup are needed to diagnose and to choose proper regiments

Uterine fold as an occupational disease in the textile industry

If we find a fairly large amount of material from both Russian and foreign authors on the influence of the profession on the female body in general, then there is still little evidence of the influence of work on the female genital area. Such an important department has not yet been sufficiently developed, meanwhile, the importance of studying this issue becomes clear if we recall at least the purpose of the sexual sphere of women to serve to maintain the human race.

Vaginal groin sarcoma in a two-year-old girl

Sch., 2.5 years old, was admitted on 12 / IX-59 with complaints of pain in the external genital area. She was born as the second child, weighing 4000.0.

Case of giant chondroma of the shoulder

Tumors reaching gigantic sizes usually belong to the group of benign neoplasms, they are found mainly in the genital area (Kedrova, etc.) and are quite rare in other areas of the body. These tumors grow slowly and in some cases, as a result of long-term growth, reach gigantic proportions. Among the huge connective tissue tumors are fibromas, lipomas, chondromas, epithelial - cystomas (Kedrova). An example of a giant chondroma that did not develop from the genital sphere is a tumor that we met at a section in 1931.

Experience of using intramuscular injections of ichthyol in acute and chronic diseases of the female genital area.

The effect of ichthyol, introduced psectually into the human body, has not yet been experimentally studied. In Russian and foreign literature, I have not found an answer to this question. Perhaps ichthyol plays the role of an activator of protoplasm, and perhaps the action of ichthyol fits into the theory of irritation of Beer. Sokolsky, Kenis and others consider the action of ichthyol as protein therapy.

To the Websïor-Baldy-Franke technique for retro-fleхio uïeri

We can confidently say at the present time that one of the diseases of the female genital area requiring surgical treatment is not replete with such a richness and variety of the proposed methods of surgical intervention as the dislocation of the uterus in the form of retroflexio. Only a year and a half ago, at a meeting of the obstetric-gynecological society in Hamburg (1/30/30), where the issue of choosing an operative method for the treatment of retroflexio uteri was debated, Grube, while demonstrating his tables in separate phases of operations, simultaneously emphasized that despite the presence of about 250 methods of surgery, yet the results of treatment are still not entirely encouraging.

Female genital mutilation remains high in Senegal: an analysis of DHS 2018

Background Female genital mutilation (FGM), also known as female genital cutting or female circumcision, threatens the health and well-being of millions of girls, women and their children across the globe. In Senegal, despite numerous health interventions, female genital mutilation is still a harmful practice. The objective of this study is to conduct a descriptive and analytical analysis of female genital mutilation practices in Senegal in 2018. Methods This study is a secondary analysis of the 2018 Senegal DHS. The analyses for this study were done on the Individual Records file. The DHS data covered 9414 women aged 15 to 49 years. A multivariate analysis was performed to consider confounding factors. The dependent variable was the existence of female genital mutilation in women. Data were analyzed with STATA 17 software. Results The prevalence of FGM was 17.18%. Women who had flesh removed from genital area represented 60.96% (1338), 29.39% (252) had genital area just nicked without removing any flesh, 6.88% (151) had genital area sown closed. Women who thought that FGM was justified by religion represented 11.52%. However, 80.59% of the women thought that it was a practice that should be stopped. The protective factors for the occurrence of FGM were women's empowerment factors (high level of education of the woman (primary ajOR=0.64 [0.50-0.83] and secondary ajOR=0.43 [0.32, 0.57]) and the fact that the head of the household is a woman ajOR (0.75 [0.59-0.97]); belonging to the central region of Senegal and the Christian religion (ajOr=0.05 [ 0.02-0.13]). The risk factors for female genital mutilation in Senegal were ethnicity and belonging to certain regions in the northeast and southeast of Senegal. Conclusions The prevalence of FGM in Senegal is still high. Ethnicity remains an important risk factor. Women's empowerment would allow the reduction of FGM. In the fight against FGM, politics should include women's autonomy strengthening like girls schooling. Key messages This study highlights the still significant extent of FGM. Women's empowerment factors would prevent these harmful traditional practices.

Recurrent Aphthous Stomatitis: Treatment and Management

Background: Recurrent aphthous stomatitis consists of the presence of abrasions or ulcerations located on mucosae (oral or genital). Objectives: The aim of this article is to review the current literature providing the main causes related to recurrent aphthous stomatitis and insights into treatment and management of this clinical condition Methods: Articles matching terms that correlated with “recurrent aphthous stomatitis” were searched on PubMed, EMBASE, and Cochrane Library and selected according to their pertinence. Results: Several forms of aphthous stomatitis have been described, based on the extent (minor, major), morphology (herpetiform), and associations to other signs (Behçet syndrome or more complex inflammatory syndromes). Topical as well as systemic treatments have been described to obtain a faster remission of the aphthosis or to reduce associated symptoms such as pain. Conclusions: Recurrent aphthous stomatitis can have a mild-to-severe clinical appearance, being mainly localized on the oral mucosa or at the level of the genital area. Different strategies have been described so far for its management and treatment.