Analysis of the first tear film break-up point in Sjögren’s syndrome and non-Sjögren’s syndrome dry eye patients

Background Tear film instability plays an important role in the course of Sjögren’s Syndrome dry eye (SSDE) even though it is generally classified as aqueous-deficient dry eye. The measurement of the first tear film break-up point (FTBUP) helps to evaluate the most unstable position of the tear film on ocular surface. We aim to investigate FTBUP in Sjögren’s Syndrome dry eye (SSDE) and non-Sjögren’s Syndrome dry eye (NSSDE) patients, and explore its correlation with dry eye indices. Methods Twenty-two SSDE patients (44 eyes) and 22 NSSDE patients (44 eyes) were enrolled in the study. Oculus Keratograph K5M was used to measure FTBUP, the first and average non-invasive keratographic breakup time (f-NIKBUT and av-NIKBUT), the tear meniscus height, and meibomian gland dropout. Other tests of tear film were also performed including Ocular Surface Dryness Index (OSDI), Schirmer I test, fluorescein break-up time and corneal fluorescein staining. Dry eye indices and the locations of the FTBUP were compared between SSDE and NSSDE patients. Generalized estimating equation (GEE) was used to ajusted the correlations between right and left eyes. The correlations between the FTBUP and ocular symptoms and signs were investigated using Pearson’s correlation coefficient test. Results The FTBUP occurred at the supranasal quadrant in 12/88 eyes, supratemporal quadrant in 8/88 eyes, inferonasal quadrant in 34/88 eyes, and inferotemporal quadrant in 34/88 eyes. The percentage eyes with inferior FTBUP was significantly higher in the SSDE than in the NSSDE subjects (86.3% vs 68.1%, P = .049). Moreover, in SSDE subjects, temporal breakup point was seen more often in those who presented corneal fluorescein staining in any location, while nasal breakup point was more frequent in those who did not present any corneal fluorescein staining (P = .045). Conclusion The location of the FTBUP in SSDE patients had specific characteristics. However, the diagnostic potential of FTBUP in early recognition of SSDE needs further validation.

Effects of auriculopalpebral nerve block on ocular parameters in dogs

The objective of this study was to compare the effects of two local anesthetics used on auriculopalpebral block on eyelid akinesia, tear production, intraocular pressure (IOP) and tear break-up time (TBUT) in conscious dogs. A blind, randomized, prospective study was conducted to determine the effects of auriculopalpebral block using ropivacaine 0.75% and bupivacaine 0.5% in 12 healthy non-brachycephalic dogs (24 eyes). Threat response and eyelid reflex tests, Schirmer tear test (STT), IOP and tear break-up time were conducted before blockage and at 30, 60, 120, 240 and 360 minutes after application. A difference was observed between the values found at 30, 60, 120 and 240 minutes compared to baseline for threat response and eyelid reflex tests in the two groups evaluated, proving eyelid akinesia after blockages. No difference was found for STT, IOP and TBUT between baseline values and post-anesthesia times or between groups. It was possible to conclude that ropivacaine and bupivacaine on auriculopalpebral block in conscious dogs promoted eyelid akinesia for at least 240 minutes, not altering ocular physiological parameters of tear production, intraocular pressure, and tear break-up time after blockages.

Utilization of continental transforms in break-up: observations, models, and a potential link to magmatism

Reactivation of continental transform faults (hereafter; transforms) is identified herein as a significant factor in continental break-up, based on a global review of divergent margins and numerical modelling. Divergent margins that have reactivated transforms are characterized by linear and abrupt terminations of thick continental crust. Transforms represent some of the largest structures on Earth, and these megastructures represent major lithospheric weaknesses and are therefore prone to reactivation upon changes in the stress field, which typically occur during plate break-up. The blunt termination of the margins is consistent with observations of very limited pre-breakup lithospheric thinning of such margins. This mode of break-up appears to occur abruptly, and contrasts notably with highly tapered and slowly extended divergent margins. Magma leakage along transforms is well-known worldwide where divergence occurs across such features. This leakage may evolve to dike injections, further reducing the plate strength. We observe that many of the blunt margins we attribute to transform reactivation have been prone to above-normal magmatism and are marked by seaward dipping reflectors underlain by high-velocity lower crustal intrusions. The magmatism may be directly related to the separation of abruptly terminated margins, whereby the large resulting lateral thermal gradients trigger edge-driven convection and melt addition.Supplementary material at https://doi.org/10.6084/m9.figshare.c.5756724

The Institutionalisation of Political Science in Post-Yugoslav States: Continuities and New Beginnings

The institutionalisation of political science in the four countries emerged after the break-up of Yugoslavia—Bosnia and Herzegovina, Croatia, Serbia, and Slovenia—has not been a uniform process. Despite the discipline’s foundation at almost the same time and in the same state, there are considerable differences among them in terms of stability and autonomy. Some of the most salient, albeit certainly not all are numbers of institutions, professors, students and study programs, development of political science fields, state funding, and hiring procedure. Our investigation on the roots of differences between them covers two periods. The first one deals with the Communist Yugoslav period, when the first institutions of political science were founded, and the discipline went through three decades of development under autocratic regime. Second period deals with the following three decades of institutionalisation, from first multi-party elections in 1990 until 2020. We finish the chapter with concluding remarks which could also be perceived as a guideline for further research in the field.

An Optimality Theory-Based Approach into the Phonotactic Constraints of English Spoken by Broadcasters in Nigeria

<p style="text-align: justify;">One of the observations in the English spoken particularly in Nigeria is phonotactic constraints. The constraints pin down the generalization which guide the articulation of sequences of phonemes. The paper examines the patterns of English consonant clusters articulation of Nigerian broadcasters in the onset and coda positions against Received Pronunciation English. The study is conducted within the framework of Optimality Theory (henceforth OT). 20 radio and television broadcasters from 4 electronic media were selected as participants. Data were obtained by means of production test and OT was employed for the analysis. The findings revealed that the participants used epenthetic vowels to break-up consonants clusters in the onset and consonant deletion to simplify clusters in the coda. The subjects’ productions can be captured by ranking Markedness constraints higher than Faithfulness constraints.</p>