The purpose of the work is to study the problems of territorial and economic development within the confines of regulated activation of urbanization processes in the Republic of Kazakhstan. To achieve it, authors analysed the statistical data on such indicators as population density, administrative-territorial division, according to which significant disproportions of territorial and economic development and settlement in the republic, the development of the regions of Kazakhstan were revealed. The authors studied the main provisions of regional policy, considered the main directions of state management of the formation of centers of urbanization with the decisive role of cities with a population of millions people in the optimization of regional economic systems. Research on this topic allowed the authors to conclude that the process of urbanization in Kazakhstan has a dynamic character and has not yet exhausted its potential, which gives reason to conclude that it is necessary to form new centers of urbanization and agglomerations. The article examines the main trends of the urbanization process at the present stage, namely, in economically developed countries, where urbanization has reached a sufficiently high level, the share of the urban population is growing at a slower pace, whereas in developing countries the urbanization process continues to grow in breadth and has a spontaneous, uncontrollable character. At the same time, the growth of population in cities far outstrips their economic development. Materials and research methods. When studying the territorial and economic features of urbanization in Kazakhstan, a complex of the following research methods were used: monographic, program-targeted, statistical analysis. In this work also used such theoretical research methods as comparisons and generalizations, scientific abstraction and synthesis.