Risk of colonoscopic post-polypectomy bleeding in patients on single antiplatelet therapy: systematic review with meta-analysis

Background It was not yet fully established whether the use of antiplatelet agents (APAs) is associated with an increased risk of colorectal post-polypectomy bleeding (PPB). Temporarily, discontinuation of APAs could reduce the risk of PPB, but at the same time, it could increase the risk of cardiovascular disease recurrence. This study aimed to assess the PPB risk in patients using APAs compared to patients without APAs or anticoagulant therapy who had undergone colonoscopy with polypectomy. Methods A systematic electronic search of the literature was performed using PubMed/MEDLINE, Scopus, and CENTRAL, to assess the risk of bleeding in patients who do not interrupt single antiplatelet therapy (P2Y12 inhibitors or aspirin) and undergone colonoscopy with polypectomy. Results Of 2417 identified articles, 8 articles (all of them were non-randomized studies of interventions (NRSI); no randomized controlled trials (RCT) were available on this topic) were selected for the meta-analysis, including 1620 patients on antiplatelet therapy and 13,321 controls. Uninterrupted APAs single therapy was associated with an increased risk of PPB compared to the control group (OR 2.31; CI 1.37–3.91). Patients on P2Y12i single therapy had a higher risk of both immediate (OR 4.43; CI 1.40–14.00) and delayed PPB (OR 10.80; CI 4.63–25.16) compared to the control group, while patients on aspirin single therapy may have a little to no difference increase in the number of both immediate and delayed PPB events. Conclusions Uninterrupted single antiplatelet therapy may increase the risk of PPB, but the evidence is very uncertain. The risk may be higher in delayed PPB. However, in deciding to discontinue APAs before colonoscopy with polypectomy, the potential higher risk of major adverse cardiovascular events should always be assessed.

Is Antibiotic Prophylaxis Necessary before Dental Implant Procedures in Patients with Orthopaedic Prostheses? A Systematic Review

As the population ages, more and more patients with orthopaedic prostheses (OPs) require dental implant treatment. Surveys of dentists and orthopaedic surgeons show that prophylactic antibiotics (PAs) are routinely prescribed with a very high frequency in patients with OPs who are about to undergo dental procedures. The present study aims to determine the need to prescribe prophylactic antibiotic therapy in patients with OPs treated with dental implants to promote their responsible use and reduce the risk of antimicrobial resistance. An electronic search of the MEDLINE database (via PubMed), Web of Science, LILACS, Google Scholar, and OpenGrey was carried out. The criteria used were those described by the PRISMA® Statement. No study investigated the need to prescribe PAs in patients with OPs, so four studies were included on the risk of infections of OPs after dental treatments with varying degrees of invasiveness. There is no evidence to suggest a relationship between dental implant surgeries and an increased risk of OP infection; therefore, PAs in these patients are not justified. However, the recommended doses of PAs in dental implant procedures in healthy patients are the same as those recommended to avoid infections of OPs.

relevance of the message of the Qur'an to the goals of national education

Indonesia has a Muslim majority population and has two sources of education that both improve the quality of its citizens' educational resources. The author believes that the two sources, namely the Koran and the national education law, have strong relevance. To prove this assumption, we have conducted a series of studies of educational literature on many literature data published in various educational journals, both national and international. We found the data source through an electronic search on many journals, books, and websites that actively discuss religious and national education issues. After the collection of literature, we further examined the data evaluation system involved in the coding of conclusions drawn after high interpretation to obtain data that answered questions validly and reliably. Based on the data and discussion, we find a high relevance between the messages in the Koran and the goals of national education in Indonesia. It is hoped that this finding will become an essential input for improving educational science that links religious messages and national education.

Inflammatory Odontogenic Cysts

Cystic conditions of the jaw cause bony destruction and may cause resorption or displacement of adjacent teeth. Odontogenic cysts have developmental or inflammatory origins. To describe in detail the inflammatory odontogenic cysts, a manual search was done in hard copy books of oral and maxillofacial pathology, and an electronic search was done in the google website, oral and maxillofacial pathology E-books, PubMed, Research Gate, Academia, and Google scholar using the keywords "odontogenic cysts," "classification of the odontogenic cysts," "radicular cyst," "periapical cyst," "lateral inflammatory cyst," "residual cyst," "paradental cyst," "collateral inflammatory cyst," "treatment of inflammatory odontogenic cysts," and matching each odontogenic inflammatory cyst subtype with these words "gross description," "pathogenesis," "microscopical," clinical," "radiographical" appearance. Articles published till February 2021 were included in this review. In conclusion, an accurate diagnosis of an inflammatory odontogenic cyst requires information relative to its clinical, radiographical, macro- and microscopical findings. In many instances, two cysts that are classified differently may exhibit similar histopathological features. In such cases, clinical and radiographic findings are necessary to make a precise diagnosis.

Coriandrum sativum L.: A Review on Ethnopharmacology, Phytochemistry, and Cardiovascular Benefits

Coriandrum sativum (C. sativum), belonging to the Apiaceae (Umbelliferae) family, is widely recognized for its uses in culinary and traditional medicine. C. sativum contains various phytochemicals such as polyphenols, vitamins, and many phytosterols, which account for its properties including anticancer, anti-inflammatory, antidiabetic, and analgesic effects. The cardiovascular benefits of C. sativum have not been summarized before, hence this review aims to further evaluate and discuss its effectiveness in cardiovascular diseases, according to the recent literature. An electronic search for literature was carried out using the following databases: PubMed, Scopus, Google Scholar, preprint platforms, and the Cochrane Database of Systematic Reviews. Articles were gathered from the inception of the database until August 2021. Moreover, the traditional uses and phytochemistry of coriander were surveyed in the original resources and summarized. As a result, most of the studies that cover cardiovascular benefits and fulfilled the eligibility criteria were in vivo, while only a few were in vitro and clinical studies. In conclusion, C. sativum can be deemed a functional food due to its wide range of cardiovascular benefits such as antihypertensive, anti-atherogenic, antiarrhythmic, hypolipidemic as well as cardioprotective effects.

Neutralizing potency of COVID-19 vaccines against the SARS-CoV-2 Omicron (B.1.1.529) variant

Background: We carried out a literature search for summarizing currently published evidence on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron (B.1.1.529) variant neutralizing properties of serum or plasma collected from recipients of coronavirus disease 2019 (COVID-19) vaccines.Methods: An electronic search was conducted in Medline and Scopus, using the keywords “vaccine” AND “Omicron” OR “B.1.1.529” AND “SARS-CoV-2” AND “neutralization” OR “antibodies”, with no language or date limits (i.e., up to December 27, 2021). Studies with complete information on neutralization properties of COVID-19 vaccines against the Omicron variant, with or without the adjunctive effects of booster vaccine doses, were included.Results: Our final analysis included 10 published studies. In all, decreased neutralisation of SARS-CoV-2 Omicron B.1.1.529 variant was evidenced in post-vaccination samples, ranging between -4.3 folds to absence of neutralization compared to an ancestral SARS-CoV-2 strain. In all studies the COVID-19 vaccine booster dose was effective to elicit sustained enhancement of SARS-CoV-2 Omicron B.1.1.529 neutralisation, with such increase being comprised between 10-42 folds compared to the pre-booster period.Conclusion: Vaccine boosters seem strongly advisable for limiting the risk of SARS-CoV-2 Omicron (B.1.1.529) breakthrough infections.

The Relationship between Best Practices of Human Resource Management and the Operational Effectiveness of MSMEs

All businesses have the main objective, namely to gain profit and be sustainable. To achieve this, the role of good human resources (HR) practices is significant. How are the relationships and dependencies of the two variables? We have collected many international publications that discuss MSMEs and HR best practice governance issues in many contexts. We get data from an electronic search for the Google Scholar application. Next, we continue the analysis process by starting with a coding system, in-depth interpretation, critical evaluation, and final summary as the findings data on the analysis questions are valid and consistent. Based on existing data, we conclude a very close relationship between governance and HR best practices towards achieving the operational effectiveness of MSMEs to achieve profit and sustainability.

Preventive Antibiotic Therapy in the Placement of Immediate Implants: A Systematic Review

Immediate implants present a high risk of early failure. To avoid this, preventive antibiotics (PAs) are prescribed; however, their inappropriate administration leads to antimicrobial resistance. The present study aims to clarify whether the prescription of PAs reduces the rate of early failure of immediate implants and to establish guidelines to avoid the overprescription of these drugs. An electronic search of the MEDLINE database (via PubMed), Web of Science, Scopus, LILACS and OpenGrey was carried out. The criteria described in the PRISMA® statement were used. The search was temporarily restricted from 2010 to 2021. The risk of bias was analysed using the SIGN Methodological Assessment Checklist for Systematic Reviews and Meta-Analyses and the JBI Prevalence Critical Appraisal Tool. After searching, eight studies were included that met the established criteria. With the limitations of this study, it can be stated that antibiotic prescription in immediate implants reduces the early failure rate. Preoperative administration of 2–3 g amoxicillin one hour before surgery followed by 500 mg/8 h for five to seven days is recommended. It is considered prudent to avoid the use of clindamycin in favour of azithromycin, clarithromycin or metronidazole in penicillin allergy patients until further studies are conducted.

Affectivity and physical habits in adolescents: A systematic review

Introduction: Affectivity has a fundamental role in educational systems' training process. However, there are no updated studies that show the different socio-affective agents used in the creation of physical habits in the child and adolescent population in school systems. Objective: To review and analyze previously published research that studied the influence of affectivity on children and adolescents' physical habits in school systems. Materials and methods: A systematic review was conducted with articles published between 2010 and 2020, which connected affectivity and physical habits. The electronic search was performed through Web of Science, Scopus, and Scielo databases. All articles that studied the influence of affectivity on the population's physical habits were included. Results: Three studies that analyzed the influence of affectivity on children and adolescents' physical habits were found. Conclusions: At the end of the systematic review, it was demonstrated that there is a significant relationship between affectivity and the physical habits in child and adolescent populations. It was also possible to observe that this influence, positive or negative, determines the child and adolescent population's interest in physical activity and sports in adult life.

Dental Implants Inserted in Fresh Extraction Sockets versus Healed Sites: A Systematic Review and Meta-Analysis

The present review aimed to evaluate the difference of dental implant failure rates and marginal bone loss (MBL) between implants inserted in fresh extraction sockets or healed sites. Electronic search was undertaken in three databases, plus manual search of journals, including studies randomized or not. Meta-analyses were performed besides meta-regressions, in order to verify how the odds ratio (OR) and MBL were associated with follow-up time. The review included 163 publications. Altogether, there were 17,278 and 38,738 implants placed in fresh extraction sockets and healed sites, respectively. Pairwise meta-analyses showed that implants in sockets had a higher failure risk in comparison to healed sites: OR 1.349, all studies included; OR 2.070, only prospective non-RCTs; OR 2.487, only RCTs (all p < 0.001). The difference in implant failure between the groups was statistically significant in the maxilla (OR 1.616, p = 0.029), but not in the mandible (OR 2.192, p = 0.075). The MBL mean difference (MD) between the groups was −0.053 mm (p = 0.089). There was an estimated decrease of 0.003 in OR (p = 0.284) and an increase of 0.006 mm (p = 0.036) in the MBL MD between groups for every additional month of follow-up. In conclusion, implants placed in fresh extraction sockets present higher risk of failure than implants placed in healed sites.