Into the second decade

Open Biology is 10 years old and we have much to celebrate. Open Biology launched as the Royal Society's first fully online, open access journal dedicated to cell and molecular biology. The underlying principle of Open Biology is to enable discoveries to be quickly and easily disseminated through the community, and in this vein in the first 10 years of the journal we have introduced format-free submission, mandated open peer review where the reviews and author responses are published with the paper, and established our enthusiastic Preprint Team under the guidance of Prof. Michael Ginger. Credit for most of this success is due to the guiding hand of David Glover, our founding editor, and the team at Royal Society Publishing.

Poetizing Everyday Life in the Works by Wilhelm Genazino

Increased interest in everyday life and routine explains a new and relevant perception of the creative agenda of contemporary German writer Wilhelm Genazino (1943-2018), known as “poetizing everyday life”. The article, thus, aims to offer a comprehensive view into the poetics of the German novelist to identify ways in which everyday life is poetized, which is an example of linguistic mastery, narrative skill, and philosophical generalization. A close reading method is used to analyze specific scenes from the novels (An Umbrella for One Day, Happiness in Unhappy Times, The Foolishness of Love, If We Were Animals), in which the characters actively practice the “extended gaze”, theoretically validated in W. Genazino’s essay, to reveal a system of special ties important to their inner world behind the routine situations and worn clothes. The writer believes that in such a way, characters experience an epiphany, which provokes further musing about art and the mystery of everyday life. In this connection, it is established that Genazino’s characters manage to avoid the negative influences of society by distancing from it via self-invented aesthetic processes. They are constantly searching for individual vision. It is also noted that the writer focuses on prolonged disappearance scenes, works with time accumulated in objects, and projects distancing from one’s own self to clothes. The extended gaze which the protagonists use to watch their own portrayals helps them overcome identity crisis and generate art, which promises salvation, through simple observance. It is concluded that W. Genazino talks about the aesthetic link between the subject and object perceived as individual “cultural significance”. It enables the protagonists to discard the routine and enter a space outside the limits they have themselves created. Everyday objects and familiar situations have the capacity to stimulate memories and boost creative perception. Their fleeting nature provides for compensatory narration, which means dropping the inessential and petty and is, consequently, perceived as a productive narration. Everyday reality emerges as something that may be perceived as visible existence, which upon some consideration may reveal unique dimensions and gain particular significance based on intermediary space between what is perceived by the eye and the invisible, actualized by the inner vision. Such reflexive vision transcends the limits of things, transforming them and constituting new reality. Such is the underlying principle that the writer used to recreate everyday life in his works.

PERKEMBANGAN ILMU SYARAH HADITH: SUATU TELAAH RINGKAS

This paper discusses the development of science of hadith commentary since early century of Hijrah. It traces its historical development and instrumental role in expanding the dynamic understanding of hadith and its science. The paper attempts to illustrate the principle and discipline of usul al-sharh as set forth in the major works of hadith commentary underlying its principle, context and method. The discussion focusses on the method and approaches (ittijahat al-sharh) of traditionalist in interpreting and commenting the texts. The study is based on qualitative method in the form of library research, focusing on content analysis. The sources of documentation was primarily derived from traditional and classical works of hadith and contemporary references that provide extensive analysis of hadith commentary. The study found that the science of hadith commentary was originated in the classical and medieval hadith works that extensively articulated its rigorous and underlying principle. This tradition was continued in modern context in the highly authoritative works of hadith commentary that brought forth modern and contextual approaches in analyzing hadith texts.

Conclusion

This chapter returns to the theme of unity. It explains how the book has revealed what is common to a diverse range of reasons—practical and epistemic, objective and subjective, possessed and unpossessed, for and against—while also revealing how they differ and how they relate to a range of overall verdicts. It also explains how the book has introduced a plurality of norms for belief that are nonetheless unified by an underlying principle. The chapter concludes by indicating two avenues for further research. One concerns norms governing combinations of attitudes rather than individual attitudes. The other concerns norms governing feeling, rather than belief and action.

The Range of Reasons

This book contributes to two debates and it does so by bringing them together. The first is a debate in metaethics concerning normative reasons, the considerations that serve to justify a person’s actions and attitudes. The second is a debate in epistemology concerning the norms for belief, the standards that govern a person’s beliefs and by reference to which they are assessed. The book starts by developing and defending a new theory of reasons for action, that is, of practical reasons. The theory belongs to a family that analyses reasons by appeal to the normative notion of rightness (fittingness, correctness); it is distinctive in making central appeal to modal notions, specifically, that of a nearby possible world. The result is a comprehensive framework that captures what is common to and distinctive of reasons of various kinds: justifying and demanding; for and against, possessed and unpossessed; objective and subjective. The framework is then generalized to reasons for belief, that is, to epistemic reasons, and combined with a substantive, first-order commitment, namely, that truth is the sole right-maker for belief. The upshot is an account of the various norms governing belief, including knowledge and rationality, and the relations among them. According to it, the standards to which belief is subject are various, but they are unified by an underlying principle.

PERSPECTIVE INSIGHT AND APPLICATION OF IN-SILICO TOOL AS VIRTUAL SCREENING METHOD FOR LEAD DESIGNING AND DEVELOPMENT

Humans are now in a bioinformatics and chemo informatics century, where we can foresee data across domains like as healthcare, the environmental, technology, and public health. The use of information sharing in silico methodologies has impacted sickness administration by predicting the absorption, distribution, metabolism, excretion, and toxicity (ADMET) patterns of synthetic compounds and efficient and environmentally succeeding pharmaceuticals upfront. The purpose of lead discovery and design is to create the appearance of novel drug candidates that can attach to a specific illness cause. The lead investigative process starts with the recognition of the lead structure, which is followed by the synthesis of its analogs and their estimation in order to produce a candidate for lead improvement. The finding of the proper lead exact is the fundamental and primary worked in the traditional lead discovery progression, and the use of computer (in silico) approaches is widely used in lead innovation. A medicinal chemist's passion for building lead structure is piqued by biomolecules, which are often made up of DNA, RNA, and proteins (such as enzymes, receptors, transporters, and ion channels). The underlying principle of such nuts and bolts is noteworthy to be acquainted with their pharmacological implication to the disease under examination. The motive of this review piece of writing is to emphasize several of the in silico methods that are used in lead discovery and to express the applications of these computational methods.

Harnessing Energy from Everyday Life

Renewable energy will drive the future. The applications of mobile phone is no longer limited to communication between each other but can also be used on an everyday basis starting from grocery shopping to watching series for entertainment. Thus our mobile phones require constant charging of power. It is almost impossible to increase the mAh capacity of the battery indefinitely; therefore the need of a battery re-charging source is inevitable. The objective of this research work is to design a sustainable, portable charger in which power is generated with the help of piezoelectric sensors embedded into the shoes of an individual. The underlying principle is to transduce the pressure applied on the piezoelectric sensors to power. This power can be used to charge mobile phones using a USB cable at any convenient time. The light weight compatibility of the device makes it easily portable. In the proposed system, a grid of piezoelectric sensors of suitable size is incorporated in the shoes and an Android application is developed to monitor the power generated as well as to suggest the optimal walking pace for the user to increase power generation. The key highlight of this prototype is that it is user friendly and is paired with an Android application to facilitate maximum power generation.

Mission of the military chaplain on the battlefield and the Orthodox ethics during the World War I (on the example of Orenburg and Siberian Cossack troops

Military clergy was one of the core translators of military norms and regulations in the Russian army during the early XX century. The goal of this article is to examine the concepts of Orthodox culture within the ethics of war of the military chaplains. Leaning on the memoirs of A. Turundaevsky and archival documents of the Orenburg and Siberian Cossack troops, the article reconstructs the mission of the military chaplain on the battlefield, analyzes the structure of concepts of Orthodox ethics therein. The study of the structure of the elements of Orthodox ethics in the mission of the military chaplain reveals the key ethical principles that are fundamental to military conflicts, when one of the parties grounds its military regulations on the Orthodox culture. It is determined that in the conditions of new requirements established for military clergy during the World War I (1914–1918), there were instances that the norms of the Orthodox ethics contradicted the mission of the chaplain on the battlefield. The acquired results reveal that the underlying principle of the mission of military chaplain, as the representative of the “militant church”, on the battlefield was “love for one's neighbor”. The understanding of Russia as the center of Orthodox culture and the perception of soldiers as “warriors of the church” prompted the clergy to implement the concept of “meekness” in their actions, as well as the concepts of “recumbence”, “Divine Providence”, etc. for comprehension of their actions.

Modified Embedded-Atom Interatomic Potential Parameters of the Ti–Cr Binary and Ti–Cr–N Ternary Systems

The second nearest-neighbor modified embedded-atom method (2NN MEAM) potential parameters of the Ti–Cr binary and Ti–Cr–N ternary systems are optimized in accordance with the 2NN MEAM method. The novel constructed potential parameters can well reproduce the multiple fundamental physical characteristics of binary and ternary systems and reasonably agree with the first-principles calculation or experimental data. Thus, the newly constructed 2NN MEAM potential parameters can be used for atomic simulations to determine the underlying principle of the hardness enhancement of TiN/CrN multilayered coatings.

Living Together as Neighbours: Rethinking the Reasonableness Standard in Nuisance Law Under the Constitution

The Covid-19 pandemic, with its concomitant "stay at home" catchphrase, has certainly made living together as neighbours in a constitutional dispensation more tangible. Conflicts between neighbours will inevitably increase, especially in a time when citizens from different social, cultural, customary or religious backgrounds and with different rights and interests are restricted to the boundaries of their properties as a result of the Covid-19 pandemic. The pandemic has provided us with the impetus to reflect upon the notion of "reasonableness" in neighbour law, particularly nuisance law in the narrow sense. In this context the role of neighbour law is ordinarily to regulate the relationship between neighbours. Therefore, neighbour law is crucial in that it resolves conflicts that arise between neighbours due to their everyday use of their properties. Whether the nuisance is objectively reasonable or goes beyond that which can be reasonably tolerable under the circumstances requires weighing up various factors dependant on the prevailing circumstances, rights, interests, values and obligations of the neighbours and the community. In the constitutional dispensation, based on the values of human dignity, equality, and freedom, this may inadvertently require courts to balance out and reconcile often opposing constitutional rights. To this end the underlying principle of nuisance law encapsulated in the phrases "give and take" and "live and let live" arguably already encapsulates the notion of balancing respective rights (constitutional or otherwise) and interests given the context of each case. However, courts do not always correctly apply the reasonableness test in a principled and coherent fashion, as illustrated in Ellaurie v Madrasah Taleemuddeen Islamic Institute 2021 2 SA 163 (KZD). This may lead to the conclusion that constitutional rights are ignored when the reasonableness test for nuisance law is applied. It is necessary to reconceptualise the reasonableness test in order to ensure that the common law is infused with constitutional values. There are numerous ways in which the ideals and values of the Constitution of the Republic of South Africa, 1996 (and even specific constitutional rights other than property rights) could be advanced if courts were more willing (not being held back by conservatism) and able (equipped with the necessary vocabulary) to apply the common law in line with the Constitution. It is pivotal that courts apply the reasonableness test correctly, considering all the relevant circumstances of the case, including the broader constitutional values and ideals such as ubuntu. It is arguable that if this were done, nuisance law would have a greater potential to incorporate a wider range of rights, interests and values so that the outcomes would be fairer and more equitable, which is, after all, the goal of the reasonableness standard in neighbour law.